A train crossing a stone bridge over a river, surrounded by lush greenery.

Perryville Vacation Rentals

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Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7

Our top choices for Perryville vacation rentals

A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

1. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.8 out of 10, Exceptional, (9 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
$88 nightly
The price is $101
Nov 7 - Nov 8
Total with taxes and fees
The Atrium - A Boutique Hotel
A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

2. Urban Lofts

Urban Lofts
3.0 star property
Perryville
9.4 out of 10, Exceptional, (22 reviews)
"Beautiful place and staff was amazing!"
United States
Grace
$295 nightly
The price is $338
Oct 19 - Oct 20
Total with taxes and fees
Urban Lofts
A modern kitchen with dark wood cabinets, a central island, and a brick wall.

3. Downtown Urban Loft #9

Downtown Urban Loft #9
Perryville
10.0 out of 10, Exceptional, (8 reviews)
"The Zen atmosphere made it really relaxing and the spa bathroom was incredible"
United States
Hunter
$277 nightly
The price is $317
Oct 19 - Oct 20
Total with taxes and fees
Downtown Urban Loft #9
A modern kitchen with stainless steel appliances, a large window, and a breakfast setup on the counter.

4. Gorgeous, downtown house!

Gorgeous, downtown house!
Perryville
10.0 out of 10, Exceptional, (1 review)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
$771 nightly
The price is $875
Oct 19 - Oct 20
Total with taxes and fees
Gorgeous, downtown house!
A spacious loft with exposed brick walls, large windows, a kitchen with bar seating, and a ceiling fan.

5. Downtown Urban Loft #1

Downtown Urban Loft #1
Perryville
$280 nightly
The price is $320
Oct 19 - Oct 20
Total with taxes and fees
Downtown Urban Loft #1
A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

6. Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (295 reviews)
"Well stocked on supplies"
United States
Nicholas T.
$181 nightly
The price is $202
Oct 28 - Oct 29
Total with taxes and fees
Beautiful Modern Loft In Wine Country!
A wooden deck with a table and chairs, a window, and a view of trees.

7. Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville.

Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville.
Ste. Genevieve
10.0 out of 10, Exceptional, (63 reviews)
"Wonderful place to stay in Ste Genevieve wine country"
United States
Nicholas S.
$400 nightly
The price is $427
Nov 10 - Nov 11
Total with taxes and fees
Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville.
A living room with a leather sofa, a coffee table, and a television on a wooden shelf.

8. Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve

Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve
Saint Mary
9.8 out of 10, Exceptional, (12 reviews)
"The house was very clean. It's located in a quiet and safe neighborhood. It was well stocked with cooking utensils. It was pet friendly with a secure fenced backyard. The host was responsive and accommodating. We stayed here while we were in town for work and would stay here again."
United States
Deborah H.
$369 nightly
The price is $402
Oct 19 - Oct 20
Total with taxes and fees
Sleeps 8 | Private Hot Tub + Fenced Yard | Near Historic Ste. Genevieve
Exterior

9. Cozy 2-bedroom cottage in charming Ste. Genevieve

Cozy 2-bedroom cottage in charming Ste. Genevieve
Ste. Genevieve
9.8 out of 10, Exceptional, (8 reviews)
"The “little brick house” was a great place for us to stay on our journey back from a trip out west. The town was fun to explore with its cute historic charm as well. Would highly recommend for anyone looking to getaway or stop through."
United States
Sarah H.
$170 nightly
The price is $184
Oct 25 - Oct 26
Total with taxes and fees
Cozy 2-bedroom cottage in charming Ste. Genevieve
A two-story cylindrical building with a covered porch and a welcoming sign.

10. Silo Farm Haus- located in the heart of wine country!

Silo Farm Haus- located in the heart of wine country!
Ste. Genevieve
10.0 out of 10, Exceptional, (158 reviews)
"We had an amazing time! Great property and cozy. We had a few dead flies in the bed but otherwise perfect stay!"
United States
Anthony S.
$331 nightly
The price is $370
Oct 19 - Oct 20
Total with taxes and fees
Silo Farm Haus- located in the heart of wine country!
A small, single-story building with a porch, red chairs, and a fan.

11. 5 Charles Farms #4 - NEW CABIN - Wineries, Hiking, and Camp Cana

5 Charles Farms #4 - NEW CABIN - Wineries, Hiking, and Camp Cana
New Offenburg
10.0 out of 10, Exceptional, (2 reviews)
"This was one of the best places I’ve ever stayed. Owner thought of everything and it was so comfortable. The space was perfect, extra blankets, both types of coffee makers, firewood on site. This is a very new property and everything was immaculate and clean. Was easy to navigate check-in and house was so cute! Would definitely recommend to anyone heading to St Gen or any of surrounding areas."
United States
Carole J.
$260 nightly
The price is $277
Oct 19 - Oct 20
Total with taxes and fees
5 Charles Farms #4 - NEW CABIN - Wineries, Hiking, and Camp Cana
A small, single-story building with a porch, a covered outdoor seating area, and a stone foundation.

