A calm lake with a wooden pier extending into the water, surrounded by tall grasses.

Panacea Vacation Rentals

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Panacea vacation rentals

A wooden bench in a natural setting with a lake and trees in the background.

1. Queen Kitchenette by the Bay #13

Queen Kitchenette by the Bay #13
Panacea
$155 nightly
The price is $171
Nov 15 - Nov 16
Total with taxes and fees
Queen Kitchenette by the Bay #13
A two-story house with a balcony, a covered porch, and a wooden deck.

2. Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat

Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat
Panacea
9.8 out of 10, Exceptional, (28 reviews)
"Great place to stay while fishing"
United States
Benjamin S.
$271 nightly
The price is $300
Nov 16 - Nov 17
Total with taxes and fees
Panacea Treehouse- Quiet- Waterfront Pet Friendly Fall Fishing Retreat
A deck with a metal lamp, overlooking a calm lake and a pier extending into the water.

3. romantic get away for 2 right on the Ochlockonee river

romantic get away for 2 right on the Ochlockonee river
Panacea
6.0 out of 10, (2 reviews)
"Wonderful accommodations-clean and comfortable. "
United States
Laurie K.
$271 nightly
The price is $299
Nov 15 - Nov 16
Total with taxes and fees
romantic get away for 2 right on the Ochlockonee river
A beach with footprints and sparse vegetation, leading to calm water under a clear sky.

4. Tiny Tides Waterfront Cottage

Tiny Tides Waterfront Cottage
Panacea
10.0 out of 10, Exceptional, (15 reviews)
"What a perfect escape! We thoroughly enjoyed our stay at Tiny Tides. The cozy, comfortable vibe, the peaceful location, and the easy access to everything made our trip truly special. We had a fantastic time and will definitely be back soon!"
United States
Jason W.
$341 nightly
The price is $377
Nov 20 - Nov 21
Total with taxes and fees
Tiny Tides Waterfront Cottage
A wooden bench in a natural setting with a lake and trees in the background.

5. 09) Queen Kitchenette by the Bay

09) Queen Kitchenette by the Bay
Panacea
$154 nightly
The price is $170
Nov 15 - Nov 16
Total with taxes and fees
09) Queen Kitchenette by the Bay
A wooden bench in a natural setting with a lake and trees in the background.

6. Perfect Panacea 1 Bedroom Apt, #2

Perfect Panacea 1 Bedroom Apt, #2
Panacea
$154 nightly
The price is $170
Nov 16 - Nov 17
Total with taxes and fees
Perfect Panacea 1 Bedroom Apt, #2
A tree silhouetted against a sunset sky, a body of water, and a snowy landscape.

7. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
9.0 out of 10, Wonderful, (2 reviews)
"Great communication. Comfortable"
United States
Faith V.
$154 nightly
The price is $170
Nov 15 - Nov 16
Total with taxes and fees
Cozy Panacea Retreat #3 (King)
A wooden pier extending into calm blue waters, leading to a sandy beach with sparse vegetation.

8. Private beach winter escape on the bay with fishing and kayaks

Private beach winter escape on the bay with fishing and kayaks
Panacea
10.0 out of 10, Exceptional, (5 reviews)
"Had a great stay! We would book here again."
United States
Ashley D.
$416 nightly
The price is $461
Nov 15 - Nov 16
Total with taxes and fees
Private beach winter escape on the bay with fishing and kayaks
A wooden bench in a natural setting with a lake and trees in the background.

9. Queen Kitchenette by the Bay #16

Queen Kitchenette by the Bay #16
Panacea
10.0 out of 10, Exceptional, (1 review)
$155 nightly
The price is $171
Nov 16 - Nov 17
Total with taxes and fees
Queen Kitchenette by the Bay #16
A wooden bench in a natural setting with a lake and trees in the background.

10. Cozy Panacea Retreat #3 (King)

Cozy Panacea Retreat #3 (King)
Panacea
$154 nightly
The price is $170
Nov 15 - Nov 16
Total with taxes and fees
Cozy Panacea Retreat #3 (King)
A wooden bench in a natural setting with a lake and trees in the background.

11. Queen Kitchenette by the Bay #10

Queen Kitchenette by the Bay #10
Panacea
$154 nightly
The price is $170
Nov 15 - Nov 16
Total with taxes and fees
Queen Kitchenette by the Bay #10
A wooden bench in a natural setting with a lake and trees in the background.

12. Queen Kitchenette by the Bay #15

Queen Kitchenette by the Bay #15
Panacea
$155 nightly
The price is $171
Nov 16 - Nov 17
Total with taxes and fees
Queen Kitchenette by the Bay #15
A wooden bench in a natural setting with a lake and trees in the background.

