Title: Santa Cruz Vacation Rentals from $39: Search Short-Term Rentals | Expedia.com

[Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6297178)[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides)

![San Lorenzo Cathedral which includes a church or cathedral, heritage architecture and heritage elements](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Top Cities in Santa Cruz

![San Lorenzo Cathedral showing a garden](https://images.trvl-media.com/place/6098830/62a42b3d-1dbd-4a81-8566-cea655ebca33.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Santa Cruz

[](https://expedia.com/Santa-Cruz-Vacation-Rentals.d6053940.Travel-Guide-VacationRentals)

![Mountain view in Samaipata, Florida Province of the Santa Cruz Department, Bolivia](https://images.trvl-media.com/place/6200976/99855abd-1497-49bc-91a5-ef76c4e902cb.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Samaipata

[](https://expedia.com/Samaipata-Vacation-Rentals.d6200976.Travel-Guide-VacationRentals)

![Portrait of a Tobas warrior during carnival called The Devil Dance (La Diablada), Oruro, Bolivia](https://images.trvl-media.com/place/6352296/feec42f5-cbd9-4576-97cc-129e51391796.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Warnes

[](https://expedia.com/Warnes-Vacation-Rentals.d6352296.Travel-Guide-VacationRentals)

![Jesuit Mission wall paintings in San Jose de Chiquitos, Bolivia](https://images.trvl-media.com/place/6344854/c34a2d19-1f8b-4361-810e-e1669bf071f5.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### San Jose de Chiquitos

[](https://expedia.com/San-Jose-De-Chiquitos-Vacation-Rentals.d6344854.Travel-Guide-VacationRentals)

## Our top choices for Santa Cruz vacation rentals

![Standard Suite, 1 Queen Bed | Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e2b53d65.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Suite, 1 Queen Bed | Private kitchen | Mini-fridge, microwave, dishwasher, toaster](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/e1ac9300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/3e13fa51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 Queen Bed | Hypo-allergenic bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/91000000/90600000/90599400/90599395/9ccfefc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

9.0/10

Wonderful

(12 reviews)

"Perfect hotel"

![Turkey](https://a.travel-assets.com/egds/marks/flags/tr.svg)

Yener

$48 nightly

$48 total

Mar 17 - Mar 18

[](https://www.expedia.com/Santa-Cruz-Hotels-Equipetrol-Suites-Apart-Hotel.h90599395.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/w1125h1510x0y0-a0234ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/1c1dec0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/00e02072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Classic Apartment, City View | Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/121000000/120450000/120442100/120442096/c3714572.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

10/10

Exceptional

(1 review)

"Clean room, great staff "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

Peter

$55 nightly

$55 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-AMERICA-APARTMENTS.h120442096.Hotel-Information)

![Outdoor pool, open 9:00 AM to 8:00 PM, sun loungers](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/0144c46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Panoramic Apartment, 1 King Bed with Sofa bed, Terrace | Premium bedding, down comforters, Tempur-Pedic beds, in-room safe](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/3e7101b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast (USD 2.40 per person)](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/e3b6b11f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

9.0/10

Wonderful

(86 reviews)

"Good price, great hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

$39 nightly

$39 total

Mar 8 - Mar 9

[](https://www.expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/7e27a563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge, microwave, electric kettle, cookware/dishes/utensils](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/6fc90c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/1f2b7f07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/11000000/10960000/10950300/10950250/47df2d8c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

8.0/10

Very Good

(90 reviews)

"Easy to access"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dorothy

$47 nightly

$47 total

Mar 10 - Mar 11

[](https://www.expedia.com/Santa-Cruz-Hotels-Terranova-Suites.h10950250.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/b3756d0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/130e8dcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/a0b45827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103790000/103788400/103788309/aa4340a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Samaipata

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

$238 nightly

$238 total

Mar 12 - Mar 13

[](https://www.expedia.com/Samaipata-Hotels-Samaipata-Glaming.h103788309.Hotel-Information)

![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/9a481119.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, 2 Bedrooms (Plus) | In-room dining](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/db59d5da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business Apartment, Terrace (Plus) | Terrace/patio](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/e5844260.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/6000000/5930000/5928300/5928237/b0eabde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

8.6/10

Excellent

(99 reviews)

"Yes, staff were very friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

veronica

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Premium-Suites-Santa-Cruz.h5928237.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/w1290h2293x0y251-5b08e5b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/21992b29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f8f1dd6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, toilet paper](https://images.trvl-media.com/lodging/120000000/119980000/119976800/119976771/f6e53b9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

