Title: Panacea Vacation Rentals from $397: Search Short-Term Rentals | Expedia.com

[Panacea Travel Guide](https://expedia.com/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.com/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Flights to Panacea](https://expedia.com/Cheap-Flights-To-Panacea.d3000431554.Travel-Guide-Flights)[Car Rentals in Panacea](https://expedia.com/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.com/Panacea.d3000431554.Destination-Travel-Guides)

![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 17 - Apr 19](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 29 - May 31](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 26 - Jun 28](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-06-26&endDate=2026-06-28&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 24 - Jul 26](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-07-24&endDate=2026-07-26&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Panacea vacation rentals

![Beach nearby, sun loungers](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/1674545d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/90-642a3a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/7710be2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/90-cb6090de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Secluded Florida Beach Bungalow-best of both worlds-BEACH TIME & FISHING TIME!!

[](https://www.expedia.com/Panacea-Hotels-The-Spotted-Grouper-Old-Florida-Beach-Bungalow.h48526748.Hotel-Information)

Panacea

10/10

Exceptional

(247 reviews)

"2nd time staying here and it was so beautiful we will definitely be back, everything was wonderful and the host was amazing."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carrie J.

$364 nightly

$397 total

Apr 26 - Apr 27

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-The-Spotted-Grouper-Old-Florida-Beach-Bungalow.h48526748.Hotel-Information)

![Beach nearby, sun loungers](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/79dc0bc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/5a7da15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, DVD player, foosball](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/6a94050e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/b3eacf7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### ☼ Short Walk to Beach! Canal Front w/ Game Room @ Flip-Flop Hideaway

[](https://www.expedia.com/Panacea-Hotels-Short-Walk-To-Beach-Canal-Front-Flip-Flop-Hideaway.h79662203.Hotel-Information)

Alligator Point

10/10

Exceptional

(35 reviews)

"We loved our stay! Dog friendly & close to the beach, beautiful home! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

rideitlikeyoustolei1

$359 nightly

$392 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Short-Walk-To-Beach-Canal-Front-Flip-Flop-Hideaway.h79662203.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/b0e689e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/6c75a857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/2d8aa8b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/1f3d2a77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### romantic get away for 2 right on the Ochlockonee river

[](https://www.expedia.com/Panacea-Hotels-Romantic-Get-Away-For-2-Right-On-The-Ochlockonee-River.h122111093.Hotel-Information)

Panacea

6.0/10

(2 reviews)

"Wonderful accommodations-clean and comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laurie K.

$282 nightly

$311 total

Apr 1 - Apr 2

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Romantic-Get-Away-For-2-Right-On-The-Ochlockonee-River.h122111093.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/81744a78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/65a7bfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/46241804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/589530a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

[](https://www.expedia.com/Panacea-Hotels-Skipper-Extends-From-Beach-Front-To-Harbor-With-Kayaks.h51876637.Hotel-Information)

Panacea

9.8/10

Exceptional

(96 reviews)

"We really enjoyed our time at Skipper! It's location on the west end of Alligator Point is perfect for walking the beach for miles in either direction. With so many shells to search for and so many dolphins to watch, our time there was so relaxing that we can't wait to go back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen R.

$433 nightly

$473 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Skipper-Extends-From-Beach-Front-To-Harbor-With-Kayaks.h51876637.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/e5db1abd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/6b49306d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/b2afa767.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/a4523a31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #3 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h112942331.Hotel-Information)

Panacea

9.0/10

Wonderful

(2 reviews)

"Great communication. Comfortable"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Faith V.

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h112942331.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/ccee74a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/07b6fb25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/2323819a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/e0212a42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### NEW - St. Teresa Beach Escape w/ Private Beach Acc

[](https://www.expedia.com/Panacea-Hotels-NEW-St-Teresa-Beach-Escape-W-Private-Beach-Acc.h115458502.Hotel-Information)

Lanark Village

$474 nightly

$518 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-NEW-St-Teresa-Beach-Escape-W-Private-Beach-Acc.h115458502.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/2350f42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/11210b60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/90b66298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/427ce933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Coastal Cottage- a nature lover's paradise!

[](https://www.expedia.com/Panacea-Hotels-Coastal-Cottage-A-Nature-Lovers-Paradise.h112965202.Hotel-Information)

Panacea

10/10

Exceptional

(1 review)

"This place is amazing. It is the cleanest cutest cottage we have stayed in throughout all of Florida. Monica was an excellent host and set us up. Praise Jesus for that! You can walk to two restaurants which are next door. It is hard to find places to stay with my wife having miold illness, especially in Florida, but this has the cleanest, clearest air . We are able to stay with confidence that it is clean. Views of the sunrise on the bay are excellent. We brought our boat to fish and enjoyed...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lonnie L N.

