Otay Mesa Vacations from $618
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The Latest Otay Mesa Vacation Packages
Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at The Welk, San Diego Area
Lawrence Welk Resort Village
$666
per person
Nov 25 - Nov 29
found 1 day ago
Roundtrip flight included
Dallas (DFW) to San Diego (SAN)
8.6/10 Excellent! (2,060 reviews)
Family trip kids enjoy we had a wonderful time
Reviewed on Sep 20, 2026
Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego
3 out of top 10 points of interest in this area
Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.
Pacific Beach
Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.
Mission Beach
Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.
Gaslamp Quarter
Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.
Mission Bay
1 out of top 10 points of interest in this area
If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.
Otay Mesa Hotel Deals
Handlery Hotel
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
$111 nightly
$128 total
Sep 21 - Sep 22
Total with taxes and fees
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
$85 nightly
$97 total
Sep 21 - Sep 22
Total with taxes and fees
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
$239 nightly
$274 total
Oct 4 - Oct 5
Total with taxes and fees
8.8/10 Excellent! (2,881 reviews)
"Our stay was great! Everything was easy to get to, and the whole family had a really good time. We will definitely be back. The only downside was the pricing. The food at the BearFoot Bar and Grill was a little expensive, and we felt the General Store was way overpriced. Other than that, we had a ..."
Reviewed on Sep 20, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Things to do
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
$40
per adult
Introduction Rosarito Day Tour from San Diego
$157
per adult
Explore a world of travel with Expedia
- Kaiser Permanente Otay Mesa Medical Offices
- Balboa Park Carousel
- Ski Beach
- Seaport Village
- San Diego Yacht Club
- Presidio Park
- A National Salute to Bob Hope & the Military
- San Diego Automotive Museum
- Casa de Estudillo
- Coronado Beach
- Our Lady of the Rosary Catholic Church
- Chula Vista Elite Athlete Training Center
- Mccoy Museum House
- San Diego-Coronado Bridge
- San Diego Hall of Champions Sports Museum
- Adams Avenue Park
- Glorietta Bay Park Beach
- Casa de Balboa
- San Diego Opera
- Coronado Shopping Plaza Shopping Center
- Point Loma Nazarene University
- San Diego Natural History Museum
- Botanical Building
- Timken Museum of Art
- The Rady Shell at Jacobs Park
- Firehouse Museum
- Old Town San Diego Vacations
- Mission Valley Vacations
- Eastlake Country Club
- Marston House
- Alcazar Garden
- New Children's Museum
- Heritage Park
- Museum of Us
- Casa del Rey Moro African Museum
- Coronado Municipal Golf Course
- Mission Beach Vacations
- Black's Beach
- Mission Beach Boardwalk
- Humphreys Concerts by the Bay
- Rock Church
- San Diego Chinese Historical Museum
- Waterfront Park
- Bayshore Bikeway
- Fashion Valley Mall
- Red Spade Theater
- San Diego Vacations
- Mission Basilica San Diego de Alcala
- The Coronado Playhouse
- San Diego Mormon Temple
- North Park Vacations
- Port of San Diego
- San Ysidro Vacations
- American Plaza
- San Diego County Vacations
- Hotel Circle
- Balboa Stadium
- Lyceum Theatre
- San Diego Museum of Art
- Harbor Island Vacations
- Gaslamp Quarter Vacations
- Women's Museum
- Las Americas Premium Outlets
- House of Pacific Relations International Cottages
- Bahia Point Beach
- Clairemont Village Shopping Center
- San Ysidro Border Crossing
- San Diego City College
- Mission Valley Mall
- Kate Sessions Memorial Park
- Centennial Park
- Balboa Park
- Sky Zone San Diego Indoor Trampoline Park
- San Diego Zoo
- Uss Midway Museum
- North Island Credit Union Amphitheatre
- University of San Diego
- White Water Canyon
- Little Italy Vacations
- Star of India
- Sharp Chula Vista Medical Center
- Point Loma Vacations
- Museum of Photographic Arts
- B Street Cruise Ship Terminal
- Downtown San Diego Vacations
- Chula Vista Vacations
- Amsd Concerts
- Naval Base San Diego
- Pechanga Arena
- Len Moore Skate Park
- Desert Garden
- The Promenade at Pacific Beach
- Copley Symphony Hall
- Inez Grant Parker Memorial Rose Garden
- Ocean Beach Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.