Find 5 Star Hotels in Uptown, TN from $95

Start date: Check-in selected.
To Date
End date: Check-out

  • Upfront pricing

    Our total price for your stay includes taxes and fees

  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Uptown 5 Star Hotels

Our top choices for Uptown 5-star hotels

Exterior
Big Cypress Lodge

Big Cypress Lodge

Big Cypress Lodge
5.0 star property
Uptown
9.0 out of 10, Wonderful, (1715)
"The lodge was amazing, we will be back soon."
United States
Carl
$246 nightly
The price is $294
Jan 12 - Jan 13, 2026
Total with taxes and fees
Big Cypress Lodge
4 bedrooms, premium bedding, memory foam beds, individually decorated
Abode Memphis - Pontotoc

Abode Memphis - Pontotoc

Abode Memphis - Pontotoc
5.0 star property
Downtown Memphis
10.0 out of 10, Exceptional, (6)
"The house was absolutely excellent. The space was perfect, clean, and quiet. "
United States
Myra
$441 nightly
The price is $501
Jan 12 - Jan 13, 2026
Total with taxes and fees
Abode Memphis - Pontotoc
Premium Apartment, 1 Bedroom, River View | View from room
The River City Flats

The River City Flats

The River City Flats
5.0 star property
Downtown Memphis
6.6 out of 10, (156)
"Nice little getaway "
United States
Rheagan
The River City Flats
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Uptown.
The Guest House at Graceland

The Guest House at Graceland

3600 Elvis Presley Blvd Memphis TN
$229 nightly
The price is $279 total per night from Dec 17 to Dec 18
$279 total
Dec 17 - Dec 18
Total with taxes and fees
9.4/10 Exceptional! (2,849 reviews)
Still don't see what you're looking for?
See all properties in Uptown.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Uptown Hotel Reviews

Big Cypress Lodge

Big Cypress Lodge

10/10 Excellent
"The room was excellent. The balcony in the room was really cool. "
Ashley 2-night trip
Posted 7 days ago
Big Cypress Lodge

Frequently asked questions

What are the best 5-star hotels in Uptown?
Relax in luxurious surroundings at Big Cypress Lodge. Highly rated by our guests for its superior level of comfort and opulence, this 5-star hotel located around the Memphis neighborhood of Uptown will not disappoint.
How much does it cost to stay in a 5-star hotel in Uptown?
How much you pay for a 5-star hotel in Uptown depends on factors such as when you plan to travel and the length of your escape. An insider tip for bagging the best deal? Use our pricing filters to check out the available accommodations for your preferred dates.

  • Search for the lowest price per night from $95

What makes a hotel 5 stars in Uptown?
Faultless guest service is the hallmark of every 5-star hotel in Uptown. From the moment you enter the lobby, staff attend to your every whim, whether offering luggage assistance and storage or providing a turn-down service. Additionally, hotels have to feature superior conveniences to qualify for a 5-star rating. These can include luxury bathrooms, spas or saunas, pools, fine dining kitchens and knowledgeable concierge.

Explore a world of travel with Expedia