Mission Valley Vacations from $335

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Mission Valley Vacation

With a vacation package to Mission Valley, you can spend less time planning and more time experiencing this interesting neighborhood. From its shopping to its dining, there's so much to discover here. Can't wait to do some sightseeing during your trip to Mission Valley? Don't miss nearby attractions like San Diego Zoo, Balboa Park and University of San Diego. Stop daydreaming and start doing. When you're ready to book your ideal vacation to Mission Valley, Expedia will help get you there.

The Latest Mission Valley Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Guesthouse Hotel at La Valle

Guesthouse Hotel at La Valle

Save 100% on your flight
$335
per person
Nov 6 - Nov 9
found 15 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9.4/10 Exceptional! (188 reviews)
The Sofia Hotel

The Sofia Hotel

Downtown San Diego
$606
per person
Oct 7 - Oct 11
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
8.6/10 Excellent! (2,462 reviews)
Staff are friendly. Rooms are always great here. The gym is nice and I really enjoy the yoga studio.

Reviewed on Aug 20, 2026

Ocean Villas of Carlsbad

Ocean Villas of Carlsbad

Carlsbad Village
Save 100% on your flight
$1,274
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (20 reviews)
Great location and incredible views. Large deck and living room. Ellie in the office is great

Reviewed on Jun 17, 2026

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

Downtown San Diego
Save 100% on your flight
$1,638
per person
Oct 6 - Oct 13
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
9/10 Wonderful! (1,466 reviews)
The location of this hotel is stellar. We walked to many places we went. And if you are young and love to party, this is the place for you. We had to discover nearby sites and venues on our own. The staff have not been trained to give tips and help to out of town travelers, especially seniors. With our white hair we got stares poolside. The food at their two restaurants was quite good. If you're not a walker you need to rent a car and pay for the valet parking.

Reviewed on Aug 19, 2026

Coronado Beach Resort

Coronado Beach Resort

Historic Downtown Coronado
Save 100% on your flight
$666
per person
Oct 25 - Oct 31
found 1 day ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
9/10 Wonderful! (808 reviews)
What a wonderful staff

Reviewed on Aug 19, 2026

Where to stay in Mission Valley

Find the best Mission Valley areas and neighborhoods for the activities you enjoy most. Learn more about Mission Valley
A grand building with a central fountain, palm trees, and a flag.

Downtown San Diego

3 out of top 10 points of interest in this area

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

A pier extending into calm waters with people on it and a sandy beach with seaweed and a few individuals.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

A sandy beach with a lifeguard tower, ocean waves, and people in the distance.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

A lively street scene with outdoor seating at various bars and restaurants, including 'The Field' and 'Sloppy Joe's'.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

1 out of top 10 points of interest in this area

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Mission Valley Hotel Deals

Handlery Hotel

Handlery Hotel

950 Hotel Cir N San Diego CA
$119 nightly
$137 total
Aug 26 - Aug 27
Total with taxes and fees
Handlery Hotel
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

543 Hotel Circle S San Diego CA
Fully refundableReserve now, pay when you stay
$88 nightly
$102 total
Sep 7 - Sep 8
Total with taxes and fees
Days Inn by Wyndham San Diego Hotel Circle
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

2270 Hotel Cir N San Diego CA
Fully refundable
$114 nightly
$131 total
Aug 24 - Aug 25
Total with taxes and fees
8.4/10 Very Good! (1,213 reviews)
"Terrible rude management with ZERO people skills. I have escalated my concern to corporate on this manger specifically and the employees he has clearly trained to follow his lead in poor customer service, Snide and insulting remarks, racist views of black people that hold that anything more than ..."

Reviewed on Aug 20, 2026

Crowne Plaza San Diego - Mission Valley by IHG
See all 8,924 properties in Mission Valley
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mission Valley attractions

A bridge at night with its lights reflecting on the water.

Hotel Circle

8.2/10 (6,358 reviews)
Hotel Circle is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Check out the shops and top-notch restaurants in this family-friendly area.
See properties
A large stadium with a parking structure, surrounded by hills and a highway.

Snapdragon Stadium

8.4/10 (243 reviews)
Catch an event at Snapdragon Stadium during your trip to San Diego. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

Fashion Valley Mall

9.0/10 (111 reviews)
You can search for that perfect souvenir at Fashion Valley Mall during your stay in San Diego. Take in the fascinating museums and beautiful sunsets in this walkable area.
See properties

Mission Valley Mall

8.8/10 (53 reviews)
You can do some window-shopping at Mission Valley Mall during your trip to San Diego. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
See properties

Town and Country San Diego

Learn about the events happening at Town and Country San Diego during your trip to San Diego. Wander the beautiful beaches and seaside in this family-friendly area.
See properties

SDSU Mission Valley

Explore the campus of SDSU Mission Valley as part of your travels around San Diego. Check out the shops and top-notch restaurants in this family-friendly area.
See properties

Legacy International Center

Enjoy an outing to Legacy International Center during your stay in San Diego. Amble around this family-friendly area's beautiful beaches and enjoy its top-notch restaurants.
See properties

Things to do

San Diego Padres Baseball Game at Petco Park

San Diego Padres Baseball Game at Petco Park

$44
per adult
San Diego Padres Baseball Game at Petco Park
San Diego: 3 Hour Whale Watching Cruise

San Diego: 3 Hour Whale Watch Cruise with Legacy Whale Watch

$34
per adult
94% of travellers recommend
San Diego: 3 Hour Whale Watch Cruise with Legacy Whale Watch
See all activities in San Diego

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.