Title: Visit Irene: 2026 Travel Guide for Irene, South Dakota | Expedia.com

[Hotels in Irene](https://expedia.com/Irene-Hotels.d3000353315.Travel-Guide-Hotels)[Vacation Rentals in Irene](https://expedia.com/Irene-Vacation-Rentals.d3000353315.Travel-Guide-VacationRentals)[Flights to Irene](https://expedia.com/Cheap-Flights-To-Irene.d3000353315.Travel-Guide-Flights)[Car Rentals in Irene](https://expedia.com/Car-Rentals-In-Irene.d3000353315.Car-Rental-Guide)[Irene Vacation Packages](https://expedia.com/Irene.d3000353315.Destination-Travel-Guides)

# Irene, SD

## Travel Guide

## Visit Irene

- Irene Hotel Deals
- Vacation Rentals in Irene

![Best Western Kelly Inn](https://images.trvl-media.com/lodging/7000000/6850000/6847000/6846956/2110bd4e_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Best Western Kelly Inn

1607 E Highway 50 Yankton SD

$98 nightly

$109 total

Feb 15 - Feb 16

Total with taxes and fees

Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

8/10 Very Good! (659 reviews)

Very friendly staff!!

Reviewed on Feb 1, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F15%2F2026&endDate=2%2F16%2F2026&selected=6846956&PinnedHotelID=6846956&HadPinnedHotel=true&regionId=3000353315)

![Comfort Inn Yankton SD](https://images.trvl-media.com/lodging/11000000/10450000/10440200/10440162/70f394ec_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Comfort Inn Yankton SD

611 W 23rd Street Yankton SD

$97 nightly

$107 total

Feb 16 - Feb 17

Total with taxes and fees

Book a stay at this business-friendly hotel in Yankton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

8.8/10 Excellent! (688 reviews)

It was good

Reviewed on Jan 16, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F16%2F2026&endDate=2%2F17%2F2026&selected=10440162&PinnedHotelID=10440162&HadPinnedHotel=true&regionId=3000353315)

![Fairfield Inn & Suites by Marriott Yankton](https://images.trvl-media.com/lodging/87000000/86190000/86189100/86189086/7b3b8474_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Fairfield Inn & Suites by Marriott Yankton

508 WEST 21ST STREET Yankton SD

$124 nightly

$137 total

Feb 16 - Feb 17

Total with taxes and fees

Stay at this hotel in Yankton. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff in our reviews. Popular attractions ...

9.4/10 Exceptional! (161 reviews)

The room was immaculate!! Beautiful facility and probably the best hotel in Yankton. Very happy!

Reviewed on Jan 2, 2026

[](https://expedia.com/Hotel-Search?startDate=2%2F16%2F2026&endDate=2%2F17%2F2026&selected=86189086&PinnedHotelID=86189086&HadPinnedHotel=true&regionId=3000353315)

[See all 83 properties in Irene](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=2%2F9%2F2026&endDate=2%2F10%2F2026&regionId=3000353315)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![Charming Lake House within Walking Distance from Lake](https://images.trvl-media.com/lodging/28000000/27120000/27116700/27116625/d37f9a63_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Charming Lake House within Walking Distance from Lake

 Yankton SD

Stay at this vacation home in Yankton. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lewis and Clark Recreation Area and Midway Recreation ...

9.6/10 Exceptional! (37 reviews)

Nice place, lots of space. Different areas to hang out, play games, watch TV. Nice outdoor patio area. Good location, easy access to Lewis & Clark recreation area.

Reviewed on Oct 30, 2025

[](https://expedia.com/Vermillion-Hotels-Charming-Lake-House-Within-Walking-Distance-From-Lake.h27116625.Hotel-Information)

![Haven by the Lake](https://images.trvl-media.com/lodging/83000000/82960000/82951700/82951676/77c0b851_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Haven by the Lake

 Yankton SD

Book a stay at this family-friendly vacation home in Yankton. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Lewis and Clark Recreation ...

10/10 Exceptional! (22 reviews)

GREAT HOST!

Reviewed on Nov 24, 2025

[](https://expedia.com/Yankton-Hotels-Haven-By-The-Lake.h82951676.Hotel-Information)

![Shady Creek Cabin - Family Friendly Getaway Near Lake](https://images.trvl-media.com/lodging/76000000/75620000/75612000/75611913/67639cf4_y.jpg?impolicy=resizecrop&rw=340&ch=150)

### 

Shady Creek Cabin - Family Friendly Getaway Near Lake

 Yankton SD

Book a stay at this family-friendly cabin in Yankton. Enjoy a water park, a garden, and laundry facilities. Popular attractions Gavins Point Recreation Area ...

10/10 Exceptional! (88 reviews)

The hosts were helpful when we couldn't find access to the cabin. The house was well stocked with everyday use items. The only two things we would have liked to see is better, warmer bedding, and better quality pans as those available made it very difficult to cook in. We have a large. local family. ...

Reviewed on Jan 23, 2026

[](https://expedia.com/Yankton-Hotels-Shady-Creek-Cabin-Family-Friendly-Getaway-Near-Lake.h75611913.Hotel-Information)

[See all properties in Irene](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&regionId=3000353315&sort=VACATION_RENTAL)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Check Irene hotel availability

[Tonight

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2026-02-08&endDate=2026-02-09)[Feb 8 - Feb 9](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2026-02-08&endDate=2026-02-09)

[Tomorrow night

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2026-02-09&endDate=2026-02-10)[Feb 9 - Feb 10](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2026-02-09&endDate=2026-02-10)

[Next weekend

](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)[Feb 13 - Feb 15](https://expedia.com/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true&regionId=3000353315&startDate=2%2F13%2F2026&endDate=2%2F15%2F2026)

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- [Visit Wakonda ](https://www.expedia.com/Wakonda.dx3000353331)
- [Visit Viborg ](https://www.expedia.com/Viborg.dx3000353329)
- [Visit Volin ](https://www.expedia.com/Volin.dx3000456439)
- [Volin Vacations ](https://www.expedia.com/Volin.d3000456439.Destination-Travel-Guides)
- [Visit Gayville ](https://www.expedia.com/Gayville.dx3000353310)
- [Spirit Mound ](https://www.expedia.com/Spirit-Mound-Vermillion.d553248621532648839.Vacation-Attraction)
- [Visit Yankton ](https://www.expedia.com/Yankton.dx3984)
- [Riverside Park ](https://www.expedia.com/Riverside-Park-Yankton.d6303846.Vacation-Attraction)
- [Visit Beresford ](https://www.expedia.com/Beresford.dx183951)
- [Yankton Vacations ](https://www.expedia.com/Yankton.d3984.Destination-Travel-Guides)

- [Car rentals near Volin ](https://www.expedia.com/Car-Rentals-In-Volin.d3000456439.Car-Rental-Guide)
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- [Car rentals near Yankton ](https://www.expedia.com/Car-Rentals-In-Yankton.d3984.Car-Rental-Guide)
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- [Gayville Vacation Rentals ](https://www.expedia.com/Gayville-Vacation-Rentals.d3000353310.Travel-Guide-VacationRentals)
- [Yankton Vacation Rentals ](https://www.expedia.com/Yankton-Vacation-Rentals.d3984.Travel-Guide-VacationRentals)

- Cities near Irene
- Places of interest

[Menno](https://expedia.com/Menno.dx3000353318)[Viborg](https://expedia.com/Viborg.dx3000353329)[Wakonda](https://expedia.com/Wakonda.dx3000353331)[Volin](https://expedia.com/Volin.dx3000456439)

- [Missouri River ](https://expedia.com/Missouri-River-United-States-of-America.d553248621532651824.Vacation-Attraction)
- [Lewis and Clark Recreation Area ](https://expedia.com/Lewis-And-Clark-Recreation-Area-South-Dakota.d553248621593151470.Vacation-Attraction)
- [Riverside Park ](https://expedia.com/Riverside-Park-Yankton.d6303846.Vacation-Attraction)
- [Spirit Mound ](https://expedia.com/Spirit-Mound-Vermillion.d553248621532648839.Vacation-Attraction)
- [Dakota Territorial Museum ](https://expedia.com/Dakota-Territorial-Museum-Yankton.d6303842.Vacation-Attraction)

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