Irene, SD

Travel Guide

Comfort Inn Yankton SD

Comfort Inn Yankton SD

2.5 out of 5
611 W 23rd Street Yankton SD
$95 nightly
The price is $105 total per night from Oct 18 to Oct 19
$105 total
Oct 18 - Oct 19
Total with taxes and fees
Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Inn Yankton SD
Lewis and Clark Resort

Lewis and Clark Resort

2.5 out of 5
43496 Shore Drive Yankton SD
$119 nightly
The price is $126 total per night from Sep 27 to Sep 28
$126 total
Sep 27 - Sep 28
Total with taxes and fees
Book a stay at this beach hotel in Yankton. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Lewis and Clark Recreation Area and Midway ...
Lewis and Clark Resort
Econo Lodge Inn & Suites Yankton

Econo Lodge Inn & Suites Yankton

2 out of 5
2410 Broadway Ave Yankton SD
$77 nightly
The price is $85 total per night from Oct 14 to Oct 15
$85 total
Oct 14 - Oct 15
Total with taxes and fees
Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Fox Run Plaza and Augusta Park ...
7.4/10 Good! (788 reviews)
"My response/ rating from just going to the room says it all. If all the hotels weren't full, we would have left."

Reviewed on Sep 21, 2026

Econo Lodge Inn & Suites Yankton
See all 87 properties in Irene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

Crofton NE
Stay at this vacation home in Crofton. Enjoy a garden, laundry facilities, and patios. Popular attractions Hideaway Acres State Recreation Area and Deep Water ...
10/10 Exceptional! (10 reviews)
"Everything was great!"

Reviewed on Sep 8, 2026

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!
Charming Lake House within Walking Distance from Lake

Charming Lake House within Walking Distance from Lake

Yankton SD
Stay at this vacation home in Yankton. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lewis and Clark Recreation Area and Midway Recreation ...
9.6/10 Exceptional! (47 reviews)
"It was a great place to stay , it was nice the kids had their own area to hang out"

Reviewed on Sep 9, 2026

Charming Lake House within Walking Distance from Lake
Spacious Lakeview Cabin Minutes from Private Beach

Spacious Lakeview Cabin Minutes from Private Beach

Crofton NE
Stay at this cabin in Crofton. Enjoy free WiFi, laundry facilities, and patios. Popular attractions Deep Water Recreation Area and Lewis and Clark Lake State ...
Spacious Lakeview Cabin Minutes from Private Beach
See all properties in Irene
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

When is the best time to visit Irene?
The best time to visit Irene is from May through September, when the climate is most favorable. For fewer crowds and better value, the quieter months of December through March are a good option, offering a cooler season to explore the area.
Can I book a refundable hotel in Irene?
Yes, Expedia offers many flexible booking options, and you can look for refundable hotels in Irene by entering your dates and using the refundable or fully refundable filter. Always check the hotel's cancellation policy before you book, since terms can vary by hotel, and visit Expedia help center for further details.
Why book a trip to Irene with Expedia?
Expedia makes it easier to plan your Irene trip with travel tools, flexible search options, and bookable trip components all in one place. You can organize your plans in one account and use Expedia to help build a trip that fits your budget and travel style. Find out more about how by visiting Expedia's Trip Planner page.
Should I stay in a hotel or vacation rental in Irene?
The best choice depends on your travel style. Hotels in Irene can be a good fit for convenience, on-site amenities, and shorter stays, while vacation rentals may offer more space, privacy, and home-style amenities for longer trips, families, or groups. With Expedia, you can compare both options side by side, read traveler reviews, and filter by amenities to find the right fit for your trip.
How can I manage my Irene trip on Expedia?
Once you've booked your Irene trip, you can manage it through your Expedia account or the Expedia app. You can view your itinerary, access booking details, make eligible changes, and check for updates in My Trips. The Expedia app can also help you stay organized while you travel.
What if I need help during my Irene trip?
Expedia offers customer support before, during, and after your Irene trip. If your plans change or something unexpected happens, you can review your booking in My Trips and use Expedia help center channels for help with eligible changes, cancellations, or travel issues.
How can Expedia help me plan my first trip to Irene?
If it's your first trip to Irene, Expedia can help you plan by bringing together stays, flights, activities, traveler reviews, and trip-planning tools in one place. With Expedia's Trip Planner you can compare options, read reviews from other travelers, and build an itinerary that matches your interests and budget.
How can I save on my Irene hotel booking with Expedia?
Join One Key™ for free to unlock instant discounts with Member Prices on select hotels. You can also earn and use OneKeyCash™* on eligible bookings on Expedia. Booking in advance is usually another great way to save on your Irene hotel.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

Explore a world of travel with Expedia