$468 nightly

$491 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Coastal-Cottage-A-Nature-Lovers-Paradise.h112965202.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/084a0dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/b570c91b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/0ff2a3a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/35fa330e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fisherman's Retreat Entire home in Panacea, Florida

[](https://www.expedia.com/Panacea-Hotels-Fishermans-Retreat-Entire-Home-In-Panacea.h126359315.Hotel-Information)

Panacea

$255 nightly

$281 total

Apr 6 - Apr 7

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Fishermans-Retreat-Entire-Home-In-Panacea.h126359315.Hotel-Information)

![On the beach](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/da44be87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/9af5aa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/8fcbe9b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/cb91d7d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

[](https://www.expedia.com/Panacea-Hotels-7-Bedroom-Beach-House-With-POOL-Gulf-Front-And-Bay-Front.h19008298.Hotel-Information)

Alligator Point

10/10

Exceptional

(124 reviews)

"Love this house! Plenty of beds, great views and the house was stocked as well as I’ve ever seen in a rental property (I’m serious!!!). Thank you!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott G.

$2,027 nightly

$2,213 total

Apr 4 - Apr 5

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-7-Bedroom-Beach-House-With-POOL-Gulf-Front-And-Bay-Front.h19008298.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/a1fd53d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Marina](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/20ef87c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/e5492dc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/b2492e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Private Beach & Dock - Quiet Waterfront Retreat on Ochlockonee Bay

[](https://www.expedia.com/Panacea-Hotels-Private-Beach-Dock-Quiet-Waterfront-Retreat-On-Ochlockonee-Bay.h116784001.Hotel-Information)

Panacea

10/10

Exceptional

(1 review)

"host and the peace and ouietness of the area great for relaxing with out all of the giltter and gallyer"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

william C.

$406 nightly

$447 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Private-Beach-Dock-Quiet-Waterfront-Retreat-On-Ochlockonee-Bay.h116784001.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/29b9886d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/9a035d54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sun loungers, beach towels](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/713cab07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/9e91ad83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Point & Paddle Waterfront Retreat @Alligator Point

[](https://www.expedia.com/Panacea-Hotels-Alligator-Point-Paddle-Pond-Home-Short-Walk-To-The-Beach.h120270445.Hotel-Information)

Alligator Point

10/10

Exceptional

(1 review)

"Not only is this house adorable and roomy, it is the perfect mix of secluded and convenient. I hosted my girls for a little weekend birthday celebration and we had the best time watching the sunset from the dock, then enjoying a bonfire with smores! We played games and laughed well in to the night before finally retiring to the super comfy beds. The next morning we took the short walk to the beach and enjoyed discovering all types of nature while walking through the beaches of bald point state...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Holley C.

$520 nightly

$568 total

Apr 27 - Apr 28

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Alligator-Point-Paddle-Pond-Home-Short-Walk-To-The-Beach.h120270445.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/0af239f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/98483b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/13e11b09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/48a381b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 09) Queen Kitchenette by the Bay

[](https://www.expedia.com/Panacea-Hotels-09-Queen-Kitchenette-By-The-Bay.h121547082.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-09-Queen-Kitchenette-By-The-Bay.h121547082.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/366856fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/6edfdcd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/4486fd18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/eb981fcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #15

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-15.h121547164.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-15.h121547164.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/8277bb47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/7ccf5fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/e84e3a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/fc8b590d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #12

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-12.h121547124.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-12.h121547124.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/dacdf48b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/ed3a4685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/8e791adf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/96116d33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #11

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-11.h121547110.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-11.h121547110.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/debbcb36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/c0425b17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/34864a39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/17d21d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #3 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h121547023.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h121547023.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/e6dd40c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/9ec6838c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/84444893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/7083d6e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #16

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-16.h121547174.Hotel-Information)

Panacea

$163 nightly

$178 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-16.h121547174.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/4acea5b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/70ef9d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/484491eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/8504ddb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #7 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-7.h121547053.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-7.h121547053.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547095/f1e8b85e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547095/e1baa354.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547095/825655e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547095/27152a55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #10

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-10.h121547095.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-10.h121547095.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/9d969f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/9f07c512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/78c013f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/b38ef5f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #13

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-13.h121547139.Hotel-Information)

Panacea

$162 nightly

$177 total

Mar 31 - Apr 1

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-13.h121547139.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-13&endDate=2026-04-14&regionId=3000431554&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=CABIN)

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=CONDO)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=VILLA)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=APARTMENT)

Houseboats

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-28&d1=2026-06-28&endDate=2026-07-01&d2=2026-07-01&lodging=HOUSE_BOAT)

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## Top Panacea Hotel Reviews

![Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +](https://images.trvl-media.com/lodging/108000000/107290000/107284100/107284077/5342dafe_y.jpg)

### Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

10/10 Excellent

"This was a wonderful place to stay for both kids and adults. The house is right on the beach with plenty of beach supplies to keep everyone entertained! Inside there were toiletries, detergents, kitchen spices, as well as extra towels and blankets which made our stay a lot more comfortable. We would love to come back and stay here again! "

[](https://expedia.com/Panacea-Hotels-Private-Beachfront-W-Golf-Cart.h107284077.Hotel-Information)

![Hideaway Beach Cottage on waterfront with amazing views.](https://images.trvl-media.com/lodging/89000000/89000000/88994400/88994349/8441415a_y.jpg)

### Hideaway Beach Cottage on waterfront with amazing views.

10/10 Excellent

"It was a wonderful place and the area was as well. There were many great beaches and state and national parks. We really enjoyed our stay! "

[](https://expedia.com/Panacea-Hotels-Hideaway-Beach-Cottage-On-Waterfront-With-Amazing-Views.h88994349.Hotel-Information)

![The Best Beach-Front House “Get-A-Way” in Florida](https://images.trvl-media.com/lodging/69000000/68410000/68408000/68407918/5df681ac_y.jpg)

### The Best Beach-Front House “Get-A-Way” in Florida

8/10 Good

"Excellent beach front location, wonderful amenities like beach chairs, umbrellas, toys and towels made the stay easy and stress free! "

[](https://expedia.com/Panacea-Hotels-The-Best-Beach-Front-House-Get-A-Way-In-Florida.h68407918.Hotel-Information)

![Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations](https://images.trvl-media.com/lodging/116000000/115690000/115681700/115681652/908f3d2c_y.jpg)

### Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations

10/10 Excellent

"The location of the house was perfect. Beautiful views!"

[](https://expedia.com/Panacea-Hotels-Gulf-Breeze-Pet-Friendly-3BR-Beachfront-Stay-With-Stunning-Views-Renovations.h115681652.Hotel-Information)

![Beautiful Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes & Tennis](https://images.trvl-media.com/lodging/123000000/122930000/122925400/122925353/6bf09396_y.jpg)

### Beautiful Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes & Tennis

10/10 Excellent

"This place was perfect!!!! Host was amazing, super clean and so so so cute!! We can't wait to come back and stay again!"

[](https://expedia.com/Panacea-Hotels-Gorgeous-WaterfrontHot-TubPoolGolf-CartKayaksFishingTennisPickle-Ball.h122925353.Hotel-Information)

![ Secluded Florida Beach Bungalow-best of both worlds-BEACH TIME & FISHING TIME!!](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/1674545d_y.jpg)

###  Secluded Florida Beach Bungalow-best of both worlds-BEACH TIME & FISHING TIME!!

8/10 Good

"Loved the cottage. Only drawback is the seclusion. I’m sure in the busy season things are livelier. But we were looking for quiet and that’s what we got!"

[](https://expedia.com/Panacea-Hotels-The-Spotted-Grouper-Old-Florida-Beach-Bungalow.h48526748.Hotel-Information)

![The Panacea Motel](https://images.trvl-media.com/lodging/96000000/95080000/95072000/95071987/7ddc9d09_y.jpg)

### The Panacea Motel

8/10 Good

"Parking was easy, right outside the room. The room was tiny but wonderful and really nice for what it was. AC kept the room comfortable and is extremely quiet. Great communication from the staff about the only issue with the tv but beyond their control. Definitely will book again when we go back to Panacea. "

[](https://expedia.com/Panacea-Hotels-The-Panacea-Motel.h95071987.Hotel-Information)

![Gorgeous Ocean Views in Modern Beachfront Home](https://images.trvl-media.com/lodging/83000000/82940000/82939000/82938909/bee39842_y.jpg)

### Gorgeous Ocean Views in Modern Beachfront Home

10/10 Excellent

"What a great place to stay. Clean. Right on the beach. "

[](https://expedia.com/Panacea-Hotels-Gorgeous-Ocean-Views-In-Modern-Beachfront-Home.h82938909.Hotel-Information)

![7 Bedroom Beach House with POOL!! Gulf Front and Bay Front](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/da44be87_y.jpg)

### 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

10/10 Excellent

"Beautiful house with awesome views of the gulf and the bay from all rooms. Fenced in yard was perfect for our dog. Location is very relaxing. I can't wait to go back."

