A pier extending into calm waters with a small boat docked at the end.

Panacea Vacation Rentals

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Check prices for these dates

In two weeks
Sep 11 - Sep 13
In two months
Oct 23 - Oct 25
In three months
Nov 20 - Nov 22
In four months
Dec 18 - Dec 20

Our top choices for Panacea vacation rentals

A modern kitchen with a wooden countertop, a built-in sink, and a dining area with a table and chairs.

1. Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience

Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience
Panacea
10.0 out of 10, Exceptional, (25 reviews)
"Great place to stay while fishing"
United States
Benjamin S.
$293 nightly
The price is $323
Aug 31 - Sep 1
Total with taxes and fees
Panacea Treehouse⭐️ Quiet Waterfront- Boat Friendly Old Florida Experience
A dock extending into a body of water with a covered structure at the end.

2. Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks

Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks
Panacea
10.0 out of 10, Exceptional, (4 reviews)
"Had a great stay! We would book here again."
United States
Ashley D.
$426 nightly
The price is $469
Sep 1 - Sep 2
Total with taxes and fees
Waterfront home on Ochlockonee Bay, private beach, fishing, dock and kayaks
A covered outdoor area with a wooden deck, white furniture, and a view of the water.

3. Tiny Tides Waterfront Cottage

Tiny Tides Waterfront Cottage
Panacea
10.0 out of 10, Exceptional, (11 reviews)
"What a perfect escape! We thoroughly enjoyed our stay at Tiny Tides. The cozy, comfortable vibe, the peaceful location, and the easy access to everything made our trip truly special. We had a fantastic time and will definitely be back soon!"
United States
Jason W.
$352 nightly
The price is $388
Aug 30 - Aug 31
Total with taxes and fees
Tiny Tides Waterfront Cottage
A spacious living area with a high ceiling, a ceiling fan, a TV, and a view of the beach through the windows.

4. Cozy bayfront farmhouse!

Cozy bayfront farmhouse!
Panacea
10.0 out of 10, Exceptional, (13 reviews)
"Such a relaxing few days. Beautiful view from the back porch. Will definitely stay here again."
United States
Scottie H.
$483 nightly
The price is $508
Sep 4 - Sep 5
Total with taxes and fees
Cozy bayfront farmhouse!
A tree silhouetted against a sunset sky, a body of water, and a snowy landscape.

5. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
9.0 out of 10, Wonderful, (2 reviews)
"Great communication. Comfortable"
United States
Faith V.
$163 nightly
The price is $179
Sep 2 - Sep 3
Total with taxes and fees
Cozy Panacea Retreat #3 (King)
A wooden deck with wicker furniture, a small round table, and a view of the ocean.

6. Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
Panacea
9.6 out of 10, Exceptional, (106 reviews)
"Well stocked home with a beautiful elevated view of the ocean. The host was quick to respond to my inquiry."
United States
Gordon C.
$426 nightly
The price is $465
Aug 30 - Aug 31
Total with taxes and fees
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
A wooden deck with wicker chairs and a long table, overlooking a beach and ocean.

7. The Best Beach-Front House “Get-A-Way” in Florida

The Best Beach-Front House “Get-A-Way” in Florida
Panacea
10.0 out of 10, Exceptional, (99 reviews)
"Excellent beach front location, wonderful amenities like beach chairs, umbrellas, toys and towels made the stay easy and stress free! "
United States
Juliet H.
$593 nightly
The price is $648
Aug 31 - Sep 1
Total with taxes and fees
The Best Beach-Front House “Get-A-Way” in Florida
A two-story house with a balcony on each floor, a front porch with steps, and a clear sky.

8. NEW - St. Teresa Beach Escape w/ Private Beach Acc

NEW - St. Teresa Beach Escape w/ Private Beach Acc
Lanark Village
10.0 out of 10, Exceptional, (2 reviews)
"This house was very comfortable, beds, pillows, towels, sofa, etc. Quiet, peaceful, serene setting. Close proximity to beach and the pool was an added bonus!Thank you for a very enjoyable stay!"
United States
Debra M.
$686 nightly
The price is $753
Aug 30 - Aug 31
Total with taxes and fees
NEW - St. Teresa Beach Escape w/ Private Beach Acc
A porch with wicker chairs and a small table, overlooking a lake and trees.

9. Point & Paddle Waterfront Retreat @Alligator Point

Point & Paddle Waterfront Retreat @Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"We really enjoyed the place. It was quiet, cozy, and perfect for a quick getaway with our family. I would highly recommend others checking this place out and tho we don’t visit the area much we would love staying here again!"
United States
Scott A.
$427 nightly
The price is $468
Aug 30 - Aug 31
Total with taxes and fees
Point & Paddle Waterfront Retreat @Alligator Point
A cozy living room with a brown leather sofa, a dining table set with plates, and a view of the sea through large windows.

10. romantic get away for 2 right on the Ochlockonee river

romantic get away for 2 right on the Ochlockonee river
Panacea
6.0 out of 10, (2 reviews)
"Wonderful accommodations-clean and comfortable. "
United States
Laurie K.
$286 nightly
The price is $314
Sep 3 - Sep 4
Total with taxes and fees
romantic get away for 2 right on the Ochlockonee river
A beach with clear water, white sand, and a boat in the distance.

