Title: Santa Cruz Vacation Rentals from $39: Search Short-Term Rentals | Expedia.com

[Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6297178)[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides)

![San Lorenzo Cathedral which includes a church or cathedral, heritage architecture and heritage elements](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_bundle_and_save.svg)  
###  
Bundle & Save  
Get more, spend less whenever you see Bundle & Save deals
- ![](https://a.travel-assets.com/travel-assets-manager/pictograms-expedia/light__onekey.svg)  
###  
OneKeyCash  
Earn OneKeyCash on all your eligible bookings
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light_ftc.svg)  
###  
Upfront pricing  
We are not like the others - we include taxes and fees

## Top Cities in Santa Cruz

![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Santa Cruz

[](https://expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)

![Mountain view in Samaipata, Florida Province of the Santa Cruz Department, Bolivia](https://images.trvl-media.com/place/6200976/99855abd-1497-49bc-91a5-ef76c4e902cb.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Samaipata

[](https://expedia.com/Samaipata-Vacation-Rentals.d6200976.Travel-Guide-VacationRentals)

![Portrait of a Tobas warrior during carnival called The Devil Dance (La Diablada), Oruro, Bolivia](https://images.trvl-media.com/place/6352296/feec42f5-cbd9-4576-97cc-129e51391796.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Warnes

[](https://expedia.com/Warnes-Vacation-Rentals.d6352296.Travel-Guide-VacationRentals)

## Our top choices for Santa Cruz vacation rentals

![Standard Suite, 1 Queen Bed | Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e2b53d65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e1ac9300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/6f15dda8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Equipetrol Suites Apart Hotel

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

Santa Cruz

9.0/10

Wonderful

(11 reviews)

"Perfect hotel"

![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg)

Yener

$55 nightly

$55 total

Mar 9 - Mar 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down comforters, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/3e7101b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b5037c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/0144c46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Premium Suites Deluxe Aparthotel Equipetrol

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

Santa Cruz

9.0/10

Wonderful

(83 reviews)

"Good price, great hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

$39 nightly

$39 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic area](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1500x0y7-eed47d03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/00e02072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AMERICA APARTMENTS

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

Santa Cruz

$55 nightly

$55 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/b3756d0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/894e0ecb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/130e8dcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/aa4340a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Samaipata Glamping

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

Samaipata

$240 nightly

$240 total

Feb 11 - Feb 12

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/912c7493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/c0d4ffcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apart Hotel Toborochi

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

Santa Cruz

8.8/10

Excellent

(60 reviews)

"Very comfortable and quiet place and very good location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![House | Pool | Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/16000000/15040000/15030900/15030862/cb1eeefb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Vida

[](https://www.expedia.com/Santa-Cruz-Hotels-Casa-Vida.h15030862.Hotel-Information)

Santa Cruz

9.0/10

Wonderful

(2 reviews)

"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"

![Chile](https://a.travel-assets.com/egds/marks/flags/cl.svg)

FERNANDO

[](https://www.expedia.com/Santa-Cruz-Hotels-Casa-Vida.h15030862.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/w1290h2293x0y251-5b08e5b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/21992b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, toilet paper](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f6e53b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/edb1b53e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa de 2 Habitaciones en zona norte

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

Santa Cruz de la Sierra

"Muy buen departamento, bien ubicado"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elva

$59 nightly

$59 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge, microwave, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/6fc90c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/1f2b7f07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Room | Living area | 32-inch flat-screen TV with cable channels](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/ffaa8f14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Terranova Suites

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

Santa Cruz

8.0/10

Very Good

(90 reviews)

"Easy to access"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dorothy

$48 nightly

$48 total

Feb 20 - Feb 21

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/7d62effa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/85781538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/55cf49f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### POX: 24th Floor Green Tower | Luxury and Panoramic View

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

Santa Cruz de la Sierra

$83 nightly

$83 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/fdb44263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/080d90c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1583x0y0-5b3fde27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Spa](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1049x0y0-23015e62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Dppto Luminoso y Lujoso en Equipe Zona Empresarial

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

Santa Cruz de la Sierra

$65 nightly

$65 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122864700/122864649/2f58f31e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122870000/122864700/122864649/4d4834a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122864700/122864649/ab7ec0e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/123000000/122870000/122864700/122864649/a215d420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### POX: Green Tower 16th floor : Luxury and elegance - 2H

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-Green-Tower-16th-Floor-Luxury-And-Elegance-2H.h122864649.Hotel-Information)

Santa Cruz de la Sierra

$89 nightly

$89 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-Green-Tower-16th-Floor-Luxury-And-Elegance-2H.h122864649.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, electric kettle](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/d7013903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/9a14a6db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

Santa Cruz de la Sierra

$67 nightly

$67 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/9c745b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/ee5e58e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/46d56e16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/91978058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lujo y confort en zona exclusiva

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

Santa Cruz de la Sierra

$55 nightly

$55 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/w689h954x0y0-7d2c5be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/bde12cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/0169c880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/af1568a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy and independent.<br>Downtown house JH.

