
Southern Indiana Luxury Vacations
Book a Luxury Hotel + Flight or Car together to unlock savings
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Top Luxury vacation packages in Southern Indiana

Galt House Hotel Trademark Collection by Wyndham
Reviewed on Jan 3, 2026


The Brown Hotel
Reviewed on Jan 1, 2026


Hyatt Regency Louisville
Reviewed on Jan 2, 2026
3 Night Luxury vacations in Southern Indiana

Galt House Hotel Trademark Collection by Wyndham
Reviewed on Jan 3, 2026


The Brown Hotel
Reviewed on Jan 1, 2026
4 Night Luxury vacations in Southern Indiana

21c Museum Hotel Louisville
Reviewed on Dec 9, 2025

Embassy Suites Louisville Downtown
Reviewed on Jan 1, 2026

The Brown Hotel
Reviewed on Jan 1, 2026
All you need to know about luxury vacations in Southern Indiana
What can I expect from a luxury Southern Indiana vacation?
Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Southern Indiana vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views.
How can I find all-inclusive luxury vacation packages in Southern Indiana?
By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5* filter to find truly sensational stays. You barely need to lift a finger.
Can I book a cheap Southern Indiana luxury vacation?
Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $536. Prices and availability are subject to change. Additional terms may apply.
How can I book a luxury family vacation in Southern Indiana?
Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi.
Can I book a package in Southern Indiana with a luxury vacation home?
A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package.
How can I find the best luxury vacation deals in Southern Indiana?
Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months.
Can I book a luxury holiday in Southern Indiana with free cancellation and/or flexible dates?
Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan.
Why should I book my luxury trip to Southern Indiana with Expedia?
A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind.
Top Luxury Southern Indiana Hotels

21c Museum Hotel Louisville
The room was great! The bar was fantastic. The hotel accommodated all of my requests. My husband and I have stayed here a few times. I'm truly grateful for the kindness of the staff.
Reviewed on Dec 19, 2025

West Baden Springs Hotel
The hotel West Baden is awesome they have 24 hour trolley that runs every 15 minutes and will take you anywhere in the area.
Reviewed on Dec 25, 2018

The Brown Hotel
Courteous staff, well-attended rooms, great amenities.
Reviewed on Dec 28, 2025



