13. Queen Kitchenette by the Bay #11

Queen Kitchenette by the Bay #11
Panacea
$155 nightly
The price is $171
Nov 16 - Nov 17
Total with taxes and fees
Queen Kitchenette by the Bay #11
A wooden bench in a natural setting with a lake and trees in the background.

14. Queen Kitchenette by the Bay #14

Queen Kitchenette by the Bay #14
Panacea
$154 nightly
The price is $170
Nov 16 - Nov 17
Total with taxes and fees
Queen Kitchenette by the Bay #14
A wooden bench in a natural setting with a lake and trees in the background.

15. Cozy Panacea Retreat #7 (King)

Cozy Panacea Retreat #7 (King)
Panacea
$154 nightly
The price is $170
Nov 16 - Nov 17
Total with taxes and fees
Cozy Panacea Retreat #7 (King)
A beach with sand, grass, and the ocean.

16. Point & Paddle Waterfront Retreat @Alligator Point

Point & Paddle Waterfront Retreat @Alligator Point
Alligator Point
10.0 out of 10, Exceptional, (2 reviews)
"We really enjoyed the place. It was quiet, cozy, and perfect for a quick getaway with our family. I would highly recommend others checking this place out and tho we don’t visit the area much we would love staying here again!"
United States
Scott A.
$404 nightly
The price is $445
Nov 15 - Nov 16
Total with taxes and fees
Point & Paddle Waterfront Retreat @Alligator Point
A wooden bench in a natural setting with a lake and trees in the background.

17. Queen Kitchenette by the Bay #8

Queen Kitchenette by the Bay #8
Panacea
$190 nightly
The price is $210
Nov 15 - Nov 16
Total with taxes and fees
Queen Kitchenette by the Bay #8
A wooden deck with wicker chairs and a long table, overlooking a beach and ocean.

18. The Best Beach-Front House “Get-A-Way” in Florida

The Best Beach-Front House “Get-A-Way” in Florida
Panacea
10.0 out of 10, Exceptional, (103 reviews)
"Wonderful place on the beach. My sister and I had a great time here. I especially love that the beach is dog-friendly!"
United States
Lisa R.
$583 nightly
The price is $640
Nov 15 - Nov 16
Total with taxes and fees
The Best Beach-Front House “Get-A-Way” in Florida
Two twin beds with matching headboards, a nightstand with a lamp, a framed picture on the wall, and an American flag.

19. Panacea Cozy Retreat #4 (DQ)

Panacea Cozy Retreat #4 (DQ)
Panacea
$191 nightly
The price is $211
Nov 15 - Nov 16
Total with taxes and fees
Panacea Cozy Retreat #4 (DQ)
Two twin beds with matching headboards, a nightstand with a lamp, a framed picture on the wall, and an American flag.

20. Panacea Cozy Retreat #6 (DQ)

Panacea Cozy Retreat #6 (DQ)
Panacea
$191 nightly
The price is $211
Nov 15 - Nov 16
Total with taxes and fees
Panacea Cozy Retreat #6 (DQ)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panacea Hotel Reviews

Great sunrise view from dining area and decks. Easy beach access.

Great sunrise view from dining area and decks. Easy beach access.

10/10 Excellent
"Perfect"
Jonna D. 2-night trip
Posted 6 days ago
Great sunrise view from dining area and decks. Easy beach access.

Find out more about Panacea

Everything you need to know about Panacea vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Panacea vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Panacea vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Panacea vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Panacea. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Panacea in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $300 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

How to find incredible deals on Panacea rentals

At Expedia, we put the best Panacea vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Panacea rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Panacea vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Panacea. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Panacea?

Yes, there are vacation rentals in Panacea close to Gulf Specimen Public Aquarum, or you can go with a secluded option if you'd like a relaxing place to stay. Visitors to Panacea speak positively about the beaches and seafood restaurants in this destination.

What are some of the best vacation rentals in Panacea?

BEACH FRONT to BAY with boatdock, swimming pool, pickleball courts and kayaks.: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has an outdoor pool, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 6 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. Some other homes for rent in Panacea include Your Fall Escape: FSU Football & Scalloping and Coastal Getaway on canal-steps to the beach.

How many vacation rentals are there in Panacea?

Choose from 177 Expedia vacation rentals in Panacea for a memorable vacation.

What’s there to see and do in Panacea?

Mashes Sand Beach and Alligator Point Beach are a couple of lovely local spots to enjoy the outdoors, whereas family-friendly attractions include Gulf Specimen Public Aquarum. While here, Bald Point State Park and Wilson Beach are other places worth a visit.

What’s a vacation rental in Panacea like?

Vacation rentals are privately owned properties where you can stay for a few weeks or just a few days in Panacea. Vacation rentals offer amenities like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of seclusion away from shared hotel elevators and busy reception areas while still allowing you the experience of travel. You'll also find more space in a vacation rental than in a hotel, which makes a vacation rental a popular choice for family trips or small group gatherings.