Vacation Rentals in Santa Cruz

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Top Cities in Santa Cruz

Our top choices for Santa Cruz vacation rentals

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
$33 nightly
The price is $33
Dec 15 - Dec 16
Premium Suites Deluxe Aparthotel Equipetrol

Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel
2.5 star property
Santa Cruz
8.4 out of 10, Very Good, (7)
"Perfect hotel"
Turkey
Yener
$41 nightly
The price is $41
Jan 11 - Jan 12, 2026
Equipetrol Suites Apart Hotel

Terranova Suites

Terranova Suites
3.5 star property
Santa Cruz
8.0 out of 10, Very Good, (90)
"Easy to access"
United States
Dorothy
$47 nightly
The price is $47
Dec 18 - Dec 19
Terranova Suites

AMERICA APARTMENTS

AMERICA APARTMENTS
3.0 star property
Santa Cruz
$55 nightly
The price is $55
Dec 14 - Dec 15
AMERICA APARTMENTS

Apart Hotel Toborochi

Apart Hotel Toborochi
3.0 star property
Santa Cruz
8.8 out of 10, Excellent, (60)
"Property is close to nice dining options and entertainment places in Santa Cruz. The room is confortable and spacious "
United States
Stefany
$61 nightly
The price is $61
Dec 14 - Dec 15
Apart Hotel Toborochi

Casa Vida

Casa Vida
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (2)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Chile
FERNANDO
Casa Vida

A must-see studio apartment in Sirari-Equipetrol

A must-see studio apartment in Sirari-Equipetrol
Santa Cruz de la Sierra
$53 nightly
The price is $53
Dec 14 - Dec 15
A must-see studio apartment in Sirari-Equipetrol

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC
Santa Cruz de la Sierra
$43 nightly
The price is $43
Dec 16 - Dec 17
Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!
Santa Cruz de la Sierra
$67 nightly
The price is $67
Dec 14 - Dec 15
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

Dppto Luminoso y Lujoso en Equipe Zona Empresarial

Dppto Luminoso y Lujoso en Equipe Zona Empresarial
Santa Cruz de la Sierra
$65 nightly
The price is $65
Dec 14 - Dec 15
Dppto Luminoso y Lujoso en Equipe Zona Empresarial

Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.
Santa Cruz de la Sierra
$35 nightly
The price is $35
Dec 14 - Dec 15
Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

Traveler's Hideout

Traveler's Hideout
Santa Cruz de la Sierra
10.0 out of 10, Exceptional, (1)
"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"
United States
Mauricio O.
$49 nightly
The price is $49
Dec 14 - Dec 15
Traveler's Hideout

Buena Vista Rental House

Buena Vista Rental House
3.0 star property
Santa Cruz
Buena Vista Rental House

"Modern 2-bedroom apartment in an exclusive building in Santa Cruz, Bolivia."

"Modern 2-bedroom apartment in an exclusive building in Santa Cruz, Bolivia."
Santa Cruz de la Sierra
"Modern 2-bedroom apartment in an exclusive building in Santa Cruz, Bolivia."

Luxury apartment

Luxury apartment
Santa Cruz de la Sierra
$45 nightly
The price is $45
Dec 15 - Dec 16
Luxury apartment

Apartamento confortable para 2 personas

Apartamento confortable para 2 personas
2.0 star property
Santa Cruz de la Sierra
$42 nightly
The price is $42
Dec 17 - Dec 18
Apartamento confortable para 2 personas

Apartment in Patio Design with private garage

Apartment in Patio Design with private garage
Santa Cruz de la Sierra
$53 nightly
The price is $53
Dec 14 - Dec 15
Apartment in Patio Design with private garage

Apartamentos ARTECI

Apartamentos ARTECI
2.0 star property
Santa Cruz
Apartamentos ARTECI

Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto

Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto
Santa Cruz de la Sierra
$87 nightly
The price is $87
Dec 16 - Dec 17
Hermoso Departamento 4 Habitaciones con Baño a 10 min del Aeropuerto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Discover your perfect Santa Cruz vacation rental with Expedia

How many vacation rentals are available in Santa Cruz?


Expedia has plenty of vacation rentals to choose from in and around  Santa Cruz, so you’re guaranteed to find the right one for you. 


How much is a vacation rental in Santa Cruz?


The selection of Santa Cruz vacation rentals we have selected for you start as low as $33 per night. Entering your travel dates in the search wizard you might find even better deals!


What type of vacation rental can I get in Santa Cruz?


Vacation rentals in Santa Cruz come in all shapes and sizes, and your options depend on your chosen travel dates. You could entertain in a blissful vacation home, chill in a private apartment, or find family fun at a resort. Expedia offers a superb choice of Santa Cruz vacation rentals to suit everyone. 


Why should I choose a vacation rental in Santa Cruz?


Expedia’s vacation rentals provide cozy comforts you can sink into on your own schedule. You’ll enjoy your own space in a property with a kitchen, a pool, a garden etc. Maybe you’ll prefer somewhere with a spa or kids activities. A Santa Cruz vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. 


How do I find the best deal on a vacation rental in Santa Cruz?


Find vacation rentals in Santa Cruz by viewing Expedia’s latest deals, or enter your travel dates and use the filters to select by amenities, price, or rating. Dive into the reviews to get a true feeling of which is your favorite vacation rental in Santa Cruz.  


What amenities are available in a vacation rental in Santa Cruz?


The choice is yours! Perhaps you love cooking in a well-equipped kitchen. Or maybe a late breakfast and a swimming pool is more your thing. Of course, there’s always the treat of having your own hot tub. Expedia has a vast range of amenities in Santa Cruz vacation rentals designed to suit every budget and trip type.


When is the best time to stay in a vacation rental in Santa Cruz?   


Everytime is a great time to head to Santa Cruz! Staying in a Santa Cruz vacation rentals you will always find lots going on to keep you entertained. 


Why book a vacation rental with Expedia?


Expedia has locked in amazing deals on a huge selection of impressive vacation rentals in Santa Cruz. We give you the information and inspiration you need all in one place. With so many properties to choose from, you know you can book your perfect Santa Cruz vacation rental with confidence. ANd don’t forget, if you bundle with a flight or a car rental in Santa Cruz, you can save even more.


Can I cancel my vacation rental through Expedia?  


Yes, you can cancel or change your Santa Cruz vacation rental by contacting your property manager directly. Contact details are easy to find on your itinerary in Trips. For more information, check out our Customer Service Portal and we’ll help you get everything sorted.