Title: Santa Cruz Resorts & Hotels with Spas from $56 - Fully Refundable Options - Expedia.com [Santa Cruz Travel Guide](https://expedia.com/Santa-Cruz.dx6297178)[Santa Cruz Hotels](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Hotel-Destinations)[Vacation Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Vacation-Rental-Destinations)[Santa Cruz Flights](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Flight-Destinations)[Car Rentals in Santa Cruz](https://expedia.com/Destinations-In-Santa-Cruz.d6297178.Car-Rental-Destinations)[Santa Cruz Vacations](https://expedia.com/Santa-Cruz.d6297178.Destination-Travel-Guides) ![San Lorenzo Cathedral which includes a church or cathedral, heritage architecture and heritage elements](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6098830/d6a325c3-d504-4e1a-ab2b-0e430beefd40.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Upfront pricing Our total price for your stay includes taxes and fees - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save 10% or more on over 100,000 hotels worldwide with Member Prices [Learn about One Key](https://www.expedia.com/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Santa Cruz ![San Lorenzo Cathedral showing a garden](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/115000/115563-Santa-Cruz.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santa Cruz [](https://expedia.com/Santa-Cruz-Hotels-Spa-Hotel.0-0-d6053940-tSpaHotel.Travel-Guide-Filter-Hotels) ## Check availability on Santa Cruz Resorts & Hotels with Spas Tonight [Feb 15 - Feb 16](https://www.expedia.com/Hotel-Search?regionId=6297178&startDate=2026-02-15&endDate=2026-02-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 16 - Feb 17](https://www.expedia.com/Hotel-Search?regionId=6297178&startDate=2026-02-16&endDate=2026-02-17&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 20 - Feb 22](https://www.expedia.com/Hotel-Search?regionId=6297178&startDate=2026-02-20&endDate=2026-02-22&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 27 - Mar 1](https://www.expedia.com/Hotel-Search?regionId=6297178&startDate=2026-02-27&endDate=2026-03-01&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz hotels with a spa ![Couples treatment rooms, sauna, hot tub, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/0c12ee33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/7d01dcfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/ce43592e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/9bf66d6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel [](https://www.expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) Santa Cruz 9.0/10 Wonderful (360 reviews) "Welcoming clean rooms, friendly staff, continental breakfast with natural drinks " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victor $136 nightly $136 total Mar 14 - Mar 15 [](https://www.expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ![Massages](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/6b27e04a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/d2cd08da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/9c172db1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served](https://images.trvl-media.com/lodging/61000000/60340000/60335700/60335614/1b68b7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Swissôtel Santa Cruz De La Sierra [](https://www.expedia.com/Santa-Cruz-Hotels-Swissotel-Santa-Cruz-De-La-Sierra.h60335614.Hotel-Information) Santa Cruz 9.2/10 Wonderful (82 reviews) "Beautiful hotel" ![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg) Joanna $126 nightly $126 total Mar 2 - Mar 3 [](https://www.expedia.com/Santa-Cruz-Hotels-Swissotel-Santa-Cruz-De-La-Sierra.h60335614.Hotel-Information) ![Sauna, hot tub, steam room, massages](https://images.trvl-media.com/lodging/14000000/13460000/13455900/13455822/bb874c3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/14000000/13460000/13455900/13455822/baf4d4d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/14000000/13460000/13455900/13455822/97b153fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/14000000/13460000/13455900/13455822/98bdb5e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Cortez [](https://www.expedia.com/Santa-Cruz-Hotels-Hotel-Cortez.h13455822.Hotel-Information) Santa Cruz 9.2/10 Wonderful (124 reviews) "The staff and property are second to none! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia $103 nightly $103 total Mar 1 - Mar 2 [](https://www.expedia.com/Santa-Cruz-Hotels-Hotel-Cortez.h13455822.Hotel-Information) ![Massage/treatment rooms](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/bdafe3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/00c20228.