A calm lake with mountains in the background.

Search Guest Houses in Seneca

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Check prices for these dates

Next weekend
Aug 14 - Aug 16
In two weeks
Aug 21 - Aug 23
In one month
Sep 4 - Sep 6
In two months
Oct 2 - Oct 4
No exact matches found, but these alternatives could be just right

Recommended hotels in Seneca

Terrace/patio

1. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
2.5 star property
Seneca
9.2 out of 10, Wonderful, (872 reviews)
"Room was clean staff was great breakfast was good"
United States
Jason
$98 nightly
The price is $108
Aug 30 - Aug 31
Total with taxes and fees
Tru by Hilton Seneca Clemson
Property amenity

2. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
3.0 star property
Seneca
9.4 out of 10, Exceptional, (259 reviews)
"Great view of the lake, comfortable beds great pillows"
United States
Ronald
$129 nightly
The price is $142
Aug 9 - Aug 10
Total with taxes and fees
Fairfield Inn & Suites Seneca Clemson Univ Area
Reception

3. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
2.5 star property
Seneca
9.2 out of 10, Wonderful, (733 reviews)
"Check in people were very friendly and polite!"
United States
Mabel
$119 nightly
The price is $131
Aug 20 - Aug 21
Total with taxes and fees
Hampton Inn & Suites Seneca-Clemson Area
Free daily on-the-go breakfast

4. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
2.0 star property
Seneca
6.8 out of 10, (772 reviews)
"The room was clean"
United States
John
$71 nightly
The price is $79
Aug 16 - Aug 17
Total with taxes and fees
Days Inn by Wyndham Seneca / Clemson Area
Standard Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

5. Best Western Seneca-Clemson

Best Western Seneca-Clemson
2.5 star property
Seneca
8.4 out of 10, Very Good, (681 reviews)
"Friendly staff, comfortable bed"
United States
Michelle
$101 nightly
The price is $111
Aug 16 - Aug 17
Total with taxes and fees
Best Western Seneca-Clemson
Free daily on-the-go breakfast

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
2.5 star property
Seneca
8.0 out of 10, Very Good, (741 reviews)
"Great place"
United States
Anthony
$88 nightly
The price is $96
Aug 9 - Aug 10
Total with taxes and fees
Quality Inn Seneca US-123
Aerial view

7. Lakeside Lodge Clemson

Lakeside Lodge Clemson
2.5 star property
Seneca
9.0 out of 10, Wonderful, (1,008 reviews)
"Lovely pool, yummy on site restaurant"
United States
Kathryn
$123 nightly
The price is $135
Aug 5 - Aug 6
Total with taxes and fees
Lakeside Lodge Clemson
View from property

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
2.0 star property
Seneca
9.8 out of 10, Exceptional, (93 reviews)
"Cabin very cozy, pet friendly… great place to be disconnected for a couple days!! "
United States
LUIS EDUARDO
$124 nightly
The price is $136
Sep 2 - Sep 3
Total with taxes and fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Interior

9. Boutique hotel in historic downtown Seneca. Room #5, two King beds.

Boutique hotel in historic downtown Seneca. Room #5, two King beds.
Downtown
9.4 out of 10, Exceptional, (18 reviews)
"Great place to stay in Seneca. Very clean, comfortable beds, great location. Will definitely stay again!"
United States
Joseph K.
$189 nightly
The price is $205
Aug 4 - Aug 5
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #5, two King beds.
Interior

10. Boutique hotel in historic downtown Seneca. Room #4, King bed.

Boutique hotel in historic downtown Seneca. Room #4, King bed.
Downtown
9.2 out of 10, Wonderful, (25 reviews)
"Great location option for our visit to watch the Clemson game. Room was very comfortable with restaurant downstairs and fun brew pub nearby."
United States
Melissa T.
$189 nightly
The price is $205
Aug 4 - Aug 5
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #4, King bed.
Interior

11. Private Room #3

Private Room #3
Downtown
9.2 out of 10, Wonderful, (17 reviews)
"Very clean and comfortable! Will stay again!"
United States
Joseph K.
$189 nightly
The price is $205
Aug 4 - Aug 5
Total with taxes and fees
Private Room #3
Interior

12. Boutique hotel in historic downtown Seneca. Room #6, King Bed.

Boutique hotel in historic downtown Seneca. Room #6, King Bed.
Downtown
9.0 out of 10, Wonderful, (28 reviews)
"Great room, very clean and comfortable bed!"
United States
Joseph K.
$189 nightly
The price is $205
Aug 4 - Aug 5
Total with taxes and fees
Boutique hotel in historic downtown Seneca. Room #6, King Bed.
Exterior

