Title: Santa Cruz Vacation Rentals from $27: Search Short-Term Rentals | Expedia.com

[Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6297178)[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides)

![San Lorenzo Cathedral which includes a church or cathedral, heritage architecture and heritage elements](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Top Cities in Santa Cruz

![San Lorenzo Cathedral showing a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Santa Cruz

[](https://expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)

![Samaipata is one of Bolivia's hidden gems. Staying in this quiet town gives you access to the beautiful natural areas that surround it.

Quick Tip: Taking a stroll down the streets outside the town offer some pretty jungle views and a glimpse of local life in the countryside. #Bolivia #Travel](https://mediaim.expedia.com/destination/2/06496d3cec9b6cad4a738ddeb6156d1c.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Samaipata

[](https://expedia.com/Samaipata-Vacation-Rentals.d6200976.Travel-Guide-VacationRentals)

## Our top choices for Santa Cruz vacation rentals

![Standard Suite, 1 Queen Bed | Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e2b53d65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/6f15dda8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e1ac9300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Equipetrol Suites Apart Hotel

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

Santa Cruz

9.0/10

Wonderful

(12 reviews)

"Perfect hotel"

![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg)

Yener

$48 nightly

$48 total

Feb 27 - Feb 28

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b5037c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down comforters, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/3e7101b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/0144c46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Premium Suites Deluxe Aparthotel Equipetrol

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

Santa Cruz

9.0/10

Wonderful

(85 reviews)

"Good price, great hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

$39 nightly

$39 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/00e02072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1500x0y7-eed47d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AMERICA APARTMENTS

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

Santa Cruz

10/10

Exceptional

(1 review)

"Clean room, great staff "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Peter

$55 nightly

$55 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Room | Living area | 32-inch flat-screen TV with cable channels](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/ffaa8f14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge, microwave, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/6fc90c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/47df2d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Terranova Suites

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

Santa Cruz

8.0/10

Very Good

(90 reviews)

"Easy to access"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dorothy

$48 nightly

$48 total

Mar 1 - Mar 2

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/9a481119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, 2 Bedrooms (Plus) | In-room dining](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/db59d5da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/3d263a1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apart Hotel Premium Suites Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

Santa Cruz

8.6/10

Excellent

(98 reviews)

"Yes, staff were very friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

veronica

$27 nightly

$27 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/b3756d0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/894e0ecb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/a0b45827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/aa4340a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Samaipata Glamping

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

Samaipata

$243 nightly

$243 total

Feb 22 - Feb 23

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/2d334027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/912c7493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apart Hotel Toborochi

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

Santa Cruz

8.8/10

Excellent

(60 reviews)

"Very comfortable and quiet place and very good location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/w1290h2293x0y251-5b08e5b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/21992b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/edb1b53e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f8f1dd6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa de 2 Habitaciones en zona norte

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

Santa Cruz de la Sierra

8.0/10

Very Good

(1 review)

"Muy buen departamento, bien ubicado"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elva

$59 nightly

$59 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/9c745b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/af761024.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/ee5e58e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/46d56e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lujo y confort en zona exclusiva

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

Santa Cruz de la Sierra

$55 nightly

$55 total

Feb 28 - Mar 1

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

![1 bedroom, free WiFi](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/9c6cc778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/ada57e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/b5dde86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, electric kettle, blender](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/27ac2eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Traveler's Hideout

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

Santa Cruz de la Sierra

10/10

Exceptional

(1 review)

"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mauricio O.

$76 nightly

$76 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/55cf49f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/d11c7efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/85781538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### POX: 24th Floor Green Tower | Luxury and Panoramic View

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

Santa Cruz de la Sierra

$83 nightly

$83 total

Feb 24 - Feb 25

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/fdb44263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/080d90c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1927x0y24-b8c75958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Spa](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1049x0y0-23015e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dppto Luminoso y Lujoso en Equipe Zona Empresarial

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

Santa Cruz de la Sierra

$65 nightly

$65 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/0ab047ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/5ceba07c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/bdb54fab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/643fec6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxury apartment

[](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information)

Santa Cruz de la Sierra

$45 nightly

$45 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/43ed5064.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, electric kettle](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/d7013903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

Santa Cruz de la Sierra

$67 nightly

$67 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/b0b12908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's activities](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/7ea6ea10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment | Living room | 42-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/e3241ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment | In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/5afb2720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Santos Apartamentos

[](https://www.expedia.com/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information)

Santa Cruz

$147 nightly

$147 total

Feb 28 - Mar 1

[](https://www.expedia.com/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/206167b0_edited_22cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/0c7b09d8_edited_c88f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/32a88bcf_edited_de17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/2b580d05_edited_a80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tranquil apartment with WiFi in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

Santa Cruz de la Sierra

10/10

Exceptional

(2 reviews)

"Zona tranquila y todo cerca supermercados tiendas etc"

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Fabricio O.

