$99 Cheap Flights from Myrtle Beach (MYR) to St. Louis (STL)

View $99 flight on Sun, Jun 15, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Myrtle Beach to St. Louis (MYR-STL)

Prices were available within the past 7 days and start at $99 for one-way flights and $197 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Thu, Jun 12 - Sun, Jun 22
MYR
Myrtle Beach
STL
St. Louis
$197 Roundtrip, found 21 hours ago
$197
Roundtrip
found 21 hours ago
Select Delta flight, departing Thu, Jun 12 from Myrtle Beach to St. Louis, returning Sun, Jun 22, priced at $197 found 21 hours ago
Delta
Sun, May 25 - Tue, May 27
MYR
Myrtle Beach
STL
St. Louis
$198 Roundtrip, just found
$198
Roundtrip
just found
Select Delta flight, departing Sun, May 25 from Myrtle Beach to St. Louis, returning Tue, May 27, priced at $198 just found
American Airlines
Sun, Aug 10 - Sun, Aug 17
MYR
Myrtle Beach
STL
St. Louis
$199 Roundtrip, found 15 hours ago
$199
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sun, Aug 10 from Myrtle Beach to St. Louis, returning Sun, Aug 17, priced at $199 found 15 hours ago
American Airlines
Sun, Aug 10 - Sun, Aug 17
MYR
Myrtle Beach
STL
St. Louis
$201 Roundtrip, found 15 hours ago
$201
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sun, Aug 10 from Myrtle Beach to St. Louis, returning Sun, Aug 17, priced at $201 found 15 hours ago
Delta
Thu, May 29 - Sun, Jun 1
MYR
Myrtle Beach
STL
St. Louis
$218 Roundtrip, found 19 hours ago
$218
Roundtrip
found 19 hours ago
Select Delta flight, departing Thu, May 29 from Myrtle Beach to St. Louis, returning Sun, Jun 1, priced at $218 found 19 hours ago
American Airlines
Thu, May 29 - Sun, Jun 1
MYR
Myrtle Beach
STL
St. Louis
$219 Roundtrip, found 19 hours ago
$219
Roundtrip
found 19 hours ago
Select American Airlines flight, departing Thu, May 29 from Myrtle Beach to St. Louis, returning Sun, Jun 1, priced at $219 found 19 hours ago
Spirit Airlines
Mon, Jun 23 - Thu, Jun 26
MYR
Myrtle Beach
STL
St. Louis
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Mon, Jun 23 from Myrtle Beach to St. Louis, returning Thu, Jun 26, priced at $230 found 1 day ago
American Airlines
Sun, Aug 10 - Sun, Aug 17
MYR
Myrtle Beach
STL
St. Louis
$236 Roundtrip, found 15 hours ago
$236
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Sun, Aug 10 from Myrtle Beach to St. Louis, returning Sun, Aug 17, priced at $236 found 15 hours ago
Delta
Sun, May 25 - Wed, May 28
MYR
Myrtle Beach
STL
St. Louis
$240 Roundtrip, just found
$240
Roundtrip
just found
Select Delta flight, departing Sun, May 25 from Myrtle Beach to St. Louis, returning Wed, May 28, priced at $240 just found
American Airlines
Tue, May 20 - Thu, May 22
MYR
Myrtle Beach
STL
St. Louis
$241 Roundtrip, found 11 hours ago
$241
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Tue, May 20 from Myrtle Beach to St. Louis, returning Thu, May 22, priced at $241 found 11 hours ago
Flights from Myrtle Beach (MYR) to St. Louis (STL)
Origin airport
Myrtle Beach Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$196
Distance
726 mi

Myrtle Beach to St. Louis Flights

The cheapest times to fly from Myrtle Beach to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to St. Louis are during the month of June. You can find some of the cheapest flights from Myrtle Beach to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to St. Louis

Sunday is one of the best days to book for cheap flights from Myrtle Beach to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $99 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Cheap round-trip fares from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) start at $397. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Southwest Airlines flight leaving MYR on May 17 2025 and touching down at STL. The price was last updated on April 28 2025 and has not changed since.
What is the cheapest month to fly from MYR to STL?
The cheapest flights from MYR to STL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MYR to STL?
With prices starting from $199 for a one-way journey from MYR to STL, Southwest Airlines is currently the cheapest airline for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MYR on June 21 2025. Prices were last updated on April 28 2025 and have not changed since.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with Expedia’s filter tool. Enter your travel details and choose either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from MYR to STL?
Usually you’ll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from MYR to STL?
Consider traveling with United Airlines if you’d like to fly straight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) without any delays. This carrier has the strongest track record for punctuality, with an on-time score of 100%. Want to get notified of any changes? You can check your flight status using the Expedia App.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute bookings from MYR to STL are typically more expensive. To secure the best rates, start looking for flights ahead of time. That said, if your travel plans are flexible, you may find a cheap ticket right before you leave.
Is it cheaper to book a MYR to STL flight and hotel package?
Securing a MYR to STL flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our impressive range of stays and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your MYR to STL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you’d like more information.

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*Available to One Key members.