Find luxury hotels in Perryville, MO

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Perryville Luxury Hotels

No exact matches found, but these alternatives could be just right

Recommended hotels in Perryville

Private kitchen
Gorgeous, downtown house!

Gorgeous, downtown house!

Gorgeous, downtown house!
Perryville
10.0 out of 10, Exceptional, (1)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
$771 nightly
The price is $875
Dec 15 - Dec 16
Total with taxes and fees
Gorgeous, downtown house!
Property grounds
TreeLoft at BaseCamp

TreeLoft at BaseCamp

TreeLoft at BaseCamp
2.0 star property
Perryville
10.0 out of 10, Exceptional, (5)
"This place is perfect if you want a private upscale experience that is immersed in natural beauty. The treehouse is luxurious and so comfortable. We loved every minute of our stay. "
United States
joel r.
$583 nightly
The price is $614
Dec 20 - Dec 21
Total with taxes and fees
TreeLoft at BaseCamp
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (539)
"Clean room and pleasant staff"
United States
David
$87 nightly
The price is $100
Dec 14 - Dec 15
Total with taxes and fees
Holiday Inn Express & Suites Perryville by IHG
Interior
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
Perryville
10.0 out of 10, Exceptional, (1)
"Everything was perfect!"
United States
Thor L.
$277 nightly
The price is $317
Dec 15 - Dec 16
Total with taxes and fees
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
Full-size fridge, microwave, oven, stovetop
Urban Lofts

Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.2 out of 10, Wonderful, (17)
"Great place to stay! "
United States
Eric
$208 nightly
The price is $238
Dec 31 - Jan 1, 2026
Total with taxes and fees
Urban Lofts
Interior
Downtown Urban Loft above Restaurants

Downtown Urban Loft above Restaurants

Downtown Urban Loft above Restaurants
2.0 star property
Perryville
$273 nightly
The price is $313
Dec 15 - Dec 16
Total with taxes and fees
Downtown Urban Loft above Restaurants
Interior
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques

Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques

Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques
2.0 star property
Perryville
$185 nightly
The price is $213
Dec 12 - Dec 13
Total with taxes and fees
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques
Interior
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques

Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques

Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques
Perryville
$227 nightly
The price is $261
Dec 31 - Jan 1, 2026
Total with taxes and fees
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques
Suite, 1 King Bed, Non Smoking (1 Bedroom) | In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very Good, (937)
"The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet."
United States
Cynthia
$63 nightly
The price is $72
Dec 22 - Dec 23
Total with taxes and fees
Super 8 by Wyndham Perryville
Lobby
Quality Inn Perryville I-55

Quality Inn Perryville I-55

Quality Inn Perryville I-55
2.5 star property
Perryville
6.6 out of 10, (124)
"Nice place would recommend Mary Jane’s if you’re looking for good food "
United States
Andrew
$69 nightly
The price is $79
Dec 18 - Dec 19
Total with taxes and fees
Quality Inn Perryville I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Perryville Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Perryville vacation?
Let Expedia help you arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are an important consideration when you plan a trip, so we make it easy to get what you need to make your stay relaxing and comfortable. If you want a posh hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Perryville offers. Perryville has some interesting things to see and do including National Shrine of Our Lady of the Miraculous Medal and Perryville Country Club, so you might want to take in the local sights during your visit.
When can I expect good weather in Perryville?
Planning for the weather is an important factor for making your trip to Perryville a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 39°F. Average annual precipitation for Perryville is 48 inches.
What's there to see and do in Perryville?
Take in some sights and attractions while you're in Perryville by visiting National Shrine of Our Lady of the Miraculous Medal, Perryville Country Club, and Mark Twain National Forest. If you have extra time while you're in the area, you might want to stop by Mississippi River and Saint Marys Lake.

Explore a world of travel with Expedia