Find 5 Star Hotels in Lower Matecumbe Key, FL from $246
Upfront pricing
Our total price for your stay includes taxes and fees
Treat yourself
Save 10% or more on over 100,000 hotels worldwide with Member Prices
Be picky
Search almost a million properties worldwide
Check availability on Lower Matecumbe Key 5 Star Hotels
Compare Lower Matecumbe Key 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.
Cheeca Lodge & Spa
Cheeca Lodge & Spa
9.0 out of 10, Wonderful, (1156)
$219 nightly
The price is $246
Aug 24 - Aug 25
Total with taxes and fees
Condo in the Keys
Condo in the Keys
8.8 out of 10, Excellent, (9)
Waterfront House with Boat Dock
Waterfront House with Boat Dock
6.0 out of 10, (1)
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Lower Matecumbe Key.
Baker's Cay Resort Key Largo, Curio Collection by Hilton
97000 Overseas Hwy, Key Largo, FL
$303 nightly
The price is $341 total per night from Sep 15 to Sep 16
$341 total
Sep 15 - Sep 16
Total with taxes and fees
8.6/10 Excellent! (1,000 reviews)
Still don't see what you're looking for?
See all properties in Lower Matecumbe Key.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Lower Matecumbe Key
Check out the local area in Lower Matecumbe Key—home to attractions like Anne's Beach and Sunset Drive Beach.
Top Lower Matecumbe Key Hotel Reviews
Cheeca Lodge & Spa
10/10 Excellent
Find out more about Lower Matecumbe Key
Find out more about Lower Matecumbe Key
Lower Matecumbe Key Five Star Hotel Information
If you’re searching for the celebrity treatment, the 5 star hotels in Lower Matecumbe Key are your dreams come true. From sprawling resorts to fancy hot spots, theseLower Matecumbe Key 5 star hotels immerse each traveler in the most elite experience money can buy. Want to unwind with a VIP-worthy spa treatment? These hotels have the leisure you're looking for.
Interested in sampling world-class cuisine? The on-site restaurants at the 5 stars hotels in Lower Matecumbe Key, Islamorada, let you do just that. You’ll even be able to book a room (or perhaps a penthouse?) at first-rate hotels near the region’s can’t-miss sights and most bustling shopping centers. Plus, many globe-trotters who visit Lower Matecumbe Key five star hotels find incredible rates and deep discounts thanks to Expedia, so you can score a deal without sacrificing an ounce of quality.
Everything you could possibly want (and a few things you didn’t know you needed): That’s what you’ll receive when you stay at Lower Matecumbe Key 5 star hotels.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Hotels near Sunset Drive Beach
- Hotels near Lower Matecumbe Beach
- Hotels near Anne's Beach
- Lignumvitae Key Botanical State Park Hotels
- Hotels near Bud n' Mary's Dive Center
- Islamorada Hotels
- Hotels near Matecumbe
- Hotels near Hurricane Monument
- Hotels near Florida Keys Brewing Co.
- Hotels near Matecumbe United Methodist Church
- Upper Matecumbe Key Hotels
- 5 Star Hotels in Islamorada
- 4 Star Hotels in Islamorada
- 3 Star Hotels in Islamorada
- Resorts in Islamorada
- Cheap Hotels in Islamorada
- Oceanfront Hotels in Islamorada
- All-inclusive Resorts in Islamorada
- Pet-friendly Hotels in Islamorada
- Beach Hotels in Islamorada
- Luxury Hotels in Islamorada
- Adults Only Resorts & in Islamorada
- Hilton Hotels in Islamorada
- Marriott Hotels & Resorts in Islamorada
- Houseboats in Islamorada
- Cottages in Islamorada
- Family Hotels in Islamorada
- Motels in Islamorada
- Hotels with a Swim-up Bar in Islamorada
- Hotels with Bars in Islamorada
- Fishing Resorts & in Islamorada
- Condo Rentals in Islamorada
- Boutique Hotels in Islamorada
- Wyndham Hotels in Islamorada
- Layton Hotels
- Honeymoon Resorts & in Islamorada
- Villas in Islamorada
- Hotels with Free Breakfast in Islamorada
- Resorts & Hotels with Spas in Islamorada
- RV Parks in Islamorada
- Hotels with Restaurants in Islamorada
- Hotel Wedding Venues Hotels in Islamorada
- Romantic Hotels in Islamorada
- Vacation Homes in Islamorada
- Gay friendly Hotels in Islamorada
- Apartments in Islamorada
- Hotels with Kitchenettes in Islamorada
- Hotels with Suites in Islamorada
- Hotels with Hot Tubs in Islamorada
- Hotels with Laundry Facilities in Islamorada
- Hotels with Connecting Rooms in Islamorada
- Historic Hotels in Islamorada
- Treehouses in Islamorada
- Golf Hotels in Islamorada
- Guest Houses in Islamorada
- Hotels with a Gym in Islamorada
- Hotels & Resorts for Couples in Islamorada
- B&B in Islamorada
- Hersha Hospitality Hotels in Islamorada
- Hotels with smoking rooms in Islamorada
- Hotels with Room Service in Islamorada
- Aimbridge Hospitality Hotels in Islamorada
- Hotels with Tennis Courts in Islamorada
- Hotels with a Pool in Islamorada
- Best Western Hotels in Islamorada
- Hotels with Childcare in Islamorada
- Lodges in Islamorada
- Rainforest & Jungle Hotels in Islamorada
- Quiet Resorts & in Islamorada
- Hotels with a View in Islamorada
- Flights to Lignumvitae Key Botanical State Park
- Flights to Islamorada
- Flights from Islamorada
- Flights from Tampa to Islamorada
- Flights from New York to Islamorada
- Flights from Cleveland to Islamorada
- Flights from Kansas City to Islamorada
- Flights from Columbus to Islamorada
- Flights from Boston to Islamorada
- Flights from Atlanta to Islamorada
- Flights from Baltimore to Islamorada
- Car rentals near Bud n' Mary's Dive Center
- Car rentals near Fiesta Key
- Car rentals near Hurricane Monument
- Car rentals near Islamorada
- Hertz Rental Cars in Islamorada
- Enterprise Rental Cars in Islamorada
- Thrifty Car Rental Rental Cars in Islamorada
- Budget Rental Cars in Islamorada
- Van Car Rentals in Islamorada
- Avis Rental Cars in Islamorada
- Alamo Rent A Car Rental Cars in Islamorada
- Luxury Car Rentals in Islamorada
- National Car Rental Rental Cars in Islamorada