Mesopotamia Vacations from $1,388

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Your Mesopotamia Vacation

When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with Corrientes. Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favorite with Mesopotamia travelers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're traveling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.

The Latest Mesopotamia vacation packages

Price found within the past 48 hours. Click for updated prices.
Howard Johnson by Wyndham Ezeiza Convention Center

Howard Johnson by Wyndham Ezeiza Convention Center

3.5 out of 5
Price was $1,780, price is now $1,388 per person
$1,388
per person
Jan 2 - Jan 9
found 1 day ago
Roundtrip non-stop flight included
San José (SJO) to Buenos Aires (EZE)
7.2/10 Good! (316 reviews)

Palacio Duhau - Park Hyatt Buenos Aires

Palacio Duhau - Park Hyatt Buenos Aires

5 out of 5
Recoleta
Price was $3,362, price is now $2,350 per person
$2,350
per person
Dec 9 - Dec 12
found 1 day ago
Roundtrip non-stop flight included
San José (SJO) to Buenos Aires (EZE)
9.4/10 Exceptional! (525 reviews)
Las instalaciones son muy buenas sin embargo considero que deben de mejorar algunas cosas del cuarto. Cortinas y alfombras. Además el room services no tiene whisky después que cierra el bar del hotel, ilógico que un hotel con esa categoría tenga un problema tan sencillo de resolver.

Reviewed on Nov 5, 2026

Hotel Europa

Hotel Europa

3 out of 5
El Centro
Save 100% on your flight
Price was $8,176, price is now $6,349 per person
$6,349
per person
Jan 2 - Jan 9
found 1 day ago
Roundtrip non-stop flight included
San José (SJO) to Buenos Aires (EZE)
No reviews

Estancia Villa Maria

Estancia Villa Maria

4 out of 5
Price was $3,880, price is now $2,523 per person
$2,523
per person
Dec 27 - Jan 2
found 1 day ago
Roundtrip flight included
Miami (MIA) to Buenos Aires (EZE)
9.4/10 Exceptional! (118 reviews)

SLS Buenos Aires Puerto Madero

SLS Buenos Aires Puerto Madero

5 out of 5
Puerto Madero
Price was $2,104, price is now $1,399 per person
$1,399
per person
Jan 21 - Jan 27
found 2 hours ago
Roundtrip flight included
Miami (MIA) to Buenos Aires (EZE)
9.6/10 Exceptional! (399 reviews)

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Stay near popular Mesopotamia attractions

A dirt path through a dense palm tree forest.

El Palmar National Park

8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
See properties

Mesopotamia Hotel Deals

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
$144 nightly
The price is $144 total per night from Nov 29 to Nov 30
$144 total
Nov 29 - Nov 30
9.8/10 Exceptional! (54 reviews)
"👍"

Reviewed on Nov 3, 2026

Marriott Corrientes Hotel
Costarenas Hotel & Spa

Costarenas Hotel & Spa

3.5 out of 5
12 de Abril y Quiros Colon Entre Rios
Fully refundableReserve now, pay when you stay
$122 nightly
The price is $122 total per night from Nov 10 to Nov 11
$122 total
Nov 10 - Nov 11
8.8/10 Excellent! (65 reviews)
"Estaba todo muy lindo"

Reviewed on Jun 8, 2026

Costarenas Hotel & Spa
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
$42 nightly
The price is $42 total per night from Nov 15 to Nov 16
$42 total
Nov 15 - Nov 16
7.8/10 Good! (98 reviews)
"Clean, convenient and friendly staff."

Reviewed on Oct 30, 2026

O2 Hotel Gualeguaychú
See all 533 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Mesopotamia Vacation Packages

Mesopotamia Essential Information

Language
Spanish
Currency
Argentine pesos
Local Welcome
¡Hola!
Local Goodbye
Adiós
Closest Airport
Ministro Pistarini Intl. Airport (EZE)

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Frequently asked questions

What's included in a Mesopotamia vacation package?
A Mesopotamia vacation package in Colon lets you combine flights, hotel stays, and rental cars. Most hotels in Colon offer free breakfast, and some provide airport shuttle service.