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/02f3d22f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/22000000/21500000/21490300/21490226/f930f88b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Santa Cruz de la Sierra Hotel [](https://www.expedia.com/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) Santa Cruz 9.0/10 Wonderful (213 reviews) "Great hotel, food and location albeit a little expensive " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Reinaldo $127 nightly $127 total Feb 27 - Feb 28 [](https://www.expedia.com/Santa-Cruz-Hotels-Marriott-Santa-Cruz-De-La-Sierra-Hotel.h21490226.Hotel-Information) ![Indoor spa tub](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/9d3a14b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; garden views](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/01205665.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool, pool umbrellas](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/0ffe84ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Camino Real Hotel [](https://www.expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) Santa Cruz 9.0/10 Wonderful (418 reviews) "Rooms were very clean and service was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) JESUS $126 nightly $126 total Mar 15 - Mar 16 [](https://www.expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/c21617f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 2 Queen Beds, Pool View | View from room](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/5c906787.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor banquet area](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/fd471fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/f5261f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sun Hotel [](https://www.expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) Santa Cruz 8.2/10 Very Good (342 reviews) "Awesome place " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) John $97 nightly $97 total Feb 20 - Feb 21 [](https://www.expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/18000000/17520000/17512600/17512569/71ca5d29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/18000000/17520000/17512600/17512569/8d7c06c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/18000000/17520000/17512600/17512569/531892a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/18000000/17520000/17512600/17512569/a80d15c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cosmopolitano Hotel Boutique [](https://www.expedia.com/Santa-Cruz-Hotels-Cosmopolitano-Hotel-Boutique.h17512569.Hotel-Information) Santa Cruz 9.2/10 Wonderful (125 reviews) "Wonderful staff, great food, big bathroom, just wonderful" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) John [](https://www.expedia.com/Santa-Cruz-Hotels-Cosmopolitano-Hotel-Boutique.h17512569.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/0b114a98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/83c0e879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/809a343e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/11000000/10040000/10032000/10031984/912c7493.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Apart Hotel Toborochi [](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) Santa Cruz 8.8/10 Excellent (60 reviews) "Very comfortable and quiet place and very good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis [](https://www.expedia.com/Santa-Cruz-Hotels-Apart-Hotel-Toborochi.h10031984.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/efaab5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, minibar, in-room safe, blackout drapes](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/b93ef62e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/a8bc5939.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, free cabanas](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/78f237b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### TRYP by Wyndham Santa Cruz [](https://www.expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information) Santa Cruz 9.2/10 Wonderful (152 reviews) "Yes! Room was spotless. The staff are very patient and professional. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pluetina $99 nightly $99 total Feb 16 - Feb 17 [](https://www.expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/118000000/117980000/117976200/117976126/db53d748.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/118000000/117980000/117976200/117976126/82e6695c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Single Room, Balcony, City View | Living area | 45-inch plasma TV with cable channels, Netflix, DVD player](https://images.trvl-media.com/lodging/118000000/117980000/117976200/117976126/43ef311c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Suite | Down comforters, minibar, desk, laptop workspace](https://images.trvl-media.com/lodging/118000000/117980000/117976200/117976126/dd7ea04d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Prince Hotel [](https://www.expedia.com/Santa-Cruz-Hotels-Prince-Hotel.h117976126.Hotel-Information) Santa Cruz $56 nightly $56 total Feb 16 - Feb 17 [](https://www.expedia.com/Santa-Cruz-Hotels-Prince-Hotel.h117976126.