Find Resorts & Hotels with Spas in Southern Indiana

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Check availability on Southern Indiana Resorts & Hotels with Spas

Our top choices for Southern Indiana hotels with a spa

Belterra Casino Resort

Belterra Casino Resort
3.5 star property
Florence
8.6 out of 10, Excellent, (1,000 reviews)
  • cleanliness
    Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
$155 nightly
The price is $173
Apr 19 - Apr 20
Total with taxes and fees
Belterra Casino Resort

Caesars Southern Indiana - A Caesars Rewards Destination

Caesars Southern Indiana - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very Good, (1,012 reviews)
  • cleanliness
    Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
$113 nightly
The price is $126
May 14 - May 15
Total with taxes and fees
Caesars Southern Indiana - A Caesars Rewards Destination

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,005 reviews)
  • cleanliness
    Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness center in downtown Louisville.
$173 nightly
The price is $204
May 10 - May 11
Total with taxes and fees
21c Museum Hotel Louisville

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,832 reviews)
  • cleanliness
    Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
$199 nightly
The price is $234
May 7 - May 8
Total with taxes and fees
Omni Louisville Hotel

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,153 reviews)
  • cleanliness
    Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
$147 nightly
The price is $173
Apr 19 - Apr 20
Total with taxes and fees
Galt House Hotel Trademark Collection by Wyndham

Central Park Bed & Breakfast

Central Park Bed & Breakfast
4.0 star property
Old Louisville
9.2 out of 10, Wonderful, (72 reviews)
  • cleanliness
    Rejuvenate at this Victorian bed & breakfast featuring deep soaking tubs, fireplaces in rooms, and personalized spa services.
$136 nightly
The price is $157
Apr 16 - Apr 17
Total with taxes and fees
Central Park Bed & Breakfast

Quality Inn Seymour I-65

Quality Inn Seymour I-65
2.5 star property
Seymour
7.0 out of 10, Good, (580 reviews)
  • cleanliness
    Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness center.
$85 nightly
The price is $95
May 14 - May 15
Total with taxes and fees
Quality Inn Seymour I-65

Pillow and Paddock B&B

Pillow and Paddock B&B
3.5 star property
La Grange
10.0 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
$266 nightly
The price is $293
Apr 20 - Apr 21
Total with taxes and fees
Pillow and Paddock B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Choose what matters most at spa hotels in Southern Indiana

Find out more about Southern Indiana

Top Southern Indiana attractions for a relaxing vacation

Southern Indiana offers a unique blend of nature, culture, and relaxation perfect for travelers seeking spa hotels. Begin your journey at the stunning Brown County State Park, known for its rolling hills and scenic trails—ideal for a morning hike or a leisurely bike ride. After a day outdoors, unwind at the local wineries, such as the Oliver Winery, where you can indulge in wine tastings and picturesque vineyard views. For a taste of history, visit the charming town of Nashville, filled with artisan shops and art galleries that showcase local talent. Don't miss the opportunity to explore the limestone caves at the Indiana Caverns, where guided tours reveal breathtaking underground formations. Finally, consider staying near the vibrant city of Bloomington, home to luxurious hotels with full-service spas, where you can pamper yourself with massages and rejuvenating treatments after a day of exploration. The region’s welcoming atmosphere and high-top hotels ensure an enriching experience that caters to your every comfort.

Top Southern Indiana Hotel Reviews

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