A wooden bench in a forest with a natural backdrop of trees and foliage.

Find Resorts & Hotels with Spas in Southeastern Indiana

Check availability on Southeastern Indiana Resorts & Hotels with Spas

Tonight
Oct 23 - Oct 24
Tomorrow
Oct 24 - Oct 25
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Southeastern Indiana hotels with a spa

A restaurant with round tables, chairs, chandeliers, and a bar area.
A spacious lobby with a geometric chandelier, a reception desk, and a red accent wall.
A hot tub with a pool, indoor seating area, and a view of the pool.
A large hotel with a prominent 'Caesars' sign, multiple floors, and a symmetrical facade.

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
Elizabeth
  • Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
$89 nightly
$99 total
Nov 22 - Nov 23
Total with taxes and fees
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
A cozy room with a geometric-patterned ceiling, a sofa, and a chair.
A modern bathroom with a shower, a sink, and a large mirror.
A cozy room with wooden walls, a table with a lamp, and shelves displaying books and decorative items.
A steam fountain in a brick alleyway.

2. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
$156 nightly
$184 total
Nov 22 - Nov 23
Total with taxes and fees
21c Museum Hotel Louisville
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.
A lobby with a marble floor, a reception desk, and a large chandelier.
A modern interior with a fireplace, bookshelves, and seating areas.
A modern building entrance with a glass facade, wooden ceiling, and illuminated fixtures.

3. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
  • Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
$203 nightly
$239 total
Nov 16 - Nov 17
Total with taxes and fees
Omni Louisville Hotel
A modern interior with large windows offering a city view, a circular light fixture, and leather seating.
An outdoor patio with black tables and chairs, surrounded by large windows and a row of arches.
A modern hotel room with a large window, a sofa, a red armchair, and a small table.
A nighttime view of The GALT and The Galthouse buildings with illuminated signage, a busy street with light trails from moving vehicles, and a modern urban setting.

4. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
$136 nightly
$160 total
Nov 8 - Nov 9
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham
A treatment room with a massage table, a desk with a computer, and a large mirror.
A golf course with a flag, a sand bunker, and a building in the background.
A luxurious bathroom with a large mirror, a bathtub, and a shower area.
A poolside area with lounge chairs and a towel with a monogram.

5. Belterra Casino Resort

Belterra Casino Resort
Florence
  • Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
$117 nightly
$131 total
Nov 5 - Nov 6
Total with taxes and fees
Belterra Casino Resort
A hotel lobby with a chandelier, wooden railings, a reception desk, and a large arched doorway.
An indoor swimming pool with clear water, surrounded by lounge chairs and a small seating area.
A hotel room with a bed, desk, chair, and a green accent wall.
A spacious indoor area with a staircase, a vending machine, and a business center sign.

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
Seymour
  • Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
$76 nightly
$86 total
Nov 22 - Nov 23
Total with taxes and fees
Quality Inn Seymour I-65
A rustic bar area with a wooden bar counter, stools, and a variety of bottles and glasses.
A porch with white rocking chairs and a table, a window with blinds, and a view of a green landscape.
A modern bathroom with a shower, a vanity with a sink, and a toilet. There are wooden shelves and a vase with flowers on the vanity.
A living room with a sofa, coffee table, and a television mounted on the wall.

7. Pillow and Paddock B&B

Pillow and Paddock B&B
La Grange
  • Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
$379 nightly
$417 total
Nov 23 - Nov 24
Total with taxes and fees
Pillow and Paddock B&B
View all properties

Choose what matters most at spa hotels in Southeastern Indiana

Pool
Breakfast included
Hot tub
4 stars
5 stars

Find out more about Southeastern Indiana

Top Southeastern Indiana attractions for a relaxing vacation

Southeastern Indiana offers a delightful blend of relaxation and adventure for travelers seeking spa hotel experiences. Begin your escape in the charming town of French Lick, home to the historic French Lick Resort, where luxurious spa services meet opulent surroundings. After a rejuvenating massage, explore the beautiful grounds, including the stunning gardens and nearby hiking trails. Just a short drive away, the Hoosier National Forest invites you to immerse yourself in nature, with miles of scenic trails perfect for hiking or biking, providing a refreshing contrast to your spa days. For a taste of local culture, visit the quaint town of Madison, known for its well-preserved 19th-century architecture and vibrant arts scene, where galleries and boutiques offer delightful shopping experiences. Additionally, the area boasts several wineries, like the nearby Lane's End Winery, where you can indulge in tastings that pair perfectly with your spa retreat. Traveling with family? The region also offers family-friendly activities like the Clifty Falls State Park, where you can enjoy picnics and gentle hikes while surrounded by stunning waterfalls. Staying in Southeastern Indiana means you can enjoy a pampering experience in luxurious accommodations, where attentive service ensures you feel valued and cared for throughout your stay.

Top Southeastern Indiana Hotel Reviews

Hyatt Select Louisville North

Hyatt Select Louisville North

8/10 Good
"If you have a ground level room in front, the exterior lights will make your room seem like daylight even with the room darkening shade pulled."
Brenda 1-night trip
Posted less than an hour ago
Hyatt Select Louisville North
Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

10/10 Excellent
"Nice hotel as expected like most Hampton Inns. Very satisfied with our short 1-night stay."
Wayne 1-night trip
Posted 1 day ago
Hampton Inn New Albany Louisville West
Ramada by Wyndham Sellersburg/Louisville North

Ramada by Wyndham Sellersburg/Louisville North

10/10 Excellent
"remodeled recently. very clean. nice. comfy bed..at least for us. quiet.. but we were at end of the hall. room had plenty of space. nice long bathroom counter for toiletries etc. that was outside of tub and potty area. plenty of choices for breakfast. employees friendly. would definitely stay again!!"
Marilyn 1-night trip
Posted 9 days ago
Ramada by Wyndham Sellersburg/Louisville North

Explore a world of travel with Expedia