COVID-19 alert: Travel requirements are changing rapidly, including need for pre-travel COVID-19 testing and quarantine on arrival.

South San Francisco Vacation Packages

Choose one or more items to build your trip:

South San Francisco Vacation: Coronavirus Information

Most South San Francisco hotels offer free cancellation. Consider booking refundable hotels rather than non-refundable ones. Just look for the ‘free cancellation’ message during your hotel search. Prices can vary, but right now we believe that flexibility matters.

For more information about the impact of COVID-19 on your South San Francisco trip, please visit our Coronavirus Information page (opens in new window).

Top South San Francisco Flight + Hotel Deals

Napa Valley Hotel & Suites
Chablis Inn
Calistoga Inn Restaurant and Brewery
Hilton Garden Inn Napa
Pullman San Francisco Bay

Top Hotels in South San Francisco

Travelodge by Wyndham San Francisco Airport North
Travelodge by Wyndham San Francisco Airport North
2 out of 5
326 S Airport Blvd, South San Francisco, CA
Free CancellationReserve now, pay when you stay
The price is $48 per night from Mar 8 to Mar 9
3/5 (2,899 reviews)

"I have stayed multiple times at this location. This last stay the first room I had, had bugs and the shower was like a locker room. The staff was great and got a new room right away. The rest of my stay was wonderful."…"

Reviewed on Feb 27, 2021

Travelodge by Wyndham San Francisco Airport North
La Quinta Inn & Suites by Wyndham San Francisco Airport N
La Quinta Inn & Suites by Wyndham San Francisco Airport N
2.5 out of 5
20 Airport Blvd, South San Francisco, CA
Free CancellationReserve now, pay when you stay
The price is $63 per night from Apr 4 to Apr 5
4/5Very Good! (2,084 reviews)

"Close to the airport and the aiport shuttle runs from 5 am."…"

Reviewed on Mar 6, 2021

La Quinta Inn & Suites by Wyndham San Francisco Airport N
Holiday Inn Express San Francisco-Airport North
Holiday Inn Express San Francisco-Airport North
2.5 out of 5
373 S Airport Blvd, South San Francisco, CA
Free Cancellation
The price is $72 per night from Mar 21 to Mar 22
4/5Very Good! (976 reviews)

"Staff very nice and helpful, and easy to find elevators and room."…"

Reviewed on Feb 27, 2021

Holiday Inn Express San Francisco-Airport North
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top things to do in South San Francisco

What are the advantages of a road trip to South San Francisco?

There’s nothing quite like a South San Francisco road trip. And Expedia makes it easy for you to turn all those road trip ideas into reality. You can find cheap deals on hotels in South San Francisco or bundle your hotels with car rentals to save even more. With our South San Francisco packages, you’ll find hitting the highway for that road trip adventure is more affordable than ever.  

How to plan a road trip to South San Francisco?

Planning a road trip can feel daunting, especially when you’ll be making multiple bookings for your itinerary. But you can find car rentals in South San Francisco and low rates on hotels all in one place— Expedia. How you plan your road trip depends on what’s important to you. People love to take road trips to experience the great outdoors, bond with friends or family and see more of the world. When planning, bundle your car rental and hotel into one discounted package to maximize savings on both. Or, leave room for spontaneity, booking what you need when you need it with our last-minute deals.  

What to do on a road trip to South San Francisco?

When taking a road trip adventure, it’s best to plan how you want to spend your time on your road trip itinerary. We don’t want you to miss out on any of the best things to do in South San Francisco. You can book all the road trip activities on your South San Francisco wishlist, and even plan activities along your route as well.  

How to rent a car for a road trip?

For an epic road trip, you'll need the perfect car. Renting a car for a road trip is the best option that doesn’t put miles or strain on your vehicle, and especially when it's also so affordable. Because when you book on Expedia, it doesn't need to be expensive. You can pick up a cheap car rental and head out to one of these incredible vacation rentals in South San Francisco. And when you bundle car rentals with hotel stays, you'll save even more on each part of your journey.

Frequently asked questions

How much does a South San Francisco vacation package cost?
Browse and book everything in one place with our South San Francisco vacation packages, which start from a low $496. Handpick the hotels and flights that match your travel style. Then, add on some enriching experiences to round off your unique adventure.
If I'm not able to travel, can I cancel my South San Francisco vacation package?
You can amend or cancel your booking, but whether or not you’ll incur a fee will depend on a few things. If you’ve booked a South San Francisco vacation package in the last 24 hours, you may be able to cancel or change your itinerary at no cost. If it’s been more than 24 hours, your hotel, airline or car rental company may impose additional charges. Browse our Customer Service Portal for further information.
How do I get a cheap travel package to South San Francisco?
By bundling. Flights, hotels and rental cars — combine whatever you need into a South San Francisco vacation package and save up to $583. Score even better deals when you include extras such as sightseeing tours to your booking. But that’s not the only impressive part. You have the freedom to tailor your vacation your way. We offer more than 550 airlines and 1,000,000 hotels across the globe, so that everyone has a chance to travel and live out those vacation dreams.
Where should I stay in South San Francisco?
There’s plenty to do in South San Francisco, so spend your nights close to its top sights and treat yourself to more time sightseeing. Sees Candies is one place to add to your itinerary.
What are the top hotels in South San Francisco?
Get your vacation off to a great start by booking a stay at Best Western Plus Grosvenor Airport Hotel. It’s one of most sought-after hotels in South San Francisco. Another top option is Travelodge by Wyndham San Francisco Airport North.
When is the best time of year to visit South San Francisco?
South San Francisco is a busy place in . If you don’t like big crowds and prefer a calmer pace, book your trip for . Need to watch your bank balance? Pick up one of the good deals on offer in . is usually when prices rise and hotel rates are at their highest.
How far in advance should I book my South San Francisco vacation?
Savvy travelers book early. Air carriers generally advertise flight tickets up to 12 months in advance, and this is your chance to land some rock-bottom prices. Boss just told you to use up all your vacation days next month? No sweat. Expedia are never short of fantastic deals to whisk you away on the getaway of your dreams, at a price you can afford.
What does an Expedia South San Francisco travel package include?
Hotels, car rentals and flights — we connect you to all the best deals. All you have to do is pick and choose your ideal combination. After you’ve made your booking, you can add on the exciting stuff like tours and experiences. Our travel packages make it simple to put together an amazing South San Francisco getaway.
What should I know before booking a South San Francisco travel package?
So many places to wander around, so many things to do. With a package, you’ll be able to cross more of them off your list. Combine your hotels, flights and rental cars and make big savings.
Does Expedia offer Book Now, Pay Later South San Francisco vacation packages?
Thanks to the partnership between Expedia and online lender Affirm, you can split the price of your travel package over multiple payments. For financial freedom, take advantage of our Book Now, Pay Later option and work out a payment arrangement that matches your circumstances.
Can I choose my airline with a South San Francisco Expedia vacation package?
You can. We offer more than 550 partner airlines globally, so choose the carrier that suits your travel preferences.