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

Santa Cruz de la Sierra

$52 nightly

$52 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/9a481119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, 2 Bedrooms (Plus) | In-room dining](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/db59d5da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/3d263a1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apart Hotel Premium Suites Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

Santa Cruz

8.6/10

Excellent

(98 reviews)

"Yes, staff were very friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

veronica

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/0ab047ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/5ceba07c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/643fec6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/118000000/117690000/117687800/117687703/bdb54fab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Luxury apartment

[](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information)

Santa Cruz de la Sierra

$45 nightly

$45 total

Feb 12 - Feb 13

[](https://www.expedia.com/Santa-Cruz-Hotels-Luxury-Apartment.h117687703.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/fbbf5c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/2b7e7464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/e8ecf36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/a66dc8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful Loft in a brand new Condo, 10 minutes from business center. 

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

Santa Cruz de la Sierra

$60 nightly

$60 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/7409bf98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/5af8579d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartamento confortable para 2 personas

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

Santa Cruz de la Sierra

$42 nightly

$42 total

Feb 12 - Feb 13

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/494b7af9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/bc52c455.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/6649134a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/103000000/102560000/102550900/102550831/2b5f2b52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

[](https://www.expedia.com/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information)

Santa Cruz de la Sierra

$35 nightly

$35 total

Feb 9 - Feb 10

[](https://www.expedia.com/Santa-Cruz-Hotels-Chalet-Indept.h102550831.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/89a86d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/80f980e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/5c4a14d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/3e497282.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

Santa Cruz de la Sierra

$50 nightly

$50 total

Feb 12 - Feb 13

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-02-22&endDate=2026-02-23&regionId=6297178&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=VACATION_HOME)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=APART_HOTEL)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=CONDO)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=CABIN)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=COTTAGE)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-05-08&d1=2026-05-08&endDate=2026-05-11&d2=2026-05-11&lodging=CHALET)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[

Sign up, it's free

](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)

## Top Santa Cruz Hotel Reviews

![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg)

### Ibis Santa Cruz DE LA Sierra

10/10 Excellent

"Awesome "

[](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information)

![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/d021f216_y.jpg)

### Sun Hotel

10/10 Excellent

"Awesome place "

[](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information)

![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg)

### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent

"Welcoming clean rooms, friendly staff, continental breakfast with natural drinks "

[](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information)

![HOTEL OSHO](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/286f65b1_y.jpg)

### HOTEL OSHO

10/10 Excellent

"Room was great and staff were very accommodating!"

[](https://expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information)

![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg)

### Camino Real Hotel

10/10 Excellent

"Rooms were very clean and service was excellent "

[](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information)

![TRYP by Wyndham Santa Cruz](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/78f237b9_y.jpg)

### TRYP by Wyndham Santa Cruz

10/10 Excellent

"Yes! Room was spotless. The staff are very patient and professional. "

[](https://expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information)

![Lido Hotel](https://images.trvl-media.com/lodging/99000000/98240000/98237600/98237549/da03536f_y.jpg)

### Lido Hotel

10/10 Excellent

"We stayed at the fabulous Lido Hotel for 2 nights in December 2025\. The hotel is located in central Santa Cruz, within a 4 block walk from Plaza 24 de Septiembre, and also a short 10 minute walk from the iconic Cristo Redentor statue. Check in was quick and painless, and the front desk staff was friendly and helpful. The room itself was spacious, clean and comfortable, with a large attached full bathroom. The air conditioner did a great job of cooling the room. Breakfast was served each morning in the attached Chinese restaurant, and featured eggs, breakfast meats, fruits, juices, cereal and yogurt, and was a great way to fuel up before venturing out to explore Santa Cruz. Without equivocation, I highly recommend the Lido Hotel to anyone in search of a clean comfortable hotel at an affordable price in the enchanting metrolopolis of Santa Cruz de la Sierra, Bolivia. Dr. Kingstone Shih and Laura Meneses Los Altos, California USA "

[](https://expedia.com/Santa-Cruz-Hotels-Hotel-Lido.h98237549.Hotel-Information)

