Find hotels in Santa Ana, Panama City

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Discover Santa Ana hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Casco View Apartments

3.5 star property
Santa Ana
9.2 out of 10, Wonderful, (52)
"Great stay, would recommend."
United States
Brooke
$83 nightly
The price is $91
Dec 7 - Dec 8
Total with taxes and fees
Casco View Apartments

Hostal La Cigarra

2.0 star property
Santa Ana
7.6 out of 10, Good, (55)
"Excelente "
Mexico
David
$24 nightly
The price is $27
Jan 2 - Jan 3, 2026
Total with taxes and fees
Hostal La Cigarra

Hotel República

2.0 star property
Santa Ana
6.6 out of 10, (182)
"Fantastic customer service"
United States
OLGA
$27 nightly
The price is $30
Dec 12 - Dec 13
Total with taxes and fees
Hotel República

La Manzana by Wynwood House

3.0 star property
Santa Ana
7.2 out of 10, Good, (15)
"Great hotel. Very close to Casco viejo"
United States
LUCILA
$98 nightly
The price is $108
Dec 7 - Dec 8
Total with taxes and fees
La Manzana by Wynwood House

ART CASCO The Hotel

2.0 star property
Santa Ana
5.8 out of 10, (10)
"Walkable location and free secure parking! The price is really affordable, but the condition of the hotel is not the best"
United States
Eldris
ART CASCO The Hotel

Room-sofa Bed Stay Rooftop Pool & Gym, A

2.0 star property
Santa Ana
2.0 out of 10, (1)
"You pay for a space in the apartment, it’s not the whole apartment be careful. The owner or whoever manages doesn’t give care about you as costumers they just want the money"
United States
Cristian Camilo Betancur
$146 nightly
The price is $161
Dec 9 - Dec 10
Total with taxes and fees
Room-sofa Bed Stay Rooftop Pool & Gym, A

Casa Quijano 06 By Wynwood House

4.0 star property
Santa Ana
9.0 out of 10, Wonderful, (4)
"Easy to find, seamless check-in "
Canada
Matthew
$135 nightly
The price is $149
Dec 15 - Dec 16
Total with taxes and fees
Casa Quijano 06 By Wynwood House

Hotel Riu Plaza Panama

5.0 star property
Campo Alegre, 2.2 mi from Santa Ana
9.0 out of 10, Wonderful, (4617)
"Awesome great place to stay "
United States
Herbert
$114 nightly
The price is $126
Dec 8 - Dec 9
Total with taxes and fees
Hotel Riu Plaza Panama

The Westin Playa Bonita Panama

5.0 star property
4.7 mi from Santa Ana
8.0 out of 10, Very Good, (1002)
"Clean rooms , friendly staff , had great experience "
United States
Saro
$175 nightly
The price is $193
Dec 15 - Dec 16
Total with taxes and fees
The Westin Playa Bonita Panama

Megapolis Hotel Panamá

4.5 star property
Punta Paitilla, 2.2 mi from Santa Ana
8.4 out of 10, Very Good, (1249)
"Its a very beautiful hotel with view and very good breakfast "
United States
Patrick
$106 nightly
The price is $117
Dec 20 - Dec 21
Total with taxes and fees
Megapolis Hotel Panamá

Crowne Plaza Panama Airport by IHG

4.0 star property
13.1 mi from Santa Ana
8.4 out of 10, Very Good, (2292)
"The room was clean and the staff were nice! "
United States
CECILIA
$110 nightly
The price is $121
Dec 23 - Dec 24
Total with taxes and fees
Crowne Plaza Panama Airport by IHG

ORHO HOTEL BOUTIQUE PANAMA Airport

2.0 star property
12.7 mi from Santa Ana
9.0 out of 10, Wonderful, (32)
"Very nice boutique hotel"
United States
Fernando
$142 nightly
The price is $156
Dec 7 - Dec 8
Total with taxes and fees
ORHO HOTEL BOUTIQUE PANAMA Airport

Riande Aeropuerto Hotel & Casino

4.0 star property
12.3 mi from Santa Ana
8.6 out of 10, Excellent, (1857)
"I love the included shuttle and breakfast and how close it is to the airport"
United States
leon
$125 nightly
The price is $138
Dec 13 - Dec 14
Total with taxes and fees
Riande Aeropuerto Hotel & Casino

