Find all hotels by Best Western in Otay Mesa West, CA from $85

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Dec 8 - Dec 9
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Dec 12 - Dec 14
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Dec 19 - Dec 21

Compare rooms and suites by Best Western in Otay Mesa West with rates, reviews, and availability. Most hotels are fully refundable.

Standard Room, 2 Queen Beds, Non Smoking | Premium bedding, desk, laptop workspace, blackout drapes
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 star property
Mission Valley
8.0 out of 10, Very Good, (2304)
"It was a good family hotel. "
United States
Jurida
$119 nightly
The price is $136
Dec 15 - Dec 16
Total with taxes and fees
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Exterior
Best Western Seven Seas

Best Western Seven Seas

3.0 star property
Mission Valley
7.8 out of 10, Good, (3048)
"In spite of the construction, we enjoyed our short stay and will come again!"
United States
Patricia
$74 nightly
The price is $85
Dec 10 - Dec 11
Total with taxes and fees
Best Western Seven Seas
Free continental breakfast
Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
Otay
7.8 out of 10, Good, (1540)
"Great place to stay, staff was fantastic "
United States
Pamela
$101 nightly
The price is $111
Dec 15 - Dec 16
Total with taxes and fees
Best Western Chula Vista/Otay Valley Hotel
Pillowtop beds, in-room safe, desk, laptop workspace
Best Western Americana Inn

Best Western Americana Inn

2.5 star property
San Ysidro
9.0 out of 10, Wonderful, (1188)
"Amazing time at this place "
United States
Maria de Los Angeles
$101 nightly
The price is $115
Jan 4 - Jan 5, 2026
Total with taxes and fees
Best Western Americana Inn
Desk, blackout drapes, iron/ironing board, cribs/infant beds
Best Western Yacht Harbor Hotel

Best Western Yacht Harbor Hotel

2.5 star property
Point Loma
8.6 out of 10, Excellent, (1627)
"The breakfast options were good and the staff were very helpful."
Canada
Gail or Rob
$98 nightly
The price is $113
Dec 10 - Dec 11
Total with taxes and fees
Best Western Yacht Harbor Hotel
Outdoor pool
Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay

2.5 star property
Bay Park
8.2 out of 10, Very Good, (185)
"Great stay, the staff was very friendly! "
United States
frances
$80 nightly
The price is $92
Dec 15 - Dec 16
Total with taxes and fees
Best Western San Diego Pacific Beach/Mission Bay
Premium bedding, desk, iron/ironing board, cribs/infant beds
Best Western Santee Lodge

Best Western Santee Lodge

2.5 star property
Santee
7.8 out of 10, Good, (586)
" Room was clean and the staff was friendly"
United States
Daniel
$104 nightly
The price is $114
Dec 14 - Dec 15
Total with taxes and fees
Best Western Santee Lodge
Terrace/patio
Best Western Downtown San Diego

Best Western Downtown San Diego

2.5 star property
Downtown San Diego
8.4 out of 10, Very Good, (921)
"Staff was exceptionally helpful and the room was very clean. Will definitely stay here again!"
United States
Blanca
$122 nightly
The price is $139
Dec 29 - Dec 30
Total with taxes and fees
Best Western Downtown San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Otay Mesa West Hotel Reviews

Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

10/10 Excellent
"clean room"
Akshay 7-night trip
Posted 6 hours ago
Hampton Inn San Diego/Mission Valley

Find out more about Otay Mesa West

Otay Mesa West, San Diego County Hotel Guide

Otay Mesa West is 11 miles from San Diego County's downtown.

San Diego County is home to the San Diego State University, the San Diego Zoo and the Balboa Park.

If you're in need of some caffeine to help you get through the day, Starbucks is among the best places in Otay Mesa West to enjoy a fix. Still hungry? Giant New York Pizza is also close and dishes up a good range of meals. Are you up for a drink? Cap off an enjoyable day with an icy beer or a satisfying red at Bobar Liquor.

Accommodation Options Near Otay Mesa West

For those keen on coming to Otay Mesa West, you can stay in San Ysidro, a neighborhood which is 2 miles south of the center of Otay Mesa West. Explore Expedia's San Ysidro hotels guide to find great accommodation options such as the Rodeway Inn and Quality Inn & Suites Near The Border. You could also choose to try South Bay hotels, such as the Holiday Inn Express San Diego South - Chula Vista and Holiday Inn Express San Diego South - National City. South Bay is located 3 miles to the northeast of the center of Otay Mesa West.

Check out our San Diego County hotels page for quality places to stay in Otay Mesa West and beyond. If you want to be inspired about things to see and do there, don’t miss our San Diego County vacation travel guide.

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