Title: Panacea Vacation Rentals from $397: Search Short-Term Rentals | Expedia.com

[Panacea Travel Guide](https://expedia.com/Panacea.dx3000431554)[Hotels in Panacea](https://expedia.com/Panacea-Hotels.d3000431554.Travel-Guide-Hotels)[Flights to Panacea](https://expedia.com/Cheap-Flights-To-Panacea.d3000431554.Travel-Guide-Flights)[Car Rentals in Panacea](https://expedia.com/Car-Rentals-In-Panacea.d3000431554.Car-Rental-Guide)[Panacea Vacation Packages](https://expedia.com/Panacea.d3000431554.Destination-Travel-Guides)

![Sunset over a lake at Panacea, northern Florida, USA | NONE |](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/3000431554/82102cb8-9bdc-4f33-be26-bab6063d4ccd.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Apr 3 - Apr 5](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[May 15 - May 17](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-05-15&endDate=2026-05-17&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Jun 12 - Jun 14](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-06-12&endDate=2026-06-14&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Jul 10 - Jul 12](https://www.expedia.com/Hotel-Search?regionId=3000431554&startDate=2026-07-10&endDate=2026-07-12&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Panacea vacation rentals

![Beach nearby, sun loungers](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/1674545d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/90-642a3a19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player, books](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/90-76bf8e48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/49000000/48530000/48526800/48526748/7710be2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

###  Secluded Florida Beach Bungalow-best of both worlds-BEACH TIME & FISHING TIME!!

[](https://www.expedia.com/Panacea-Hotels-The-Spotted-Grouper-Old-Florida-Beach-Bungalow.h48526748.Hotel-Information)

Panacea

10/10

Exceptional

(246 reviews)

"2nd time staying here and it was so beautiful we will definitely be back, everything was wonderful and the host was amazing."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carrie J.

$364 nightly

$397 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-The-Spotted-Grouper-Old-Florida-Beach-Bungalow.h48526748.Hotel-Information)

![TV](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/b0e689e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/b746d807.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/2d8aa8b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/123000000/122120000/122111100/122111093/1f3d2a77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### romantic get away for 2 right on the Ochlockonee river

[](https://www.expedia.com/Panacea-Hotels-Romantic-Get-Away-For-2-Right-On-The-Ochlockonee-River.h122111093.Hotel-Information)

Panacea

10/10

Exceptional

(1 review)

"Wonderful accommodations-clean and comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laurie K.

$278 nightly

$307 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Romantic-Get-Away-For-2-Right-On-The-Ochlockonee-River.h122111093.Hotel-Information)

![Beach nearby, sun loungers](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/79dc0bc6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, video games, DVD player, foosball](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/6a94050e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/5a7da15c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/80000000/79670000/79662300/79662203/b3eacf7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### ☼ Short Walk to Beach! Canal Front w/ Game Room @ Flip-Flop Hideaway

[](https://www.expedia.com/Panacea-Hotels-Short-Walk-To-Beach-Canal-Front-Flip-Flop-Hideaway.h79662203.Hotel-Information)

Alligator Point

10/10

Exceptional

(35 reviews)

"We loved our stay! Dog friendly & close to the beach, beautiful home! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

rideitlikeyoustolei1

$359 nightly

$392 total

Apr 5 - Apr 6

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Short-Walk-To-Beach-Canal-Front-Flip-Flop-Hideaway.h79662203.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/e5db1abd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/6b49306d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/bc45e68a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112950000/112942400/112942331/a4523a31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #3 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h112942331.Hotel-Information)

Panacea

9.0/10

Wonderful

(2 reviews)

"The room is a typical motel room as expected. Loved the retro fridge and microwave!Hosts were extremely accommodating and friendly. Thank you"

![Australia](https://a.travel-assets.com/egds/marks/flags/au.svg)

Janine C.

$172 nightly

$189 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h112942331.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/084a0dbd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/0ff2a3a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/35fa330e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/127000000/126360000/126359400/126359315/b570c91b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fisherman's Retreat Entire home in Panacea, Florida

[](https://www.expedia.com/Panacea-Hotels-Fishermans-Retreat-Entire-Home-In-Panacea.h126359315.Hotel-Information)

Panacea

$254 nightly

$280 total

Mar 24 - Mar 25

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Fishermans-Retreat-Entire-Home-In-Panacea.h126359315.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/97000000/96760000/96752500/96752463/509a1cc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/97000000/96760000/96752500/96752463/c4640e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/97000000/96760000/96752500/96752463/f9546f5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/97000000/96760000/96752500/96752463/ff0403f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Beach Nest - A Peaceful Paradise!

