A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Resorts & Hotels with Spas in Southern Indiana

Check availability on Southern Indiana Resorts & Hotels with Spas

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Our top choices for Southern Indiana hotels with a spa

1. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
$156 nightly
The price is $184
Nov 23 - Nov 24
Total with taxes and fees
21c Museum Hotel Louisville

2. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very good, (1,010 reviews)
  • cleanliness
    Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
$107 nightly
The price is $119
Oct 29 - Oct 30
Total with taxes and fees
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

3. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,422 reviews)
  • cleanliness
    Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
$136 nightly
The price is $160
Nov 8 - Nov 9
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham

4. Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (2,204 reviews)
  • cleanliness
    Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
$203 nightly
The price is $239
Nov 16 - Nov 17
Total with taxes and fees
Omni Louisville Hotel

5. Belterra Casino Resort

Belterra Casino Resort
3.5 star property
Florence
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
$138 nightly
The price is $154
Nov 15 - Nov 16
Total with taxes and fees
Belterra Casino Resort

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
2.5 star property
Seymour
7.0 out of 10, Good, (653 reviews)
  • cleanliness
    Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
$81 nightly
The price is $90
Nov 27 - Nov 28
Total with taxes and fees
Quality Inn Seymour I-65

7. Pillow and Paddock B&B

Pillow and Paddock B&B
3.5 star property
La Grange
10.0 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
$362 nightly
The price is $399
Nov 6 - Nov 7
Total with taxes and fees
Pillow and Paddock B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southern Indiana

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Top Southern Indiana attractions for a relaxing vacation

Southern Indiana offers a delightful escape for travelers seeking rejuvenation and relaxation at hotels with spas. Begin your journey at the stunning natural wonders of the region, such as the breathtaking scenic overlook that provides panoramic views of the rolling hills and vibrant autumn foliage. This picturesque backdrop is perfect for unwinding before indulging in a soothing spa treatment. For those who appreciate history, the charming towns in the area boast beautifully preserved architecture and quaint boutiques, inviting you to explore at a leisurely pace. After a day of exploration, unwind at a local vineyard where you can savor exquisite wines while enjoying the serene countryside atmosphere. If you’re in the mood for a little adventure, explore the nearby trails that wind through lush forests, offering a perfect blend of tranquility and exploration. Finally, treat yourself to a night out at an upscale restaurant, where culinary delights await, ensuring your evenings are as memorable as your days. Each of these experiences complements the pampering you’ll find in Southern Indiana’s spa hotels, making it a perfect getaway for those who appreciate the finer things in life.

Top Southern Indiana Hotel Reviews

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