![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg)

### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

10/10 Excellent

"Maria in front desk was extremely helpful . Especially since we did not know the language and we checked in too late. She was kidn to arrange a taxi for us to get some fruits for dinner from supermarket. Maria is extremely responsive and was supportive throughout my entire stay. Thank you maria"

[](https://expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information)

![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg)

### Chairú Eco Hotel

10/10 Excellent

"Clean room and friendly staff "

[](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information)

## Find out more about Santa Cruz

## Discover your perfect Santa Cruz vacation rental with Expedia

#### How many vacation rentals are available in Santa Cruz? 
  
Expedia has plenty of vacation rentals to choose from in and around Santa Cruz, so you’re guaranteed to find the right one for you. 
  
#### How much is a vacation rental in Santa Cruz? 
  
The selection of Santa Cruz vacation rentals we have selected for you start as low as $39 per night. Entering your travel dates in the search wizard you might find even better deals! 
  
#### What type of vacation rental can I get in Santa Cruz? 
  
Vacation rentals in Santa Cruz come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Santa Cruz vacation rentals to suit everyone. 
  
#### Why should I choose a vacation rental in Santa Cruz? 
  
 Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Santa Cruz vacation rental often works out to be a fantastic, cost-effective option for [groups](https://www.expedia.com/lp/b/vr/large) and [families](https://www.expedia.com/lp/b/vr/family) visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 
  
#### How do I find the best deal on a vacation rental in Santa Cruz? 
  
 Find vacation rentals in Santa Cruz by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Santa Cruz. 
  
#### What amenities are available in a vacation rental in Santa Cruz? 
  
 The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a [swimming pool](https://www.expedia.com/lp/b/vr/private-pool) is more your thing. Of course, there’s always the treat of having [your own hot tub](https://www.expedia.com/lp/b/vr/hot-tub). Expedia has a vast range of amenities in Santa Cruz vacation rentals designed to suit every budget and trip type. 
  
#### When is the best time to stay in a vacation rental in Santa Cruz? 
  
 Everytime is a great time to head to Santa Cruz! Staying in a Santa Cruz vacation rentals you will always find lots going on to keep you entertained. 
  
#### Why book a vacation rental with Expedia? 
  
 Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Santa Cruz. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Santa Cruz vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Santa Cruz, you can save even more. 
  
#### Can I cancel my vacation rental through Expedia? 
  
 Yes, you can cancel or change your Santa Cruz vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted. 
  
## Explore a world of travel with Expedia

- Popular Santa Cruz Cities
- All accommodation types in Santa Cruz

- [Santa Cruz Vacation Rentals ](https://expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)
- [Samaipata Vacation Rentals ](https://expedia.com/Samaipata-Vacation-Rentals.d6200976.Travel-Guide-VacationRentals)
- [Warnes Vacation Rentals ](https://expedia.com/Warnes-Vacation-Rentals.d6352296.Travel-Guide-VacationRentals)
- [Roboré Vacation Rentals ](https://expedia.com/Robore-Vacation-Rentals.d3000408084.Travel-Guide-VacationRentals)
- [San Jose de Chiquitos Vacation Rentals ](https://expedia.com/San-Jose-De-Chiquitos-Vacation-Rentals.d6344854.Travel-Guide-VacationRentals)
- [Puerto Quijarro Vacation Rentals ](https://expedia.com/Puerto-Quijarro-Vacation-Rentals.d3000389058.Travel-Guide-VacationRentals)
- [San Ignacio de Velasco Vacation Rentals ](https://expedia.com/San-Ignacio-De-Velasco-Vacation-Rentals.d6161202.Travel-Guide-VacationRentals)
- [Cuevas Vacation Rentals ](https://expedia.com/Cuevas-Vacation-Rentals.d6350209.Travel-Guide-VacationRentals)
- [San Javier Vacation Rentals ](https://expedia.com/San-Javier-Vacation-Rentals.d6350629.Travel-Guide-VacationRentals)
- [Camiri Vacation Rentals ](https://expedia.com/Camiri-Vacation-Rentals.d770.Travel-Guide-VacationRentals)
- [Buena Vista Vacation Rentals ](https://expedia.com/Buena-Vista-Vacation-Rentals.d3000445595.Travel-Guide-VacationRentals)
- [Santa Rosa De La Mina Vacation Rentals ](https://expedia.com/Santa-Rosa-De-La-Mina-Vacation-Rentals.d3000007078.Travel-Guide-VacationRentals)
- [El Torno Vacation Rentals ](https://expedia.com/El-Torno-Vacation-Rentals.d3000419675.Travel-Guide-VacationRentals)
- [La Belgica Vacation Rentals ](https://expedia.com/La-Belgica-Vacation-Rentals.d6350205.Travel-Guide-VacationRentals)
- [Estancia Bella Vista Vacation Rentals ](https://expedia.com/Estancia-Bella-Vista-Vacation-Rentals.d6350895.Travel-Guide-VacationRentals)

