Find 4 Star Hotels in Santa Cruz from $64

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Compare Santa Cruz 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
$180 nightly
The price is $180
Dec 25 - Dec 26
Camino Real Hotel

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
$99 nightly
The price is $99
Dec 9 - Dec 10
TRYP by Wyndham Santa Cruz

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"Nice hotel "
United States
Narciso Lorenzo
$64 nightly
The price is $64
Dec 14 - Dec 15
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
$118 nightly
The price is $118
Jan 1 - Jan 2, 2026
Swissôtel Santa Cruz De La Sierra

Hotel Maywa

4.0 star property
Santa Cruz
9.4 out of 10, Exceptional, (11)
"The structure and service was fantastic"
United States
Alex
Hotel Maywa

Buganvillas Hotel Suites & Spa

4.0 star property
Santa Cruz
7.4 out of 10, Good, (93)
"The correct description would be that it is a Air & B without a Stowe/owen/kitchen supplies but with a refrigerator. What they claim at the web page IS NOT correct. The pool is correct and there is a restaurant, a one man show. We were the only ones at breakfast, one day no one was even there. A scam. Majority are residents in this complex. The ladies at the receptions was sweet though and did their best. "
Sweden
Charlotte
Buganvillas Hotel Suites & Spa

Royal Lodge Hotel

4.5 star property
Santa Cruz
6.4 out of 10, (29)
"Esta cerrado, ya no deberia dejar reservar, se nota q tiene tiempo fuera de servicio."
Argentina
Anonymous traveler
Royal Lodge Hotel
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

The preparation of any trip kicks off with choosing a spot. Santa Cruz has been a popular destination with guests because of everything it offers. Location is everything, but that applies to more than the area you are flying into. Now that you have got a feel for this city, it's time you to learn a little more about your home away from home.

Hotels as Gorgeous as the City

Santa Cruz saw its fair share of visitors last year. Expedia's comment section contains comments which can help you select which hotel is the right fit for your trip. The hotels found here aim to make your stay as delightful as your days spent exploring Santa Cruz. These hotels work to make their facilities and grounds inviting from the minute you step out of your car. You won't need to venture far to find a delectable breakfast, to keep up with your exercise schedule, or for an invigorating plunge during your stay with everything they provide. Santa Cruz has terrific accommodations that offer the absolute perfect holiday.

Rooms have been fashioned to keep your utmost comfort in mind, with amenities like premium bedding, specially designed bathroom products, and in-room coffee or tea. So, lay back and relax. Moreover, if you find that you are need of anything else, you can trust the staff will work their hardest to ensure you stay happy during your time. These hotels are so nice that you'll regret the day you have to leave.

Book a 4-Star Hotel in Santa Cruz Today!

Your getaway to Santa Cruz should be one where you don't have to trouble yourself about the little things. Make sure to book soon. With so few hotels, and plenty of people desiring to take a trip to here, you may miss out on your perfect room.

Frequently asked questions

What are the best 4-star hotels in Santa Cruz?
Kick back and relax in 4-star hotel comfort at TRYP by Wyndham Santa Cruz. Highly recommended by many of our guests, it comes with a swimming pool and concierge services. Also consider Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Concierge services and complimentary breakfast help make this getaway another sought-after choice in Santa Cruz.
How much does it cost to stay in a 4-star hotel in Santa Cruz?
With Expedia's handy filter tool, locking in a fabulous deal on a 4-star hotel in Santa Cruz just got easier. Start by keying in your chosen travel dates and length of your trip. Then sort the results by price and choose a hotel that best suits your style and budget.

  • Search for the lowest price from $85

What's the difference between 5-star and 4-star hotels in Santa Cruz?
If you decide to spend your vacation at a 4-star hotel in Santa Cruz, you'll usually find lots of conveniences to ensure you're relaxed, such as a pool, restaurant and gym. You can experience top-quality service and upmarket surroundings. Choose a 5-star hotel and you'll get a few extra bells and whistles — think on-site spas, 24-hour front desk and indulgent turndown services. You'll most likely get more amenities and premium services at a 5-star stay, though both are fabulous options for luxury guests.

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