Find Extended Stay Hotels in Southeast Missouri, MO

Start date: Check-in selected.
To Date
End date: Check-out
  • Upfront pricing

    Our total price for your stay includes taxes and fees
  • Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
  • Be picky

    Search almost a million properties worldwide

Top Southeast Missouri Extended Stay Hotels | Reserve now, pay later

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
$143 nightly
The price is $152
Dec 28 - Dec 29
Total with taxes and fees
Echo Bluff State Park

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
$98 nightly
The price is $109
Jan 4 - Jan 5, 2026
Total with taxes and fees
Hampton Inn Poplar Bluff

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
$116 nightly
The price is $131
Dec 21 - Dec 22
Total with taxes and fees
Courtyard by Marriott Cape Girardeau Downtown

Shepherd Mountain Inn

2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
$120 nightly
The price is $131
Dec 7 - Dec 8
Total with taxes and fees
Shepherd Mountain Inn

Drury Inn & Suites Hayti Caruthersville

3.0 star property
Hayti
9.4 out of 10, Exceptional, (1000)
"Great stay. Clean room, and Drury Inns always seem to have the most comfortable beds."
United States
Ted
$94 nightly
The price is $107
Dec 13 - Dec 14
Total with taxes and fees
Drury Inn & Suites Hayti Caruthersville

Comfort Inn Festus - St Louis South

2.5 star property
Festus
7.8 out of 10, Good, (906)
"Vary clean"
United States
George
$82 nightly
The price is $94
Jan 1 - Jan 2, 2026
Total with taxes and fees
Comfort Inn Festus - St Louis South

Candlewood Suites Cape Girardeau by IHG

2.5 star property
Cape Girardeau
8.0 out of 10, Very Good, (875)
"Great room"
United States
Kevin
$70 nightly
The price is $85
Dec 7 - Dec 8
Total with taxes and fees
Candlewood Suites Cape Girardeau by IHG

Bullwinkles Rustic Lodge

2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (210)
"Room was not clean, one bath towel for two people, no hand tools or wash cloths, no hand soap or shampoo. Parking is not the best. Could hear person next door snoring all night. For anyone expecting to eat breakfast early then take off you will have to wait until 9:00 am because the lobby doesn’t open until then so you can eat. "
United States
Floyd
$79 nightly
The price is $89
Dec 10 - Dec 11
Total with taxes and fees
Bullwinkles Rustic Lodge

Lake Wappapello

2.0 star property
Williamsville
10.0 out of 10, Exceptional, (1)
"We did loose internet connection so gps did not always help but the local stores did. Also the managers answered their phones and were so helpful in many ways! I’m very glad we went."
United States
Dyann
$138 nightly
The price is $146
Dec 10 - Dec 11
Total with taxes and fees
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southeast Missouri

Discover top Southeast Missouri attractions

Southeast Missouri offers a paradise of experiences perfect for the adventurous traveler. Begin your journey at the stunning Ozark National Scenic Riverways, where you can paddle through crystal-clear waters or hike scenic trails. Families will love exploring the interactive exhibits at the Cape Girardeau Discovery Playhouse, which blends learning with fun for children of all ages. For a taste of local culture, visit the historic downtown area of Cape Girardeau, filled with charming boutiques and delightful eateries, perfect for a leisurely afternoon. Don't miss a trip to the picturesque Garden of the Gods, where breathtaking views and unique rock formations create a stunning backdrop for family photos. After a day of exploration, unwind in one of the many luxurious hotels in the area, where attentive service and top hotels ensure a relaxing stay. Enjoy the convenience of nearby attractions while indulging in the comfort of spacious rooms and on-site dining options, making your Southeast Missouri getaway both enjoyable and memorable.

Expand your search

Most booked related extended stays in Southeast Missouri in 2026

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia