A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Central San Diego vacation rentals

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (242 reviews)
"Location is great because it is so close to the airport and you won’t even be able to hear the planes. The room is so roomy and has every utility you need !"
United States
Stephanie
$140 nightly
The price is $157
Dec 9 - Dec 10
Total with taxes and fees
City24 Hotel Little Italy Mission Hills
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (515 reviews)
"Front desk service was amazing and love the central location to all the LGBTQ bars and restaurants."
United States
Victor
$102 nightly
The price is $115
Nov 10 - Nov 11
Total with taxes and fees
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A two-story house with a prominent front entrance, a balcony, and a garage.

3. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (2 reviews)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
$174 nightly
The price is $183
Nov 30 - Dec 1
Total with taxes and fees
San Diego Centralized Retreat
A bedroom with a large bed, a wall-mounted artwork, a bedside table with a lamp, and a view through a sliding glass door to an outdoor area.

4. Private 1-bedroom suite close to it all in San Diego

Private 1-bedroom suite close to it all in San Diego
Middletown
$110 nightly
The price is $123
Nov 10 - Nov 11
Total with taxes and fees
Private 1-bedroom suite close to it all in San Diego
A modern living room with a sofa, coffee table, and a dining area with chairs and a table.

5. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Such a great experience here! The host was very communicative and attentive. Spot was clean and perfect for our weekend getaway. There are plenty of bars and cool shops within walking distance. We will definitely be booking the same spot on our next trip!"
United States
Madison S.
$216 nightly
The price is $227
Nov 16 - Nov 17
Total with taxes and fees
Modern Hideaway in North Park - 3941
A hotel room with two beds, a large mirror, and decorative wall art.

6. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
$262 nightly
The price is $294
Nov 30 - Dec 1
Total with taxes and fees
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
A sunset over a beach with a pier in the background.

7. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (65 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
$272 nightly
The price is $305
Nov 13 - Nov 14
Total with taxes and fees
Adorable 1 bedroom house 8 min from La Jolla!
A patio with outdoor furniture, a pathway, and a fence.

8. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (13 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
$251 nightly
The price is $281
Nov 10 - Nov 11
Total with taxes and fees
Cozy 2-Bedroom Cottage Near Balboa Park
A beachside hotel with multiple floors, a sandy beach in the foreground, and palm trees lining the shore.

9. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"Very big and nice place. We really enjoyed it"
United States
Jose U.
$272 nightly
The price is $305
Nov 16 - Nov 17
Total with taxes and fees
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
A living room with a flat-screen TV, a fireplace, a ceiling fan, a green couch, and a view of the outdoors through large windows.

10. 1BR King Bed Apartment with AC in sunny San Diego

1BR King Bed Apartment with AC in sunny San Diego
Mid-City
$238 nightly
The price is $267
Nov 30 - Dec 1
Total with taxes and fees
1BR King Bed Apartment with AC in sunny San Diego
A modern living room with a sofa, a coffee table, a TV, and a kitchen area in the background.

11. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
$238 nightly
The price is $267
Nov 10 - Nov 11
Total with taxes and fees
Luxury San Diego 1BR with Premium Conveniences
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

12. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
$252 nightly
The price is $283
Nov 10 - Nov 11
Total with taxes and fees
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A balcony with a fire feature, a grill, and a view of a cityscape at sunset.

13. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
$277 nightly
The price is $313
Nov 25 - Nov 26
Total with taxes and fees
Close to Airport | Walk to Restaurants
A living room with a dark gray sofa, a wooden coffee table, a ceiling fan, and a flat-screen TV displaying various streaming services.

14. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (10 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
$283 nightly
The price is $283
Nov 11 - Nov 12
Total with taxes and fees
Prime North Park Stay: Walkable 95/100 + Parking!
A modern living room with a grey sofa, a wooden coffee table, and a dining area with a small table and chairs.

15. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
8.0 out of 10, Very good, (3 reviews)
"Host is very responsive which I always appreciate. The place is very practical and the location is great."
United States
Andrea S.
$216 nightly
The price is $227
Nov 19 - Nov 20
Total with taxes and fees
Relaxing Retreat in North Park – 3943
Interior

16. Cozy caravan in San Diego with AC & Wifi

Cozy caravan in San Diego with AC & Wifi
Miramar
2.0 out of 10, (1 review)
$156 nightly
The price is $175
Nov 10 - Nov 11
Total with taxes and fees
Cozy caravan in San Diego with AC & Wifi
A bedroom with a bed, a TV, a ceiling fan, and a view of a living room with a blue sofa.

17. Stylish & Comfy Gem: Walk To Everything ~ Parking!

Stylish & Comfy Gem: Walk To Everything ~ Parking!
North Park
9.4 out of 10, Exceptional, (3 reviews)
"Absolutely wonderful first experience with Vrbo. Rebecca was always available & is definitely a top notch host!Lovely home & hope to be back on San Diego soon &!would definitely recommend those property to everyone."
United States
Martha M.
$288 nightly
The price is $288
Nov 17 - Nov 18
Total with taxes and fees
Stylish & Comfy Gem: Walk To Everything ~ Parking!
A building with a covered outdoor seating area, surrounded by various plants and a large rock.

18. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (309 reviews)
"Very clean place, the host Joan was amazing. Very kind to give a little tour of the place and let me know where to park. Easy to communicate with. Place was very quiet and I appreciated that and the location was great. Right in Old Town pretty much which was fun to experience! I definitely recommend this place to anyone who is looking to stay in SD!"
United States
Paulina
$176 nightly
The price is $196
Nov 10 - Nov 11
Total with taxes and fees
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
A kitchen counter with a coffee maker, coffee beans, a coffee grinder, and a bag of coffee pods.

19. 2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (238 reviews)
"We loved being within walking distance of historic Old Town. The safe parking gave us total peace of mind, and having so many restaurants right around the corner was so convenient. Great place for a family of 5!"
Australia
Young ran
$183 nightly
The price is $204
Nov 17 - Nov 18
Total with taxes and fees
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
A coastal cityscape with a wide beach, clear blue sky, and distant hills.

20. New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy

New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy
Middletown
6.2 out of 10, (20 reviews)
"Perfect location if you are traveling and wanting to see San Diego!"
United States
Jeanette P.
$153 nightly
The price is $171
Nov 16 - Nov 17
Total with taxes and fees
New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Central San Diego Hotel Reviews

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

10/10 Excellent
"At first there was an issue with checking into my room, but the person helping (Swale) was so nice and helpful. Everyone was nice, helpful, and the place was clean. Hotel parking is around $40 a night, just a heads up!"
Alexis 3-night trip
Posted less than an hour ago
Hilton San Diego Mission Valley

Find out more about Central San Diego

Everything you need to know about Central San Diego vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Central San Diego vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Central San Diego vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Central San Diego vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Central San Diego. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Central San Diego in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $115 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Central San Diego rentals

At Expedia, we put the best Central San Diego vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Central San Diego rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Central San Diego vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Central San Diego. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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