A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

Check prices for these dates

In two weeks
Sep 11 - Sep 13
In two months
Oct 23 - Oct 25
In three months
Nov 20 - Nov 22
In four months
Dec 18 - Dec 20

Our top choices for Central San Diego vacation rentals

A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

1. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very Good, (446 reviews)
"Room was perfect for our short trip. Clean room and friendly staff."
United States
Diana
$97 nightly
The price is $110
Sep 1 - Sep 2
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

2. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (192 reviews)
"Enjoyed my stay! Clean spacious room and friendly staff."
United States
omokayode
$178 nightly
The price is $201
Sep 2 - Sep 3
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A two-story house with a prominent front entrance, a balcony, and a garage.

3. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$223 nightly
The price is $236
Sep 7 - Sep 8
Total with taxes and fees
San Diego Centralized Retreat
A modern living room with a grey sofa, a wooden coffee table, and a dining area with a small table and chairs.

4. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
10.0 out of 10, Exceptional, (1 review)
"The stay and experience there and with the owner was absolutely great. The place was cozy and clean. He was on the spot with all needs that we're needing to be met. "
United States
Jamall D.
$239 nightly
The price is $249
Aug 30 - Aug 31
Total with taxes and fees
Relaxing Retreat in North Park – 3943
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

5. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$296 nightly
The price is $332
Sep 1 - Sep 2
Total with taxes and fees
Close to Airport | Walk to Restaurants
A rustic interior with wooden walls, a long row of wooden paddles, and metal barrels.

6. Private Cozy Clean, close to EVERYTHING

Private Cozy Clean, close to EVERYTHING
Mid-City
9.8 out of 10, Exceptional, (71 reviews)
"Location was perfect for daily outings in San Diego. Would stay again. "
United States
Caitlin M.
$308 nightly
The price is $343
Sep 21 - Sep 22
Total with taxes and fees
Private Cozy Clean, close to EVERYTHING

7. Explore San Diego from a Central Location with Canyon Views

Explore San Diego from a Central Location with Canyon Views
North Park
10.0 out of 10, Exceptional, (5 reviews)
"Check in was nice and easy. Hosts were very responsive and helped out with a small supply issue in minutes. The space was clean and organized and made for a great stay on my work trip."
United States
Corey M.
$280 nightly
The price is $311
Aug 31 - Sep 1
Total with taxes and fees
Explore San Diego from a Central Location with Canyon Views
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

8. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (302 reviews)
"Super cute, private little cottage in a great location. Loved the stay, very easy process and great host!"
United States
Ross
$180 nightly
The price is $200
Aug 30 - Aug 31
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
A sunset over a beach with a pier in the background.

9. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (58 reviews)
$285 nightly
The price is $317
Aug 31 - Sep 1
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A modern living room with a sofa, coffee table, and a view of the city.

10. Central Mission Hills Condo with Spectacular Views

Central Mission Hills Condo with Spectacular Views
Mission Hills
9.8 out of 10, Exceptional, (7 reviews)
"Great location, quiet, clean, perfect for a small family. The host is very responsive."
United States
Tamar O.
$321 nightly
The price is $356
Sep 1 - Sep 2
Total with taxes and fees
Central Mission Hills Condo with Spectacular Views
A living room with a blue sofa, a round coffee table, and a world map on the wall.

11. Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Mid-City
8.0 out of 10, Very Good, (4 reviews)
"We thoroughly appreciated the communications provided by the host. Initially had a few teething issues, with the keylock code not working, and a smell in the bedroom and the living area, but this was rectified and a cleaning crew came in twice for it. Place is perfectly situated (with car use) but a bit less so if on foot, or public transportation. The laundry in the shed and the kitchen are always welcome especially as our booking was over 2 weeks long! Thanks again for a suitable stay for us!"
United States
Carlo Luis
$461 nightly
The price is $461
Sep 1 - Sep 2
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
A modern living room with a sofa, coffee table, and a dining area with chairs and a table.

12. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (2 reviews)
"Cozy spot in a convenient location. Easy fast communication with the host. Did not rent/use a car this trip, but there is a garage behind the unit with a parking space that seems vital if you’re planning to stay in this area with a vehicle."
United States
William K.
$236 nightly
The price is $246
Sep 1 - Sep 2
Total with taxes and fees
Modern Hideaway in North Park - 3941
A bedroom with a bed, a TV, a ceiling fan, and a view of a living room with a blue sofa.

13. Stylish & Comfy Gem: Walk To Everything ~ Parking!

Stylish & Comfy Gem: Walk To Everything ~ Parking!
North Park
9.0 out of 10, Wonderful, (2 reviews)
"Great stay, very tight parking spot though!"
United States
Alana M.
$352 nightly
The price is $352
Aug 31 - Sep 1
Total with taxes and fees
Stylish & Comfy Gem: Walk To Everything ~ Parking!
A neatly made bed with a white comforter and pillows, a bedside lamp, and a macrame wall hanging.

14. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$249 nightly
The price is $277
Sep 2 - Sep 3
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A modern hotel room with a bed, bedside table, TV, and a glass dining table.

15. Classic Hillcrest Escape – Near University Heights, Balboa Park & Zoo

Classic Hillcrest Escape – Near University Heights, Balboa Park & Zoo
University Heights
10.0 out of 10, Exceptional, (3 reviews)
"The host was great. The location was great. The place was very clean, and had all the basics."
United States
Kevin A.
$346 nightly
The price is $385
Sep 8 - Sep 9
Total with taxes and fees
Classic Hillcrest Escape – Near University Heights, Balboa Park & Zoo
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

16. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.2 out of 10, Wonderful, (66 reviews)
"My overall experience was excellent. The place is close by several restaurants and shops. The place was decent stay and spacious enough for 4-5 people. The host communicated outstanding and open to be available with any questions or concerns which was appreciated. "
United States
Michelle A.
$345 nightly
The price is $384
Sep 3 - Sep 4
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
A patio with outdoor furniture, a pathway, and a fence.

17. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (11 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$273 nightly
The price is $303
Sep 21 - Sep 22
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A bedroom with a bed, a desk, a chair, a ceiling fan, and a door leading to another room.

18. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
$133 nightly
The price is $147
Sep 15 - Sep 16
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
A hot tub with a wooden deck and string lights, surrounded by potted plants and a wooden fence.

19. Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC

Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC
Golden Hill
10.0 out of 10, Exceptional, (17 reviews)
"We really enjoyed our stay! Place is clean and just so calming with all the fun amenities!! Would certainly come back and stay here any time! Chelsea is very approachable and very nice."
United States
Muhib H.
$1,287 nightly
The price is $1,310
Sep 27 - Sep 28
Total with taxes and fees
Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC
A modern living room with a dark blue sofa, a matching ottoman, and a coffee table. There is a ceiling fan, a lamp, and a view of the outdoors through large windows.

20. Hideaway in the heart of San Diego!

Hideaway in the heart of San Diego!
Mid-City
10.0 out of 10, Exceptional, (8 reviews)
"Very pet friendly. Parking right behind the house. Overall excellent stay."
United States
Lisa S.
$258 nightly
The price is $287
Sep 2 - Sep 3
Total with taxes and fees
Hideaway in the heart of San Diego!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

10/10 Excellent
"Was not expecting much but I was surprised, hotel is excellent. Location as well. Front desk very nice , courtesy and helpful. Room very spacious , clean ; restroom as well , spacious and clean . Highly recommend"
Irma 1-night trip
Posted 2 hours ago
Crowne Plaza San Diego - Mission Valley by IHG

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $110 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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