Courtyard by Marriott Panama Metromall

4.0 star property
9.1 mi from Santa Ana
8.8 out of 10, Excellent, (1002)
"Conveniently located near the airport and major shopping outlets."
United States
Greg
$105 nightly
The price is $116
Jan 5 - Jan 6, 2026
Total with taxes and fees
Courtyard by Marriott Panama Metromall

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

4.5 star property
Obarrio, 2.6 mi from Santa Ana
8.8 out of 10, Excellent, (1000)
"Clean room nice location "
United States
daniel
$159 nightly
The price is $175
Dec 8 - Dec 9
Total with taxes and fees
Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz, 7.9 mi from Santa Ana
9.6 out of 10, Exceptional, (635)
"As usual the stay was amazing in this hotel"
United States
Jose
$232 nightly
The price is $255
Dec 12 - Dec 13
Total with taxes and fees
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

JW Marriott Panama

5.0 star property
Punta Pacifica, 2.7 mi from Santa Ana
9.0 out of 10, Wonderful, (1004)
"Spotless, friendly and great food. Great pools a restaurants. "
Canada
David
$251 nightly
The price is $276
Jan 4 - Jan 5, 2026
Total with taxes and fees
JW Marriott Panama

Plaza Paitilla Inn Hotel

3.5 star property
Punta Paitilla, 2.1 mi from Santa Ana
9.4 out of 10, Exceptional, (2129)
"Great location, friendly staff, excellent views and the best breakfast around."
Canada
Gregory
$158 nightly
The price is $174
Dec 7 - Dec 8
Total with taxes and fees
Plaza Paitilla Inn Hotel

Decapolis Hotel Panama City

4.0 star property
Punta Paitilla, 2.2 mi from Santa Ana
8.6 out of 10, Excellent, (1428)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
$76 nightly
The price is $84
Dec 14 - Dec 15
Total with taxes and fees
Decapolis Hotel Panama City

Ramada Plaza by Wyndham Panama Punta Pacifica

4.0 star property
San Francisco, 3.2 mi from Santa Ana
9.6 out of 10, Exceptional, (1098)
"Property and location was excellent. Staff is very accommodating and helpful. "
Canada
Helen
$100 nightly
The price is $110
Jan 6 - Jan 7, 2026
Total with taxes and fees
Ramada Plaza by Wyndham Panama Punta Pacifica
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Learn more about Santa Ana

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Francisco

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top Santa Ana Hotel Reviews

Find out more about Santa Ana

Top reasons to visit Santa Ana

  • Historic Santa Ana Cathedral: Visit this iconic landmark for a glimpse into the rich history and architecture of the area.
  • Vibrant Santa Ana Park: Enjoy the lively atmosphere, perfect for family outings and relaxation.
  • Exciting Panama Bar Crawl: Experience the energetic nightlife and local culture through a fun bar-hopping adventure.
  • Scenic Views: Explore the hills around Santa Ana for breathtaking views of the city and surrounding landscapes.
  • Rich Local Cuisine: Indulge in delicious local dishes at various eateries, showcasing Panama's diverse culinary heritage.

Find great hotels near Santa Ana

Discover a variety of accommodation options in Santa Ana, Panama City, perfect for every traveler. Whether you're seeking a pet-friendly hotel or a business-themed stay, you'll find a range of choices that cater to your needs. Enjoy city-themed experiences while exploring Santa Ana's vibrant culture, with properties like Hotel El Panama and more, ensuring your visit is both comfortable and memorable.

  • Central Hotel Panama Casco Viejo: Embrace a romantic and business-friendly atmosphere at the Central Hotel Panama Casco Viejo, a charming 4-star hotel located 0.5 miles from Santa Ana. This hotel features a luxurious spa and a range of relaxation services, including manicures, body scrubs, and massage treatments. Ideal for couples, guests can indulge in exquisite romance packages complete with 24-hour room service and champagne service. Business travelers will appreciate amenities such as accessible business centers, conference spaces, and meeting rooms, ensuring a productive stay without sacrificing comfort.
  • American Trade Hotel: Situated just 0.4 miles from Santa Ana, the American Trade Hotel offers a sophisticated 4.5-star experience that caters to both romantic getaways and business needs. Guests can enjoy stunning garden views from the on-site restaurant while relishing in limited-hour room service and champagne service. The hotel features a pet-friendly policy, welcoming furry companions alongside their owners. Relax at the outdoor pool with sun loungers and indulge in in-room massages, making it perfect for a serene escape after a busy day of sightseeing or meetings.
  • Innfiniti Hotel & Suites: Located 0.9 miles from Santa Ana, Innfiniti Hotel & Suites offers a modern 3.5-star experience, perfect for business-minded travelers seeking a city-themed retreat. Nestled in the city center, this hotel provides essential business facilities, ensuring that guests can stay productive during their visit. With comfortable accommodations and a friendly environment, Innfiniti Hotel & Suites serves as a practical base for exploring the vibrant city, all while being close to local attractions and dining options.

