A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

Check prices for these dates

In two weeks
Nov 6 - Nov 8
In two months
Dec 18 - Dec 20
In three months
Jan 15 - Jan 17
In four months
Feb 12 - Feb 14

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (230 reviews)
"Friendly staff!"
United States
Donavin
$157 nightly
The price is $177
Oct 26 - Oct 27
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (495 reviews)
"We had a great stay! The room had a charming Parisian feel—compact and studio-style, but completely modern and spotlessly clean."
United States
Josh
$102 nightly
The price is $115
Oct 26 - Oct 27
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A bedroom with a bed, a desk, a chair, a ceiling fan, and a door leading to another room.

3. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
10.0 out of 10, Exceptional, (1 review)
"Simple property that does the job! Pleasant experience!"
United States
Brandon S.
$128 nightly
The price is $142
Oct 25 - Oct 26
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
A two-story house with a prominent front entrance, a balcony, and a garage.

4. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$180 nightly
The price is $188
Oct 21 - Oct 22
Total with taxes and fees
San Diego Centralized Retreat
A hotel room with two beds, a large mirror, and decorative wall art.

5. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$282 nightly
The price is $314
Oct 21 - Oct 22
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A patio with outdoor furniture, a pathway, and a fence.

6. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (13 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$270 nightly
The price is $300
Oct 21 - Oct 22
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A modern living room with a sofa, coffee table, and a dining area with chairs and a table.

7. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Such a great experience here! The host was very communicative and attentive. Spot was clean and perfect for our weekend getaway. There are plenty of bars and cool shops within walking distance. We will definitely be booking the same spot on our next trip!"
United States
Madison S.
$233 nightly
The price is $243
Nov 16 - Nov 17
Total with taxes and fees
Modern Hideaway in North Park - 3941
A modern living room with a green sofa, a white coffee table, a flat-screen TV mounted on the wall, and a small table with a lamp and a plant.

8. Casa Carlos - In the heart of San Diego

Casa Carlos - In the heart of San Diego
Mid-City
9.0 out of 10, Wonderful, (7 reviews)
"Great location"
United States
Jason D.
$219 nightly
The price is $244
Oct 21 - Oct 22
Total with taxes and fees
Casa Carlos - In the heart of San Diego
A two-story house with a garage, a covered porch, and a small outdoor seating area.

9. The Hideaway of Silver Terrace

The Hideaway of Silver Terrace
Linda Vista
9.4 out of 10, Exceptional, (71 reviews)
"Perfect for one or two people "
United States
Jim P.
$212 nightly
The price is $236
Oct 28 - Oct 29
Total with taxes and fees
The Hideaway of Silver Terrace
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

10. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (307 reviews)
"A wonderful place to stay in a fun area with great hosts!"
United States
Alison W.
$181 nightly
The price is $201
Oct 25 - Oct 26
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
A living room with a green sofa, a coffee table, and a dining area with a table and chairs. There are plants and framed pictures on the walls.

11. Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg

Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Very kind host and great walkable location. The yard made it very convenient for my dog and the bed was super comfy"
United States
Rae-Matthew E.
$322 nightly
The price is $322
Oct 22 - Oct 23
Total with taxes and fees
Colorful & Cozy Oasis: Walk Score 95/100, Free Pkg
A sunset over a beach with a pier in the background.

12. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (64 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
$297 nightly
The price is $330
Oct 27 - Oct 28
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A modern kitchen with white cabinetry, a built-in microwave, a dishwasher, and a stainless steel refrigerator.

13. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$258 nightly
The price is $287
Nov 3 - Nov 4
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

14. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$271 nightly
The price is $302
Oct 21 - Oct 22
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A rustic interior with wooden walls, a long row of wooden paddles, and metal barrels.

15. Private Cozy Clean, close to EVERYTHING

Private Cozy Clean, close to EVERYTHING
Mid-City
9.8 out of 10, Exceptional, (74 reviews)
"Location was perfect for daily outings in San Diego. Would stay again. "
United States
Caitlin M.
$303 nightly
The price is $336
Nov 3 - Nov 4
Total with taxes and fees
Private Cozy Clean, close to EVERYTHING
A modern living room with a grey sofa, a wooden coffee table, and a dining area with a small table and chairs.

16. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
8.0 out of 10, Very good, (3 reviews)
"Host is very responsive which I always appreciate. The place is very practical and the location is great."
United States
Andrea S.
$236 nightly
The price is $246
Oct 26 - Oct 27
Total with taxes and fees
Relaxing Retreat in North Park – 3943
A living room with a dark gray sofa, a wooden coffee table, a ceiling fan, and a flat-screen TV displaying various streaming services.

17. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (10 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
$322 nightly
The price is $322
Oct 21 - Oct 22
Total with taxes and fees
Prime North Park Stay: Walkable 95/100 + Parking!
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

18. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"It was okay"
United States
Nicole
$315 nightly
The price is $350
Oct 25 - Oct 26
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

19. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$294 nightly
The price is $329
Nov 2 - Nov 3
Total with taxes and fees
Close to Airport | Walk to Restaurants
A modern living room with a sectional sofa, a coffee table, and a dining area with chairs and a small table.

20. The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit

The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Middletown
8.4 out of 10, Very good, (5 reviews)
"Perfect amount of space for 3 people, no issues in the house, everything worked fine. You can hear everything that happens upstairs but that's kind of expected when staying on the bottom level of anything. Hosts were very helpful, let us check in early which was convenient for us! Close to airport and downtown which was nice. Overall great stay!"
United States
Gabby W.
$394 nightly
The price is $438
Nov 9 - Nov 10
Total with taxes and fees
The Great Escape 1| Free Beach Gear | Hot Tub, Harbor Views & Fire Pit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Best Western Seven Seas

Best Western Seven Seas

10/10 Excellent
"The security watching over the parking lot at night made me feel safe! And the front office staff was extremely helpful"
Hector 1-night trip
Posted less than an hour ago
Best Western Seven Seas

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $115 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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