Central San Diego Vacation Rentals

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Our top choices for Central San Diego vacation rentals

4.5 star property
9.6 out of 10, Exceptional, (128 reviews)
"Clean nice place to stay at"
United States
Luis
$186 nightly
The price is $210
Mar 23 - Mar 24
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
2.5 star property
8.4 out of 10, Very Good, (315 reviews)
"I had a great visit. Rooms were clean. Beautiful area. Amazing view from the patio. Polite staff. I will definitely stay again. "
United States
Harold
$101 nightly
The price is $114
Apr 7 - Apr 8
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
10.0 out of 10, Exceptional, (272 reviews)
"We enjoyed our time in the back cottage. Everything we needed was available. We were able to just walk to so many sites and restaurants. Will definitely try to come back again! "
United States
Phillip
$172 nightly
The price is $191
Mar 17 - Mar 18
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
8.0 out of 10, Very Good, (2 reviews)
"Wir hatten eine tolle Zeit in San Diego und in der Wohnung. Die Kommunikation mit Rebecca hat super geklappt. Sie hat uns die nötigen Infos für den Check In zur rightigen Zeit gegeben und war während des Aufenthaltes sehr hilfsbereit. Die Wohnung ist für 4 Personen ausreichend groß und perfekt ausgestattet, inkl Waschmaschine und Trockner. Vor allem die Küche haben wir ausgiebig genutzt und haben sehr viel selbst gekocht. Es fehlten lediglich eine Schere und ein Gemüsemesser. Rebecca hat uns...
Germany
Hanna S.
$503 nightly
The price is $503
Mar 22 - Mar 23
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
10.0 out of 10, Exceptional, (199 reviews)
"Perfect location for enjoying the city of San Diego. We walked every night in old San Diego. Ten minutes from the beach, ten minutes from the zoo. Here is the big question, would i stay here again? Oh heck yea!!!"
United States
Ted H.
$200 nightly
The price is $222
Mar 24 - Mar 25
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
10.0 out of 10, Exceptional, (48 reviews)
"The home is beautiful, everything was fantastic! The hosts were very helpful and accommodating. The location was convenient and quiet. "
United States
Paulina B.
$219 nightly
The price is $244
Mar 23 - Mar 24
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!

Vacation Home in Mid-City

Beautiful Normal Heights Living
10.0 out of 10, Exceptional, (77 reviews)
"Great location, nice cozy place, had everything we needed. Would definitely stay again."
United States
Sheila S.
$286 nightly
The price is $318
Mar 21 - Mar 22
Total with taxes and fees
Beautiful Normal Heights Living
9.4 out of 10, Exceptional, (45 reviews)
"This place was well stocked and very inviting. We also enjoyed the design and layout of the property because it allowed for those who wanted to continue the night to do so downstairs while the other who wished to go to bed could find their resting place upstairs. Not to mention the back area that clean and great for keeping the night alive. "
United States
Paris W.
$294 nightly
The price is $327
Mar 24 - Mar 25
Total with taxes and fees
Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
9.8 out of 10, Exceptional, (6 reviews)
"It’s within 15 minutes of Riverwalk Golf club and plenty of restaurants. I was very pleased with my stay "
United States
Tyler
$234 nightly
The price is $256
Apr 3 - Apr 4
Total with taxes and fees
Stylish 1Br Retreat w/Garage AC Close 2 Everything
8.6 out of 10, Excellent, (12 reviews)
"Love the backyard. Everything was just as described and the stay was easy. Thank you!"
United States
cassie n.
$384 nightly
The price is $427
Mar 18 - Mar 19
Total with taxes and fees
San Diego Fun: Jacuzzi-Golf-PoolTable-GmRm!
9.4 out of 10, Exceptional, (30 reviews)
" Our family enjoyed the proximity to everything we wanted to do. The house was very comfortable and spacious. The neighborhood was really quiet and easy to get around in. Every interaction we had with the host was pleasant and helpful. We would definitely stay here again."
United States
Justin H.
$533 nightly
The price is $593
Mar 17 - Mar 18
Total with taxes and fees
Relax at this Family Home w/ Solar heated Pool & Game Room. Close to everything!
9.2 out of 10, Wonderful, (57 reviews)
" 100% satisfied. Would stay again if in the area."
United States
Eugene
$299 nightly
The price is $332
Mar 22 - Mar 23
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
9.8 out of 10, Exceptional, (27 reviews)
"Nice house. Good location."
United States
Andrew K.
$527 nightly
The price is $587
Apr 7 - Apr 8
Total with taxes and fees
Art Gallery Family Home - Southern California Style - Excellent Location
10.0 out of 10, Exceptional, (14 reviews)
"Absolutely beautiful with very polite and responsive host! Thank you for the stay! "
United States
Krystal T.
$220 nightly
The price is $245
Mar 23 - Mar 24
Total with taxes and fees
1b1b Central Hillcrest, San Diego condo. Walkable neighborhood and central to SD
10.0 out of 10, Exceptional, (13 reviews)
"Tiny but clean as a whistle and easy access to Balboa Park and Coronado Island."
United States
Dee Dee S.
$1,252 nightly
The price is $1,271
Apr 7 - Apr 8
Total with taxes and fees
1 mile to Gaslamp—eScooters, Hot tub, Sauna
10.0 out of 10, Exceptional, (3 reviews)
"This is such a charming cottage in San Diego! Loved our convenient stay and were close to everything that we needed. Thanks!"
United States
Ryne R.
$297 nightly
The price is $330
Mar 22 - Mar 23
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
9.8 out of 10, Exceptional, (18 reviews)
"My family of four had a wonderful week-long stay here! The apartment was clean, had everything we needed, and we appreciated the secured parking garage. The provided high chair and pack-n-play also worked very well for us. We loved being so close to San Diego's many attractions; it was easy to drive anywhere from this relatively central location. Our host was responsive, helpful, and made sure we had a great stay. We would not hesitate to book this again in the future!"
United States
Benjamin C.
$422 nightly
The price is $469
Mar 30 - Mar 31
Total with taxes and fees
Artistic + FastWi-Fi + Parking + Pets + EV Charging!
6.8 out of 10, (12 reviews)
"Me and my girlfriend stayed here for a weekend to kind of just enjoy not having to be home for a weekend and staying here was very nice; the view from the living room and balcony was amazing, was close to all the hotspots in SD and just felt like a second home. I was a bit of a chaotic guest leading up to the check-in and that is because of my work but the host Daniel was very helpful and patient with my mistakes and I appreciate what he did for us."
United States
Nico E.
$367 nightly
The price is $408
Mar 15 - Mar 16
Total with taxes and fees
2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views

Vacation Home in Mira Mesa

Super Spacious Family Vacation Home!
9.6 out of 10, Exceptional, (28 reviews)
"Rented this exact place last year around this time and it’s still just as amazing as the last time!! Thank you so much again for allowing me to book my stay here :))"
United States
Marshquellin
$669 nightly
The price is $743
Mar 22 - Mar 23
Total with taxes and fees
Super Spacious Family Vacation Home!

Vacation Home in Golden Hill

Sunkissed home in Golden Hill San Diego
8.6 out of 10, Excellent, (4 reviews)
"Everything was perfect. We enjoyed our stay and the property was fantastic. Perfect location, close to downtown and everything San Diego has to offer. Would definitely stay again. "
United States
brannan t.
$404 nightly
The price is $452
Mar 15 - Mar 16
Total with taxes and fees
Sunkissed home in Golden Hill San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Top Central San Diego Hotel Reviews

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $114 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.