Where to stay near Santa Ana

Santa Ana, a vibrant neighborhood in Panama City, offers a unique blend of family-friendly and business atmospheres. Visitors can explore the local culture and enjoy the warm hospitality of friendly locals. Nearby attractions enhance the experience, providing a mix of relaxation and luxury. Whether you're wandering through the charming streets or indulging in local cuisine, Santa Ana is a perfect base for discovering the richness of Panama's capital.

  • Panama City: As the vibrant capital of Panama, Panama City is a bustling metropolis that combines modernity with rich history. Santa Ana is located within this dynamic city, offering easy access to a wealth of attractions. Visitors can enjoy a diverse travel experience, from family outings to business ventures. Popular activities include exploring shopping centers and malls, while local landmarks such as parks and beaches provide a refreshing escape. With peak visitor numbers in January, July, and September, the city buzzes with energy year-round, making it an exciting destination for all types of travelers.
  • Casco Viejo: Just 0.4 miles from Santa Ana, Casco Viejo is a charming neighborhood known for its cobblestone streets and colonial architecture. This UNESCO World Heritage site offers a blend of history and modern amenities, attracting visitors seeking cultural experiences and family-friendly activities. The area's shopping centers and resorts provide great spots for leisure and relaxation. With peak travel seasons occurring in January and from March to April, Casco Viejo’s vibrant atmosphere and local attractions such as parks and beaches make it a must-visit during your stay.
  • Barrio Chino: Located only 0.2 miles from Santa Ana, Barrio Chino is a vibrant neighborhood that showcases the rich Chinese heritage of Panama. This culturally rich area is perfect for families and those interested in cultural experiences. Visitors can enjoy shopping at local centers, catch a show at the theater, or explore nearby museums and historic sites. With peak visitor numbers in February to March and December, Barrio Chino offers a lively atmosphere and unique attractions, making it an exciting addition to your Panama City itinerary.

Things to do near Santa Ana

Santa Ana, located in Panama City, offers a variety of family-friendly and business-themed activities. Visitors can explore vibrant shopping malls and centers, making it a great destination for those who enjoy retail therapy. Additionally, don't miss out on the exciting Panama bar crawl, which showcases the lively nightlife and local culture. With plenty of options, Santa Ana is perfect for a memorable vacation experience.

Shopping

Albrook Shopping Mall, located 1 mile from Santa Ana, offers a vibrant mix of entertainment and shopping. For a local experience, visit Avenida Central, just 0.3 miles away, featuring a variety of shops. Don't miss Uruguay Street, 2 miles away, known for its family-friendly atmosphere.

Recreation

Maracana Stadium, located 0.8 miles from Santa Ana, offers a vibrant atmosphere with various sports events. For a broader sports experience, Estadio Rommel Fernandez and Estadio Nacional Rod Carew, situated 7 miles and 6 miles away respectively, provide thrilling games that energize and uplift visitors in a lively setting.

Adventure

Embark on the Honeycreeper Ridge Trail, located 27 miles from Santa Ana, where breathtaking scenery and the thrill of hiking await. For an exhilarating experience, visit Gatun Eco Adventures, 30 miles away, and soar through the treetops on an exciting zipline ropes course surrounded by lush landscapes.

