A calm lake with mountains in the background.

Search Guest Houses in Seneca

Check prices for these dates

Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8
In one month
Nov 20 - Nov 22
In two months
Dec 18 - Dec 20
No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

An outdoor patio area with a fire pit, seating, and string lights.

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (900 reviews)
"Great stay!"
United States
Melissa
$102 nightly
The price is $112
Nov 19 - Nov 20
Total with taxes and fees
Tru by Hilton Seneca Clemson
A hotel dining area with a long table, multiple chairs, and a bar in the background.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (762 reviews)
"Room was clean and staff was friendly and helpful."
United States
Sasha
$133 nightly
The price is $146
Oct 25 - Oct 26
Total with taxes and fees
Hampton Inn & Suites Seneca-Clemson Area
A poolside area with outdoor seating and a view of a lake and forested hills.

3. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (288 reviews)
"Excellent in every way!"
United States
Bonnie
$120 nightly
The price is $132
Nov 1 - Nov 2
Total with taxes and fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very good, (694 reviews)
"Friendly staff, comfortable bed"
United States
Michelle
$94 nightly
The price is $103
Oct 26 - Oct 27
Total with taxes and fees
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,004 reviews)
"Friendly front desk and bar staff. We had a really nice overnight stay."
United States
Sherry
$123 nightly
The price is $135
Oct 26 - Oct 27
Total with taxes and fees
Lakeside Lodge Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very good, (761 reviews)
"Clean rooms clean parking area nice staff all good"
United States
Barry
$91 nightly
The price is $99
Oct 30 - Oct 31
Total with taxes and fees
Quality Inn Seneca US-123
A modern dining area with a high ceiling, large windows, and a buffet setup.

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (789 reviews)
"Staff were nice and accommodating"
United States
Rosario
$73 nightly
The price is $80
Oct 26 - Oct 27
Total with taxes and fees
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (115 reviews)
"My wife and I enjoyed our stay here. 10/10 experience."
United States
Winston
$133 nightly
The price is $146
Oct 28 - Oct 29
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.

9. Boutique hotel in historic downtown Seneca. Room #5, two King beds.

Boutique hotel in historic downtown Seneca. Room #5, two King beds.
Downtown
9.0 out of 10, Wonderful, (22 reviews)
"Great place to stay in Seneca. Very clean, comfortable beds, great location. Will definitely stay again!"
United States
Joseph K.
$189 nightly
The price is $205
Oct 26 - Oct 27
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #5, two King beds.
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.

10. Private Room #3

Private Room #3
Downtown
9.0 out of 10, Wonderful, (20 reviews)
"Perfection. That's all that needs to be said !"
United States
Kimberly
$189 nightly
The price is $205
Oct 26 - Oct 27
Total with taxes and fees
Private Room #3
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.

11. Boutique hotel in historic downtown Seneca. Room #4, King bed.

Boutique hotel in historic downtown Seneca. Room #4, King bed.
Downtown
9.2 out of 10, Wonderful, (28 reviews)
"Great location and great price."
United States
Julie C.
$189 nightly
The price is $205
Oct 26 - Oct 27
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #4, King bed.
A hallway with a wooden floor, a large mirror, and framed pictures on the walls.

12. Boutique hotel in historic downtown Seneca. Room #6, King Bed.

Boutique hotel in historic downtown Seneca. Room #6, King Bed.
Downtown
9.0 out of 10, Wonderful, (36 reviews)
"We have stayed here several times. Another great experience!"
United States
Ali R.
$189 nightly
The price is $205
Oct 25 - Oct 26
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #6, King Bed.
A blue building with a wooden deck and two Adirondack chairs.

13. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Extremely clean and well maintained, suited our needs for a long weekend just fine. We even cooked a couple of meals. We enjoyed using the fire pit for the first campfire of the season."
United States
Rebecca J.
$199 nightly
The price is $219
Oct 26 - Oct 27
Total with taxes and fees
Cozy Clemson TIny House Cabin
A modern kitchen with a marble island, stainless steel appliances, and a dining area with a sofa and chairs.

14. Peaceful 3-bedroom home 4 miles from Clemson.

Peaceful 3-bedroom home 4 miles from Clemson.
Seneca
$259 nightly
The price is $285
Oct 26 - Oct 27
Total with taxes and fees
Peaceful 3-bedroom home 4 miles from Clemson.
A bedroom with a wooden headboard, white bedding, and a dark blue throw blanket.

15. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (16 reviews)
"Perfect pet friendly spot to enjoy a weekend getaway! Quiet campground, homey vibe, and awesome location!"
United States
Josie G.
$183 nightly
The price is $201
Oct 26 - Oct 27
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
A living room with a sofa, a coffee table, and a TV mounted on the wall.

16. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (31 reviews)
"Great place to stay. The rooms were clean and we had plenty of space. Definitely would come back!"
United States
Brandon P.
$342 nightly
The price is $376
Oct 26 - Oct 27
Total with taxes and fees
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
A modern kitchen with wooden cabinets, stainless steel appliances, granite countertops, and pendant lighting.

17. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
Seneca
2.0 out of 10, (1 review)
$411 nightly
The price is $427
Oct 27 - Oct 28
Total with taxes and fees
Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
A living room with a large tiger mural, a fireplace, a sofa, and a coffee table.

18. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (23 reviews)
"Great host! We had a great experience during our stay. "
United States
David E.
$333 nightly
The price is $366
Oct 26 - Oct 27
Total with taxes and fees
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
A modern kitchen with white cabinets, stainless steel appliances, and a granite countertop.

19. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
$333 nightly
The price is $365
Oct 26 - Oct 27
Total with taxes and fees
Renovated 3BR near Lake Keowee & Clemson
A modern kitchen with a central island, wooden cabinets, and a built-in refrigerator.

20. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (13 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
$347 nightly
The price is $382
Oct 25 - Oct 26
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson.

Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson.

10/10 Excellent
"Beautiful, spacious home, perfect location. Would definitely return."
Anonymous traveler 3-night trip
Posted 1 day ago
Lake House with Dock, Pool, and Pet Friendly. 8 Minutes from Clemson.

Find out more about Seneca

Seneca Guest Houses information

Number of reviews
4,336
Accommodation
5 Guest Houses
Lowest Price
$80
Highest Price
$427

Frequently asked questions

What is the nightly rate for a guest house in Seneca?
Rates for Seneca guest houses vary, but travelers can find great-value prices from $80 with Expedia. A range of factors can affect nightly rates, such as the location, the breakfast offering, and the range of amenities. Travelers looking for a good deal should consider looking for a midweek stay, as weekend rates at Seneca guest houses tend to be higher. Remember to also use our filters to sort prices from low to high.
What's the difference between a Seneca guest house and a B&B?
A guest house in Seneca is typically a larger establishment with more rooms, offering a more hotel-like experience, and may provide additional amenities including luxury bedding. In contrast, a B&B is usually a smaller property that focuses primarily on providing a room and breakfast. A B&B is often more personal, and breakfast is typically included as part of the stay, but other services might be more limited compared to a guest house.

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