$73 Cheap Flights from Panama City (ECP) to St. Louis (STL)

View $73 flight on Wed, Sep 17, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to St. Louis Lambert Intl. Airport (STL)

Cheap Flights from Panama City to St. Louis (ECP-STL)

Prices were available within the past 7 days and start at $73 for one-way flights and $157 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Southwest Airlines
Tue, Sep 9 - Fri, Sep 12
ECP
Panama City
STL
St. Louis
$157 Roundtrip, found 4 hours ago
$157
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Tue, Sep 9 from Panama City to St. Louis, returning Fri, Sep 12, priced at $157 found 4 hours ago
Southwest Airlines
Wed, Oct 29 - Wed, Nov 5
ECP
Panama City
STL
St. Louis
$161 Roundtrip, found 1 hour ago
$161
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Oct 29 from Panama City to St. Louis, returning Wed, Nov 5, priced at $161 found 1 hour ago
Delta
Sun, Aug 31 - Sun, Sep 7
ECP
Panama City
STL
St. Louis
$167 Roundtrip, found 4 hours ago
$167
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Aug 31 from Panama City to St. Louis, returning Sun, Sep 7, priced at $167 found 4 hours ago
American Airlines
Tue, Sep 9 - Fri, Sep 12
ECP
Panama City
STL
St. Louis
$172 Roundtrip, found 4 hours ago
$172
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Panama City to St. Louis, returning Fri, Sep 12, priced at $172 found 4 hours ago
Delta
Wed, Oct 29 - Wed, Nov 5
ECP
Panama City
STL
St. Louis
$177 Roundtrip, found 1 hour ago
$177
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Oct 29 from Panama City to St. Louis, returning Wed, Nov 5, priced at $177 found 1 hour ago
Delta
Wed, Oct 29 - Wed, Nov 5
ECP
Panama City
STL
St. Louis
$183 Roundtrip, found 1 hour ago
$183
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, Oct 29 from Panama City to St. Louis, returning Wed, Nov 5, priced at $183 found 1 hour ago
American Airlines
Sat, Aug 23 - Sun, Aug 24
ECP
Panama City
STL
St. Louis
$184 Roundtrip, found 23 hours ago
$184
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Aug 23 from Panama City to St. Louis, returning Sun, Aug 24, priced at $184 found 23 hours ago
Southwest Airlines
Wed, Oct 29 - Wed, Nov 5
ECP
Panama City
STL
St. Louis
$186 Roundtrip, found 1 hour ago
$186
Roundtrip
found 1 hour ago
Select Southwest Airlines flight, departing Wed, Oct 29 from Panama City to St. Louis, returning Wed, Nov 5, priced at $186 found 1 hour ago
American Airlines
Wed, Oct 29 - Wed, Nov 5
ECP
Panama City
STL
St. Louis
$187 Roundtrip, found 1 hour ago
$187
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Wed, Oct 29 from Panama City to St. Louis, returning Wed, Nov 5, priced at $187 found 1 hour ago
United
Tue, Sep 9 - Fri, Sep 12
ECP
Panama City
STL
St. Louis
$192 Roundtrip, found 4 hours ago
$192
Roundtrip
found 4 hours ago
Select United flight, departing Tue, Sep 9 from Panama City to St. Louis, returning Fri, Sep 12, priced at $192 found 4 hours ago

Find the cheapest month to fly from Panama City (ECP) to St. Louis (STL)

September is typically the cheapest month to fly

From $157 - $679 per traveler.

Graph displaying average flight prices per month

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $374
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $374
Flights from Panama City (ECP) to St. Louis (STL)
Origin airport
Northwest Florida Beaches Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$157
Distance
634 mi
Average flight time
1 hour 50 mins

Panama City to St. Louis Flights

The cheapest times to fly from Panama City to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to St. Louis are during the month of September. You can find some of the cheapest flights from Panama City to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to St. Louis

Sunday is one of the best days to book for cheap flights from Panama City to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $73 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) cost?
You can score affordable return tickets from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) starting at $383. Grab your seat and be on your way. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Southwest Airlines flight leaving ECP on August 15 2025 and touching down at STL. The price was last updated on July 23 2025 and has not changed since.
What is the cheapest month to fly from ECP to STL?
The cheapest flights from ECP to STL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from ECP to STL?
With fares starting at $79 for a one-way flight from ECP to STL, Southwest Airlines is currently the cheapest airline operating this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from ECP on August 20 2025. Prices were last updated on July 23 2025 and have not changed since.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
You'll have to catch a flight with a layover when traveling from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL). There are no daily direct flights on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from ECP to STL?
Typically you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can change based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
Select a flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) that leaves before 3 PM to reduce the risk of cancellations and delays. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your departure to book a ticket from ECP to STL generally means paying more. Although you may find some last-minute offers, they aren't always guaranteed. Keep your travel plans flexible for a better chance of landing a bargain.
Is it cheaper to book an ECP to STL flight and hotel package?
Compared with arranging flights and hotels separately, booking an ECP to STL flight and hotel package with Expedia could result in significant savings. Better still, having everything in one convenient place will take the stress out of travel planning. Just pick your flights and choose from our wide range of stays, then personalize your trip with extras like tours, car rentals and activities.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your ECP to STL flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

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*Available to One Key members.