- [Lodges in Santa Cruz ](https://expedia.com/Santa-Cruz-Lodges.d6297178-aaLodges.Travel-Guide-Accommodation)
- [Cabin Rentals in Santa Cruz ](https://expedia.com/Santa-Cruz-Cabins.d6297178-aaCabins.Travel-Guide-Accommodation)

### Expedia's Latest Trends

Hotels

- [Resorts & Hotels with Spas in La Paz](https://expedia.com/Destinations-In-La-Paz-Spa-Hotel.0-0-d6297090-tSpaHotel.Hotel-Filter-Destinations)
- [Extended Stay Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Golf Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz-Golf-Hotel.0-0-d6297090-tGolfHotel.Hotel-Filter-Destinations)
- [Santa Cruz Pet-friendly Hotels](https://expedia.com/Santa-Cruz-Hotels-Pet-Friendly-Hotel.0-0-d6053940-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Santa Cruz Hotels](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
- [Hotels with Hot Tubs in Cochabamba](https://expedia.com/Destinations-In-Cochabamba-Hotels-With-Hot-Tubs.0-0-d6297089-tHotelsWithHotTubs.Hotel-Filter-Destinations)
- [Santa Cruz Casinos](https://expedia.com/Santa-Cruz-Hotels-Casino-Hotel.0-0-d6053940-tCasinoHotel.Travel-Guide-Filter-Hotels)
- [Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Hotel-Destinations)
- [Amboró National Park hotels](https://expedia.com/Amboro-National-Park-Hotels.0-l6098839-0.Travel-Guide-Filter-Hotels)
- [Family Hotels in Florida Province](https://expedia.com/Destinations-In-Florida-Province-Family-Hotel.0-0-d553248635975751209-tFamilyHotel.Hotel-Filter-Destinations)
- [Colinas del Urubo Hotels](https://expedia.com/Colinas-Del-Urubo-Hotels.d6349680.Travel-Guide-Hotels)
- [Resorts & Hotels with Spas in Potosi](https://expedia.com/Destinations-In-Potosi-Spa-Hotel.0-0-d6297171-tSpaHotel.Hotel-Filter-Destinations)
- [Samaipata Hotels](https://expedia.com/Samaipata-Hotels.d6200976.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Oruro](https://expedia.com/Destinations-In-Oruro.d553248628939824197.Flight-Destinations)
- [Cheap Flights to Chuquisaca](https://expedia.com/Destinations-In-Chuquisaca.d6053936.Flight-Destinations)
- [Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)
- [Cheap Flights to La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Flight-Destinations)

Cars

- [suv Car Rentals in Santa Cruz](https://expedia.com/SUV-Car-Rentals-In-Santa-Cruz.d6053940-tSUV.Car-Rental-Guide-Class)
- [Car rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)

Activities

- [Things to do in La Paz](https://expedia.com/Things-To-Do-In-La-Paz.d6297090.Travel-Guide-Activities)

Packages

- [Santa Cruz Zoo](https://expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction)
- [Santa Cruz la Vieja Historical Park](https://expedia.com/Santa-Cruz-La-Vieja-Historical-Park-San-Jose-de-Chiquitos.d553248621532375546.Vacation-Attraction)
- [Noel Kempff Mercado National Park](https://expedia.com/Noel-Kempff-Mercado-National-Park-Santa-Cruz.d6098841.Vacation-Attraction)
- [Santa Cruz Vacation Packages](https://expedia.com/Santa-Cruz.d6053940.Destination-Travel-Guides)
- [Cochabamba Vacation Packages](https://expedia.com/Cochabamba.d6297089.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Beni](https://expedia.com/Destinations-In-Beni.d6297087.Vacation-Rental-Destinations)

General

- [Visit Cochabamba](https://expedia.com/Cochabamba.dx6297089)
- [Visit La Paz](https://expedia.com/La-Paz.dx6297090)
- [Visit Santa Cruz](https://expedia.com/Santa-Cruz.dx6053940)
- [Visit Tarija](https://expedia.com/Tarija.dx6297175)