A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (224 reviews)
"Friendly staff!"
United States
Donavin
$157 nightly
The price is $177
Nov 2 - Nov 3
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (489 reviews)
"We had a great stay! The room had a charming Parisian feel—compact and studio-style, but completely modern and spotlessly clean."
United States
Josh
$103 nightly
The price is $116
Oct 26 - Oct 27
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A hotel room with two beds, a large mirror, and decorative wall art.

3. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$282 nightly
The price is $314
Oct 18 - Oct 19
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

4. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"It was okay"
United States
Nicole
$310 nightly
The price is $345
Oct 18 - Oct 19
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
A sunset over a beach with a pier in the background.

5. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (63 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
$297 nightly
The price is $330
Oct 19 - Oct 20
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A rustic interior with wooden walls, a long row of wooden paddles, and metal barrels.

6. Private Cozy Clean, close to EVERYTHING

Private Cozy Clean, close to EVERYTHING
Mid-City
9.8 out of 10, Exceptional, (73 reviews)
"Location was perfect for daily outings in San Diego. Would stay again. "
United States
Caitlin M.
$315 nightly
The price is $350
Nov 3 - Nov 4
Total with taxes and fees
Private Cozy Clean, close to EVERYTHING
A bedroom with a bed, a desk, a chair, a ceiling fan, and a door leading to another room.

7. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
10.0 out of 10, Exceptional, (1 review)
"Simple property that does the job! Pleasant experience!"
United States
Brandon S.
$128 nightly
The price is $142
Oct 20 - Oct 21
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
A modern kitchen with a gas stove, a microwave, and a dishwasher. There is a wooden cutting board with utensils on it, and a potted plant on the counter.

8. Beautiful Normal Heights Living

Beautiful Normal Heights Living
Mid-City
10.0 out of 10, Exceptional, (111 reviews)
"Great location."
United States
James R.
$286 nightly
The price is $318
Oct 18 - Oct 19
Total with taxes and fees
Beautiful Normal Heights Living
A two-story house with a prominent front entrance, a balcony, and a garage.

9. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$188 nightly
The price is $197
Oct 21 - Oct 22
Total with taxes and fees
San Diego Centralized Retreat
A living room with a large flat-screen TV, a fireplace, a sofa, and a large window.

10. 3 Story Spanish Style House, Best Location in SD. Views of North Park, With AC

3 Story Spanish Style House, Best Location in SD. Views of North Park, With AC
North Park
8.4 out of 10, Very good, (34 reviews)
"Check-in and check-out went smoothly. The location was easy to find and the surrounding area was quiet, allowing for a relaxing stay. Tissues and paper towels were not provided, so I recommend bringing your own."
Japan
t
$301 nightly
The price is $334
Oct 19 - Oct 20
Total with taxes and fees
3 Story Spanish Style House, Best Location in SD. Views of North Park, With AC
A spacious kitchen with white cabinets, a built-in microwave, and a stainless steel refrigerator.

11. Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!

Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
Bankers Hill
9.2 out of 10, Wonderful, (54 reviews)
"Clean place, very close to the zoo"
United States
dyana H.
$303 nightly
The price is $337
Oct 19 - Oct 20
Total with taxes and fees
Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

12. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (307 reviews)
"A wonderful place to stay in a fun area with great hosts!"
United States
Alison W.
$181 nightly
The price is $201
Oct 25 - Oct 26
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
An outdoor patio area with seating, potted plants, and string lights.

13. Chic Brand-New Penthouse overlooking North Park

Chic Brand-New Penthouse overlooking North Park
North Park
9.8 out of 10, Exceptional, (30 reviews)
"Location is excellent very safe parking garage and secure parkingPlace was very cozy and clean with all the basics provided will definitely come back again"
United States
Spomenka S.
$380 nightly
The price is $407
Oct 22 - Oct 23
Total with taxes and fees
Chic Brand-New Penthouse overlooking North Park
A living room with a dark gray sofa, a wooden coffee table, a ceiling fan, and a flat-screen TV displaying various streaming services.

14. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
$326 nightly
The price is $326
Oct 19 - Oct 20
Total with taxes and fees
Prime North Park Stay: Walkable 95/100 + Parking!
A wooden gate with a wooden archway above it, surrounded by lush greenery and flowering plants.

15. 2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (231 reviews)
"We enjoyed our stay and would recommend staying here."
United States
Robin D.
$199 nightly
The price is $221
Oct 19 - Oct 20
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
A patio with outdoor furniture, a pathway, and a fence.

16. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (13 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$273 nightly
The price is $303
Oct 19 - Oct 20
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

17. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$275 nightly
The price is $306
Oct 19 - Oct 20
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A living room with a flat-screen TV, a fireplace, a sofa with yellow cushions, and a large potted plant.

18. Luxury 3-Bedroom House in Marvelous San Diego

Luxury 3-Bedroom House in Marvelous San Diego
Mid-City
9.6 out of 10, Exceptional, (22 reviews)
"Clean roomReserved parking for midsize or small cars"
United States
Ivan R.
$385 nightly
The price is $430
Nov 15 - Nov 16
Total with taxes and fees
Luxury 3-Bedroom House in Marvelous San Diego
A neatly arranged bedroom with a bed, bedside tables, and wall-mounted artwork.

19. The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit

The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Middletown
8.4 out of 10, Very good, (5 reviews)
"Perfect amount of space for 3 people, no issues in the house, everything worked fine. You can hear everything that happens upstairs but that's kind of expected when staying on the bottom level of anything. Hosts were very helpful, let us check in early which was convenient for us! Close to airport and downtown which was nice. Overall great stay!"
United States
Gabby W.
$349 nightly
The price is $388
Oct 26 - Oct 27
Total with taxes and fees
The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
An outdoor patio with seating, string lights, and potted plants.

20. Eclectic : 65” TVs : Fast Wi-Fi : Parking : Pets : Bohemian

Eclectic : 65” TVs : Fast Wi-Fi : Parking : Pets : Bohemian
North Park
10.0 out of 10, Exceptional, (27 reviews)
"Great location, dedicated parking space, very clean and well-maintained. Would happily stay here again if we return to San Diego "
United States
Benjamin S.
$381 nightly
The price is $424
Oct 19 - Oct 20
Total with taxes and fees
Eclectic : 65” TVs : Fast Wi-Fi : Parking : Pets : Bohemian
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Lafayette Hotel & Club

Lafayette Hotel & Club

10/10 Excellent
"An amazing experience. So accommodating and original!"
Kathryn 3-night trip
Posted 4 hours ago
Lafayette Hotel & Club

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $116 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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