Downtown St. Louis Vacations from $496
Book a Hotel + Flight or Car together to unlock savings
Your Downtown St. Louis Vacation
A sought-after riverside neighborhood, Downtown St. Louis tempts visitors with its festivals, bars and pubs and dining. Lock in a vacation package to Downtown St. Louis and look forward to experiencing all the best bits for yourself. Some top nearby attractions to check out during your trip to Downtown St. Louis include Busch Stadium, Gateway Arch and Dome at America’s Center. Expedia will help you turn your ideal Downtown St. Louis vacation into reality, no matter your travel plans or budget.
The Latest Downtown St. Louis Vacation Packages
Price found within the past 48 hours. Click for updated prices.
The Knight Center at Washington University
Price was $637, price is now $496 per person
$496
per person
May 28 - May 31
found 1 day ago
Roundtrip flight included
New York (NYC) to St. Louis (STL)
9.4/10 Exceptional! (496 reviews)
Great place to stay on campus. Extremely helpful and friendly staff you don’t typically find at the chain hotels.
Reviewed on Mar 14, 2026
The Wildwood Hotel
Save 100% on your flight
Price was $1,151, price is now $674 per person
$674
per person
Apr 29 - May 6
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
9.2/10 Wonderful! (1,620 reviews)
the hotel is very comfortable and the staff was very helpful.
Reviewed on Mar 20, 2026
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
Save 100% on your flight
Price was $1,194, price is now $814 per person
$814
per person
Apr 29 - May 6
found 10 hours ago
Roundtrip flight included
Boston (BOS) to St. Louis (STL)
8.8/10 Excellent! (1,065 reviews)
Super close to the center. Great Breakfast. Clean room and very friendly staff. However, it would be most likely cheaper to buy breakfast the day off then prepay while booking. I got vouchers because I paid for breakfast in advance but could see what my bill would have been and I paid more when booking the room.
Reviewed on Mar 16, 2026
Where to stay in Downtown St. Louis
Find the best Downtown St. Louis areas and neighborhoods for the activities you enjoy most. Learn more about Downtown St. Louis
Clayton
1 out of top 10 points of interest in this area
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
Downtown St. Louis Hotel Deals
Drury Plaza Hotel St. Louis at the Arch
2 South 4th Street St. Louis MO
Fully refundableReserve now, pay when you stay
$162 nightly
The price is $189 total per night from Mar 29 to Mar 30
$189 total
Mar 29 - Mar 30
Total with taxes and fees
9.4/10 Exceptional! (3,348 reviews)
Yes
Reviewed on Mar 20, 2026
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
$159 nightly
The price is $188 total per night from Apr 2 to Apr 3
$188 total
Apr 2 - Apr 3
Total with taxes and fees
8.4/10 Very Good! (3,980 reviews)
Good
Reviewed on Mar 21, 2026
Live by Loews - St.Louis
799 Clark ave St. Louis MO
$159 nightly
The price is $189 total per night from Mar 22 to Mar 23
$189 total
Mar 22 - Mar 23
Total with taxes and fees
9.4/10 Exceptional! (1,127 reviews)
Clean room, helpful staff. Easy check-in and parking
Reviewed on Mar 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Downtown St. Louis
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Dome at America’s Center
Catch an event at Dome at America’s Center during your trip to St. Louis. Experience the area's acclaimed art scene and fascinating museums.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
$24
per adult
Lemp Haunted Neighborhood Walking Tour
$30
per adult
84% of travellers recommend
St. Louis Premium Driving Tour with Boat Ride & Arch
$174
per adult
100% of travellers recommend
Explore a world of travel with Expedia
- St. Louis Hotels
- Hotels near Busch Stadium
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- Hotels near Gateway Arch
- Hotels near Enterprise Center
- Hotels near Dome at America’s Center
- Hotels near Old Courthouse
- Hotels near Gateway Arch National Park
- Hotels near St. Louis Cathedral
- Hotels near Kiener Plaza
- Hotels near Wainwright Building
- Hotels near Cardinals Hall of Fame and Museum
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- Hotels near Federal Reserve Bank of St. Louis
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- Gateway Arch
- Gateway Arch National Park
- Old Courthouse
- Busch Stadium
- St. Louis Vacations
- Kiener Plaza
- Wainwright Building
- Cardinals Hall of Fame and Museum
- Gateway Arch Visitor Center
- Federal Reserve Bank of St. Louis
- National Blues Museum
- Old Post Office
- Eugene Field House & St. Louis Toy Museum
- America's Center Convention Complex
- St. Louis City Hall
- Dome at America’s Center
- Eads Bridge
- Laclede's Landing Vacations
- St. Mary of Victories Catholic Church
- City Museum
- Central Public Library
- Christ Church Cathedral
- Citygarden
- Peabody Opera House
- Campbell House Museum
- Enterprise Center
- Anheuser-Busch Brewery
- St. Louis Aquarium at Union Station
- St. Louis Union Station
- Visit St. Louis
- St. Louis Union Station Mini Golf
- Meeting of the Waters Fountain
- Soulard Farmer's Market
- Car rentals near St. Louis
- Car rentals near Gateway Arch National Park
- Car rentals near Kiener Plaza
- Car rentals near Gateway Arch
- Car rentals near Busch Stadium
- Car rentals near America's Center Convention Complex
- Car rentals near Dome at America’s Center
- Car rentals near Laclede's Landing
- Car rentals near Enterprise Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.