$60 nightly

$60 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/w689h954x0y0-7d2c5be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/af1568a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/0169c880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/bde12cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy and independent.<br>Downtown house JH.

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

Santa Cruz de la Sierra

$52 nightly

$52 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/2254dc50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/5af8579d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartamento confortable para 2 personas

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

Santa Cruz de la Sierra

$42 nightly

$42 total

Feb 25 - Feb 26

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/89a86d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/80f980e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/08ad0327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/5c4a14d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

Santa Cruz de la Sierra

$50 nightly

$50 total

Feb 26 - Feb 27

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/fbbf5c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/2b7e7464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/e8ecf36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/a66dc8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Loft in a brand new Condo, 10 minutes from business center. 

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

Santa Cruz de la Sierra

$60 nightly

$60 total

Feb 22 - Feb 23

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-07&endDate=2026-03-08&regionId=6297178&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

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## 

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Members save up to 40% on hotels and homes. Plan this year’s big trip and save.

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## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=CABIN)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=APART_HOTEL)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=APARTMENT)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=CONDO)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=VACATION_HOME)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-22&d1=2026-05-22&endDate=2026-05-25&d2=2026-05-25&lodging=CHALET)

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## Top Santa Cruz Hotel Reviews

![Premium Suites Deluxe Aparthotel Equipetrol](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/12ef5e8d_y.jpg)

### Premium Suites Deluxe Aparthotel Equipetrol

10/10 Excellent

"Clean rooms, friendly people who work there. Parking always a plus "

[](https://expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Delfines Collection Hotel By Mercure](https://images.trvl-media.com/lodging/91000000/90310000/90301900/90301892/fd3e0846_y.jpg)

### Delfines Collection Hotel By Mercure

10/10 Excellent

"Yes room was tidy and clean. Beds were very comfortable "

[](https://expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information)

![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg)

### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

10/10 Excellent

"Convenient location clean rooms good breakfast with a view "

[](https://expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information)

![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg)

### Ibis Santa Cruz DE LA Sierra

10/10 Excellent

"Nice place"

[](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information)

![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg)

### Chairú Eco Hotel

10/10 Excellent

"Staff was very courteous. They went above & beyond. Location was great!"

[](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information)

![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg)

### Camino Real Hotel

10/10 Excellent

"Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options."

[](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information)

![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/d021f216_y.jpg)

### Sun Hotel

10/10 Excellent

"Awesome place "

[](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information)

![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg)

### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent

"Welcoming clean rooms, friendly staff, continental breakfast with natural drinks "

[](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information)

![HOTEL OSHO](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/286f65b1_y.jpg)

### HOTEL OSHO

10/10 Excellent

"Room was great and staff were very accommodating!"

[](https://expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information)

## Find out more about Santa Cruz

## Discover your perfect Santa Cruz vacation rental with Expedia

#### How many vacation rentals are available in Santa Cruz? 
  
Expedia has plenty of vacation rentals to choose from in and around Santa Cruz, so you’re guaranteed to find the right one for you. 
  
#### How much is a vacation rental in Santa Cruz? 
  
The selection of Santa Cruz vacation rentals we have selected for you start as low as $27 per night. Entering your travel dates in the search wizard you might find even better deals! 
  
#### What type of vacation rental can I get in Santa Cruz? 
  
Vacation rentals in Santa Cruz come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Santa Cruz vacation rentals to suit everyone. 
  
#### Why should I choose a vacation rental in Santa Cruz? 
  
 Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Santa Cruz vacation rental often works out to be a fantastic, cost-effective option for [groups](https://www.expedia.com/lp/b/vr/large) and [families](https://www.expedia.com/lp/b/vr/family) visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 
  
#### How do I find the best deal on a vacation rental in Santa Cruz? 
  
 Find vacation rentals in Santa Cruz by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Santa Cruz. 
  
