A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Resorts & Hotels with Spas in Southern Indiana

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Check availability on Southern Indiana Resorts & Hotels with Spas

Tonight
Oct 24 - Oct 25
Tomorrow
Oct 25 - Oct 26
Next weekend
Oct 30 - Nov 1
In two weeks
Nov 6 - Nov 8

Our top choices for Southern Indiana hotels with a spa

1. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
$156 nightly
$184 total
Nov 22 - Nov 23
Total with taxes and fees
21c Museum Hotel Louisville

2. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
$136 nightly
$160 total
Nov 8 - Nov 9
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham

3. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
Elizabeth
  • Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
$89 nightly
$99 total
Nov 23 - Nov 24
Total with taxes and fees
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

4. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
  • Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
$203 nightly
$239 total
Nov 16 - Nov 17
Total with taxes and fees
Omni Louisville Hotel

5. Belterra Casino Resort

Belterra Casino Resort
Florence
  • Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
$130 nightly
$146 total
Nov 24 - Nov 25
Total with taxes and fees
Belterra Casino Resort

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
Seymour
  • Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
$81 nightly
$90 total
Nov 23 - Nov 24
Total with taxes and fees
Quality Inn Seymour I-65

7. Pillow and Paddock B&B

Pillow and Paddock B&B
La Grange
  • Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
$383 nightly
$422 total
Oct 27 - Oct 28
Total with taxes and fees
Pillow and Paddock B&B
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Choose what matters most at spa hotels in Southern Indiana

Pool
Breakfast included
Hot tub
4 stars
5 stars

Find out more about Southern Indiana

Top Southern Indiana attractions for a relaxing vacation

Southern Indiana offers a delightful escape for travelers seeking rejuvenation and relaxation at hotels with spas. Begin your journey at the stunning natural wonders of the region, such as the breathtaking scenic overlook that provides panoramic views of the rolling hills and vibrant autumn foliage. This picturesque backdrop is perfect for unwinding before indulging in a soothing spa treatment. For those who appreciate history, the charming towns in the area boast beautifully preserved architecture and quaint boutiques, inviting you to explore at a leisurely pace. After a day of exploration, unwind at a local vineyard where you can savor exquisite wines while enjoying the serene countryside atmosphere. If you’re in the mood for a little adventure, explore the nearby trails that wind through lush forests, offering a perfect blend of tranquility and exploration. Finally, treat yourself to a night out at an upscale restaurant, where culinary delights await, ensuring your evenings are as memorable as your days. Each of these experiences complements the pampering you’ll find in Southern Indiana’s spa hotels, making it a perfect getaway for those who appreciate the finer things in life.

Top Southern Indiana Hotel Reviews

Drury Inn & Suites Evansville East

Drury Inn & Suites Evansville East

10/10 Excellent
"Perfect place for our family for a weekend away for softball tournament"
Tiffany 1-night trip
Posted 2 days ago
Drury Inn & Suites Evansville East
Hampton Inn Evansville/Airport

Hampton Inn Evansville/Airport

10/10 Excellent
"H"
robert 1-night trip
Posted 4 days ago
Hampton Inn Evansville/Airport
Ramada by Wyndham Sellersburg/Louisville North

Ramada by Wyndham Sellersburg/Louisville North

10/10 Excellent
"remodeled recently. very clean. nice. comfy bed..at least for us. quiet.. but we were at end of the hall. room had plenty of space. nice long bathroom counter for toiletries etc. that was outside of tub and potty area. plenty of choices for breakfast. employees friendly. would definitely stay again!!"
Marilyn 1-night trip
Posted 10 days ago
Ramada by Wyndham Sellersburg/Louisville North

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