[](https://www.expedia.com/Panacea-Hotels-The-Beach-Nest-A-Newly-Renovated-Paradise.h96752463.Hotel-Information)

Alligator Point

9.8/10

Exceptional

(28 reviews)

"Very peaceful and relaxing. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Becca R.

$416 nightly

$433 total

Apr 18 - Apr 19

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-The-Beach-Nest-A-Newly-Renovated-Paradise.h96752463.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/ccee74a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/e0212a42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/2323819a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/116000000/115460000/115458600/115458502/09177221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### NEW - St. Teresa Beach Escape w/ Private Beach Acc

[](https://www.expedia.com/Panacea-Hotels-NEW-St-Teresa-Beach-Escape-W-Private-Beach-Acc.h115458502.Hotel-Information)

Lanark Village

$471 nightly

$514 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-NEW-St-Teresa-Beach-Escape-W-Private-Beach-Acc.h115458502.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/2350f42b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/90b66298.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/7eae8f89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/113000000/112970000/112965300/112965202/11210b60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Coastal Cottage- a nature lover's paradise!

[](https://www.expedia.com/Panacea-Hotels-Coastal-Cottage-A-Nature-Lovers-Paradise.h112965202.Hotel-Information)

Panacea

10/10

Exceptional

(1 review)

"This place is amazing. It is the cleanest cutest cottage we have stayed in throughout all of Florida. Monica was an excellent host and set us up. Praise Jesus for that! You can walk to two restaurants which are next door. It is hard to find places to stay with my wife having miold illness, especially in Florida, but this has the cleanest, clearest air . We are able to stay with confidence that it is clean. Views of the sunrise on the bay are excellent. We brought our boat to fish and enjoyed...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lonnie L N.

$465 nightly

$488 total

Mar 29 - Mar 30

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Coastal-Cottage-A-Nature-Lovers-Paradise.h112965202.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/81744a78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/589530a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/65a7bfaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/52000000/51880000/51876700/51876637/46241804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

[](https://www.expedia.com/Panacea-Hotels-Skipper-Extends-From-Beach-Front-To-Harbor-With-Kayaks.h51876637.Hotel-Information)

Panacea

9.8/10

Exceptional

(96 reviews)

"We really enjoyed our time at Skipper! It's location on the west end of Alligator Point is perfect for walking the beach for miles in either direction. With so many shells to search for and so many dolphins to watch, our time there was so relaxing that we can't wait to go back!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Karen R.

$521 nightly

$569 total

Apr 17 - Apr 18

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Skipper-Extends-From-Beach-Front-To-Harbor-With-Kayaks.h51876637.Hotel-Information)

![Beach](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/a1fd53d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/6a1354bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/b2492e51.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/117000000/116790000/116784100/116784001/e5492dc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Private Beach & Dock - Quiet Waterfront Retreat on Ochlockonee Bay

[](https://www.expedia.com/Panacea-Hotels-Private-Beach-Dock-Quiet-Waterfront-Retreat-On-Ochlockonee-Bay.h116784001.Hotel-Information)

Panacea

10/10

Exceptional

(1 review)

"host and the peace and ouietness of the area great for relaxing with out all of the giltter and gallyer"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

william C.

$424 nightly

$467 total

Apr 12 - Apr 13

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Private-Beach-Dock-Quiet-Waterfront-Retreat-On-Ochlockonee-Bay.h116784001.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/29b9886d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/97a88bed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Sun loungers, beach towels](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/713cab07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/121000000/120280000/120270500/120270445/9e91ad83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Point & Paddle Waterfront Retreat @Alligator Point

[](https://www.expedia.com/Panacea-Hotels-Alligator-Point-Paddle-Pond-Home-Short-Walk-To-The-Beach.h120270445.Hotel-Information)

Alligator Point

10/10

Exceptional

(1 review)

"Not only is this house adorable and roomy, it is the perfect mix of secluded and convenient. I hosted my girls for a little weekend birthday celebration and we had the best time watching the sunset from the dock, then enjoying a bonfire with smores! We played games and laughed well in to the night before finally retiring to the super comfy beds. The next morning we took the short walk to the beach and enjoyed discovering all types of nature while walking through the beaches of bald point state...

