Santa Cruz Vacation Rentals

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Our top choices for Santa Cruz vacation rentals

Aparthotel in Santa Cruz

Equipetrol Suites Apart Hotel
2.5 star property
8.4 out of 10, Very Good, (7)
"Perfect hotel"
Turkey
Yener
$36 nightly
The price is $36
Jan 21 - Jan 22, 2026
Equipetrol Suites Apart Hotel
3.5 star property
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
$39 nightly
The price is $39
Dec 27 - Dec 28
Premium Suites Deluxe Aparthotel Equipetrol
$35 nightly
The price is $35
Dec 26 - Dec 27
Chalet indept, amplio, acogedor, hermoso jardin Aire C wifi, espa.xcocinar.

Apartment in Santa Cruz de la Sierra

A must-see studio apartment in Sirari-Equipetrol
$53 nightly
The price is $53
Dec 26 - Dec 27
A must-see studio apartment in Sirari-Equipetrol

Apartment in Santa Cruz de la Sierra

Traveler's Hideout
10.0 out of 10, Exceptional, (1)
"The place was cozy, neat, and th host was very attentive and supportive. I recomend this place"
United States
Mauricio O.
$49 nightly
The price is $49
Dec 26 - Dec 27
Traveler's Hideout
3.5 star property
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
$27 nightly
The price is $27
Dec 26 - Dec 27
Apart Hotel Premium Suites Santa Cruz
$43 nightly
The price is $43
Dec 28 - Dec 29
Cozy studio in enchanting Santa Cruz de la Sierra with WiFi, AC

Apartment in Santa Cruz

AMERICA APARTMENTS
3.0 star property
$55 nightly
The price is $55
Dec 26 - Dec 27
AMERICA APARTMENTS

Aparthotel in Santa Cruz

Terranova Suites
3.5 star property
8.0 out of 10, Very Good, (90)
"Easy to access"
United States
Dorothy
$45 nightly
The price is $45
Dec 28 - Dec 29
Terranova Suites

Apartment in Santa Cruz de la Sierra

Casa de 2 Habitaciones en zona norte
"Muy buen departamento, bien ubicado"
United States
Elva
$59 nightly
The price is $59
Dec 26 - Dec 27
Casa de 2 Habitaciones en zona norte

Aparthotel in Santa Cruz

Apart Hotel Toborochi
3.0 star property
8.8 out of 10, Excellent, (60)
"Property is close to nice dining options and entertainment places in Santa Cruz. The room is confortable and spacious "
United States
Stefany
Apart Hotel Toborochi

Apartment in Santa Cruz de la Sierra

Dppto Luminoso y Lujoso en Equipe Zona Empresarial
$65 nightly
The price is $65
Dec 26 - Dec 27
Dppto Luminoso y Lujoso en Equipe Zona Empresarial

Apartment in Santa Cruz de la Sierra

Apartamento confortable para 2 personas
2.0 star property
$42 nightly
The price is $42
Dec 30 - Dec 31
Apartamento confortable para 2 personas

Apartment in Santa Cruz de la Sierra

Luxury apartment
$45 nightly
The price is $45
Dec 27 - Dec 28
Luxury apartment
$50 nightly
The price is $50
Dec 30 - Dec 31
Cozy 2-bedroom apartment with AC, WiFi in enjoyable Santa Cruz
$63 nightly
The price is $63
Jan 1 - Jan 2, 2026
Apartment with balcony, swimming pool, gym, co-work at Equipe
$67 nightly
The price is $67
Dec 26 - Dec 27
COMODO MONOAMBIENTE EN EQUIPETROL CON PISCINA EN CONDOMINIO!

Apartment in Santa Cruz de la Sierra

POX: Your favorite corner in the heart of Equipe!
2.0 star property
$48 nightly
The price is $48
Dec 26 - Dec 27
POX: Your favorite corner in the heart of Equipe!

Vacation Home in Santa Cruz

Casa Vida
3.5 star property
9.0 out of 10, Wonderful, (2)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Chile
FERNANDO
$95 nightly
The price is $95
Dec 26 - Dec 27
Casa Vida

Apartment in Santa Cruz de la Sierra

1-bedroom Modern Apartment in Sirari, Equipetrol
$47 nightly
The price is $50
Dec 26 - Dec 27
1-bedroom Modern Apartment in Sirari, Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

Find out more about Santa Cruz

Everything you need to know about Santa Cruz vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Santa Cruz vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santa Cruz vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Santa Cruz vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santa Cruz. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Santa Cruz in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $27 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Santa Cruz rentals

At Expedia, we put the best Santa Cruz vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Santa Cruz rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santa Cruz vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santa Cruz. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently asked questions

Can I find a vacation rental in Santa Cruz?

Yes, we have vacation rentals in Santa Cruz near Santa Cruz Zoo, or you can go with a secluded option if you're looking for a relaxing stay. Discover why Santa Cruz is known for its shops. Make sure you have time to check out the cafes and zoo during your trip.

What are some of the best vacation home rentals in Santa Cruz?

Casa Vida: This highly rated vacation home rental in Santa Cruz is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. Some other top choices in Santa Cruz are Cozy and independent.
Downtown house JH.
and Jose Luis Noya.

How many vacation rentals will I find in Santa Cruz?

With 23 Expedia vacation rentals, you're sure to find just the right place for your Santa Cruz stay.

What can I see and do in Santa Cruz?

Enjoy the outdoors at Guembe Biocenter and Municipal Botanical Garden of Santa Cruz, or simply take in cultural attractions like Cine Center and Ethno-folkloric Museum. Plaza 24 de Septiembre and Ramon Tahuichi Aguilera Stadium are other places to visit while you're in town.

What are vacation rentals like in Santa Cruz?

Vacation rentals are private accommodations you can stay in for several days or more in Santa Cruz. Vacation rentals provide amenities such as laundry facilities and kitchens so you'll have everything you want. If you're concerned about a sanitized environment, a vacation rental can offer a sense of privacy away from shared hotel elevators and busy reception areas while still allowing you the enjoyment of travel. You'll also get more space in a vacation rental than in a traditional hotel, which makes a vacation rental a popular option for a family trip.