$331 Cheap Flights from Cusco (CUZ) to San Francisco (SFO)

View $331 flight on Thu, Dec 11, 2025Opens in a new window

Popular airlines from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)

Cheap Flights from Cusco to San Francisco (CUZ-SFO)

Prices were available within the past 7 days and start at $331 for one-way flights and $673 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

LATAM Airlines Group
Wed, Dec 3 - Sat, Dec 6
CUZ
Cusco
SFO
San Francisco
$673 Roundtrip, found 13 hours ago
$673
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Wed, Dec 3 from Cusco to San Francisco, returning Sat, Dec 6, priced at $673 found 13 hours ago
LATAM Airlines Group
Wed, Dec 3 - Sat, Dec 6
CUZ
Cusco
SFO
San Francisco
$699 Roundtrip, found 13 hours ago
$699
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Wed, Dec 3 from Cusco to San Francisco, returning Sat, Dec 6, priced at $699 found 13 hours ago
LATAM Airlines Group
Wed, Dec 3 - Sat, Dec 6
CUZ
Cusco
SFO
San Francisco
$705 Roundtrip, found 13 hours ago
$705
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Wed, Dec 3 from Cusco to San Francisco, returning Sat, Dec 6, priced at $705 found 13 hours ago
LATAM Airlines Group
Wed, Dec 3 - Sat, Dec 6
CUZ
Cusco
SFO
San Francisco
$731 Roundtrip, found 13 hours ago
$731
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Wed, Dec 3 from Cusco to San Francisco, returning Sat, Dec 6, priced at $731 found 13 hours ago
LATAM Airlines Group
Thu, Nov 13 - Mon, Nov 17
CUZ
Cusco
SFO
San Francisco
$733 Roundtrip, found 1 day ago
$733
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Thu, Nov 13 from Cusco to San Francisco, returning Mon, Nov 17, priced at $733 found 1 day ago
LATAM Airlines Group
Wed, Dec 3 - Sat, Dec 6
CUZ
Cusco
SFO
San Francisco
$737 Roundtrip, found 13 hours ago
$737
Roundtrip
found 13 hours ago
Select LATAM Airlines Group flight, departing Wed, Dec 3 from Cusco to San Francisco, returning Sat, Dec 6, priced at $737 found 13 hours ago
LATAM Airlines Group
Mon, Dec 22 - Mon, Dec 29
CUZ
Cusco
SFO
San Francisco
$737 Roundtrip, found 2 days ago
$737
Roundtrip
found 2 days ago
Select LATAM Airlines Group flight, departing Mon, Dec 22 from Cusco to San Francisco, returning Mon, Dec 29, priced at $737 found 2 days ago
Delta
Thu, Aug 20 - Fri, Aug 28
CUZ
Cusco
SFO
San Francisco
$760 Roundtrip, found 2 days ago
$760
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Aug 20 from Cusco to San Francisco, returning Fri, Aug 28, priced at $760 found 2 days ago
avianca
Fri, Mar 13 - Sat, Mar 21
CUZ
Cusco
SFO
San Francisco
$900 Roundtrip, found 11 hours ago
$900
Roundtrip
found 11 hours ago
Select avianca flight, departing Fri, Mar 13 from Cusco to San Francisco, returning Sat, Mar 21, priced at $900 found 11 hours ago
American Airlines
Thu, Dec 11 - Mon, Jan 5
CUZ
Cusco
SFO
San Francisco
$915 Roundtrip, found 11 hours ago
$915
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Thu, Dec 11 from Cusco to San Francisco, returning Mon, Jan 5, priced at $915 found 11 hours ago

Frequently asked questions

How much does a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO) cost?
Secure a cheap one-way flight from $331 or cheap return flight from $673 from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)?
The cheapest month to fly from CUZ to SFO is December, when there's less demand. Off-peak season is generally when airlines offer lower prices between these airports.
What is the cheapest airline that flies from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to see which carrier offers the cheapest CUZ to SFO flight.
How many flights per day from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)?
There aren't any daily direct flights departing from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO). But you can choose flights with layovers. Filter your search results on Expedia to include one or more stops, and you'll be cruising above the clouds in no time.
What day of the week has the most flights from CUZ to SFO?
You'll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)?
Opt for a flight from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO) last-minute?
Waiting until just before your trip to book a ticket from CUZ to SFO generally means paying more. While it's possible to find some last-minute discounts, there's no guarantee. Be flexible with your travel plans to boost your chances of getting a bargain.
Is it cheaper to book a CUZ to SFO flight and hotel package?
Compared with arranging hotels and flights separately, booking a CUZ to SFO flight and hotel package with Expedia could result in significant savings. What's more, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and select from our wide range of hotels, then tailor your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Alejandro Velasco Astete Intl. Airport (CUZ) to San Francisco Intl. Airport (SFO)?
It's generally possible to reschedule or cancel your CUZ to SFO flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are allowed and if any costs are involved. You'll also find more information on our Customer Service portal.

Travel information

Origin airport
Alejandro Velasco Astete Intl.
Destination airport
San Francisco Intl.
Airlines serving
American Airlines, Delta, LATAM Airlines Group, avianca
Roundtrip price
$672
Distance
4813 mi

Book with confidence

Cusco to San Francisco Flights

The cheapest times to fly from Cusco to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cusco to San Francisco are during the month of December. You can find some of the cheapest flights from Cusco to San Francisco with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Cusco to San Francisco

Sunday is one of the best days to book for cheap flights from Cusco to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Cusco to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cusco to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $331 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cusco to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cusco to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Cusco to San Francisco Flights

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*Available to One Key members.