Exactly what's included will vary by hotel and package, so it's worth reviewing the details before you confirm your booking.
How can I save money on a Mesopotamia vacation package?
When you bundle, you can save up to 30%*. To save money on a Mesopotamia package, consider traveling during the quieter months or be flexible with your dates to find more options. Bundling your flights and hotel together often unlocks savings compared to booking separately. *Members only. Savings vary.
What is the best time to visit Mesopotamia?
The best time for a Mesopotamia vacation package is generally during the peak season from September through November, with October being the most popular month for visitors. This timing reflects regional demand, and conditions may vary slightly across the different cities within Mesopotamia, Argentina.
Which destinations should I consider for a Mesopotamia vacation?
For a Mesopotamia vacation, the region offers several distinct cities to consider as your base, each catering to different travel styles:
  • Colon: A strong choice for families and those seeking adventure, with many outdoor activities and entertainment options.
  • Parana: Ideal for romantic getaways and travelers interested in cultural attractions and sports activities.
  • Gualeguaychú: Another excellent option for families, known for its outdoor activities and entertainment scene.
  • Corrientes: Perfect for beach lovers, also offering a mix of outdoor activities and romantic settings.
  • Federacion: A great base for family-friendly fun, adventure, and entertainment, particularly focused on outdoor experiences.
Is Mesopotamia better suited for a beach vacation or a cultural trip?
Mesopotamia, Argentina, offers a diverse range of experiences, making it suitable for various travel styles. While Corrientes is primarily known for its beaches, such as the Costanera de Corrientes, other cities in the region lean towards outdoor activities and cultural exploration.

For those seeking cultural immersion, Parana features attractions like the Museo Provincial de Bellas Artes Dr. Pedro E. Martinez. Meanwhile, cities like Colon, Gualeguaychú, and Federacion are popular for family-friendly attractions, adventure, and outdoor activities, including thermal parks like Termas De Colón. A Mesopotamia vacation can be tailored to include a mix of these experiences.
Which airport should I use for a Mesopotamia vacation?
For a Mesopotamia vacation, several airports serve the broader region. Asuncion (ASU-Silvio Pettirossi Intl.) in Paraguay is a major international gateway, offering connections to the area. Within Argentina, key airports include Posadas (PSS-Libertador General Jose de San Martin), Resistencia (RES-Resistencia Intl.), and Corrientes (CNQ-Corrientes Intl.). These airports provide convenient access to the various cities and attractions across Mesopotamia, Argentina.
What are the top things to do in Mesopotamia?
A Mesopotamia vacation is best explored from a base like Colon, which offers a variety of family-friendly attractions and outdoor activities:

Browse and book things to do in Mesopotamia on Expedia.
Can I change or cancel my Mesopotamia vacation package if my plans change?
Yes, you can cancel your vacation package via your itinerary page on Expedia or by contacting customer service. Remember that some packages are fully refundable, but the details vary based on each unique booking. A fully refundable package may depend on how far out from the travel dates you're canceling and what airline you are traveling with.
Do One Key members get extra savings when booking Mesopotamia vacation packages?
Yes, members who join our free One Key™ travel rewards program can instantly unlock additional savings and save 10% or more on over 500,000 stays worldwide with Member Prices and over 1 million car rentals.
Does Expedia offer Book Now, Pay Later Mesopotamia vacation packages?
Yes, with Expedia's Book Now, Pay Later option, powered by Affirm, you can spread the cost of your Mesopotamia vacation over 3, 6, or 12 months. With no late payment fees or hidden costs, it's easy to secure your ideal vacation package as soon as you spot it.
How do I find last-minute vacation packages to Mesopotamia?
To find last-minute vacation packages to Mesopotamia, explore the last-minute deals section for the latest package offers, including flights, departing in the coming weeks. Being flexible with your travel dates and hotel preferences can help you secure the best prices.
How does free cancellation work on Mesopotamia vacation packages?
Free cancellation on a Mesopotamia vacation package depends on the specific hotel and rate combination you book. Many bookings allow free cancellation up to a stated deadline (often a few days before travel) where eligible. Read the cancellation terms carefully when reviewing the package, and visit Expedia help center for further details.
Is it cheaper to book a Mesopotamia vacation as a package or separately?
An Expedia vacation package could land you great savings when compared to arranging flights and hotels separately. Better still, you can tailor your Mesopotamia getaway to match your exact preference. Pick your preferred flight time, select the hotel type and add a car rental. Explore our bundles to see how much you can save.
Why should I book my Mesopotamia vacation package with Expedia?
Booking your vacation package on Expedia makes it easier to get more out of your trip from the start. With a wide choice of hotels, you can compare prices, reviews and amenities all in one place, then bundle your hotel with flights which could help you save even more. Flexible booking options on selected stays also make it easier to plan with confidence.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.