Central San Diego Vacation Rentals

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Check prices for these dates

In two weeks
Mar 20 - Mar 22
In two months
May 1 - May 3
In three months
May 29 - May 31
In four months
Jun 26 - Jun 28

Our top choices for Central San Diego vacation rentals

Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio

Aparthotel in Middletown

City24 Hotel Little Italy Mission Hills
4.5 star property
9.6 out of 10, Exceptional, (125 reviews)
"Very clean, quiet, walking distance to great food"
United States
Amanda
$186 nightly
The price is $210
Mar 10 - Mar 11
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
Lobby sitting area

Aparthotel in Hillcrest

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
8.4 out of 10, Very Good, (312 reviews)
"The room was very small but very clean. Great place to stay for the short amount of time we needed it. "
United States
Debra
$112 nightly
The price is $126
Apr 6 - Apr 7
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
Beach towels

Vacation Home in Bay Ho

Adorable 1 bedroom house 8 min from La Jolla!
10.0 out of 10, Exceptional, (47 reviews)
"The home is beautiful, everything was fantastic! The hosts were very helpful and accommodating. The location was convenient and quiet. "
United States
Paulina B.
$220 nightly
The price is $245
Mar 9 - Mar 10
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
Fridge, microwave, oven, stovetop

Vacation Home in Mid-City

Beautiful Normal Heights Living
10.0 out of 10, Exceptional, (77 reviews)
"Great location, nice cozy place, had everything we needed. Would definitely stay again."
United States
Sheila S.
$286 nightly
The price is $318
Mar 7 - Mar 8
Total with taxes and fees
Beautiful Normal Heights Living
Property grounds

Cottage in Old Town San Diego

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
10.0 out of 10, Exceptional, (271 reviews)
"Convenient and comfortable "
United States
Anya B.
$170 nightly
The price is $189
Mar 24 - Mar 25
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
TV

Vacation Home in Mid-City

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
8.0 out of 10, Very Good, (2 reviews)
"Wir hatten eine tolle Zeit in San Diego und in der Wohnung. Die Kommunikation mit Rebecca hat super geklappt. Sie hat uns die nötigen Infos für den Check In zur rightigen Zeit gegeben und war während des Aufenthaltes sehr hilfsbereit. Die Wohnung ist für 4 Personen ausreichend groß und perfekt ausgestattet, inkl Waschmaschine und Trockner. Vor allem die Küche haben wir ausgiebig genutzt und haben sehr viel selbst gekocht. Es fehlten lediglich eine Schere und ein Gemüsemesser. Rebecca hat uns...
Germany
Hanna S.
$531 nightly
The price is $531
Mar 8 - Mar 9
Total with taxes and fees
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Pool

Vacation Home in Mid-City

Stylish 1Br Retreat w/Garage AC Close 2 Everything
9.6 out of 10, Exceptional, (5 reviews)
"It’s within 15 minutes of Riverwalk Golf club and plenty of restaurants. I was very pleased with my stay "
United States
Tyler
$209 nightly
The price is $229
Mar 16 - Mar 17
Total with taxes and fees
Stylish 1Br Retreat w/Garage AC Close 2 Everything
Private kitchen

Vacation Home in Mid-City

Cozy Private Home, 10-min From DT, Beach & Parks
8.0 out of 10, Very Good, (11 reviews)
"Our family stayed for spring break. We found that the location was perfect to be able to get anywhere we needed to go quite conveniently. The house was perfect for what we needed and we were always able to find a parking spot. "
United States
Leah S.
$246 nightly
The price is $273
Mar 10 - Mar 11
Total with taxes and fees
Cozy Private Home, 10-min From DT, Beach & Parks
Outdoor dining

Apartment in North Park

Artistic + FastWi-Fi + Parking + Pets + EV Charging!
9.8 out of 10, Exceptional, (18 reviews)
"My family of four had a wonderful week-long stay here! The apartment was clean, had everything we needed, and we appreciated the secured parking garage. The provided high chair and pack-n-play also worked very well for us. We loved being so close to San Diego's many attractions; it was easy to drive anywhere from this relatively central location. Our host was responsive, helpful, and made sure we had a great stay. We would not hesitate to book this again in the future!"
United States
Benjamin C.
$411 nightly
The price is $457
Mar 10 - Mar 11
Total with taxes and fees
Artistic + FastWi-Fi + Parking + Pets + EV Charging!
Terrace/patio

Vacation Home in North Park

Charming Mid-Century Craftsman ~ Hot Tub • Serene Yard
10.0 out of 10, Exceptional, (104 reviews)
"My family and I loved our stay here. Check-in and communication with Tasha was a breeze. We thoroughly enjoyed the enclosed yard, jacuzzi, and close proximity to numerous restaurants and cafes."
United States
Jason & Cass
$407 nightly
The price is $453
Mar 10 - Mar 11
Total with taxes and fees
Charming Mid-Century Craftsman ~ Hot Tub • Serene Yard
Property grounds