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Holley C.

$537 nightly

$586 total

Apr 14 - Apr 15

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Alligator-Point-Paddle-Pond-Home-Short-Walk-To-The-Beach.h120270445.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/122000000/121880000/121872500/121872496/676a078e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![On the beach](https://images.trvl-media.com/lodging/122000000/121880000/121872500/121872496/a6cfc0b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/122000000/121880000/121872500/121872496/25ea066f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121880000/121872500/121872496/c274aed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### This Cape Cod style beauty will make you fall in love with the Forgotten Coast!

[](https://www.expedia.com/Panacea-Hotels-This-Cape-Cod-Style-Beauty-Will-Make-You-Fall-In-Love-With-The-Forgotten-Coast.h121872496.Hotel-Information)

Alligator Point

10/10

Exceptional

(7 reviews)

"The host was wonderful. Always friendly and helpful. The house was beautiful and perfectly on the water. Loved the porch and laying on the couch out there reading or napping and listening to the gulf gently lapping ashore. Love the long walks on the beach with no one around. Saw a bald eagle one morning on my walk. Great place to unwind and just chill. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David R.

$705 nightly

$745 total

Mar 27 - Mar 28

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-This-Cape-Cod-Style-Beauty-Will-Make-You-Fall-In-Love-With-The-Forgotten-Coast.h121872496.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/debbcb36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/17d21d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/34864a39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547023/2d400668.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #3 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h121547023.Hotel-Information)

Panacea

$172 nightly

$189 total

Mar 23 - Mar 24

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-3.h121547023.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/366856fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/4486fd18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/6edfdcd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547164/eb981fcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #15

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-15.h121547164.Hotel-Information)

Panacea

$174 nightly

$191 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-15.h121547164.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/8277bb47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/a6a220d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/e84e3a5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547124/7ccf5fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #12

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-12.h121547124.Hotel-Information)

Panacea

$174 nightly

$191 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-12.h121547124.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/dacdf48b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/cabecd79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/96116d33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547110/8e791adf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #11

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-11.h121547110.Hotel-Information)

Panacea

$174 nightly

$191 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-11.h121547110.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/e6dd40c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/deeee0a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/9ec6838c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547174/84444893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #16

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-16.h121547174.Hotel-Information)

Panacea

$174 nightly

$191 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-16.h121547174.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/4acea5b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/8504ddb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/70ef9d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547053/81dd3aeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy Panacea Retreat #7 (King)

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-7.h121547053.Hotel-Information)

Panacea

$172 nightly

$189 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Cozy-Panacea-Retreat-7.h121547053.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/9d969f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/3bc0390e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/b38ef5f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547200/121547139/78c013f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Queen Kitchenette by the Bay #13

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-13.h121547139.Hotel-Information)

Panacea

$174 nightly

$191 total

Mar 22 - Mar 23

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-Queen-Kitchenette-By-The-Bay-13.h121547139.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/0af239f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![WiFi, bed sheets](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/bffdca0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/13e11b09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Miscellaneous](https://images.trvl-media.com/lodging/122000000/121550000/121547100/121547082/48a381b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 09) Queen Kitchenette by the Bay

[](https://www.expedia.com/Panacea-Hotels-09-Queen-Kitchenette-By-The-Bay.h121547082.Hotel-Information)

Panacea

$172 nightly

$189 total

Mar 25 - Mar 26

Total with taxes and fees

[](https://www.expedia.com/Panacea-Hotels-09-Queen-Kitchenette-By-The-Bay.h121547082.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.com/Hotel-Search?startDate=2026-04-02&endDate=2026-04-03&regionId=3000431554&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Private vacation homes

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=COTTAGE)

Condos

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=CONDO)

Cabins

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=CABIN)

Villas

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=VILLA)

Apartments

[](https://www.expedia.com/Hotel-Search?destination=Panacea%2C+Florida%2C+United+States+of+America&regionId=3000431554&latLong=30.02912%2C-84.398613&adults=2&startDate=2026-06-17&d1=2026-06-17&endDate=2026-06-20&d2=2026-06-20&lodging=APARTMENT)

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## Top Panacea Hotel Reviews

![Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +](https://images.trvl-media.com/lodging/108000000/107290000/107284100/107284077/5342dafe_y.jpg)

### Private Beachfront w/ Sauna, Hottub, Golf Cart, Kayaks, Paddle Boards & Bikes +

10/10 Excellent

"The hosts made every effort to make the property feel as welcoming as possible."