8.0/10

Very Good

(1 review)

"Muy buen departamento, bien ubicado"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elva

$59 nightly

$59 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Vrbo-Property.h119976771.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/2d334027.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/c0d4ffcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Aparthotel in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

8.8/10

Excellent

(60 reviews)

"Very comfortable and quiet place and very good location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

$77 nightly

$77 total

Mar 6 - Mar 7

[](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information)

![1 bedroom, free WiFi](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/9c6cc778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/ada57e01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/b5dde86c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, electric kettle, blender](https://images.trvl-media.com/lodging/101000000/100980000/100979600/100979521/27ac2eed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

10/10

Exceptional

(1 review)

"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mauricio O.

$76 nightly

$76 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Travelers-Hideout.h100979521.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/1b6db924.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/85781538.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/d11c7efc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122870000/122865200/122865145/55cf49f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

$83 nightly

$83 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-POX-24th-Floor-Green-Tower-Luxury-And-Panoramic-View.h122865145.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/fdb44263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1927x0y24-b8c75958.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/w1440h1583x0y0-5b3fde27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/105000000/104270000/104261800/104261770/080d90c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

$65 nightly

$65 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Dppto-Luminoso-Y-Lujoso-En-Equipe-Zona-Empresarial.h104261770.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/6d55bdca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/9a14a6db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, electric kettle](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/d7013903.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/101000000/100290000/100284400/100284354/1c0d3586.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Condo in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

$67 nightly

$67 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-COMODO-MONOAMBIENTE-EN-EQUIPETROL-CON-PISCINA-EN-CONDOMINIO.h100284354.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/206167b0_edited_22cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/e59e23c9_edited_fb52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/2b580d05_edited_a80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112230000/112222100/112222028/32a88bcf_edited_de17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

10/10

Exceptional

(2 reviews)

"Zona tranquila y todo cerca supermercados tiendas etc"

![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg)

Fabricio O.

$60 nightly

$60 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Tranquil-Apartment-With-WiFi-In-Santa-Cruz-De-La-Sierra.h112222028.Hotel-Information)

![Outdoor pool](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/b0b12908.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/102fdf2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Apartment | Living room | 42-inch Smart TV with cable channels, TV, Netflix](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/e3241ef3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's activities](https://images.trvl-media.com/lodging/40000000/39200000/39191300/39191276/7ea6ea10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz

[](https://www.expedia.com/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information)

$147 nightly

$147 total

Mar 10 - Mar 11

[](https://www.expedia.com/Santa-Cruz-Hotels-Santos-Apartamentos.h39191276.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/89a86d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/5c4a14d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/08ad0327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112830000/112829600/112829576/3e497282.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

$50 nightly

$50 total

Mar 8 - Mar 9

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-2-Bedroom-Apartment-With-AC.h112829576.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/w689h954x0y0-7d2c5be0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/af1568a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/0169c880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90330000/90324500/90324441/bde12cb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

$52 nightly

$52 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Furnished-Independent-House.h90324441.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/9c745b9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/af761024.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/ee5e58e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/114000000/113960000/113955300/113955297/91978058.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

$55 nightly

$55 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Lujo-Y-Confort-En-Zona-Exclusiva.h113955297.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/fbbf5c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/2b7e7464.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/d44635cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97250000/97247500/97247414/a66dc8d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

$60 nightly

$60 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Beautiful-Loft-In-A-Brand-New-Condo.h97247414.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/0f570e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/7409bf98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/5af8579d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, toilet paper](https://images.trvl-media.com/lodging/109000000/108060000/108056200/108056147/09ebee18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

$42 nightly

$42 total

Mar 8 - Mar 9

[](https://www.expedia.com/Santa-Cruz-Hotels-Apartamento-Confortable-Para-2-Personas.h108056147.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/6663a26a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/f8c2e918.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/20029dec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/119000000/118520000/118517600/118517530/ad376765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Santa Cruz de la Sierra

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information)

$48 nightly

$48 total

Mar 5 - Mar 6

[](https://www.expedia.com/Santa-Cruz-Hotels-Cozy-Studio-In-Enchanting-Santa-Cruz-De-La-Sierra-With-WiFi.h118517530.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-18&endDate=2026-03-19&regionId=6297178&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

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## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=VACATION_HOME)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CABIN)

