Central San Diego Vacation Rentals

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Our top choices for Central San Diego vacation rentals

City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (138 reviews)
"Clean nice place to stay at"
United States
Luis
$195 nightly
The price is $219
Apr 26 - Apr 27
Total with taxes and fees
City24 Hotel Little Italy Mission Hills

Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very Good, (338 reviews)
"It is a clean place to stay and budget friendly. Unfortunately the noise from the road can make it hard to sleep."
United States
Afia
$117 nightly
The price is $132
Apr 20 - Apr 21
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Large Group Wellness Retreat w Spa & Gym

Large Group Wellness Retreat w Spa & Gym
3.0 star property
University City
$975 nightly
The price is $1,099
May 13 - May 14
Total with taxes and fees
Large Group Wellness Retreat w Spa & Gym

NEW Lux North Park Gem~King Beds~Workspaces~Parking~Central Location!

NEW Lux North Park Gem~King Beds~Workspaces~Parking~Central Location!
North Park
10.0 out of 10, Exceptional, (4 reviews)
"Beautiful place!! Enjoyed the location, furnishings and the kitchen. Lovely condo!"
United States
Erika H.
$570 nightly
The price is $634
Apr 20 - Apr 21
Total with taxes and fees
NEW Lux North Park Gem~King Beds~Workspaces~Parking~Central Location!

Beautiful Normal Heights Living

Beautiful Normal Heights Living
Mid-City
10.0 out of 10, Exceptional, (82 reviews)
"Great location, nice cozy place, had everything we needed. Would definitely stay again."
United States
Sheila S.
$283 nightly
The price is $315
Apr 26 - Apr 27
Total with taxes and fees
Beautiful Normal Heights Living

Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!

Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
Bankers Hill
9.4 out of 10, Exceptional, (45 reviews)
"Clean and cozy. "
United States
Jason B.
$392 nightly
The price is $436
Apr 20 - Apr 21
Total with taxes and fees
Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!

✔Remote Work✔A/C✔200Mbps✔Kitchen✔Streaming

✔Remote Work✔A/C✔200Mbps✔Kitchen✔Streaming
University City
10.0 out of 10, Exceptional, (33 reviews)
"Great property, very well maintained & the hosts were wonderful. "
United States
Ryan B.
$511 nightly
The price is $569
Apr 19 - Apr 20
Total with taxes and fees
✔Remote Work✔A/C✔200Mbps✔Kitchen✔Streaming

Family-Friendly 3BR Home Near San Diego Zoo

Family-Friendly 3BR Home Near San Diego Zoo
Linda Vista
$695 nightly
The price is $773
Apr 19 - Apr 20
Total with taxes and fees
Family-Friendly 3BR Home Near San Diego Zoo

Super Spacious Family Vacation Home!

Super Spacious Family Vacation Home!
Mira Mesa
9.6 out of 10, Exceptional, (28 reviews)
"Plenty of room. Convenient location."
United States
Brian R.
$863 nightly
The price is $960
Apr 19 - Apr 20
Total with taxes and fees
Super Spacious Family Vacation Home!

10 minutes from San Diego Zoo, Balboa Park, Gas Lamp District, Public Beaches.

10 minutes from San Diego Zoo, Balboa Park, Gas Lamp District, Public Beaches.
South Park
10.0 out of 10, Exceptional, (129 reviews)
"Lovely home; well equipped; great location; wonderful, responsive host."
United States
Ilene B.
$508 nightly
The price is $566
Apr 19 - Apr 20
Total with taxes and fees
10 minutes from San Diego Zoo, Balboa Park, Gas Lamp District, Public Beaches.

