Otay Mesa Vacations from $438
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The Latest Otay Mesa Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel
Downtown San Diego
Price was $1,592, price is now $632 per person
$632
per person
Aug 30 - Sep 5
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
8.6/10 Excellent! (2,251 reviews)
The ac could be better I had it set in 69 and the room didn’t feel like it
Reviewed on Jun 21, 2026
Los Bungalows
Save 100% on your flight
Price was $1,065, price is now $609 per person
$609
per person
Jul 30 - Aug 4
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
8.2/10 Very Good! (537 reviews)
Honestly one of the best hotels I’ve stayed in the views the vibes overall very very peaceful place loved it
Reviewed on Jun 7, 2026
Shore House at The Del, LXR Hotels & Resorts
Historic Downtown Coronado
Save 100% on your flight
Price was $2,562, price is now $1,493 per person
$1,493
per person
Sep 10 - Sep 15
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.2/10 Wonderful! (159 reviews)
One of my best vacations! This is definitely a must visit property again and again!
Reviewed on Jun 15, 2026
Guesthouse Hotel at La Valle
Save 100% on your flight
Price was $1,214, price is now $718 per person
$718
per person
Aug 30 - Sep 4
found 23 hours ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
9.2/10 Wonderful! (132 reviews)
What an odd experience; being a guest at an exclusive “country club”.
The staff were kind and helpful but it felt strange to be where everyone knows each other and you are staying in the guest quarters .
Reviewed on Jun 22, 2026
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego
4 out of top 10 points of interest in this area
4.5/5(8,598 area reviews)
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
$145 nightly
The price is $165 total per night from Jul 5 to Jul 6
$165 total
Jul 5 - Jul 6
Total with taxes and fees
8.2/10 Very Good! (1,760 reviews)
"My stay at Holiday Inn Express was excellent from start to finish. The staff was one of the highlights of the experience; everyone I interacted with was friendly, welcoming, and genuinely helpful. From check-in to check-out, they made sure everything went smoothly and were always available when I ..."
Reviewed on Jun 22, 2026
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
$316 nightly
The price is $366 total per night from Jun 25 to Jun 26
$366 total
Jun 25 - Jun 26
Total with taxes and fees
9/10 Wonderful! (2,808 reviews)
"Manchester will always be my favorite hotel in down town SD! They take pride in the property and their customer service! We will always be a customer!"
Reviewed on Jun 22, 2026
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
$325 nightly
The price is $374 total per night from Jun 28 to Jun 29
$374 total
Jun 28 - Jun 29
Total with taxes and fees
8.8/10 Excellent! (2,657 reviews)
"We’ve stayed here for over 10+ years. Still an amazing choice for us. Please work on the landscaping. It used to look more lush."
Reviewed on Jun 21, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Otay Mesa
San Diego Zoo
4.5/5(3,637 reviews)
See nature up-close and personal at one of the country’s largest and most educational zoos.
San Diego Convention Center
4.5/5(1,324 reviews)
Whether you come for Comic-Con or a medical convention, this huge gathering place in the Marina District of San Diego will more than satisfy your needs.
Mission Bay
4.5/5(2,416 reviews)
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.
Things to do
Crossing Borders: Tijuana Day Trip from San Diego
$93
per adult
82% of travellers recommend
Stand up Paddle Board Lesson on The San Diego Bay
$25
per adult
100% of travellers recommend
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.