Irene, SD

Travel Guide

Comfort Inn Yankton SD

Comfort Inn Yankton SD

2.5 out of 5
611 W 23rd Street Yankton SD
$95 nightly
The price is $105 total per night from Nov 29 to Nov 30
$105 total
Nov 29 - Nov 30
Total with taxes and fees
Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Inn Yankton SD
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$108 nightly
The price is $114 total per night from Nov 8 to Nov 9
$114 total
Nov 8 - Nov 9
Total with taxes and fees
Book a stay at this beach hotel in Yankton. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway ...
Lewis and Clark Resort
Fairfield Inn & Suites by Marriott Yankton

Fairfield Inn & Suites by Marriott Yankton

3 out of 5
508 WEST 21ST STREET Yankton SD
$114 nightly
The price is $126 total per night from Nov 15 to Nov 16
$126 total
Nov 15 - Nov 16
Total with taxes and fees
Stay at this hotel in Yankton. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff in our reviews. Popular attractions ...
9.4/10 Exceptional! (200 reviews)
"The staff was amazingly nice and helpful!!!! Would have given 10 stars for service if I could."

Reviewed on Oct 29, 2026

Fairfield Inn & Suites by Marriott Yankton
See all 88 properties in Irene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Parkview Cottage ~ Charming Tiny Home ~ Queen Bed!

Parkview Cottage ~ Charming Tiny Home ~ Queen Bed!

Viborg SD
Stay at this cottage in Viborg. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker.
Parkview Cottage ~ Charming Tiny Home ~ Queen Bed!
Cozy Abode in Historic Yankton - Heart of the City

Cozy Abode in Historic Yankton - Heart of the City

Yankton SD
Stay at this apartment in Yankton. Enjoy an in-room coffeemaker and air conditioning. Popular attractions G.A.R. Hall and Meridian Bridge are located ...
9.6/10 Exceptional! (25 reviews)
"Cool little spot in Yankton.Perfect what we needed.Clean with all the amenities."

Reviewed on Oct 18, 2026

Cozy Abode in Historic Yankton - Heart of the City
Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
Stay at this vacation home in Crofton. Enjoy a garden, laundry facilities, and patios. Popular attractions Hideaway Acres State Recreation Area and Deep Water ...
10/10 Exceptional! (11 reviews)
"Family friendly"

Reviewed on Oct 25, 2026

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!
See all properties in Irene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

When is the best time to visit Irene?
The best time to visit Irene is from May through September, when the climate is most favorable. For fewer crowds and better value, the quieter months of December through March are a good option, offering a cooler season to explore the area.
Can I book a refundable hotel in Irene?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Irene by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Irene with Expedia?
Expedia makes it easier to plan your Irene trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Irene?
The best choice depends on your travel style. Hotels in Irene can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Irene trip on Expedia?
Once you've booked your Irene trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Irene trip?
Expedia offers customer support before, during, and after your Irene trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Irene?
If it's your first trip to Irene, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Irene hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Irene hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

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