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.com/Hotel-Search?startDate=2026-03-01&endDate=2026-03-02®ionId=6297178&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.com/deals?rfrr=AFFINITY_SPRING_PROMO_6297178) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.com/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz-Spa-Hotel.0-0-d6297178-tSpaHotel.Hotel-Filter-Destinations)[ Sign up, it's free ](https://expedia.com/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Santa-Cruz-Spa-Hotel.0-0-d6297178-tSpaHotel.Hotel-Filter-Destinations) ## Top Santa Cruz Hotel Reviews ![Ibis Santa Cruz DE LA Sierra](https://images.trvl-media.com/lodging/88000000/87140000/87138700/87138613/53c67151_y.jpg) ### Ibis Santa Cruz DE LA Sierra 10/10 Excellent "Nice place" [](https://expedia.com/Santa-Cruz-Hotels-Ibis-Santa-Cruz-DE-LA-Sierra.h87138613.Hotel-Information) ![Delfines Collection Hotel By Mercure](https://images.trvl-media.com/lodging/91000000/90310000/90301900/90301892/fd3e0846_y.jpg) ### Delfines Collection Hotel By Mercure 10/10 Excellent "Rooms are always spotless good breakfasts rooftop pool with decent view " [](https://expedia.com/Santa-Cruz-Hotels-Delfines-Collection-Hotel-By-Mercure.h90301892.Hotel-Information) ![Chairú Eco Hotel](https://images.trvl-media.com/lodging/83000000/82390000/82389700/82389693/a88a9ace_y.jpg) ### Chairú Eco Hotel 10/10 Excellent "Staff was very courteous. They went above & beyond. Location was great!" [](https://expedia.com/Santa-Cruz-Hotels-Chairu-Eco-Hotel.h82389693.Hotel-Information) ![Camino Real Hotel](https://images.trvl-media.com/lodging/1000000/450000/444500/444475/e96a8418_y.jpg) ### Camino Real Hotel 10/10 Excellent "Spotless, large and comfortable room was well maintained. Friendly and helpful staff. Delicious breakfast buffet. Location is near excellent shopping and dining options." [](https://expedia.com/Santa-Cruz-Hotels-Camino-Real-Hotel.h444475.Hotel-Information) ![Sun Hotel](https://images.trvl-media.com/lodging/13000000/12840000/12836300/12836211/d021f216_y.jpg) ### Sun Hotel 10/10 Excellent "Awesome place " [](https://expedia.com/Santa-Cruz-Hotels-Sun-Hotel.h12836211.Hotel-Information) ![Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/20000/18800/18758/bb34bb1f_y.jpg) ### Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel 10/10 Excellent "Welcoming clean rooms, friendly staff, continental breakfast with natural drinks " [](https://expedia.com/Santa-Cruz-Hotels-Los-Tajibos-Hotel-And-Convention-Center.h18758.Hotel-Information) ![HOTEL OSHO](https://images.trvl-media.com/lodging/76000000/75260000/75254900/75254801/286f65b1_y.jpg) ### HOTEL OSHO 10/10 Excellent "Room was great and staff were very accommodating!" [](https://expedia.com/Santa-Cruz-Hotels-HOTEL-OSHO.h75254801.Hotel-Information) ![TRYP by Wyndham Santa Cruz](https://images.trvl-media.com/lodging/46000000/45620000/45617400/45617372/78f237b9_y.jpg) ### TRYP by Wyndham Santa Cruz 10/10 Excellent "Yes! Room was spotless. The staff are very patient and professional. " [](https://expedia.com/Santa-Cruz-Hotels-TRYP-By-Wyndham-Santa-Cruz.h45617372.Hotel-Information) ![Lido Hotel](https://images.trvl-media.com/lodging/99000000/98240000/98237600/98237549/da03536f_y.jpg) ### Lido Hotel 10/10 Excellent "We stayed at the fabulous Lido Hotel for 2 nights in December 2025\. The hotel is located in central Santa Cruz, within a 4 block walk from Plaza 24 de Septiembre, and also a short 10 minute walk from the iconic Cristo Redentor statue. Check in was quick and painless, and the front desk staff was friendly and helpful. The room itself was spacious, clean and comfortable, with a large attached full bathroom. The air conditioner did a great job of cooling the room. Breakfast was served each morning in the attached Chinese restaurant, and featured eggs, breakfast meats, fruits, juices, cereal and yogurt, and was a great way to fuel up before venturing out to explore Santa Cruz. Without equivocation, I highly recommend the Lido Hotel to anyone in search of a clean comfortable hotel at an affordable price in the enchanting metrolopolis of Santa Cruz de la Sierra, Bolivia. Dr. Kingstone Shih and Laura Meneses Los Altos, California USA " [](https://expedia.com/Santa-Cruz-Hotels-Hotel-Lido.h98237549.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - [Extended Stay Hotels in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Extended-Stay-Hotels.0-0-d6053940-tExtendedStayHotels.Travel-Guide-Filter-Hotels) - [Casino Hotels in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Casino-Hotel.0-0-d6053940-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Hotels with Hot Tubs in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Hot-Tubs.0-0-d6053940-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Cheap-Hotels.0-0-d6053940-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Santa Cruz ](https://www.expedia.com/Santa-Cruz-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d6053940-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - 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