Downtown St. Louis Vacations from $677
Book a Hotel + Flight or Car together to unlock savings
Your Downtown St. Louis Vacation
A sought-after riverside neighborhood, Downtown St. Louis tempts visitors with its festivals, bars and pubs and dining. Lock in a vacation package to Downtown St. Louis and look forward to experiencing all the best bits for yourself. Some top nearby attractions to check out during your trip to Downtown St. Louis include Busch Stadium, Gateway Arch and Dome at America’s Center. Expedia will help you turn your ideal Downtown St. Louis vacation into reality, no matter your travel plans or budget.
The Latest Downtown St. Louis Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Cheshire
Price was $874, price is now $677 per person
$677
per person
May 8 - May 12
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.6/10 Excellent! (1,009 reviews)
The room was comfortable and we had the amenities we needed. It offered a generous breakfast every morning. Coffee and water were available at all times. The gym was clean and easily accessible. The pool was closed during our stay due to the season we traveled in. There was ample parking downstairs. The bar on site was really cute and the drinks were great. We were driving distance to a lot of things and it made it a great homebase. We would definitely stay here again.
Reviewed on Mar 29, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $1,255, price is now $777 per person
$777
per person
Jun 24 - Jun 28
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
The breakfaat was average, thou fresh. There was enough street parking nearby, safe.
Reviewed on Mar 30, 2026
Spacious 3-Bedroom with King Bed
Central West End
Save 100% on your flight
Price was $1,184, price is now $909 per person
$909
per person
Jun 11 - Jun 14
found 15 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to St. Louis (STL)
8.8/10 Excellent! (11 reviews)
Clean room nice area
Reviewed on Feb 1, 2026
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
Clayton
Price was $1,392, price is now $1,079 per person
$1,079
per person
May 8 - May 15
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9/10 Wonderful! (944 reviews)
Clean, convenient, good breakfast. Nice workout room. Wish there was a pool outside, like a hot tub. Should have explained that you have to pay to park on-site. We did park less than a block away on the street for free.
Reviewed on Mar 27, 2026
Ameristar Casino Resort and Spa
Price was $1,007, price is now $789 per person
$789
per person
Jun 24 - Jun 28
found 1 day ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.4/10 Very Good! (1,000 reviews)
Overall it was a positive experience but we were VERY disappointed when we found out our daughter couldn’t swim all weekend. We would not have booked it if we had known that.
Reviewed on Mar 22, 2026
Where to stay in Downtown St. Louis
Find the best Downtown St. Louis areas and neighborhoods for the activities you enjoy most. Learn more about Downtown St. Louis
Clayton
1 out of top 10 points of interest in this area
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Downtown St. Louis Hotel Deals
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
$162 nightly
The price is $189 total per night from Apr 6 to Apr 7
$189 total
Apr 6 - Apr 7
Total with taxes and fees
9.4/10 Exceptional! (3,358 reviews)
Great place, great service and definitely will be back. Oh, and the best coffee ever in the mornings!
Reviewed on Mar 31, 2026
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$169 nightly
The price is $199 total per night from Apr 12 to Apr 13
$199 total
Apr 12 - Apr 13
Total with taxes and fees
8.4/10 Very Good! (3,995 reviews)
Beautiful hotel. Staff helpful. Very clean. Great location.
Reviewed on Mar 30, 2026
Live by Loews - St.Louis
799 Clark ave St. Louis MO
Fully refundableReserve now, pay when you stay
$142 nightly
The price is $168 total per night from Apr 5 to Apr 6
$168 total
Apr 5 - Apr 6
Total with taxes and fees
9.4/10 Exceptional! (1,134 reviews)
Staff was amazing
Reviewed on Mar 30, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Downtown St. Louis
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's acclaimed art scene and fascinating museums.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- St. Louis Hotels
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- Gateway Arch
- Gateway Arch National Park
- Old Courthouse
- Busch Stadium
- St. Louis Vacations
- Kiener Plaza
- Wainwright Building
- Cardinals Hall of Fame and Museum
- Gateway Arch Visitor Center
- Federal Reserve Bank of St. Louis
- National Blues Museum
- Old Post Office
- Eugene Field House & St. Louis Toy Museum
- America's Center Convention Complex
- St. Louis City Hall
- Dome at America’s Center
- Eads Bridge
- Laclede's Landing Vacations
- St. Mary of Victories Catholic Church
- City Museum
- Central Public Library
- Christ Church Cathedral
- Citygarden
- Peabody Opera House
- Campbell House Museum
- Enterprise Center
- Anheuser-Busch Brewery
- St. Louis Aquarium at Union Station
- St. Louis Union Station
- Visit St. Louis
- St. Louis Union Station Mini Golf
- Meeting of the Waters Fountain
- Soulard Farmer's Market
- Car rentals near St. Louis
- Car rentals near Gateway Arch National Park
- Car rentals near Kiener Plaza
- Car rentals near Gateway Arch
- Car rentals near Busch Stadium
- Car rentals near America's Center Convention Complex
- Car rentals near Dome at America’s Center
- Car rentals near Laclede's Landing
- Car rentals near Enterprise Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.