11. 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
Alligator Point
10.0 out of 10, Exceptional, (131 reviews)
"Beautiful house with awesome views of the gulf and the bay from all rooms. Fenced in yard was perfect for our dog. Location is very relaxing. I can't wait to go back."
United States
V G.
$2,015 nightly
The price is $2,204
Aug 30 - Aug 31
Total with taxes and fees
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front
A wooden deck with a rocking chair and a sign reading "Alligator Point".

12. Bill's Bay Breeze- relax on the porch and enjoy the view!

Bill's Bay Breeze- relax on the porch and enjoy the view!
Alligator Point
9.0 out of 10, Wonderful, (14 reviews)
"Nice little place....right on the water....my favorite part was the huge screened in porch overlooking the water....we stayed a week and it was very relaxing....private....nothing on either side of you..."
United States
Teresa M.
$453 nightly
The price is $471
Sep 17 - Sep 18
Total with taxes and fees
Bill's Bay Breeze- relax on the porch and enjoy the view!
A wooden bench in a natural setting with a lake and trees in the background.

13. Queen Kitchenette by the Bay #8

Queen Kitchenette by the Bay #8
Panacea
$201 nightly
The price is $221
Aug 30 - Aug 31
Total with taxes and fees
Queen Kitchenette by the Bay #8
Two twin beds with matching headboards, a nightstand with a lamp, a framed picture on the wall, and an American flag.

14. Panacea Cozy Retreat #6 (DQ)

Panacea Cozy Retreat #6 (DQ)
Panacea
$202 nightly
The price is $222
Aug 30 - Aug 31
Total with taxes and fees
Panacea Cozy Retreat #6 (DQ)
A wooden bench in a natural setting with a lake and trees in the background.

15. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
$162 nightly
The price is $178
Aug 30 - Aug 31
Total with taxes and fees
Cozy Panacea Retreat #3 (King)
A wooden bench in a natural setting with a lake and trees in the background.

16. Queen Kitchenette by the Bay #13

Queen Kitchenette by the Bay #13
Panacea
$162 nightly
The price is $178
Aug 30 - Aug 31
Total with taxes and fees
Queen Kitchenette by the Bay #13
Two twin beds with matching headboards, a nightstand with a lamp, a framed picture on the wall, and an American flag.

17. Panacea Cozy Retreat #4 (DQ)

Panacea Cozy Retreat #4 (DQ)
Panacea
$202 nightly
The price is $222
Aug 31 - Sep 1
Total with taxes and fees
Panacea Cozy Retreat #4 (DQ)
A wooden bench in a natural setting with a lake and trees in the background.

18. Cozy Panacea Retreat #7 (King)

Cozy Panacea Retreat #7 (King)
Panacea
$163 nightly
The price is $179
Sep 13 - Sep 14
Total with taxes and fees
Cozy Panacea Retreat #7 (King)
A wooden bench in a natural setting with a lake and trees in the background.

19. Perfect Panacea 1 Bedroom Apt, #2

Perfect Panacea 1 Bedroom Apt, #2
Panacea
$163 nightly
The price is $179
Sep 13 - Sep 14
Total with taxes and fees
Perfect Panacea 1 Bedroom Apt, #2
An aerial view of a beach with a parking lot, beach umbrellas, and a clear view of the ocean.

20. Dragonfly on the Canal Golf cart included!

Dragonfly on the Canal Golf cart included!
Crawfordville
10.0 out of 10, Exceptional, (56 reviews)
"Was a great spacious place. We stayed for graduation weekend and could not have been happier. The porch is amazing!"
United States
Kristy B.
$303 nightly
The price is $333
Aug 30 - Aug 31
Total with taxes and fees
Dragonfly on the Canal Golf cart included!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panacea Hotel Reviews

Lighthouse- enjoy the water, bask in the view

Lighthouse- enjoy the water, bask in the view

10/10 Excellent
"Everything was as good as we expected and we enjoyed our stay there and we would book the lighthouse again in the future !!!"
grady p. 7-night trip
Posted 4 days ago
Lighthouse- enjoy the water, bask in the view

Find out more about Panacea

Everything you need to know about Panacea vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Panacea vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Panacea vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Panacea vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Panacea. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Panacea in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $323 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Panacea rentals

At Expedia, we put the best Panacea vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Panacea rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Panacea vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Panacea. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Panacea?

Yes, there are vacation rentals in Panacea close to Gulf Specimen Public Aquarum, or you can go with a secluded option if you'd like a relaxing place to stay. Visitors to Panacea speak positively about the beaches and seafood restaurants in this destination.

What are some of the best vacation rentals in Panacea?

Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has a patio, a barbecue grill, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Another good choice for your trip to Panacea is Best deal at Alligator Point.

How many vacation rentals are there in Panacea?

Choose from 179 Expedia vacation rentals in Panacea for a memorable vacation.

What’s there to see and do in Panacea?

Mashes Sand Beach and Alligator Point Beach are a couple of lovely local spots to enjoy the outdoors, whereas family-friendly attractions include Gulf Specimen Public Aquarum. While here, Bald Point State Park and Wilson Beach are other places worth a visit.

What’s a vacation rental in Panacea like?

Vacation rentals are privately owned properties where you can stay for a few weeks or just a few days in Panacea. Vacation rentals offer amenities like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a popular choice for family trips or small group gatherings.