Otay Mesa Vacations from $318
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The Latest Otay Mesa Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Glorietta Bay Inn Coronado Island
Historic Downtown Coronado
Price was $1,210, price is now $800 per person
$800
per person
Jan 27 - Jan 31
found 20 hours ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
8.6/10 Excellent! (1,005 reviews)
the basic room wasn't fancy, but the property on the whole was very nice. Great location.
Reviewed on Oct 30, 2026
Pantai Inn
Village of La Jolla
Price was $1,532, price is now $1,019 per person
$1,019
per person
Jan 6 - Jan 10
found 1 hour ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
9.4/10 Exceptional! (1,002 reviews)
In sum, perfectly located boutique hotel with friendly staff, but very overpriced and far from a 5-star stay, as advertised.
Pros:
- Location is top-tier!
- rooftop terrace and outdoor seating areas were great
- Friendly staff
- breakfast was varied each day and coffee and cookies were available in the afternoons, which was a nice touch
To take into consideration:
-outdated and would benefit from a furniture refresh
- smaller rooms have no tables, so not ideal if you have to work
- be aware that fridges are turned off and need to be manually turned on
- very noisy and lack of privacy on ground-level rooms
- there was an ant problem during my stay, which is not expected with 450$+/night rates. I received no response when reaching out for compensation
Reviewed on Nov 4, 2026
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego
3 out of top 10 points of interest in this area
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Otay Mesa Hotel Deals
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct San Diego CA
Fully refundable
$130 nightly
The price is $148 total per night from Dec 6 to Dec 7
$148 total
Dec 6 - Dec 7
Total with taxes and fees
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
Fully refundableReserve now, pay when you stay
$170 nightly
The price is $197 total per night from Nov 22 to Nov 23
$197 total
Nov 22 - Nov 23
Total with taxes and fees
8.4/10 Very Good! (6,357 reviews)
"Nice easy to get to port for cruise, good food"
Reviewed on Nov 5, 2026
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
$189 nightly
The price is $219 total per night from Dec 6 to Dec 7
$219 total
Dec 6 - Dec 7
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
From Tijuana: Valle de Guadalupe Shared Winery Tour
$78
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- Kaiser Permanente Otay Mesa Medical Offices
- Balboa Park Carousel
- Ski Beach
- Seaport Village
- San Diego Yacht Club
- Presidio Park
- A National Salute to Bob Hope & the Military
- San Diego Automotive Museum
- Casa de Estudillo
- Coronado Beach
- Our Lady of the Rosary Catholic Church
- Chula Vista Elite Athlete Training Center
- Mccoy Museum House
- San Diego-Coronado Bridge
- San Diego Hall of Champions Sports Museum
- Adams Avenue Park
- Glorietta Bay Park Beach
- Casa de Balboa
- San Diego Opera
- Coronado Shopping Plaza Shopping Center
- Point Loma Nazarene University
- San Diego Natural History Museum
- Botanical Building
- Timken Museum of Art
- The Rady Shell at Jacobs Park
- Firehouse Museum
- Old Town San Diego Vacations
- Mission Valley Vacations
- Eastlake Country Club
- Marston House
- Alcazar Garden
- New Children's Museum
- Heritage Park
- Museum of Us
- Casa del Rey Moro African Museum
- Coronado Municipal Golf Course
- Mission Beach Vacations
- Black's Beach
- Mission Beach Boardwalk
- Humphreys Concerts by the Bay
- Rock Church
- San Diego Chinese Historical Museum
- Waterfront Park
- Bayshore Bikeway
- Fashion Valley Mall
- Red Spade Theater
- San Diego Vacations
- Mission Basilica San Diego de Alcala
- The Coronado Playhouse
- San Diego Mormon Temple
- North Park Vacations
- Port of San Diego
- San Ysidro Vacations
- American Plaza
- San Diego County Vacations
- Hotel Circle
- Balboa Stadium
- Lyceum Theatre
- San Diego Museum of Art
- Harbor Island Vacations
- Gaslamp Quarter Vacations
- Women's Museum
- Las Americas Premium Outlets
- House of Pacific Relations International Cottages
- Bahia Point Beach
- Clairemont Village Shopping Center
- San Ysidro Border Crossing
- San Diego City College
- Mission Valley Mall
- Kate Sessions Memorial Park
- Centennial Park
- Balboa Park
- Sky Zone San Diego Indoor Trampoline Park
- San Diego Zoo
- Uss Midway Museum
- North Island Credit Union Amphitheatre
- University of San Diego
- White Water Canyon
- Little Italy Vacations
- Star of India
- Sharp Chula Vista Medical Center
- Point Loma Vacations
- Museum of Photographic Arts
- B Street Cruise Ship Terminal
- Downtown San Diego Vacations
- Chula Vista Vacations
- Amsd Concerts
- Naval Base San Diego
- Pechanga Arena
- Len Moore Skate Park
- Desert Garden
- The Promenade at Pacific Beach
- Copley Symphony Hall
- Inez Grant Parker Memorial Rose Garden
- Ocean Beach Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.