Vacation Home in Old Town San Diego

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
10.0 out of 10, Exceptional, (198 reviews)
"Perfect location for enjoying the city of San Diego. We walked every night in old San Diego. Ten minutes from the beach, ten minutes from the zoo. Here is the big question, would i stay here again? Oh heck yea!!!"
United States
Ted H.
$221 nightly
The price is $246
Mar 8 - Mar 9
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Beach nearby

Apartment in Mission Valley

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
9.2 out of 10, Wonderful, (57 reviews)
" 100% satisfied. Would stay again if in the area."
United States
Eugene
$300 nightly
The price is $333
Mar 11 - Mar 12
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Smart TV, offices

Condo in Hillcrest

1b1b Central Hillcrest, San Diego condo. Walkable neighborhood and central to SD
10.0 out of 10, Exceptional, (14 reviews)
"Absolutely beautiful with very polite and responsive host! Thank you for the stay! "
United States
Krystal T.
$220 nightly
The price is $245
Mar 18 - Mar 19
Total with taxes and fees
1b1b Central Hillcrest, San Diego condo. Walkable neighborhood and central to SD
Interior

Vacation Home in Bankers Hill

Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
9.4 out of 10, Exceptional, (45 reviews)
"This place was well stocked and very inviting. We also enjoyed the design and layout of the property because it allowed for those who wanted to continue the night to do so downstairs while the other who wished to go to bed could find their resting place upstairs. Not to mention the back area that clean and great for keeping the night alive. "
United States
Paris W.
$395 nightly
The price is $439
Mar 16 - Mar 17
Total with taxes and fees
Cozy 2Bed 1BA Bankers Hill Residence with Parking, no chores!
Terrace/patio

Cottage in University City

✔Remote Work✔A/C✔200Mbps✔Kitchen✔Streaming
10.0 out of 10, Exceptional, (33 reviews)
"Great property, very well maintained & the hosts were wonderful. "
United States
Ryan B.
$511 nightly
The price is $569
Mar 8 - Mar 9
Total with taxes and fees
✔Remote Work✔A/C✔200Mbps✔Kitchen✔Streaming
Outdoor dining

Vacation Home in Golden Hill

Sunkissed home in Golden Hill San Diego
10.0 out of 10, Exceptional, (3 reviews)
"Our stay was absolutely fantastic. This place has everything we needed, and was located in a great location. Hosts were super responsive and helped whenever necessary. Highly highly recommend this stay for anyone looking"
United States
Bryan W.
$420 nightly
The price is $468
Mar 8 - Mar 9
Total with taxes and fees
Sunkissed home in Golden Hill San Diego
Terrace/patio

Apartment in Golden Hill

1 mile to Gaslamp—eScooters, Hot tub, Sauna
10.0 out of 10, Exceptional, (13 reviews)
"Tiny but clean as a whistle and easy access to Balboa Park and Coronado Island."
United States
Dee Dee S.
$1,298 nightly
The price is $1,323
Apr 6 - Apr 7
Total with taxes and fees
1 mile to Gaslamp—eScooters, Hot tub, Sauna
Dining

Vacation Home in Mission Hills

2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views
6.6 out of 10, (11 reviews)
"Me and my girlfriend stayed here for a weekend to kind of just enjoy not having to be home for a weekend and staying here was very nice; the view from the living room and balcony was amazing, was close to all the hotspots in SD and just felt like a second home. I was a bit of a chaotic guest leading up to the check-in and that is because of my work but the host Daniel was very helpful and patient with my mistakes and I appreciate what he did for us."
United States
Nico E.
$367 nightly
The price is $408
Mar 8 - Mar 9
Total with taxes and fees
2 bed, Just a few Minutes to Airport & Old Town, Great City Skyline Views
Outdoor spa tub

Vacation Home in Clairemont

San Diego Fun: Jacuzzi-Golf-PoolTable-GmRm!
8.4 out of 10, Very Good, (11 reviews)
"Love the backyard. Everything was just as described and the stay was easy. Thank you!"
United States
cassie n.
$459 nightly
The price is $510
Mar 22 - Mar 23
Total with taxes and fees
San Diego Fun: Jacuzzi-Golf-PoolTable-GmRm!
Dining

Apartment in North Park

Explore San Diego from a Central Location with Canyon Views
10.0 out of 10, Exceptional, (5 reviews)
"Check in was nice and easy. Hosts were very responsive and helped out with a small supply issue in minutes. The space was clean and organized and made for a great stay on my work trip."
United States
Corey M.
$272 nightly
The price is $302
Mar 9 - Mar 10
Total with taxes and fees
Explore San Diego from a Central Location with Canyon Views
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

6/10 Okay
"The breakfast was absolutely horrendous. If you’re staying for the breakfast, don’t do that. The fact that you have to pay an extra $30 to park that’s not really mentioned on their website is also ridiculous. The staff was really fantastic although they came to clean our room and there was a huge ring around the bathtub that sat there for two days. Our bathroom was set up so far that we couldn’t reach the toilet paper and we had to put it on the back of the toilet, which is not the biggest deal except we were too grown adults so if you had kids or elderly in that room, they wouldn’t be able to make it work. The outdoor pool had wet, dirty towels, everywhere and no clean towels anywhere."
Skylar 4-night trip
Posted 2 hours ago
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $126 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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