#### What amenities are available in a vacation rental in Santa Cruz? 
  
 The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a [swimming pool](https://www.expedia.com/lp/b/vr/private-pool) is more your thing. Of course, there’s always the treat of having [your own hot tub](https://www.expedia.com/lp/b/vr/hot-tub). Expedia has a vast range of amenities in Santa Cruz vacation rentals designed to suit every budget and trip type. 
  
#### When is the best time to stay in a vacation rental in Santa Cruz? 
  
 Everytime is a great time to head to Santa Cruz! Staying in a Santa Cruz vacation rentals you will always find lots going on to keep you entertained. 
  
#### Why book a vacation rental with Expedia? 
  
 Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Santa Cruz. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Santa Cruz vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Santa Cruz, you can save even more. 
  
#### Can I cancel my vacation rental through Expedia? 
  
 Yes, you can cancel or change your Santa Cruz vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted. 
  
## Explore a world of travel with Expedia

- Popular Santa Cruz Cities
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- [Santa Rosa De La Mina Vacation Rentals ](https://expedia.com/Santa-Rosa-De-La-Mina-Vacation-Rentals.d3000007078.Travel-Guide-VacationRentals)
- [La Belgica Vacation Rentals ](https://expedia.com/La-Belgica-Vacation-Rentals.d6350205.Travel-Guide-VacationRentals)
- [Estancia Bella Vista Vacation Rentals ](https://expedia.com/Estancia-Bella-Vista-Vacation-Rentals.d6350895.Travel-Guide-VacationRentals)

- [Lodges in Santa Cruz ](https://expedia.com/Santa-Cruz-Lodges.d6297178-aaLodges.Travel-Guide-Accommodation)
- [Cabin Rentals in Santa Cruz ](https://expedia.com/Santa-Cruz-Cabins.d6297178-aaCabins.Travel-Guide-Accommodation)

### Expedia's Latest Trends

Hotels

- [Resorts & Hotels with Spas in La Paz](https://expedia.com/Destinations-In-La-Paz-Spa-Hotel.0-0-d6297090-tSpaHotel.Hotel-Filter-Destinations)
- [Extended Stay Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
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- [Santa Cruz Hotels](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
- [Hotels with Hot Tubs in Cochabamba](https://expedia.com/Destinations-In-Cochabamba-Hotels-With-Hot-Tubs.0-0-d6297089-tHotelsWithHotTubs.Hotel-Filter-Destinations)
- [Santa Cruz Casinos](https://expedia.com/Santa-Cruz-Hotels-Casino-Hotel.0-0-d6053940-tCasinoHotel.Travel-Guide-Filter-Hotels)
- [Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Hotel-Destinations)
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Flights

- [Cheap Flights to Oruro](https://expedia.com/Destinations-In-Oruro.d553248628939824197.Flight-Destinations)
- [Cheap Flights to Chuquisaca](https://expedia.com/Destinations-In-Chuquisaca.d6053936.Flight-Destinations)
- [Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)
- [Cheap Flights to La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Flight-Destinations)

Cars

- [suv Car Rentals in Santa Cruz](https://expedia.com/SUV-Car-Rentals-In-Santa-Cruz.d6053940-tSUV.Car-Rental-Guide-Class)
- [Car rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)

Activities

- [Things to do in La Paz](https://expedia.com/Things-To-Do-In-La-Paz.d6297090.Travel-Guide-Activities)

Packages

- [Santa Cruz Zoo](https://expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction)
- [Santa Cruz la Vieja Historical Park](https://expedia.com/Santa-Cruz-La-Vieja-Historical-Park-San-Jose-de-Chiquitos.d553248621532375546.Vacation-Attraction)
- [Noel Kempff Mercado National Park](https://expedia.com/Noel-Kempff-Mercado-National-Park-Santa-Cruz.d6098841.Vacation-Attraction)
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- [Cochabamba Vacation Packages](https://expedia.com/Cochabamba.d6297089.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Beni](https://expedia.com/Destinations-In-Beni.d6297087.Vacation-Rental-Destinations)

General

- [Visit Cochabamba](https://expedia.com/Cochabamba.dx6297089)
- [Visit La Paz](https://expedia.com/La-Paz.dx6297090)
- [Visit Santa Cruz](https://expedia.com/Santa-Cruz.dx6053940)
- [Visit Tarija](https://expedia.com/Tarija.dx6297175)