Title: Southern Indiana Luxury Vacations 2026 | Expedia.com ![](https://images.trvl-media.com/place/6062653/8b326703-a711-4dce-a0ec-21ab55344b9a.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southern Indiana Luxury Vacations ## Book a Luxury Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Top Luxury vacation packages in Southern Indiana Price found within the past 48 hours. Click for updated prices. ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### 21c Museum Hotel Louisville Downtown Louisville $627 per person Apr 22 - Apr 24 found 9 hours ago Roundtrip non-stop flight included New York (JFK) to Louisville (SDF) 9.2/10 Wonderful! (1,003 reviews) Room was clean. The staff is helpful, nice, welcoming. Loved the art. Room is large. Great area. Reviewed on Feb 15, 2026 ![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hyatt Regency Louisville Downtown Louisville Save 100% on your flight $863 per person Mar 26 - Mar 29 found 21 hours ago Roundtrip non-stop flight included Wilmington (ILM) to Louisville (SDF) 8.8/10 Excellent! (1,005 reviews) Very clean room, the staff was friendly as well. Looking forward to our stay again next year. Reviewed on Feb 7, 2026 ![Louisville Marriott Downtown](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Louisville Marriott Downtown Downtown Louisville $761 per person Mar 23 - Mar 26 found 4 hours ago Roundtrip non-stop flight included Phoenix (PHX) to Louisville (SDF) 9/10 Wonderful! (1,003 reviews) Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again! Reviewed on Jan 16, 2026 ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville $630 per person Mar 23 - Mar 26 found 4 hours ago Roundtrip non-stop flight included Phoenix (PHX) to Louisville (SDF) 9/10 Wonderful! (3,770 reviews) Room was remodeled, very nice and clean! Bed was Very comfy. Reviewed on Feb 17, 2026 ![The Brown Hotel](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Brown Hotel Downtown Louisville $710 per person Mar 23 - Mar 26 found 4 hours ago Roundtrip non-stop flight included Phoenix (PHX) to Louisville (SDF) 9.4/10 Exceptional! (1,110 reviews) Clean room, GREAT location, and friendly staff. Reviewed on Feb 17, 2026 Don't see what you're looking for? See all available trips from Columbus to Southern Indiana [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-20/2026-03-27/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=SDF&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 3 Night Luxury vacations in Southern Indiana Price found within the past 48 hours. Click for updated prices. ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville $605 per person Apr 23 - Apr 26 found 19 hours ago Roundtrip flight included Baltimore (BWI) to Louisville (SDF) 9/10 Wonderful! (3,770 reviews) Room was remodeled, very nice and clean! Bed was Very comfy. Reviewed on Feb 17, 2026 ![Louisville Marriott Downtown](https://images.trvl-media.com/lodging/2000000/1120000/1111400/1111358/6dbe73d1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Louisville Marriott Downtown Downtown Louisville Save 100% on your flight $687 per person Mar 25 - Mar 28 found 12 hours ago Roundtrip non-stop flight included Sioux Falls (FSD) to Louisville (SDF) 9/10 Wonderful! (1,003 reviews) Room was spotless. Staff was top notch. Amenities as expected but I did expect a microwave in the room. There wasn't one. 9/10 experience. Will definitely book again! Reviewed on Jan 16, 2026 ![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hyatt Regency Louisville Downtown Louisville Save 100% on your flight $863 per person Mar 26 - Mar 29 found 21 hours ago Roundtrip non-stop flight included Wilmington (ILM) to Louisville (SDF) 8.8/10 Excellent! (1,005 reviews) Very clean room, the staff was friendly as well. Looking forward to our stay again next year. Reviewed on Feb 7, 2026 Don't see what you're looking for? See all available trips from Columbus to Southern Indiana [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-20/2026-03-27/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=SDF&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## 4 Night Luxury vacations in Southern Indiana Price found within the past 48 hours. Click for updated prices. ![Belterra Casino Resort](https://images.trvl-media.com/lodging/2000000/1160000/1152900/1152807/04047b8f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Belterra Casino Resort $652 per person Apr 8 - Apr 12 found 3 hours ago Roundtrip non-stop flight included Albany (ABY) to Cincinnati (CVG) 8.6/10 Excellent! (1,001 reviews) Clean room, great live music venue, good food at the Stadium! Reviewed on Feb 17, 2026 ![Hyatt Regency Louisville](https://images.trvl-media.com/lodging/1000000/330000/327000/326983/f8482687_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hyatt Regency Louisville Downtown Louisville Save 100% on your flight $835 per person May 5 - May 9 found 10 hours ago Roundtrip flight included Washington (WAS) to Louisville (SDF) 8.8/10 Excellent! (1,005 reviews) Very clean room, the staff was friendly as well. Looking forward to our stay again next year. Reviewed on Feb 7, 2026 ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Galt House Hotel Trademark Collection by Wyndham Downtown Louisville $657 per person May 3 - May 7 found 7 hours ago Roundtrip flight included Phoenix (PHX) to Louisville (SDF) 9/10 Wonderful! (3,770 reviews) Room was remodeled, very nice and clean! Bed was Very comfy. Reviewed on Feb 17, 2026 Don't see what you're looking for? See all available trips from Columbus to Southern Indiana [View all trips](https://expedia.com/go/package/search/FlightHotel/2026-03-20/2026-03-27/?FromAirport=Columbus,%20Ohio,%20United%20States%20of%20America&Destination=SDF&NumRoom=1&NumAdult=2&NumChild=0&paandie=true) ## All