Santa Clara

Travel Guide

A beach with waves, a boat, and a forested hill in the background.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
$138 nightly
The price is $151 total per night from Sep 28 to Sep 29
$151 total
Sep 28 - Sep 29
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
$190 nightly
The price is $209 total per night from Sep 29 to Sep 30
$209 total
Sep 29 - Sep 30
Total with taxes and fees
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
$133 nightly
The price is $133 total per night from Oct 12 to Oct 13
$133 total
Oct 12 - Oct 13
Total with taxes and fees
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
8.6/10 Excellent! (1,762 reviews)
"loved my family suite !!! very spacious and cute ! awesome views… the pool was such a vibe even on the days it did rain the bar was still open. great location in the city"

Reviewed on Sep 27, 2026

Megapolis Hotel Panamá
See all 1,776 properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Corporate Stays Arcadia | Executive Furnished Apartments

Corporate Stays Arcadia | Executive Furnished Apartments

4 out of 5
Calle rio mar Panama City Panamá Province
Stay at this aparthotel in Panama City. Enjoy free WiFi, a rooftop terrace, and parking (surcharge). Popular attractions Panama Viejo and Multiplaza Pacific ...
Corporate Stays Arcadia | Executive Furnished Apartments
Marriott Executive Apartments Panama City, Finisterre

Marriott Executive Apartments Panama City, Finisterre

4 out of 5
Calle Colombia Y Ave.,3ra A Sur, Bella V Panama City Panama
Book a stay at this business-friendly aparthotel in Panama City. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the helpful staff in our ...
Marriott Executive Apartments Panama City, Finisterre
Torres de Alba Hotel & Suites

Torres de Alba Hotel & Suites

3.5 out of 5
Calle Eusebio A. Morales y Calle 55 Panama City Panama
Book a stay at this business-friendly aparthotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our ...
8.8/10 Excellent! (583 reviews)
"Restaurants nearby are nice. Room was quiet which is an accomplishment for Panama City."

Reviewed on Sep 27, 2026

Torres de Alba Hotel & Suites
See all properties in Santa Clara
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Santa Clara attractions

Culebra Cut

8.0/10 (14 reviews)
You can find out about the history of Santa Clara with a visit to Culebra Cut. Check out the casinos and top-notch restaurants in this walkable area.
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Things to do

Magnificent Gatun lake

Monkey Watch and Gatun Lake Wildlife Safari Private Tour

$75
per adult
Monkey Watch and Gatun Lake Wildlife Safari Private Tour
Monkey and Sloth Jungle Habitat Panama Tour

Monkey and Sloth Jungle Habitat Panama Tour

$60
per adult
96% of travellers recommend
Monkey and Sloth Jungle Habitat Panama Tour
Panamá Canal and Old Town

The Trilogy of Panama: Canal, Colonial History and Coastal Views

$80
per adult
The Trilogy of Panama: Canal, Colonial History and Coastal Views
Layover

Layover Tour: Panama city and Canal Visit (2 people minimum)

$75
per adult
Layover Tour: Panama city and Canal Visit (2 people minimum)
MiraLift

Transfer to Panama Canal (Miraflores Locks)

$14
per adult
100% of travellers recommend
Transfer to Panama Canal (Miraflores Locks)
Explore Panama Canal and Gatun Lake with Rainforest Hike

Explore Panama Canal and Gatun Lake with Rainforest Jungle Walk

$109
per adult
Explore Panama Canal and Gatun Lake with Rainforest Jungle Walk
See all activities in Santa Clara

Cities near Santa Clara

A coastal cityscape with high-rise buildings, a marina, and a clear blue sky.

Panama City

A historic stone fortress with a central dome and surrounding walls.

Colon

A river winding through a lush green valley with hills in the background and a cloudy sky above.

Gamboa

A modern building with colorful geometric shapes and a clear blue sky.

Ancon

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