A calm lake with mountains in the background.

Find all hotels by Best Western in Seneca, SC from $107

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Sep 16 - Sep 17
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Sep 17 - Sep 18
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27

Our top choices for Seneca Best Western

1. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
United States
Michelle
$97 nightly
$107 total
Sep 21 - Sep 22
Total with taxes and fees
Best Western Seneca-Clemson
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Top Seneca Hotel Reviews

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

8/10 Good
"I have not stayed at a campground in decades that this stay reminded me that you are at the mercy of those around you. We had very loud people next to us on two sides (they were together) in what was otherwise an almost empty campground. The cabins are efficient but very small. It was just two adults and a dog, but you have to coordinate your movements. Kitchen allows for making a simple meal - cooktop and fridge. No coffee pot or microwave. Shower was hot and good pressure. The bunkbed very tight to move around and get up the stairs. This cabin looked pretty new and it was clean. It was just one night for us passing through the area. They provide firewood which is great. They also provide stuff for smores, two bottles of water and two oatmeal cups. Location was pretty - we watched deer come through in the morning. The Bonvoy people fully communicate booking info and are responsive to requests."
Pamela 1-night trip
Posted 7 hours ago
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

10/10 Excellent
"Awesome hotel! The staff was so nice and the hotel was so clean. Our room was great! And the breakfast was really good as well."
Allison 1-night trip
Posted 2 days ago
Fairfield Inn & Suites Seneca Clemson Univ Area
Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area

10/10 Excellent
"Friendly and convenient hotel that I keep returning to every year for business travel."
John 1-night trip
Posted 2 days ago
Hampton Inn & Suites Seneca-Clemson Area
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"Na"
William 1-night trip
Posted 2 days ago
Best Western Seneca-Clemson
Quality Inn Seneca US-123

Quality Inn Seneca US-123

8/10 Good
"Parking was difficult but manageable"
Steve 1-night trip
Posted 3 days ago
Quality Inn Seneca US-123
4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit,  Pet Friendly!

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

10/10 Excellent
"Beautiful view. Plenty of room. Deep water at dock. Well-stocked with kitchen tools/utensils."
David B. 2-night trip
Posted 5 days ago
4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!
Charming and Entertaining Lake House Retreat for Large Groups!

Charming and Entertaining Lake House Retreat for Large Groups!

10/10 Excellent
"We arrived to a clean home. Comfortable beds and stocked kitchen. The host was very accommodating and responded quickly to questions before we arrived. Everything we expected was there. I would definitely book this property again as my daughter lives in Seneca."
Michelle P. 7-night trip
Posted 8 days ago
Charming and Entertaining Lake House Retreat for Large Groups!
Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

8/10 Good
"Decent if you’re just looking for a place to sleep. Breakfast wasn’t bad, just limited options. Room was fairly clean (didn’t look like it had been mopped) . But sheets/blankets/towels were super clean!"
Hunter 2-night trip
Posted 10 days ago
Days Inn by Wyndham Seneca / Clemson Area
Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

10/10 Excellent
"We came for some much needed R and R!! This was great and very peaceful. The beds were very comfortable. The house location was private but close to amenities."
Linn M. 3-night trip
Posted 12 days ago
Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

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