Nightlife

In Santa Ana, the National Theater showcases captivating performances just 0.6 miles away, while the Anita Villalaz Theater, located 0.8 miles from the area, offers a rich cultural experience. Amador Theater, only 0.3 miles away, rounds out the vibrant nightlife with its entertainment and family-friendly atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Ana

To save money on your trip to Santa Ana, Panama, plan your visit between September and November when prices are lower. Tuesdays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to find eco-friendly accommodations and sort by price to find the best deals. Consider booking a package for flights and hotels to save even more. Joining Expedia's One Key membership offers exclusive discounts and future cash rewards. Additionally, explore free local attractions to maximize your experience without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Santa Ana are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Santa Ana is Tuesday. The most expensive day to stay around Santa Ana is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your options based on your budget, preferred destination, and the type of hotel you’re seeking. For instance, selecting the Eco-certified filter will showcase sustainable and eco-friendly accommodations currently available. To find the best prices and deals, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in Santa Ana with your flights and activities by booking a package through Expedia.
  • Become a One Key member: Join Expedia's One Key membership program for exclusive discounts and deals on hotel bookings. You can also earn OneKeyCash to use on future selected hotels.

Find the best attractions near Santa Ana

Santa Ana, located in Panama City, offers a delightful mix of cultural and scenic attractions perfect for families and business travelers alike. Key points of interest include the historic Santa Ana Cathedral, the vibrant Santa Ana Park, and the scenic views from the hills. Don't miss the nearby Panama Canal and the charm of Casco Viejo. Explore Plaza Santa Ana and enjoy the lively atmosphere at Santa Ana Square for an enriching experience during your visit.

  • Metropolitan Cathedral of Panama: Located only half a mile from Santa Ana, this stunning cathedral boasts magnificent architecture and rich cultural significance. Inside, visitors can admire intricate artworks and experience the serene atmosphere of one of Panama’s most important religious sites.
  • Palacio de las Garzas: Also half a mile away, this historic government building is not only the official residence of the President but also a beautiful example of colonial architecture. Visitors can stroll through its picturesque gardens and enjoy the vibrant atmosphere of the surrounding area.
  • Interoceanic Canal Museum: Situated half a mile from Santa Ana, this museum offers an engaging look into the history and impact of the Panama Canal. With interactive exhibits and informative displays, it’s a must-visit for anyone interested in Panama’s unique history.

Best time to go to Santa Ana

The best time to visit Santa Ana is dependent on what kind of holiday you are seeking. April is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. November is its coolest month on average. At this time, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnySlightly HighSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudySlightly LowAverage
July79.3°F (26.3°C)Frequent RainMostly CloudyAverageAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly LowSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudyAverageSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly HighAverage

The nearest major airports for your trip to Santa Ana

When visiting Santa Ana, Panama, you have convenient access to three major airports. Panama City (PTY-Tocumen Intl.) is situated 13 miles away, with notable hotels such as JW Marriott Panama and The Santa Maria, A Luxury Collection Hotel, both offering transportation services. The closer Panama City (PAC-Marcos A. Gelabert Intl.) is only 2 miles from Santa Ana, featuring excellent options like Waldorf Astoria Panama and Hilton Panama, which provide various shuttle services. Lastly, Rio Hato (RIH-Scarlett Martinez Intl.) is 57 miles away, with hotels like The Buenaventura Golf & Beach Resort and Royal Decameron Panamá that also offer airport shuttles. Your travel options are plentiful for a seamless vacation experience.

Frequently asked questions

What are the best budget hotels in Santa Ana?
In the heart of Panama City, Hostal La Cigarra offers an inclusive setting that combines traditional design with modern comforts, making it a great choice for budget-conscious travelers. With a customer review rating of 7.4, this hostal is situated near historical districts and shopping areas, allowing families to explore the rich culture and vibrant life of the city. Guests appreciate the complimentary in-room WiFi, making it easy to stay connected while on the go.

For those seeking a luxurious experience without breaking the bank, Hotel República presents a charming option with its rooftop terrace providing partial ocean views, superb for relaxing after a day of adventures. This hotel also features free WiFi and air conditioning, ensuring comfort during your stay. Families can take advantage of the area shuttle service to explore Panama City's attractions conveniently.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Santa Ana hotel for you.
How can I save on a Santa Ana hotel booking with Expedia?
One Key™ - Expedia's free travel rewards program - gives you instant access to perks and Member Prices on Santa Ana hotels. Plus, you'll earn OneKeyCash™* on eligible bookings to use on future trips. Booking an Expedia hotel and flight package is another great way to save, where bundling can result in significant savings.

*OneKeyCash is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.
How much is the nightly rate at a Santa Ana hotel?
Hotel prices in Santa Ana often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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