$105 Cheap Flights from Des Moines (DSM) to Myrtle Beach (MYR)

View $105 flight on Wed, Nov 5, 2025Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Myrtle Beach Intl. Airport (MYR)

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Cheap Flights from Des Moines to Myrtle Beach (DSM-MYR)

Prices were available within the past 7 days and start at $105 for one-way flights and $209 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Wed, Nov 5 - Tue, Nov 11
DSM
Des Moines
MYR
Myrtle Beach
$209 Roundtrip, found 9 hours ago
$209
Roundtrip
found 9 hours ago
Select Southwest Airlines flight, departing Wed, Nov 5 from Des Moines to Myrtle Beach, returning Tue, Nov 11, priced at $209 found 9 hours ago
Southwest Airlines
Sat, Sep 27 - Tue, Sep 30
DSM
Des Moines
MYR
Myrtle Beach
$222 Roundtrip, found 1 day ago
$222
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Sat, Sep 27 from Des Moines to Myrtle Beach, returning Tue, Sep 30, priced at $222 found 1 day ago
American Airlines
Wed, Sep 24 - Tue, Sep 30
DSM
Des Moines
MYR
Myrtle Beach
$224 Roundtrip, found 1 hour ago
$224
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Sep 24 from Des Moines to Myrtle Beach, returning Tue, Sep 30, priced at $224 found 1 hour ago
Southwest Airlines
Wed, Sep 24 - Tue, Sep 30
DSM
Des Moines
MYR
Myrtle Beach
$227 Roundtrip, found 1 hour ago
$227
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Sep 24 from Des Moines to Myrtle Beach, returning Tue, Sep 30, priced at $227 found 1 hour ago
Southwest Airlines
Mon, Oct 27 - Tue, Nov 4
DSM
Des Moines
MYR
Myrtle Beach
$230 Roundtrip, found 8 hours ago
$230
Roundtrip
found 8 hours ago
Select Southwest Airlines flight, departing Mon, Oct 27 from Des Moines to Myrtle Beach, returning Tue, Nov 4, priced at $230 found 8 hours ago
Southwest Airlines
Wed, Sep 24 - Tue, Sep 30
DSM
Des Moines
MYR
Myrtle Beach
$233 Roundtrip, found 1 hour ago
$233
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Sep 24 from Des Moines to Myrtle Beach, returning Tue, Sep 30, priced at $233 found 1 hour ago
American Airlines
Wed, Sep 24 - Wed, Oct 1
DSM
Des Moines
MYR
Myrtle Beach
$235 Roundtrip, found 20 hours ago
$235
Roundtrip
found 20 hours ago
Select American Airlines flight, departing Wed, Sep 24 from Des Moines to Myrtle Beach, returning Wed, Oct 1, priced at $235 found 20 hours ago
Delta
Mon, Dec 15 - Wed, Dec 24
DSM
Des Moines
MYR
Myrtle Beach
$237 Roundtrip, found 2 days ago
$237
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Dec 15 from Des Moines to Myrtle Beach, returning Wed, Dec 24, priced at $237 found 2 days ago
American Airlines
Tue, Aug 26 - Sat, Aug 30
DSM
Des Moines
MYR
Myrtle Beach
$237 Roundtrip, found 10 hours ago
$237
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Tue, Aug 26 from Des Moines to Myrtle Beach, returning Sat, Aug 30, priced at $237 found 10 hours ago
United
Sat, Oct 25 - Sat, Nov 1
DSM
Des Moines
MYR
Myrtle Beach
$244 Roundtrip, found 3 days ago
$244
Roundtrip
found 3 days ago
Select United flight, departing Sat, Oct 25 from Des Moines to Myrtle Beach, returning Sat, Nov 1, priced at $244 found 3 days ago

Find the cheapest month to fly from Des Moines (DSM) to Myrtle Beach (MYR)

September is typically the cheapest month to fly

From $178 - $608 per traveler.

Graph displaying average flight prices per month

Alternative airports near Myrtle Beach

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Myrtle Beach Intl. Airport MYR. Cheapest and Closest option available. Average driving time to city center is 6 minutes. Flights from $333
MYR
Myrtle Beach Intl. Airport
CheapestClosest
Average driving time to city center6 min
Flights from $333
Flights from Des Moines (DSM) to Myrtle Beach (MYR)
Origin airport
Des Moines Intl.
Destination airport
Myrtle Beach Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$208
Distance
969 mi

Des Moines to Myrtle Beach Flights

The cheapest times to fly from Des Moines to Myrtle Beach

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Myrtle Beach are during the month of November. You can find some of the cheapest flights from Des Moines to Myrtle Beach with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Des Moines to Myrtle Beach

Sunday is one of the best days to book for cheap flights from Des Moines to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Des Moines to Myrtle Beach

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $105 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR) cost?
Grab a cheap one-way flight from $105 or cheap return flight from $209 from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR)?
Planning your getaway for November may help you find better deals, as it's the cheapest month for flights between DSM and MYR. You'll often find the lowest prices during off-peak months.
What is the cheapest airline that flies from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR)?
Expedia's filter tool lets you easily compare airlines, flight times and baggage options all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest DSM to MYR flight.
How many flights per day from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR)?
There aren't any daily nonstop flights from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you'll be on your way in no time.
What day of the week has the most flights from DSM to MYR?
Generally you'll have the most choice when it comes to flights on a Friday. Tuesdays are often the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR)?
To avoid potential delays on the Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR) route, aim to travel before 3 PM. Later departures are 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR) last-minute?
Last-minute fares from DSM to MYR are usually more expensive. To secure the cheapest rates, start searching for flights as early as possible. That being said, if your travel plans are flexible, you may find a cheap ticket just before your departure.
Is it cheaper to book a DSM to MYR flight and hotel package?
Opting for a DSM to MYR flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our wide range of hotels and then add flights, car rentals and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines Intl. Airport (DSM) to Myrtle Beach Intl. Airport (MYR)?
If you booked your DSM to MYR flight within the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

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*Available to One Key members.