Find Extended Stay Hotels in Southeast Missouri, MO

Start date: Check-in selected.
End date: Check-out
    price find illustration

    Upfront pricing

    Our total price for your stay includes taxes and fees
    deals illustration

    Treat yourself

    Save 10% or more on over 100,000 hotels worldwide with Member Prices
    bed illustration

    Be picky

    Search almost a million properties worldwide

Top Southeast Missouri Extended Stay Hotels | Reserve now, pay later

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Great place"
$94 nightly
The price is $107
Sep 21 - Sep 22
Total with taxes and fees
Drury Inn & Suites Hayti Caruthersville

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (30)
"Sweet cabin"
$124 nightly
The price is $133
Sep 7 - Sep 8
Total with taxes and fees
Postcard Cabins St. Francois

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (756)
"The room was clean, the staff were nice and breakfast bar was good "
$97 nightly
The price is $109
Sep 14 - Sep 15
Total with taxes and fees
Hampton Inn Poplar Bluff

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (293)
"Friendly staff."
$120 nightly
The price is $131
Sep 7 - Sep 8
Total with taxes and fees
Shepherd Mountain Inn

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (988)
"The staff was beyond friendly, the free breakfast did not disappointed, and we were just genuinely happy with our stay."
$90 nightly
The price is $102
Sep 13 - Sep 14
Total with taxes and fees
Drury Inn & Suites Cape Girardeau

Echo Bluff State Park

2.5 star property
9.4 out of 10, Exceptional, (207)
"Beautiful location & very friendly staff!"
$189 nightly
The price is $200
Sep 7 - Sep 8
Total with taxes and fees
Echo Bluff State Park

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
9.6 out of 10, Exceptional, (442)
"Historic building in downtown area, near the river, friendly staff and comfortable rooms "
$125 nightly
The price is $142
Sep 21 - Sep 22
Total with taxes and fees
Courtyard by Marriott Cape Girardeau Downtown

Comfort Inn Festus - St Louis South

2.5 star property
8.0 out of 10, Very Good, (873)
"The room was clean and the hallways were clean. The breakfast was good and the room was affordable. Just what we were looking for!"
$79 nightly
The price is $90
Sep 14 - Sep 15
Total with taxes and fees
Comfort Inn Festus - St Louis South

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 star property
9.4 out of 10, Exceptional, (151)
"Enjoyed our short stay, will definitely be back. "
$152 nightly
The price is $163
Sep 8 - Sep 9
Total with taxes and fees
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

Lake Wappapello

2.0 star property
$138 nightly
The price is $146
Sep 7 - Sep 8
Total with taxes and fees
Lake Wappapello
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find out more about Southeast Missouri

Find out more about Southeast Missouri

Discover top Southeast Missouri attractions

Southeast Missouri offers a paradise of experiences perfect for the adventurous traveler. Begin your journey at the stunning Ozark National Scenic Riverways, where you can paddle through crystal-clear waters or hike scenic trails. Families will love exploring the interactive exhibits at the Cape Girardeau Discovery Playhouse, which blends learning with fun for children of all ages. For a taste of local culture, visit the historic downtown area of Cape Girardeau, filled with charming boutiques and delightful eateries, perfect for a leisurely afternoon. Don't miss a trip to the picturesque Garden of the Gods, where breathtaking views and unique rock formations create a stunning backdrop for family photos. After a day of exploration, unwind in one of the many luxurious hotels in the area, where attentive service and top hotels ensure a relaxing stay. Enjoy the convenience of nearby attractions while indulging in the comfort of spacious rooms and on-site dining options, making your Southeast Missouri getaway both enjoyable and memorable.

Expand your search

Most booked related extended stays in Southeast Missouri in 2025

Top Southeast Missouri Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia