A wooden bench in a forest with a natural backdrop of trees and foliage.

Find Resorts & Hotels with Spas in Southeastern Indiana

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Our top choices for Southeastern Indiana hotels with a spa

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very good, (1,011 reviews)
  • cleanliness
    Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
$89 nightly
The price is $99
Nov 29 - Nov 30
Total with taxes and fees
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

2. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
$156 nightly
The price is $184
Nov 23 - Nov 24
Total with taxes and fees
21c Museum Hotel Louisville

3. Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (2,205 reviews)
  • cleanliness
    Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
$203 nightly
The price is $239
Nov 16 - Nov 17
Total with taxes and fees
Omni Louisville Hotel

4. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,425 reviews)
  • cleanliness
    Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
$136 nightly
The price is $160
Nov 8 - Nov 9
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham

5. Belterra Casino Resort

Belterra Casino Resort
3.5 star property
Florence
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
$115 nightly
The price is $127
Nov 15 - Nov 16
Total with taxes and fees
Belterra Casino Resort

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
2.5 star property
Seymour
7.0 out of 10, Good, (653 reviews)
  • cleanliness
    Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
$76 nightly
The price is $86
Nov 29 - Nov 30
Total with taxes and fees
Quality Inn Seymour I-65

7. Pillow and Paddock B&B

Pillow and Paddock B&B
3.5 star property
La Grange
10.0 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
$362 nightly
The price is $399
Nov 7 - Nov 8
Total with taxes and fees
Pillow and Paddock B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southeastern Indiana

Find out more about Southeastern Indiana

Top Southeastern Indiana attractions for a relaxing vacation

Southeastern Indiana offers a delightful blend of relaxation and adventure for travelers seeking spa hotel experiences. Begin your escape in the charming town of French Lick, home to the historic French Lick Resort, where luxurious spa services meet opulent surroundings. After a rejuvenating massage, explore the beautiful grounds, including the stunning gardens and nearby hiking trails. Just a short drive away, the Hoosier National Forest invites you to immerse yourself in nature, with miles of scenic trails perfect for hiking or biking, providing a refreshing contrast to your spa days. For a taste of local culture, visit the quaint town of Madison, known for its well-preserved 19th-century architecture and vibrant arts scene, where galleries and boutiques offer delightful shopping experiences. Additionally, the area boasts several wineries, like the nearby Lane's End Winery, where you can indulge in tastings that pair perfectly with your spa retreat. Traveling with family? The region also offers family-friendly activities like the Clifty Falls State Park, where you can enjoy picnics and gentle hikes while surrounded by stunning waterfalls. Staying in Southeastern Indiana means you can enjoy a pampering experience in luxurious accommodations, where attentive service ensures you feel valued and cared for throughout your stay.

Top Southeastern Indiana Hotel Reviews

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