A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Oct 23 - Oct 25
In two months
Dec 4 - Dec 6
In three months
Jan 1 - Jan 3
In four months
Jan 29 - Jan 31

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (221 reviews)
"Friendly staff!"
United States
Donavin
$157 nightly
The price is $177
Oct 26 - Oct 27
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (486 reviews)
"We had a great stay! The room had a charming Parisian feel—compact and studio-style, but completely modern and spotlessly clean."
United States
Josh
$102 nightly
The price is $115
Oct 26 - Oct 27
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A bedroom with a bed, a desk, a chair, a ceiling fan, and a door leading to another room.

3. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
10.0 out of 10, Exceptional, (1 review)
"Simple property that does the job! Pleasant experience!"
United States
Brandon S.
$128 nightly
The price is $142
Oct 13 - Oct 14
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
A two-story house with a prominent front entrance, a balcony, and a garage.

4. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$179 nightly
The price is $187
Oct 14 - Oct 15
Total with taxes and fees
San Diego Centralized Retreat
A living room with a blue sofa, a round coffee table, and a world map on the wall.

5. Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Mid-City
8.0 out of 10, Very good, (4 reviews)
"We thoroughly appreciated the communications provided by the host. Initially had a few teething issues, with the keylock code not working, and a smell in the bedroom and the living area, but this was rectified and a cleaning crew came in twice for it. Place is perfectly situated (with car use) but a bit less so if on foot, or public transportation. The laundry in the shed and the kitchen are always welcome especially as our booking was over 2 weeks long! Thanks again for a suitable stay for us!"
United States
Carlo Luis
$461 nightly
The price is $461
Oct 12 - Oct 13
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
A hotel room with two beds, a large mirror, and decorative wall art.

6. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$282 nightly
The price is $314
Oct 14 - Oct 15
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

7. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$289 nightly
The price is $324
Oct 12 - Oct 13
Total with taxes and fees
Close to Airport | Walk to Restaurants
A residential property with a gated entrance, a pergola, and a wooden fence.

8. 1BR King Bed Apartment with AC in sunny San Diego

1BR King Bed Apartment with AC in sunny San Diego
Mid-City
$240 nightly
The price is $267
Oct 14 - Oct 15
Total with taxes and fees
1BR King Bed Apartment with AC in sunny San Diego
A modern kitchen with white cabinetry, a built-in microwave, a dishwasher, and a stainless steel refrigerator.

9. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$260 nightly
The price is $289
Oct 29 - Oct 30
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

10. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$275 nightly
The price is $306
Oct 12 - Oct 13
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Interior

11. Cozy caravan in San Diego with AC & Wifi

Cozy caravan in San Diego with AC & Wifi
Miramar
2.0 out of 10, (1 review)
$168 nightly
The price is $187
Oct 11 - Oct 12
Total with taxes and fees
Cozy caravan in San Diego with AC & Wifi
A modern living room with a green sofa, a white coffee table, a flat-screen TV mounted on the wall, and a small table with a lamp and a plant.

12. Casa Carlos - In the heart of San Diego

Casa Carlos - In the heart of San Diego
Mid-City
9.0 out of 10, Wonderful, (7 reviews)
"Great location"
United States
Jason D.
$229 nightly
The price is $255
Oct 12 - Oct 13
Total with taxes and fees
Casa Carlos - In the heart of San Diego
A sunset over a beach with a pier in the background.

13. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (63 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
$297 nightly
The price is $330
Oct 14 - Oct 15
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
Drift off in ultra-comfy linens and a memory foam mattress where restful nights come easy.

14. The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit

The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Middletown
8.4 out of 10, Very good, (5 reviews)
"Perfect amount of space for 3 people, no issues in the house, everything worked fine. You can hear everything that happens upstairs but that's kind of expected when staying on the bottom level of anything. Hosts were very helpful, let us check in early which was convenient for us! Close to airport and downtown which was nice. Overall great stay!"
United States
Gabby W.
$355 nightly
The price is $395
Oct 26 - Oct 27
Total with taxes and fees
The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

15. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"It was okay"
United States
Nicole
$315 nightly
The price is $350
Oct 18 - Oct 19
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
A patio with outdoor furniture, a pathway, and a fence.

16. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (12 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$273 nightly
The price is $303
Oct 13 - Oct 14
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A two-story house with a garage, a covered porch, and a small outdoor seating area.

17. The Hideaway of Silver Terrace

The Hideaway of Silver Terrace
Linda Vista
9.4 out of 10, Exceptional, (71 reviews)
"Perfect for one or two people "
United States
Jim P.
$211 nightly
The price is $235
Oct 28 - Oct 29
Total with taxes and fees
The Hideaway of Silver Terrace
A rustic interior with wooden walls, a long row of wooden paddles, and metal barrels.

18. Private Cozy Clean, close to EVERYTHING

Private Cozy Clean, close to EVERYTHING
Mid-City
9.8 out of 10, Exceptional, (73 reviews)
"Location was perfect for daily outings in San Diego. Would stay again. "
United States
Caitlin M.
$322 nightly
The price is $358
Nov 3 - Nov 4
Total with taxes and fees
Private Cozy Clean, close to EVERYTHING
A modern living room with a staircase, a dining area, a kitchen, and a stone fireplace.

19. Luxe Loft Retreat – Patio, High Ceilings & Parking

Luxe Loft Retreat – Patio, High Ceilings & Parking
Tierrasanta
10.0 out of 10, Exceptional, (2 reviews)
"Very responsive!"
United States
William M.
$160 nightly
The price is $178
Oct 12 - Oct 13
Total with taxes and fees
Luxe Loft Retreat – Patio, High Ceilings & Parking
A living room with a green sofa, a coffee table, and a dining area with a table and chairs. There are plants and framed pictures on the walls.

20. Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg

Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Very kind host and great walkable location. The yard made it very convenient for my dog and the bed was super comfy"
United States
Rae-Matthew E.
$326 nightly
The price is $326
Oct 12 - Oct 13
Total with taxes and fees
Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Best Western Seven Seas

Best Western Seven Seas

10/10 Excellent
"I love the kindness from the house keeping staff"
Ariel 6-night trip
Posted less than an hour ago
Best Western Seven Seas

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $115 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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