Modern 3-bed Hub resort / ping pong & pool table. Game room

Modern 3-bed Hub resort / ping pong & pool table. Game room
Linda Vista
9.8 out of 10, Exceptional, (7 reviews)
"Host was friendly and responsive. Place was well kept. Great place overall"
United States
Frank Y.
$388 nightly
The price is $432
Apr 19 - Apr 20
Total with taxes and fees
Modern 3-bed Hub resort / ping pong & pool table. Game room

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.2 out of 10, Wonderful, (60 reviews)
" 100% satisfied. Would stay again if in the area."
United States
Eugene
$295 nightly
The price is $328
Apr 19 - Apr 20
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (277 reviews)
"We enjoyed our time in the back cottage. Everything we needed was available. We were able to just walk to so many sites and restaurants. Will definitely try to come back again! "
United States
Phillip
$195 nightly
The price is $217
Apr 21 - Apr 22
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

North Park Penthouse~King Beds~Workspaces~Parking~Near Zoo, Balboa Park!

North Park Penthouse~King Beds~Workspaces~Parking~Near Zoo, Balboa Park!
North Park
9.2 out of 10, Wonderful, (9 reviews)
"Location was great. Perfect place for the family on our weekend trip."
United States
Gabriel
$446 nightly
The price is $496
Apr 20 - Apr 21
Total with taxes and fees
North Park Penthouse~King Beds~Workspaces~Parking~Near Zoo, Balboa Park!

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
$290 nightly
The price is $323
Apr 20 - Apr 21
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Luxe Modern Escape. Pool,H.Tub+Park+ Gym, Close to beaches and walk everywhere !

Luxe Modern Escape. Pool,H.Tub+Park+ Gym, Close to beaches and walk everywhere !
Hillcrest
10.0 out of 10, Exceptional, (2 reviews)
"The condo is very well decorated and clean. The neighborhood is vibrant and full of walkable bars/restaurants. Natasha was very responsive to my questions. Would recommend her and her home to my friends and family."
United States
Hiren P.
$794 nightly
The price is $883
May 4 - May 5
Total with taxes and fees
Luxe Modern Escape. Pool,H.Tub+Park+ Gym, Close to beaches and walk everywhere !

2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views

2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views
Mission Hills
6.8 out of 10, (12 reviews)
"Me and my girlfriend stayed here for a weekend to kind of just enjoy not having to be home for a weekend and staying here was very nice; the view from the living room and balcony was amazing, was close to all the hotspots in SD and just felt like a second home. I was a bit of a chaotic guest leading up to the check-in and that is because of my work but the host Daniel was very helpful and patient with my mistakes and I appreciate what he did for us."
United States
Nico E.
$367 nightly
The price is $408
Apr 19 - Apr 20
Total with taxes and fees
2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views

Private Cozy Clean, close to EVERYTHING

Private Cozy Clean, close to EVERYTHING
Mid-City
9.8 out of 10, Exceptional, (61 reviews)
"Great stay! Host was responsive and house was tidy and comfortable. The yard adds an additional living space. "
United States
Helen P.
$347 nightly
The price is $385
May 4 - May 5
Total with taxes and fees
Private Cozy Clean, close to EVERYTHING

Sunkissed home in Golden Hill San Diego

Sunkissed home in Golden Hill San Diego
Golden Hill
8.4 out of 10, Very Good, (5 reviews)
"Our stay was absolutely fantastic. This place has everything we needed, and was located in a great location. Hosts were super responsive and helped whenever necessary. Highly highly recommend this stay for anyone looking"
United States
Bryan W.
$447 nightly
The price is $497
Apr 19 - Apr 20
Total with taxes and fees
Sunkissed home in Golden Hill San Diego

NEW BUILD-ideal San Diego location, Little Italy, Gaslamp-WiFi, AC, 2x King beds

NEW BUILD-ideal San Diego location, Little Italy, Gaslamp-WiFi, AC, 2x King beds
Bankers Hill
10.0 out of 10, Exceptional, (23 reviews)
"The host was excellent to deal with and extremely responsive to any questions we had prior to our arrival and during our stay. The accommodations were excellent. Great location."
United States
Terry R.
$435 nightly
The price is $488
Apr 20 - Apr 21
Total with taxes and fees
NEW BUILD-ideal San Diego location, Little Italy, Gaslamp-WiFi, AC, 2x King beds
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $132 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.