A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Nov 13 - Nov 15
In two months
Dec 25 - Dec 27
In three months
Jan 22 - Jan 24
In four months
Feb 19 - Feb 21

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (236 reviews)
"Friendly staff!"
United States
Donavin
$157 nightly
The price is $177
Nov 2 - Nov 3
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (502 reviews)
"It was super clean and smooth easy check in and out process!"
United States
Aviana
$102 nightly
The price is $115
Nov 1 - Nov 2
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A two-story house with a prominent front entrance, a balcony, and a garage.

3. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$169 nightly
The price is $176
Nov 3 - Nov 4
Total with taxes and fees
San Diego Centralized Retreat
A wooden house with a brick entrance and a wooden door with a glass panel.

4. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (65 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
$293 nightly
The price is $326
Oct 30 - Oct 31
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A modern living room with a sofa, coffee table, and a dining area with chairs and a table.

5. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Such a great experience here! The host was very communicative and attentive. Spot was clean and perfect for our weekend getaway. There are plenty of bars and cool shops within walking distance. We will definitely be booking the same spot on our next trip!"
United States
Madison S.
$235 nightly
The price is $246
Nov 16 - Nov 17
Total with taxes and fees
Modern Hideaway in North Park - 3941
Interior

6. Cozy caravan in San Diego with AC & Wifi

Cozy caravan in San Diego with AC & Wifi
Miramar
2.0 out of 10, (1 review)
$168 nightly
The price is $187
Oct 30 - Oct 31
Total with taxes and fees
Cozy caravan in San Diego with AC & Wifi
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

7. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$296 nightly
The price is $332
Nov 17 - Nov 18
Total with taxes and fees
Close to Airport | Walk to Restaurants
A hotel room with two beds, a large mirror, and decorative wall art.

8. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$282 nightly
The price is $314
Nov 2 - Nov 3
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A modern living room with a sofa, a coffee table, a TV, and a kitchen area in the background.

9. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$256 nightly
The price is $285
Nov 17 - Nov 18
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A patio with outdoor furniture, a pathway, and a fence.

10. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (13 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$270 nightly
The price is $300
Nov 2 - Nov 3
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

11. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$271 nightly
The price is $302
Nov 2 - Nov 3
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A modern living room with a grey sofa, a wooden coffee table, and a dining area with a small table and chairs.

12. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
8.0 out of 10, Very good, (3 reviews)
"Host is very responsive which I always appreciate. The place is very practical and the location is great."
United States
Andrea S.
$235 nightly
The price is $247
Nov 19 - Nov 20
Total with taxes and fees
Relaxing Retreat in North Park – 3943
A neatly made bed with white towels, a striped pillow, and a small plant on a shelf.

13. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (10 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
$322 nightly
The price is $322
Nov 4 - Nov 5
Total with taxes and fees
Prime North Park Stay: Walkable 95/100 + Parking!
A living room with a green sofa, a coffee table, and a dining area with a table and chairs. There are plants and framed pictures on the walls.

14. Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg

Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Very kind host and great walkable location. The yard made it very convenient for my dog and the bed was super comfy"
United States
Rae-Matthew E.
$322 nightly
The price is $322
Nov 5 - Nov 6
Total with taxes and fees
Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
An outdoor patio area with a wooden pergola covered in flowering vines, a seating area with blue chairs, and a wooden fence in the background.

15. 2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (235 reviews)
"We loved being within walking distance of historic Old Town. The safe parking gave us total peace of mind, and having so many restaurants right around the corner was so convenient. Great place for a family of 5!"
Australia
Young ran
$190 nightly
The price is $211
Nov 3 - Nov 4
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

16. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (308 reviews)
"A wonderful place to stay in a fun area with great hosts!"
United States
Alison W.
$181 nightly
The price is $201
Nov 9 - Nov 10
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
A modern kitchen with white cabinetry, a stainless steel stove, and a microwave.

17. Charming 2BR Normal Heights Home

Charming 2BR Normal Heights Home
Mid-City
6.0 out of 10, (1 review)
"Underwhelming home. Sparsely decorated. Felt like a first college apartment. Living room couches were small and uncomfortable. Overhead lighting only. So expect bright lights all the time. No bath mat, which made showering dangerous as it was very slippery. No towel ring in bathroom, so had to throw towel over shower rod. Plug ins were overwhelming (we unplugged them all and wrapped them in a towel. It was located across the street from family, so location was good for us, but you will battle...
United States
Nancy D.
$354 nightly
The price is $394
Oct 30 - Oct 31
Total with taxes and fees
Charming 2BR Normal Heights Home
A living room with a flat-screen TV, a fireplace, a ceiling fan, a green couch, and a view of the outdoors through large windows.

18. 1BR King Bed Apartment with AC in sunny San Diego

1BR King Bed Apartment with AC in sunny San Diego
Mid-City
$237 nightly
The price is $265
Nov 29 - Nov 30
Total with taxes and fees
1BR King Bed Apartment with AC in sunny San Diego
A bedroom with a bed, a TV, a ceiling fan, and a view of a living room with a blue sofa.

19. Stylish & Comfy Gem: Walk To Everything ~ Parking!

Stylish & Comfy Gem: Walk To Everything ~ Parking!
North Park
9.4 out of 10, Exceptional, (3 reviews)
"Absolutely wonderful first experience with Vrbo. Rebecca was always available & is definitely a top notch host!Lovely home & hope to be back on San Diego soon &!would definitely recommend those property to everyone."
United States
Martha M.
$324 nightly
The price is $324
Nov 1 - Nov 2
Total with taxes and fees
Stylish & Comfy Gem: Walk To Everything ~ Parking!
A hot tub with a city view, string lights, and a grill.

20. The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit

The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Middletown
8.4 out of 10, Very good, (5 reviews)
"Perfect amount of space for 3 people, no issues in the house, everything worked fine. You can hear everything that happens upstairs but that's kind of expected when staying on the bottom level of anything. Hosts were very helpful, let us check in early which was convenient for us! Close to airport and downtown which was nice. Overall great stay!"
United States
Gabby W.
$362 nightly
The price is $402
Nov 3 - Nov 4
Total with taxes and fees
The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Pleasant Inn

Pleasant Inn

10/10 Excellent
"I would come here again Great service"
Alfredo 1-night trip
Posted 4 hours ago
Pleasant Inn

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $115 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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