[](https://expedia.com/Panacea-Hotels-Private-Beachfront-W-Golf-Cart.h107284077.Hotel-Information)

![7 Bedroom Beach House with POOL!! Gulf Front and Bay Front](https://images.trvl-media.com/lodging/20000000/19010000/19008300/19008298/da44be87_y.jpg)

### 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front

10/10 Excellent

"Beautiful house with awesome views of the gulf and the bay from all rooms. Fenced in yard was perfect for our dog. Location is very relaxing. I can't wait to go back."

[](https://expedia.com/Panacea-Hotels-7-Bedroom-Beach-House-With-POOL-Gulf-Front-And-Bay-Front.h19008298.Hotel-Information)

![The Panacea Motel](https://images.trvl-media.com/lodging/96000000/95080000/95072000/95071987/7ddc9d09_y.jpg)

### The Panacea Motel

8/10 Good

"Ok"

[](https://expedia.com/Panacea-Hotels-The-Panacea-Motel.h95071987.Hotel-Information)

![Best deal at Alligator Point](https://images.trvl-media.com/lodging/34000000/33490000/33486800/33486730/f2e6bb56_y.jpg)

### Best deal at Alligator Point

8/10 Good

"A clean and well equipped home. Great waterfront view. We were greeted by lady host, we were told owner was right next door, feel free to stop by with questions, or issues. When Wifi didn't connect, I walked over to get suggestions on getting a connection, and was chewed out for disturbing him???? "

[](https://expedia.com/Panacea-Hotels-Best-Deal-At-Alligator-Point.h33486730.Hotel-Information)

![Gorgeous Ocean Views in Modern Beachfront Home](https://images.trvl-media.com/lodging/83000000/82940000/82939000/82938909/bee39842_y.jpg)

### Gorgeous Ocean Views in Modern Beachfront Home

10/10 Excellent

"Fabulous beachfront home in tranquil setting! Lots of amenities with terrific views from every window. Enjoy the sunrises, relaxing porch or long strolls on the beach. A great get-away!"

[](https://expedia.com/Panacea-Hotels-Gorgeous-Ocean-Views-In-Modern-Beachfront-Home.h82938909.Hotel-Information)

![Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations](https://images.trvl-media.com/lodging/116000000/115690000/115681700/115681652/908f3d2c_y.jpg)

### Gulf Breeze – Pet-Friendly 3BR Beachfront Stay with Stunning Views & Renovations

10/10 Excellent

"Home was not large but clean and well appointed. Excellent location. “Unapologetically beachfront” close to gulf with waves coming below deck during high tide. Best location in the area. Many dolphins swimming the week we stayed. Relaxing and quiet week with daily walks on beach and Bald Point State Park. Exactly what we needed. Shore fishing from deck was a plus. Dog friendly area. "

[](https://expedia.com/Panacea-Hotels-Gulf-Breeze-Pet-Friendly-3BR-Beachfront-Stay-With-Stunning-Views-Renovations.h115681652.Hotel-Information)

![PRIVATE LUXURY BEACHFRONT HOME!](https://images.trvl-media.com/lodging/56000000/55370000/55361200/55361115/6cd29c9b_y.jpg)

### PRIVATE LUXURY BEACHFRONT HOME!

10/10 Excellent

"We had a great time, the place was wonderful and had everything we needed right there for us. We would come again!"

