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Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Oct 2 - Oct 4
In two months
Nov 13 - Nov 15
In three months
Dec 11 - Dec 13
In four months
Jan 8 - Jan 10

Our top choices for Central San Diego vacation rentals

Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (202 reviews)
"The place was really nice and clean. Have a full kitchen, the staff was really kind I love them! For sure we will come back again."
United States
Leriger
$157 nightly
The price is $177
Sep 30 - Oct 1
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
Lobby sitting area

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (463 reviews)
"It's good hotel for small day 1 to 3 nights no more then that due to the size of the room."
Canada
patrick
$106 nightly
The price is $119
Sep 23 - Sep 24
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Exterior

3. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (1 review)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$208 nightly
The price is $219
Oct 6 - Oct 7
Total with taxes and fees
San Diego Centralized Retreat
Property grounds

4. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (302 reviews)
"Super cute, private little cottage in a great location. Loved the stay, very easy process and great host!"
United States
Ross
$171 nightly
The price is $191
Sep 23 - Sep 24
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
TV

5. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Such a great experience here! The host was very communicative and attentive. Spot was clean and perfect for our weekend getaway. There are plenty of bars and cool shops within walking distance. We will definitely be booking the same spot on our next trip!"
United States
Madison S.
$223 nightly
The price is $233
Sep 23 - Sep 24
Total with taxes and fees
Modern Hideaway in North Park - 3941
TV

6. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
9.0 out of 10, Wonderful, (2 reviews)
"The stay and experience there and with the owner was absolutely great. The place was cozy and clean. He was on the spot with all needs that we're needing to be met. "
United States
Jamall D.
$233 nightly
The price is $243
Sep 20 - Sep 21
Total with taxes and fees
Relaxing Retreat in North Park – 3943
TV

7. Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Mid-City
8.0 out of 10, Very good, (4 reviews)
"We thoroughly appreciated the communications provided by the host. Initially had a few teething issues, with the keylock code not working, and a smell in the bedroom and the living area, but this was rectified and a cleaning crew came in twice for it. Place is perfectly situated (with car use) but a bit less so if on foot, or public transportation. The laundry in the shed and the kitchen are always welcome especially as our booking was over 2 weeks long! Thanks again for a suitable stay for us!"
United States
Carlo Luis
$455 nightly
The price is $455
Sep 20 - Sep 21
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Terrace/patio

8. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (12 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$270 nightly
The price is $300
Sep 20 - Sep 21
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
Dining

9. Explore San Diego from a Central Location with Canyon Views

Explore San Diego from a Central Location with Canyon Views
North Park
10.0 out of 10, Exceptional, (5 reviews)
"Check in was nice and easy. Hosts were very responsive and helped out with a small supply issue in minutes. The space was clean and organized and made for a great stay on my work trip."
United States
Corey M.
$279 nightly
The price is $312
Sep 23 - Sep 24
Total with taxes and fees
Explore San Diego from a Central Location with Canyon Views
Property grounds

10. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$274 nightly
The price is $309
Sep 20 - Sep 21
Total with taxes and fees
Close to Airport | Walk to Restaurants
Smart TV, video games, books, stereo

11. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$246 nightly
The price is $274
Sep 20 - Sep 21
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
TV

12. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (9 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
$309 nightly
The price is $309
Sep 21 - Sep 22
Total with taxes and fees
Prime North Park Stay: Walkable 95/100 + Parking!
Beach nearby, beach towels

13. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (61 reviews)
"Clean place, great location, great AC, can’t ask for more! Perfect for a couple."
United States
Justin H.
$270 nightly
The price is $302
Sep 21 - Sep 22
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
Terrace/patio

14. Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC

Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC
Golden Hill
10.0 out of 10, Exceptional, (17 reviews)
"We really enjoyed our stay! Place is clean and just so calming with all the fun amenities!! Would certainly come back and stay here any time! Chelsea is very approachable and very nice."
United States
Muhib H.
$1,276 nightly
The price is $1,297
Sep 29 - Sep 30
Total with taxes and fees
Wellness Oasis—Cold Plunge, Hot tub, Sauna, AC
Property grounds

15. 2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (228 reviews)
"We loved our stay here. There’s a reason Joan and Dove are Premier Hosts. They’re truly amazing, kind ladies. Joan greeted us and genuinely made us feel at home. We will definitely book this place again."
United States
Leah
$213 nightly
The price is $237
Oct 7 - Oct 8
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Beach nearby

16. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"It was okay"
United States
Nicole
$327 nightly
The price is $364
Oct 6 - Oct 7
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Exterior

17. The M @ North park- Local Hot Spot

The M @ North park- Local Hot Spot
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Great location, great place!"
United States
Anonymous traveler
The M @ North park- Local Hot Spot
1 bedroom, WiFi, bed sheets

18. Private Entrance With Crisp Sheets And A Cozy Grotto Shower

Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Mid-City
$128 nightly
The price is $142
Sep 20 - Sep 21
Total with taxes and fees
Private Entrance With Crisp Sheets And A Cozy Grotto Shower
Living area

19. Newly renovated home in the heart of hillcrest

Newly renovated home in the heart of hillcrest
Hillcrest
$212 nightly
The price is $236
Sep 20 - Sep 21
Total with taxes and fees
Newly renovated home in the heart of hillcrest
Smart TV

20. Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi

Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi
North Park
7.4 out of 10, Good, (6 reviews)
"We left something at the home & host contacted us to figure it out."
United States
Blake G.
$254 nightly
The price is $283
Sep 20 - Sep 21
Total with taxes and fees
Charming 2-bedroom apartment in terrific San Diego North Park Area with WiFi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

California Suites Hotel

California Suites Hotel

10/10 Excellent
"For first time stay, we were impressed. We will consider coming back because of location and plenty of parking. Thank you"
James 3-night trip
Posted 1 hour ago
California Suites Hotel

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $119 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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