A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Oct 16 - Oct 18
In two months
Nov 27 - Nov 29
In three months
Dec 25 - Dec 27
In four months
Jan 22 - Jan 24

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (217 reviews)
"Top stay when we go out with our friends !"
United States
Jesus
$157 nightly
The price is $177
Oct 13 - Oct 14
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (477 reviews)
"It's good hotel for small day 1 to 3 nights no more then that due to the size of the room."
Canada
patrick
$100 nightly
The price is $113
Oct 5 - Oct 6
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A bedroom with a bed, a desk, a chair, a ceiling fan, and a door leading to another room.

3. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
10.0 out of 10, Exceptional, (1 review)
"Simple property that does the job! Pleasant experience!"
United States
Brandon S.
$128 nightly
The price is $142
Oct 13 - Oct 14
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
A two-story house with a prominent front entrance, a balcony, and a garage.

4. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$184 nightly
The price is $193
Oct 7 - Oct 8
Total with taxes and fees
San Diego Centralized Retreat
A living room with a blue sofa, a round coffee table, and a world map on the wall.

5. Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Mid-City
8.0 out of 10, Very good, (4 reviews)
"We thoroughly appreciated the communications provided by the host. Initially had a few teething issues, with the keylock code not working, and a smell in the bedroom and the living area, but this was rectified and a cleaning crew came in twice for it. Place is perfectly situated (with car use) but a bit less so if on foot, or public transportation. The laundry in the shed and the kitchen are always welcome especially as our booking was over 2 weeks long! Thanks again for a suitable stay for us!"
United States
Carlo Luis
$455 nightly
The price is $455
Oct 12 - Oct 13
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
A modern living room with a green sofa, a round coffee table, and a dining area with a table and chairs.

6. 1BR King Bed Apartment with AC in sunny San Diego

1BR King Bed Apartment with AC in sunny San Diego
Mid-City
$240 nightly
The price is $267
Oct 4 - Oct 5
Total with taxes and fees
1BR King Bed Apartment with AC in sunny San Diego
A patio with outdoor furniture, a pathway, and a fence.

7. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (12 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$270 nightly
The price is $300
Oct 4 - Oct 5
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A hotel room with two beds, a large mirror, and decorative wall art.

8. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$285 nightly
The price is $317
Oct 13 - Oct 14
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

9. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$271 nightly
The price is $302
Oct 5 - Oct 6
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A modern kitchen with white cabinetry, a built-in microwave, a dishwasher, and a stainless steel refrigerator.

10. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$256 nightly
The price is $285
Oct 12 - Oct 13
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A living room with a green sofa, a coffee table, and a dining area with a table and chairs. There are plants and framed pictures on the walls.

11. Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg

Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Very kind host and great walkable location. The yard made it very convenient for my dog and the bed was super comfy"
United States
Rae-Matthew E.
$322 nightly
The price is $322
Oct 4 - Oct 5
Total with taxes and fees
Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
A modern living room with a dark wood floor, a black leather sofa, a dining table with chairs, and a large potted plant.

12. Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi

Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi
North Park
7.4 out of 10, Good, (6 reviews)
"We left something at the home & host contacted us to figure it out."
United States
Blake G.
$254 nightly
The price is $283
Oct 2 - Oct 3
Total with taxes and fees
Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

13. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$295 nightly
The price is $331
Oct 27 - Oct 28
Total with taxes and fees
Close to Airport | Walk to Restaurants
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

14. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (304 reviews)
"Super cute, private little cottage in a great location. Loved the stay, very easy process and great host!"
United States
Ross
$181 nightly
The price is $201
Oct 5 - Oct 6
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
A bedroom with a bed, a TV, a ceiling fan, and a view of a living room with a blue sofa.

15. Stylish & Comfy Gem: Walk To Everything ~ Parking!

Stylish & Comfy Gem: Walk To Everything ~ Parking!
North Park
9.0 out of 10, Wonderful, (2 reviews)
"Great stay, very tight parking spot though!"
United States
Alana M.
$322 nightly
The price is $322
Oct 4 - Oct 5
Total with taxes and fees
Stylish & Comfy Gem: Walk To Everything ~ Parking!
A beach with waves and a sunset.

16. The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit

The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Middletown
8.4 out of 10, Very good, (5 reviews)
"The stay was wonderful, location was great, view was nice. Backyard was wonderful, had so much fun playing all of the games. Inside was a little small in the bedrooms but living room was spacious. But surprisingly….the best part was the bidet! We all were shocked with how nice it was as to have, will definitely be getting one of those going home!"
United States
Andrea W.
$344 nightly
The price is $383
Oct 7 - Oct 8
Total with taxes and fees
The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
A sunset over a beach with a pier in the background.

17. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (61 reviews)
"Clean place, great location, great AC, can’t ask for more! Perfect for a couple."
United States
Justin H.
$283 nightly
The price is $315
Oct 14 - Oct 15
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A modern living room with a grey sofa, a wooden coffee table, and a dining area with a small table and chairs.

18. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
8.0 out of 10, Very good, (3 reviews)
"Host is very responsive which I always appreciate. The place is very practical and the location is great."
United States
Andrea S.
$238 nightly
The price is $249
Oct 5 - Oct 6
Total with taxes and fees
Relaxing Retreat in North Park – 3943
An outdoor patio area with seating, potted plants, and string lights.

19. Chic Brand-New Penthouse overlooking North Park

Chic Brand-New Penthouse overlooking North Park
North Park
9.8 out of 10, Exceptional, (30 reviews)
"Location is excellent very safe parking garage and secure parkingPlace was very cozy and clean with all the basics provided will definitely come back again"
United States
Spomenka S.
$353 nightly
The price is $378
Oct 5 - Oct 6
Total with taxes and fees
Chic Brand-New Penthouse overlooking North Park
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

20. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"It was okay"
United States
Nicole
$303 nightly
The price is $338
Oct 6 - Oct 7
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

8/10 Good
"Hotel was very decent and clean. Staff were very good. Furnishing outdated and worned. Needs updated face-lift. I would, however, stay there again."
Sharon 4-night trip
Posted 1 hour ago
Hampton Inn San Diego/Mission Valley

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $113 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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