[](https://expedia.com/Panacea-Hotels-NEW-5-Bedroom-5-Bathroom-Beachfront-Home-With-Views-From-Every-Room.h55361115.Hotel-Information)

![Beautiful Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes & Tennis](https://images.trvl-media.com/lodging/123000000/122930000/122925400/122925353/6bf09396_y.jpg)

### Beautiful Waterfront, Pool, Private Hot Tub, Golf Cart, Kayaks, Bikes & Tennis

10/10 Excellent

"Best host ever! House was beautiful and high end finishes "

[](https://expedia.com/Panacea-Hotels-Gorgeous-WaterfrontHot-TubPoolGolf-CartKayaksFishingTennisPickle-Ball.h122925353.Hotel-Information)

![Ochlockonee Bay Waterfront Home 200 ft pier 1st floor over looking the bay](https://images.trvl-media.com/lodging/107000000/106380000/106377800/106377762/82e3e83b_y.jpg)

### Ochlockonee Bay Waterfront Home 200 ft pier 1st floor over looking the bay

10/10 Excellent

"A wonderful host who is very accommodating to any needs…. the location is absolutely beautiful and fit my needs wonderfully!"

[](https://expedia.com/Panacea-Hotels-Waterfront-Home-200-Ft-Pier1st-Floor.h106377762.Hotel-Information)

## Find out more about Panacea

**Everything you need to know about Panacea vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Panacea vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, condos, resorts, cabins, villas, motels. The list goes on, and on …and on.

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Panacea vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

**Panacea vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Panacea. If you’re looking for a little peace, consider booking during the quieter low season months. For more hustle and bustle, you may prefer to visit Panacea in high season.

Prices vary throughout the year. Your chosen location, property type, and amenities will impact the cost of your trip, too. The selection of properties we have chosen for you start as low as $397 per night. Rates vary depending on your travel dates, location, and amenities so make a search and you might find even better deals!

**How to find incredible deals on Panacea rentals**

At Expedia, we put the best Panacea vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Panacea rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Panacea vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Panacea. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

## Explore a world of travel with Expedia

- Trending destinations on Expedia.com
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- [San Diego Vacation Rentals ](https://www.expedia.com/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)
- [Siesta Key Vacation Rentals ](https://www.expedia.com/Siesta-Key-Vacation-Rentals.d6881.Travel-Guide-VacationRentals)
- [Galveston Vacation Rentals ](https://www.expedia.com/Galveston-Vacation-Rentals.d1341.Travel-Guide-VacationRentals)
- [Clearwater Beach Vacation Rentals ](https://www.expedia.com/Clearwater-Beach-Vacation-Rentals.d10759.Travel-Guide-VacationRentals)
- [Palm Springs Vacation Rentals ](https://www.expedia.com/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals)
- [Florida Keys Vacation Rentals ](https://www.expedia.com/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)
- [Lake Tahoe Vacation Rentals ](https://www.expedia.com/South-Lake-Tahoe-Vacation-Rentals.d10150.Travel-Guide-VacationRentals)
- [Lake of the Ozarks Vacation Rentals ](https://www.expedia.com/Lake-Ozark-Vacation-Rentals.d177772.Travel-Guide-VacationRentals)
- [Florida Vacation Rentals ](https://www.expedia.com/Destinations-In-Florida.d211.Vacation-Rental-Destinations)
- [Hawaii Vacation Rentals ](https://www.expedia.com/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations)
- [Michigan Vacation Rentals ](https://www.expedia.com/Destinations-In-Michigan.d224.Vacation-Rental-Destinations)

- [Vacation Homes in Panacea ](https://expedia.com/Panacea-Private-Vacation-Homes.d3000431554-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Panacea ](https://expedia.com/Panacea-Cottages.d3000431554-aaCottages.Travel-Guide-Accommodation)
- [Apartments in Panacea ](https://expedia.com/Panacea-Apartments.d3000431554-aaApartments.Travel-Guide-Accommodation)
- [Condo Rentals in Panacea ](https://expedia.com/Panacea-Condos.d3000431554-aaCondos.Travel-Guide-Accommodation)
- [Cabin Rentals in Panacea ](https://expedia.com/Panacea-Cabins.d3000431554-aaCabins.Travel-Guide-Accommodation)
- [Motels in Panacea ](https://expedia.com/Panacea-Motels.d3000431554-aaMotels.Travel-Guide-Accommodation)
- [Guest Houses in Panacea ](https://expedia.com/Panacea-Guest-Houses.d3000431554-aaGuestHouses.Travel-Guide-Accommodation)
- [Farmstay in Panacea ](https://expedia.com/Panacea-Agritourism.d3000431554-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Panacea ](https://expedia.com/Panacea-Bed-And-Breakfast.d3000431554-aaBedAndBreakfast.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Panacea?