Aparthotels

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APART_HOTEL)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=COTTAGE)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=APARTMENT)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CONDO)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=HOUSE_BOAT)

Chalets

[](https://www.expedia.com/Hotel-Search?destination=Santa+Cruz%2C+Bolivia&regionId=6297178&latLong=-17.783494%2C-63.182085&adults=2&startDate=2026-06-02&d1=2026-06-02&endDate=2026-06-05&d2=2026-06-05&lodging=CHALET)

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## Top Santa Cruz Hotel Reviews

![Swissôtel Santa Cruz De La Sierra](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/6b27e04a_y.jpg)

### Swissôtel Santa Cruz De La Sierra

10/10 Excellent

"Great room, spacious, quiet and the shower was great"

[](https://expedia.com/Santa-Cruz-Hotels-Swissotel-Santa-Cruz-De-La-Sierra.h60335614.Hotel-Information)

![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/ce43592e_y.jpg)

### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent

"Very nice and cozy"

[](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information)

![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg)

### Chairú Eco Hotel

10/10 Excellent

"I had room 29, a double bed with balcony. It was beautiful, modern, clean, and in a quiet area but only a couple blocks to restaurants. The breakfast is modest but satisfactory. To the hotel, I would suggest putting electric kettles in each room. I, as well as others, would use this to boil water and not have to rely on bottled water. Just a thought for an "eco" hotel."

[](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information)

![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/c21617f6_y.jpg)

### Sun Hotel

10/10 Excellent

"Had a great time at this hotel. I will definitely be visiting again."

[](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information)

![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/03d4f9ed_y.jpg)

### Ibis Santa Cruz DE LA Sierra

10/10 Excellent

"Great value "

[](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information)

![Premium Suites Deluxe Aparthotel Equipetrol](https://images.trvl-media.com/lodging/25000000/24410000/24404300/24404225/b86b5103_y.jpg)

### Premium Suites Deluxe Aparthotel Equipetrol

10/10 Excellent

"Clean rooms, friendly people who work there. Parking always a plus "

[](https://expedia.com/Santa-Cruz-Hotels-Premium-Suites-Deluxe-Aparthotel-Equipetrol.h24404225.Hotel-Information)

![Delfines Collection Hotel By Mercure](https://images.trvl-media.com/lodging/91000000/90310000/90301900/90301892/436d5514_edited_b786_y.jpg)

### Delfines Collection Hotel By Mercure

10/10 Excellent

"Yes room was tidy and clean. Beds were very comfortable "

[](https://expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information)

![Hampton by Hilton Santa Cruz/Equipetrol, Bolivia](https://images.trvl-media.com/lodging/14000000/13180000/13179500/13179436/65fab765_y.jpg)

### Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

10/10 Excellent

"Clean room "

[](https://expedia.com/Santa-Cruz-Hotels-Hampton-By-Hilton-Santa-Cruz.h13179436.Hotel-Information)

![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/9d61826a_y.jpg)

### Camino Real Hotel

10/10 Excellent

"Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options."

[](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information)

## Find out more about Santa Cruz

## Discover your perfect Santa Cruz vacation rental with Expedia

#### How many vacation rentals are available in Santa Cruz? 
  
Expedia has plenty of vacation rentals to choose from in and around Santa Cruz, so you’re guaranteed to find the right one for you. 
  
#### How much is a vacation rental in Santa Cruz? 
  
The selection of Santa Cruz vacation rentals we have selected for you start as low as $39 per night. Entering your travel dates in the search wizard you might find even better deals! 
  
#### What type of vacation rental can I get in Santa Cruz? 
  
Vacation rentals in Santa Cruz come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Santa Cruz vacation rentals to suit everyone. 
  
#### Why should I choose a vacation rental in Santa Cruz? 
  
 Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Santa Cruz vacation rental often works out to be a fantastic, cost-effective option for [groups](https://www.expedia.com/lp/b/vr/large) and [families](https://www.expedia.com/lp/b/vr/family) visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 
  
#### How do I find the best deal on a vacation rental in Santa Cruz? 
  
 Find vacation rentals in Santa Cruz by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Santa Cruz. 
  
#### What amenities are available in a vacation rental in Santa Cruz? 
  
 The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a [swimming pool](https://www.expedia.com/lp/b/vr/private-pool) is more your thing. Of course, there’s always the treat of having [your own hot tub](https://www.expedia.com/lp/b/vr/hot-tub). Expedia has a vast range of amenities in Santa Cruz vacation rentals designed to suit every budget and trip type. 
  