13. Cozy Clemson TIny House Cabin

Cozy Clemson TIny House Cabin
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Beautiful Tiny home! Quiet area where you can sit and enjoy nature, yet convenient to all of the needs you may have while escaping from the hustle & bustle of busy cities. Highly recommend for a quiet honey getaway that beats any hotel experience one could have! 10/10 "
United States
Charlotte C.
$199 nightly
The price is $219
Aug 4 - Aug 5
Total with taxes and fees
Cozy Clemson TIny House Cabin
Terrace/patio

14. Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University

Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"Beautiful home, no complaints."
United States
Brenda
$319 nightly
The price is $351
Aug 23 - Aug 24
Total with taxes and fees
Cozy Family Home in a Quiet Setting-12 Minutes from Clemson University
Smart TV, video games, table tennis

15. Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms

Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Seneca
10.0 out of 10, Exceptional, (25 reviews)
"Great place to stay. The rooms were clean and we had plenty of space. Definitely would come back!"
United States
Brandon P.
$307 nightly
The price is $338
Aug 23 - Aug 24
Total with taxes and fees
Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms
Coffee/tea maker, fridge, microwave, oven

16. Carolina Cottage Retreat-12 Minutes from Clemson University

Carolina Cottage Retreat-12 Minutes from Clemson University
Seneca
10.0 out of 10, Exceptional, (1 review)
"We were very pleased with our stay. Four bedrooms was perfect for us. The little coffee bar was an enjoyable perk!"
United States
Karen S.
$304 nightly
The price is $334
Aug 4 - Aug 5
Total with taxes and fees
Carolina Cottage Retreat-12 Minutes from Clemson University
Coffee/tea maker, fridge, microwave, oven

17. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (11 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
$320 nightly
The price is $352
Aug 17 - Aug 18
Total with taxes and fees
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
1 bedroom, WiFi, bed sheets

18. Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!

Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Seneca
10.0 out of 10, Exceptional, (14 reviews)
"Very clean and comfortable - very close to Clemson and easy access. "
United States
Jim A.
$182 nightly
The price is $200
Aug 4 - Aug 5
Total with taxes and fees
Cozy camper in Clemson Hills. 5 minutes from Clemson University. Pet friendly!
Property grounds

19. Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!

Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Seneca
9.8 out of 10, Exceptional, (65 reviews)
"We had a beautiful stay over Thanksgiving in this very cozy lake house. "
United States
Felicia L.
$480 nightly
The price is $528
Aug 27 - Aug 28
Total with taxes and fees
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson!
Outdoor dining

20. South Cove Cottage 5 bedroom

South Cove Cottage 5 bedroom
Indian Oaks
9.6 out of 10, Exceptional, (11 reviews)
"Cozy house on the lake that was perfect for our family’s visit to the Clemson area. So many beds and room to spread out with a beautiful sunrise over the lake in the morning. "
United States
Richard M.
$644 nightly
The price is $675
Aug 4 - Aug 5
Total with taxes and fees
South Cove Cottage 5 bedroom
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Seneca Hotel Reviews

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

8/10 Good
"Very friendly and helpful staff. Great location close to everything. Good breakfast. Needs microwave in rooms. System was down when we arrived and couldn't locate our reservation."
Noelia 2-night trip
Posted 17 hours ago
Tru by Hilton Seneca Clemson

Find out more about Seneca

Seneca Guest Houses information

Number of reviews
3,178
Accommodation
4 Guest Houses
Lowest Price
$79
Highest Price
$675

Frequently asked questions

What is the nightly rate for a guest house in Seneca?
Rates for Seneca guest houses vary, but travelers can find great-value prices from $79 with Expedia. A range of factors can affect nightly rates, such as the location, the breakfast offering, and the range of amenities. Travelers looking for a good deal should consider looking for a midweek stay, as weekend rates at Seneca guest houses tend to be higher. Remember to also use our filters to sort prices from low to high.
What's the difference between a Seneca guest house and a B&B?
A guest house in Seneca is typically a larger establishment with more rooms, offering a more hotel-like experience, and may provide additional amenities including luxury bedding. In contrast, a B&B is usually a smaller property that focuses primarily on providing a room and breakfast. A B&B is often more personal, and breakfast is typically included as part of the stay, but other services might be more limited compared to a guest house.

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