### What are some of the best vacation rentals in Panacea?

### How many vacation rentals are there in Panacea?

### What’s there to see and do in Panacea?

### What’s a vacation rental in Panacea like?

### Expedia's Latest Trends

Hotels

- [Hotels in Fort Myers](https://expedia.com/Fort-Myers-Hotels.d602729.Travel-Guide-Hotels)
- [Hotels in Pensacola Beach](https://expedia.com/Pensacola-Beach-Hotels.d6677.Travel-Guide-Hotels)
- [Hotels in Cocoa Beach](https://expedia.com/Cocoa-Beach-Hotels.d6549.Travel-Guide-Hotels)
- [Hotels in Gainesville](https://expedia.com/Gainesville-Hotels.d6048189.Travel-Guide-Hotels)
- [Hotels in West Palm Beach](https://expedia.com/West-Palm-Beach-Hotels.d2742.Travel-Guide-Hotels)
- [Oceanfront Hotels in Destin](https://expedia.com/Destin-Hotels-Oceanfront-Hotels.0-0-d6906-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Hotels in Destin](https://expedia.com/Destin-Hotels.d6906.Travel-Guide-Hotels)
- [Hotels in Sarasota](https://expedia.com/Sarasota-Hotels.d602719.Travel-Guide-Hotels)
- [Hotels in Naples](https://expedia.com/Naples-Hotels.d602724.Travel-Guide-Hotels)
- [Hotels in Pensacola](https://expedia.com/Pensacola-Hotels.d6023331.Travel-Guide-Hotels)
- [Oceanfront Hotels in Panama City Beach](https://expedia.com/Panama-City-Beach-Hotels-Oceanfront-Hotels.0-0-d8021-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [All-inclusive Resorts in Key West](https://expedia.com/Key-West-Hotels-All-Inclusive-Hotel.0-0-d1187-tAllinclusiveHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Daytona Beach](https://expedia.com/Daytona-Beach-Hotels.d6023995.Travel-Guide-Hotels)
- [Beach Hotels in Destin](https://expedia.com/Destin-Hotels-Beach-Hotel.0-0-d6906-tBeachHotel.Travel-Guide-Filter-Hotels)
- [Hotels in Key West](https://expedia.com/Key-West-Hotels.d1187.Travel-Guide-Hotels)
- [Hotels in Tallahassee](https://expedia.com/Tallahassee-Hotels.d6048214.Travel-Guide-Hotels)
- [Oceanfront Hotels in St. Augustine](https://expedia.com/St-Augustine-Hotels-Oceanfront-Hotels.0-0-d6047864-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
- [Oceanfront Hotels in Siesta Key](https://expedia.com/Siesta-Key-Hotels-Oceanfront-Hotels.0-0-d6881-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
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- [Hotels in St. Augustine](https://expedia.com/St-Augustine-Hotels.d6047864.Travel-Guide-Hotels)

Flights

- [Cheap Flights to Destin](https://expedia.com/Cheap-Flights-To-Destin.d6906.Travel-Guide-Flights)
- [Cheap Flights to Key West](https://expedia.com/Cheap-Flights-To-Key-West.d1187.Travel-Guide-Flights)
- [Cheap Flights to Fort Myers](https://expedia.com/Cheap-Flights-To-Fort-Myers.d602729.Travel-Guide-Flights)
- [Cheap Flights to Daytona Beach](https://expedia.com/Cheap-Flights-To-Daytona-Beach.d6023995.Travel-Guide-Flights)
- [Cheap Flights to Sarasota](https://expedia.com/Cheap-Flights-To-Sarasota.d602719.Travel-Guide-Flights)
- [Cheap Flights to Pensacola](https://expedia.com/Cheap-Flights-To-Pensacola.d6023331.Travel-Guide-Flights)

Cars

- [Car rentals in West Palm Beach](https://expedia.com/Car-Rentals-In-West-Palm-Beach.d2742.Car-Rental-Guide)

Packages

- [Key West Vacation](https://expedia.com/Key-West.d1187.Destination-Travel-Guides)
- [Destin Vacation](https://expedia.com/Destin.d6906.Destination-Travel-Guides)

General

- [Visit Santa Rosa Beach](https://expedia.com/Santa-Rosa-Beach.dx183118)

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