you need to know about luxury vacations in Southern Indiana #### What can I expect from a luxury Southern Indiana vacation? Luxury means the very finest of the things you enjoy most. Indulge your every waking moment—and restful night—with a luxury Southern Indiana vacation. Sip handcrafted cocktails by an infinity pool, sink into bliss at a full-service spa with a massage cabana on the beach, and chat, cheers, and laugh through exquisite breakfasts, lunches, and dinners with spectacular views. #### How can I find all-inclusive luxury vacation packages in Southern Indiana? By refining your filters, the most opulent all-inclusive vacation packages will appear before your eyes. Check the 5\* filter to find truly sensational stays. You barely need to lift a finger. #### Can I book a cheap Southern Indiana luxury vacation? Affordable luxury is only ever a few clicks away. Enter your travel dates and sort the grandiose getaways on offer by price to see the most fiscally friendly retreats first. Filter by budget, too, to find your perfect balance of luxury. Right now, luxury vacations start at $605\. Prices and availability are subject to change. Additional terms may apply. #### How can I book a luxury family vacation in Southern Indiana? Tailor your luxury family escape by checking the filters that set the whole family’s hearts a-flutter. Whether that’s wet and wild water parks, heavenly hot tubs, or the kid-quieting magic of free Wi-Fi. #### Can I book a package in Southern Indiana with a luxury vacation home? A private paradise is true luxury! Filter by property type for houses, villas, and apartments. For an amazingly affordable all-in-one luxury experience, book your accommodation, airfare, and car rental as a package. #### How can I find the best luxury vacation deals in Southern Indiana? Find absolute delight in the dropdown! Simply sort your tempting search results by deals to find that lean-budget luxury. For a budget conscious stay, consider booking a stay away from big cities or outside the peak months. #### Can I book a luxury holiday in Southern Indiana with free cancellation and/or flexible dates? Freedom and flexibility are the greatest luxuries of all. Get both when you filter by payment option and book a trip with free cancellation or on a buy now, pay later plan. #### Why should I book my luxury trip to Southern Indiana with Expedia? A luxurious trip follows a stress-free booking experience. Find, build, and book the most glorious of getaways in seconds—with ATOL protection for added peace of mind. ## Top Luxury Southern Indiana Hotels ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### 21c Museum Hotel Louisville 700 W Main Street Louisville KY - 9 min walk from KFC Yum Center 21c Museum Hotel Louisville is one of the Louisville luxury 4.5-star boutique properties where you can treat yourself to Champagne service, massage services, ... 9.4/10 Exceptional! (1,000 reviews) Room was clean. The staff is helpful, nice, welcoming. Loved the art. Room is large. Great area. Reviewed on Feb 15, 2026 [](https://expedia.com/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![West Baden Springs Hotel](https://images.trvl-media.com/lodging/2000000/1750000/1745100/1745075/220feee7_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### West Baden Springs Hotel 8538 W Baden Ave West Baden Springs IN - 2 hours drive from KFC Yum Center Treat yourself to a luxury stay at West Baden Springs Hotel, where you can enjoy amenities like plush bedding, designer toiletries, and more. Deluxe amenities ... [](https://expedia.com/West-Baden-Springs-Hotels-West-Baden-Springs-Hotel.h1745075.Hotel-Information) ![The Brown Hotel](https://images.trvl-media.com/lodging/1000000/10000/9900/9861/840e31de_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Brown Hotel 335 W Broadway Louisville KY - 14 min walk from KFC Yum Center The Brown Hotel is a Louisville luxury 4.5-star boutique property where you can pamper yourself with Egyptian cotton sheets, plush bedding, and more. The restaurant, ... 9.4/10 Exceptional! (1,197 reviews) Beautiful old hotel I loved the decor and was very clean well taken care of! Reviewed on Feb 19, 2026 [](https://expedia.com/Louisville-Hotels-The-Brown-Hotel.h9861.Hotel-Information) [See all 1,629 properties in Southern Indiana](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6059635) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) 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[Luxury Vacations in Greece ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/67/Greece) > - [Luxury Vacations in New York ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/178293/New-York) > - [Luxury Vacations in Bora Bora ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/602861/Bora-Bora) > - [Luxury Vacations in Florida ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/211/Florida) > - [Luxury Vacations in London ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/178279/London) > - [Luxury Vacations in Arizona ](https://www.expedia.com/lp/theme-vacations/luxury-vacations/204/Arizona) ## More Vacation Ideas [Flights to Southern Indiana ](https://expedia.com/Cheap-Flights-To-Southern-Indiana.d6059635.Travel-Guide-Flights)[ Southern Indiana Hotels ](https://expedia.com/Southern-Indiana-Hotels.d6059635.Travel-Guide-Hotels)[ Vacation Rentals in Southern Indiana ](https://expedia.com/Southern-Indiana-Vacation-Rentals.d6059635.Travel-Guide-VacationRentals)[ Car Rentals in Southern Indiana ](https://expedia.com/Car-Rentals-In-Southern-Indiana.d6059635.Car-Rental-Guide)[ Southern Indiana Vacations ](https://expedia.com/Southern-Indiana.d6059635.Destination-Travel-Guides) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app