[](https://expedia.com/Panacea-Hotels-7-Bedroom-Beach-House-With-POOL-Gulf-Front-And-Bay-Front.h19008298.Hotel-Information)

## Find out more about Panacea

**Everything you need to know about Panacea vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Panacea vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Panacea vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Panacea vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Panacea. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Panacea in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $397 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Panacea rentals**

At Expedia, we put the best Panacea vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Panacea rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Panacea vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Panacea. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
- All accommodation types in Panacea

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- [Ocean City Vacation Rentals ](https://www.expedia.com/Ocean-City-Vacation-Rentals.d9151.Travel-Guide-VacationRentals)
- [Outer Banks Vacation Rentals ](https://www.expedia.com/Outer-Banks-Vacation-Rentals.d602135.Travel-Guide-VacationRentals)
- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Panacea ](https://expedia.com/Panacea-Private-Vacation-Homes.d3000431554-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Panacea ](https://expedia.com/Panacea-Cottages.d3000431554-aaCottages.Travel-Guide-Accommodation)
- [Apartments in Panacea ](https://expedia.com/Panacea-Apartments.d3000431554-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Panacea ](https://expedia.com/Panacea-Condos.d3000431554-aaCondos.Travel-Guide-Accommodation)
- [Cabin Rentals in Panacea ](https://expedia.com/Panacea-Cabins.d3000431554-aaCabins.Travel-Guide-Accommodation)
- [Motels in Panacea ](https://expedia.com/Panacea-Motels.d3000431554-aaMotels.Travel-Guide-Accommodation)
- [Guest Houses in Panacea ](https://expedia.com/Panacea-Guest-Houses.d3000431554-aaGuestHouses.Travel-Guide-Accommodation)
- [Farmstay in Panacea ](https://expedia.com/Panacea-Agritourism.d3000431554-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Panacea ](https://expedia.com/Panacea-Bed-And-Breakfast.d3000431554-aaBedAndBreakfast.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Panacea?

### What are some of the best vacation rentals in Panacea?

### How many vacation rentals are there in Panacea?

### What’s there to see and do in Panacea?

### What’s a vacation rental in Panacea like?

### Expedia's Latest Trends

Hotels

- [Hotels in Fort Myers](https://expedia.com/Fort-Myers-Hotels.d602729.Travel-Guide-Hotels)
- [Hotels in Pensacola Beach](https://expedia.com/Pensacola-Beach-Hotels.d6677.Travel-Guide-Hotels)
- [Hotels in Cocoa Beach](https://expedia.com/Cocoa-Beach-Hotels.d6549.Travel-Guide-Hotels)
- [Hotels in Gainesville](https://expedia.com/Gainesville-Hotels.d6048189.Travel-Guide-Hotels)
- [Hotels in West Palm Beach](https://expedia.com/West-Palm-Beach-Hotels.d2742.Travel-Guide-Hotels)
- [Oceanfront Hotels in Destin](https://expedia.com/Destin-Hotels-Oceanfront-Hotels.0-0-d6906-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Destin](https://expedia.com/Destin-Hotels.d6906.Travel-Guide-Hotels)
- [Hotels in Sarasota](https://expedia.com/Sarasota-Hotels.d602719.Travel-Guide-Hotels)
- [Hotels in Naples](https://expedia.com/Naples-Hotels.d602724.Travel-Guide-Hotels)
- [Hotels in Pensacola](https://expedia.com/Pensacola-Hotels.d6023331.Travel-Guide-Hotels)
- [Oceanfront Hotels in Panama City Beach](https://expedia.com/Panama-City-Beach-Hotels-Oceanfront-Hotels.0-0-d8021-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [All-inclusive Resorts in Key West](https://expedia.com/Key-West-Hotels-All-Inclusive-Hotel.0-0-d1187-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Daytona Beach](https://expedia.com/Daytona-Beach-Hotels.d6023995.Travel-Guide-Hotels)
- [Beach Hotels in Destin](https://expedia.com/Destin-Hotels-Beach-Hotel.0-0-d6906-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Key West](https://expedia.com/Key-West-Hotels.d1187.Travel-Guide-Hotels)
- [Hotels in Tallahassee](https://expedia.com/Tallahassee-Hotels.d6048214.Travel-Guide-Hotels)
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Flights

- [Cheap Flights to Destin](https://expedia.com/Cheap-Flights-To-Destin.d6906.Travel-Guide-Flights)
- [Cheap Flights to Key West](https://expedia.com/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)
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- [Cheap Flights to Daytona Beach](https://expedia.com/Cheap-Flights-To-Daytona-Beach.d6023995.Travel-Guide-Flights)
- [Cheap Flights to Sarasota](https://expedia.com/Cheap-Flights-To-Sarasota.d602719.Travel-Guide-Flights)
- [Cheap Flights to Pensacola](https://expedia.com/Cheap-Flights-To-Pensacola.d6023331.Travel-Guide-Flights)

Cars

- [Car rentals in West Palm Beach](https://expedia.com/Car-Rentals-In-West-Palm-Beach.d2742.Car-Rental-Guide)

Packages

- [Key West Vacation](https://expedia.com/Key-West.d1187.Destination-Travel-Guides)
- [Destin Vacation](https://expedia.com/Destin.d6906.Destination-Travel-Guides)

General

- [Visit Santa Rosa Beach](https://expedia.com/Santa-Rosa-Beach.dx183118)

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