#### When is the best time to stay in a vacation rental in Santa Cruz? 
  
 Everytime is a great time to head to Santa Cruz! Staying in a Santa Cruz vacation rentals you will always find lots going on to keep you entertained. 
  
#### Why book a vacation rental with Expedia? 
  
 Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Santa Cruz. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Santa Cruz vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Santa Cruz, you can save even more. 
  
#### Can I cancel my vacation rental through Expedia? 
  
 Yes, you can cancel or change your Santa Cruz vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted. 
  
## Explore a world of travel with Expedia

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- [Estancia Bella Vista Vacation Rentals ](https://expedia.com/Estancia-Bella-Vista-Vacation-Rentals.d6350895.Travel-Guide-VacationRentals)

- [Lodges in Santa Cruz ](https://expedia.com/Santa-Cruz-Lodges.d6297178-aaLodges.Travel-Guide-Accommodation)
- [Cabin Rentals in Santa Cruz ](https://expedia.com/Santa-Cruz-Cabins.d6297178-aaCabins.Travel-Guide-Accommodation)

### Expedia's Latest Trends

Hotels

- [Resorts & Hotels with Spas in La Paz](https://expedia.com/Destinations-In-La-Paz-Spa-Hotel.0-0-d6297090-tSpaHotel.Hotel-Filter-Destinations)
- [Extended Stay Hotels in Santa Cruz](https://expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels)
- [Golf Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz-Golf-Hotel.0-0-d6297090-tGolfHotel.Hotel-Filter-Destinations)
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- [Santa Cruz Hotels](https://expedia.com/Santa-Cruz-Hotels.d6053940.Travel-Guide-Hotels)
- [Hotels with Hot Tubs in Cochabamba](https://expedia.com/Destinations-In-Cochabamba-Hotels-With-Hot-Tubs.0-0-d6297089-tHotelsWithHotTubs.Hotel-Filter-Destinations)
- [Santa Cruz Casinos](https://expedia.com/Santa-Cruz-Hotels-Casino-Hotel.0-0-d6053940-tCasinoHotel.Travel-Guide-Filter-Hotels)
- [Hotels in La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Hotel-Destinations)
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- [Samaipata Hotels](https://expedia.com/Samaipata-Hotels.d6200976.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Oruro](https://expedia.com/Destinations-In-Oruro.d553248628939824197.Flight-Destinations)
- [Cheap Flights to Chuquisaca](https://expedia.com/Destinations-In-Chuquisaca.d6053936.Flight-Destinations)
- [Flights to Santa Cruz](https://expedia.com/Cheap-Flights-To-Santa-Cruz.d6053940.Travel-Guide-Flights)
- [Cheap Flights to La Paz](https://expedia.com/Destinations-In-La-Paz.d6297090.Flight-Destinations)

Cars

- [suv Car Rentals in Santa Cruz](https://expedia.com/SUV-Car-Rentals-In-Santa-Cruz.d6053940-tSUV.Car-Rental-Guide-Class)
- [Car rentals in Santa Cruz](https://expedia.com/Car-Rentals-In-Santa-Cruz.d6053940.Car-Rental-Guide)

Activities

- [Things to do in La Paz](https://expedia.com/Things-To-Do-In-La-Paz.d6297090.Travel-Guide-Activities)

Packages

- [Santa Cruz Zoo](https://expedia.com/Santa-Cruz-Zoo-Santa-Cruz.d6098836.Vacation-Attraction)
- [Santa Cruz la Vieja Historical Park](https://expedia.com/Santa-Cruz-La-Vieja-Historical-Park-San-Jose-de-Chiquitos.d553248621532375546.Vacation-Attraction)
- [Noel Kempff Mercado National Park](https://expedia.com/Noel-Kempff-Mercado-National-Park-Santa-Cruz.d6098841.Vacation-Attraction)
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- [Cochabamba Vacation Packages](https://expedia.com/Cochabamba.d6297089.Destination-Travel-Guides)

Vacation Rentals

- [Vacation Rentals Beni](https://expedia.com/Destinations-In-Beni.d6297087.Vacation-Rental-Destinations)

General

- [Visit Cochabamba](https://expedia.com/Cochabamba.dx6297089)
- [Visit La Paz](https://expedia.com/La-Paz.dx6297090)
- [Visit Santa Cruz](https://expedia.com/Santa-Cruz.dx6053940)
- [Visit Tarija](https://expedia.com/Tarija.dx6297175)