Search Guest Houses in O Brien

Start date: Check-in selected.
To Date
End date: Check-out

  • Bundle & Save

    Get more, spend less whenever you see Bundle & Save deals

  • OneKeyCash

    Earn OneKeyCash on all your eligible bookings

  • Upfront pricing

    We are not like the others - we include taxes and fees

Check prices for these dates

Next weekend
Dec 12 - Dec 14
In two weeks
Dec 19 - Dec 21
In one month
Jan 2 - Jan 4
In two months
Jan 30 - Feb 1

Guest Houses in O Brien

No exact matches found, but these alternatives could be just right

Recommended hotels in O Brien

Property grounds
Our Spring Getaway Is Across The Street From Royal Springs

Our Spring Getaway Is Across The Street From Royal Springs

O'Brien
10.0 out of 10, Exceptional, (2)
"Place is as described. Nice and clean. Large property plenty of room for parking."
United States
J S.
$183 nightly
The price is $199
Dec 10 - Dec 11
Total with taxes and fees
Our Spring Getaway Is Across The Street From Royal Springs
Property grounds
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

O'Brien
9.4 out of 10, Exceptional, (59)
"We absolutely enjoyed our stay. We had 1 small issue that was quickly resolved by the host. The place was conveniently located close to royal spring and that boat ramp. The decks on this place was massive. The river deck was nice to sit on as well. We will definitely be back if they will have us."
United States
David M.
$373 nightly
The price is $405
Dec 4 - Dec 5
Total with taxes and fees
MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY
Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee

2.5 star property
Live Oak
7.2 out of 10, Good, (612)
"Clean rooms, very friendly staff"
United States
Kristin L
$68 nightly
The price is $75
Dec 18 - Dec 19
Total with taxes and fees
Quality Inn White Springs Suwanee
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

2.5 star property
Lake City
9.4 out of 10, Exceptional, (1000)
"It was a great stay "
United States
Miranda
$90 nightly
The price is $101
Dec 21 - Dec 22
Total with taxes and fees
Hampton Inn & Suites Lake City
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1020)
"Clean room, friendly staff "
United States
Bill
$83 nightly
The price is $93
Dec 14 - Dec 15
Total with taxes and fees
Best Western Plus Lake City
Standard Cabin, 1 Queen Bed | Exterior
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy

2.0 star property
High Springs
10.0 out of 10, Exceptional, (145)
"Fantastic place! Very nice amenities and service was wonderful"
United States
Annette
$124 nightly
The price is $137
Dec 8 - Dec 9
Total with taxes and fees
Postcard Cabins Gilchrest Spring, Outdoor Collection by Marriott Bonvoy
Breakfast area
Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75

2.5 star property
Alachua
9.4 out of 10, Exceptional, (471)
"Staff very helpful- clean updated facility. "
United States
bethany
$95 nightly
The price is $107
Jan 1 - Jan 2, 2026
Total with taxes and fees
Hampton Inn & Suites Alachua I-75
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

2.5 star property
Lake City
9.6 out of 10, Exceptional, (1001)
"We love to stop here when traveling to Orlando"
United States
Bridget
$95 nightly
The price is $107
Dec 14 - Dec 15
Total with taxes and fees
Comfort Suites Lake City
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
Lake City
8.8 out of 10, Excellent, (1030)
"Excellent hotel. Spacious rooms, comfortable bed, great breakfast and friendly staff. Directly off I-75 for easy on and off. "
United States
Lisa
$83 nightly
The price is $93
Dec 17 - Dec 18
Total with taxes and fees
La Quinta Inn & Suite by Wyndham Lake City
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

2.0 star property
Lake City
8.0 out of 10, Very Good, (64)
"Great little motel with extremely nice staff. "
United States
Georgiy
$52 nightly
The price is $59
Dec 4 - Dec 5
Total with taxes and fees
Motel 6 – Lake City, Fl – Medical Center
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

3.0 star property
Lake City
9.6 out of 10, Exceptional, (173)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
$101 nightly
The price is $114
Dec 14 - Dec 15
Total with taxes and fees
Courtyard By Marriott Lake City
Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

2.5 star property
Lake City
9.2 out of 10, Wonderful, (1020)
"Great place for a restful night when traveling. "
United States
Peggy
$104 nightly
The price is $117
Dec 7 - Dec 8
Total with taxes and fees
Tru by Hilton Lake City
Premium bedding, desk, blackout drapes, soundproofing
Palms Garden Inn

Palms Garden Inn

2.0 star property
Lake City
7.4 out of 10, Good, (576)
"Clean and nice staff "
United States
apollo
$65 nightly
The price is $73
Dec 4 - Dec 5
Total with taxes and fees
Palms Garden Inn
BBQ/picnic area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

2.0 star property
Lake City
8.8 out of 10, Excellent, (1001)
"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
$65 nightly
The price is $74
Dec 9 - Dec 10
Total with taxes and fees
Americas Best Value Inn Lake City
Exterior
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
Alachua
9.4 out of 10, Exceptional, (1002)
"Staff was great and the location is perfect ! "
United States
JAY
$113 nightly
The price is $127
Dec 21 - Dec 22
Total with taxes and fees
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Outdoor dining
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo
10.0 out of 10, Exceptional, (2)
"Stacey is always very welcoming & I had everything I needed. It is very calm, serene and relaxing place."
United States
Cathryn H.
$75 nightly
The price is $79
Dec 4 - Dec 5
Total with taxes and fees
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Pillowtop beds, in-room safe, desk, blackout drapes
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

2.0 star property
Lake City
7.6 out of 10, Good, (1000)
"Clean room everything I could need staff very nice and helpful I ll be back "
United States
Daphnea
$63 nightly
The price is $71
Dec 7 - Dec 8
Total with taxes and fees
Days Inn by Wyndham Lake City I-75
BBQ/picnic area
Cindys Motel

Cindys Motel

2.5 star property
Mayo
9.0 out of 10, Wonderful, (127)
"Nice place"
Australia
Marie
$82 nightly
The price is $88
Jan 2 - Jan 3, 2026
Total with taxes and fees
Cindys Motel
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

2.5 star property
Lake City
9.0 out of 10, Wonderful, (159)
"Clean property and nice staff"
United States
Thomas
$93 nightly
The price is $104
Dec 4 - Dec 5
Total with taxes and fees
Fairfield Inn & Suites Lake City
Exterior
Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City

2.0 star property
Lake City
7.2 out of 10, Good, (663)
"Nice stay"
United States
Kimberly
$66 nightly
The price is $75
Dec 7 - Dec 8
Total with taxes and fees
Super 8 by Wyndham Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top O Brien Hotel Reviews

Best Western Plus Lake City

Best Western Plus Lake City

10/10 Excellent
"This will be my go to hotel when traveling to south Florida . Excellent "
Jesse 1-night trip
Posted 21 hours ago
Best Western Plus Lake City

Find out more about O Brien

O Brien Guest Houses information

Number of reviews
11,143
Accommodation
1 Guest Houses
Lowest Price
$59
Highest Price
$405

Explore a world of travel with Expedia