12. 5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana

5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana
Ste. Genevieve
10.0 out of 10, Exceptional, (4 reviews)
"Perfect size cabin to get away and enjoy nature sitting on front porch. Very clean with all the amenities you need. Erin was very nice and prompt response to any of my questions."
United States
Matt H.
$246 nightly
The price is $262
Oct 21 - Oct 22
Total with taxes and fees
5 Charles Farms Cabin #1 - NEW CABIN - Wineries, Hiking, & Camp Cana
Private kitchen

13. Pleasant 2-bedroom mobile home with AC /heat in Friedheim 2 Queen beds 1 Bath.

Pleasant 2-bedroom mobile home with AC /heat in Friedheim 2 Queen beds 1 Bath.
Friedheim
$232 nightly
The price is $243
Oct 19 - Oct 20
Total with taxes and fees
Pleasant 2-bedroom mobile home with AC /heat in Friedheim 2 Queen beds 1 Bath.
A modern outdoor seating area with Adirondack chairs and a fire pit, surrounded by a gravel patio.

14. THE CAAMP. Gorgeous 2-bedroom tiny home. Very close to the Barn/Pebble Creek

THE CAAMP. Gorgeous 2-bedroom tiny home. Very close to the Barn/Pebble Creek
Ste. Genevieve
10.0 out of 10, Exceptional, (13 reviews)
"Lovely place, communicative owners, would definitely stay there again!"
United States
Jana R.
$258 nightly
The price is $275
Oct 21 - Oct 22
Total with taxes and fees
THE CAAMP. Gorgeous 2-bedroom tiny home. Very close to the Barn/Pebble Creek
A compact kitchen with a stone floor, a microwave, a stove, and a refrigerator. There are wooden cabinets and a window with blinds.

15. Fishing Cabin next to Kinkaid Lake

Fishing Cabin next to Kinkaid Lake
Murphysboro
10.0 out of 10, Exceptional, (3 reviews)
"Very clean, very nice well stocked cabin"
United States
Charles B.
$240 nightly
The price is $254
Oct 31 - Nov 1
Total with taxes and fees
Fishing Cabin next to Kinkaid Lake
A dining area with a table, chairs, and a curtain with a pattern.

16. Lois' Hideout Comfy 1 bedroom camper within 7 minutes of Kinkaid Lake.

Lois' Hideout Comfy 1 bedroom camper within 7 minutes of Kinkaid Lake.
Oraville
9.4 out of 10, Exceptional, (3 reviews)
"Great place great communication"
United States
Kevin E.
$130 nightly
The price is $138
Oct 19 - Oct 20
Total with taxes and fees
Lois' Hideout Comfy 1 bedroom camper within 7 minutes of Kinkaid Lake.
A log cabin interior with a stone fireplace, leather sofa, and a mounted deer head.

17. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
$313 nightly
The price is $313
Oct 19 - Oct 20
Total with taxes and fees
Gorgeous 1856 Log Cabin, Completely Renovated
A hot tub in a covered outdoor area with a view of a swimming pool and a wooden play structure in the background.

18. Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool

Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
Fredericktown
10.0 out of 10, Exceptional, (14 reviews)
"This was one of the best stays we have ever had! The owners Cathy and Richard are absolutely incredible! They go above and beyond to make sure you have the best time possible! The amities are just non stop! I 100% recommend and will definitely be back!"
United States
Lexis
$200 nightly
The price is $212
Oct 19 - Oct 20
Total with taxes and fees
Charming 2-bedroom country mobile home with game room, hot tub, seasonal pool
A modern living room with a sectional sofa, a coffee table, a TV mounted on the wall, and a window with blinds.

19. The Lab! Come stay in our brand new space.

The Lab! Come stay in our brand new space.
Murphysboro
9.4 out of 10, Exceptional, (33 reviews)
"We enjoyed our visit"
United States
Tim P.
$194 nightly
The price is $205
Oct 19 - Oct 20
Total with taxes and fees
The Lab! Come stay in our brand new space.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

20. Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress

Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress
Oraville
9.4 out of 10, Exceptional, (3 reviews)
"Had a nice time. Loved staying in the camper. The host was very prompt when communicating. Would definitely stay again."
United States
Joseph S.
$146 nightly
The price is $155
Oct 19 - Oct 20
Total with taxes and fees
Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perryville Hotel Reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"We have stayed here frequently. Great place to stay."
Michele 1-night trip
Posted 2 hours ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Find out more about Perryville

Everything you need to know about Perryville vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Perryville vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Perryville vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Perryville vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Perryville. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Perryville in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $101 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Perryville rentals

At Expedia, we put the best Perryville vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Perryville rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Perryville vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Perryville. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find a vacation rental in Perryville?

Yes, you can find vacation rentals near top local attractions in Perryville, or you can choose a more secluded option if you'd like a relaxing place to stay. Perryville is known for its wineries and golf courses. Make sure you have time to check out the coffeehouses and festivals during your trip.

What are some of the best vacation rentals that Perryville has to offer?

Silo Farm Haus- located in the heart of wine country!: This vacation home rental outside of Perryville is in a rural location and offers a Smart TV to help you feel perfectly comfortable in your new surroundings.

How many vacation rentals will I find in Perryville?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Perryville stay.

What’s there to see and do in Perryville?

Mark Twain National Forest and Mississippi River are a couple of lovely local spots to get outside and enjoy nature. While here, National Shrine of Our Lady of the Miraculous Medal and Saint Marys Lake are other places worth a visit.

What’s a vacation rental in Perryville like?

Vacation rentals are privately owned properties you can book for short or long periods in Perryville. Vacation rentals offer amenities such as laundry facilities and kitchens so you'll have all the comforts of home. If you're concerned about a clean environment, vacation rentals can provide a sense of security away from public hotel elevators and bustling concierge desks while still allowing you to travel. You'll also find more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is an attractive choice for family gatherings.