Title: Top Independent in Southern Minnesota, MN - Expedia.com [Southern Minnesota Travel Guide](https://expedia.com/Southern-Minnesota.dx6059950)[Hotels in Southern Minnesota](https://expedia.com/Southern-Minnesota-Hotels.d6059950.Travel-Guide-Hotels)[Vacation Rentals in Southern Minnesota](https://expedia.com/Southern-Minnesota-Vacation-Rentals.d6059950.Travel-Guide-VacationRentals)[Flights to Southern Minnesota](https://expedia.com/Cheap-Flights-To-Southern-Minnesota.d6059950.Travel-Guide-Flights)[Car Rentals in Southern Minnesota](https://expedia.com/Car-Rentals-In-Southern-Minnesota.d6059950.Car-Rental-Guide)[Southern Minnesota Vacation Packages](https://expedia.com/Southern-Minnesota.d6059950.Destination-Travel-Guides) ![Lake Pepin & Mississippi River Scenic View](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248621532649642/b0facbcd-16cb-4461-946e-105f314f35fc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 17 - Mar 18](https://www.expedia.com/Hotel-Search?regionId=6059950&startDate=2026-03-17&endDate=2026-03-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 18 - Mar 19](https://www.expedia.com/Hotel-Search?regionId=6059950&startDate=2026-03-18&endDate=2026-03-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 20 - Mar 22](https://www.expedia.com/Hotel-Search?regionId=6059950&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.com/Hotel-Search?regionId=6059950&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Minnesota-Hotels-Independent.0-0-d6059950--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouthern-Minnesota-Hotels-Independent.0-0-d6059950--bIndependent.Travel-Guide-Filter-Hotels) ## Top Southern Minnesota Hotel Reviews ![Hampton Inn Rochester-South](https://images.trvl-media.com/lodging/1000000/20000/16600/16522/c73455d9_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "Excellent facility. Friendly staff, clean and quiet..l" [](https://expedia.com/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](https://images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 8/10 Good "Breakfast was good. The faucet.i. iur room did not work properly, turned it on and would not shut off no matter where you moved the single.handle. then you would either get hot on bith sides or cold. Beds were comfortable." [](https://expedia.com/Rochester-Hotels-AmericInn-By-Wyndham-Rochester-Near-Mayo-Clinic.h8008.Hotel-Information) ![Best Western Rochester Hotel Mayo Clinic Area/St. Mary's](https://images.trvl-media.com/lodging/1000000/10000/3700/3682/w3837h2560x3y0-1092e125_y.jpg) ### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's 10/10 Excellent "Rooms were clean. Amenities were nice. Breakfast was delicious." [](https://expedia.com/Rochester-Hotels-Best-Western-Rochester-Hotel-Mayo-Clinic-AreaSt-Marys.h3682.Hotel-Information) ![Holiday Inn Express Rochester South - Mayo Area by IHG](https://images.trvl-media.com/lodging/3000000/2190000/2185000/2184971/d5501184_y.jpg) ### Holiday Inn Express Rochester South - Mayo Area by IHG 8/10 Good "It was great my daughter enjoyed it" [](https://expedia.com/Rochester-Hotels-Comfort-Suites.h2184971.Hotel-Information) ![Hilton Rochester Mayo Clinic Area](https://images.trvl-media.com/lodging/28000000/27430000/27426400/27426319/c7a0b093_y.jpg) ### Hilton Rochester Mayo Clinic Area 10/10 Excellent "Perfect getaway for two!" [](https://expedia.com/Rochester-Hotels-Hilton-Rochester-Mayo-Clinic-Area.h27426319.Hotel-Information) ![Kahler Grand Hotel](https://images.trvl-media.com/lodging/1000000/30000/25600/25516/1062bbaa_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Very friendly staff, clean & quiet rooms, nice pool and hot tub. The location makes it easy for us to get to where we need to go. No complaints." [](https://expedia.com/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![EVEN Hotel Rochester - Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/60000000/59620000/59619600/59619526/21638bcd_y.jpg) ### EVEN Hotel Rochester - Mayo Clinic Area by IHG 10/10 Excellent "Easy airport shuttle. Cleanest hotel ever stayed in. " [](https://expedia.com/Rochester-Hotels-Even-Rochester-St-Marys-Area.h59619526.Hotel-Information) ![Hyatt House Rochester/Mayo Clinic Area](https://images.trvl-media.com/lodging/57000000/56840000/56833100/56833067/369065b1_y.jpg) ### Hyatt House Rochester/Mayo Clinic Area 10/10 Excellent "It was a nice relax place " [](https://expedia.com/Rochester-Hotels-Hyatt-House-RochesterMayo-Clinic.h56833067.Hotel-Information) ![Hotel Indigo Rochester – Mayo Clinic Area by IHG](https://images.trvl-media.com/lodging/1000000/10000/5400/5327/bba1b373_y.jpg) ### Hotel Indigo Rochester – Mayo Clinic Area by IHG 10/10 Excellent "Good hotels " [](https://expedia.com/Rochester-Hotels-Hotel-Indigo-Rochester-Downtown.h5327.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - [Cabin Rentals in Southwest Minnesota ](https://www.expedia.com/Southwest-Minnesota-Cabins.d6233999-aaCabins.Travel-Guide-Accommodation) - [Casino Hotels in Southwest Minnesota ](https://www.expedia.com/Southwest-Minnesota-Hotels-Casino-Hotel.0-0-d6233999-tCasinoHotel.Travel-Guide-Filter-Hotels) - 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