$103 Cheap Flights from Myrtle Beach (MYR) to St. Louis (STL)

View $103 flight on Tue, Nov 4, 2025Opens in a new window

Popular airlines from Myrtle Beach Intl. Airport (MYR) to St. Louis Lambert Intl. Airport (STL)

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Cheap Flights from Myrtle Beach to St. Louis (MYR-STL)

Prices were available within the past 7 days and start at $103 for one-way flights and $201 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Thu, Aug 28 - Sun, Aug 31
MYR
Myrtle Beach
STL
St. Louis
$201 Roundtrip, found 3 days ago
$201
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Sun, Aug 31, priced at $201 found 3 days ago
American Airlines
Sat, Aug 30 - Sun, Aug 31
MYR
Myrtle Beach
STL
St. Louis
$205 Roundtrip, found 2 days ago
$205
Roundtrip
found 2 days ago
Select American Airlines flight, departing Sat, Aug 30 from Myrtle Beach to St. Louis, returning Sun, Aug 31, priced at $205 found 2 days ago
Southwest Airlines
Thu, Aug 28 - Sun, Aug 31
MYR
Myrtle Beach
STL
St. Louis
$206 Roundtrip, found 3 days ago
$206
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Sun, Aug 31, priced at $206 found 3 days ago
Spirit Airlines
Sat, Nov 1 - Tue, Nov 4
MYR
Myrtle Beach
STL
St. Louis
$211 Roundtrip, found 2 days ago
$211
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Sat, Nov 1 from Myrtle Beach to St. Louis, returning Tue, Nov 4, priced at $211 found 2 days ago
Southwest Airlines
Thu, Aug 28 - Sun, Aug 31
MYR
Myrtle Beach
STL
St. Louis
$212 Roundtrip, found 3 days ago
$212
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Sun, Aug 31, priced at $212 found 3 days ago
Southwest Airlines
Thu, Aug 28 - Mon, Sep 1
MYR
Myrtle Beach
STL
St. Louis
$220 Roundtrip, found 12 hours ago
$220
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Mon, Sep 1, priced at $220 found 12 hours ago
American Airlines
Thu, Aug 28 - Mon, Sep 1
MYR
Myrtle Beach
STL
St. Louis
$220 Roundtrip, found 12 hours ago
$220
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Mon, Sep 1, priced at $220 found 12 hours ago
Southwest Airlines
Thu, Aug 28 - Mon, Sep 1
MYR
Myrtle Beach
STL
St. Louis
$225 Roundtrip, found 12 hours ago
$225
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Thu, Aug 28 from Myrtle Beach to St. Louis, returning Mon, Sep 1, priced at $225 found 12 hours ago
Delta
Mon, Aug 25 - Tue, Sep 2
MYR
Myrtle Beach
STL
St. Louis
$227 Roundtrip, found 3 days ago
$227
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Aug 25 from Myrtle Beach to St. Louis, returning Tue, Sep 2, priced at $227 found 3 days ago
United
Thu, Sep 4 - Sat, Sep 6
MYR
Myrtle Beach
STL
St. Louis
$232 Roundtrip, found 6 days ago
$232
Roundtrip
found 6 days ago
Select United flight, departing Thu, Sep 4 from Myrtle Beach to St. Louis, returning Sat, Sep 6, priced at $232 found 6 days ago

Find the cheapest month to fly from Myrtle Beach (MYR) to St. Louis (STL)

September is typically the cheapest month to fly

From $158 - $416 per traveler.

Graph displaying average flight prices per month

Alternative airports near St. Louis

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Lambert-St. Louis Intl. STL. Cheapest option available. Average driving time to city center is 20 minutes. Flights from $336
STL
Lambert-St. Louis Intl.
Cheapest
Average driving time to city center20 min
Flights from $336
Flights from Myrtle Beach (MYR) to St. Louis (STL)
Origin airport
Myrtle Beach Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, Spirit Airlines, United
Roundtrip price
$201
Distance
726 mi
Average flight time
2 hours 5 mins

Myrtle Beach to St. Louis Flights

The cheapest times to fly from Myrtle Beach to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to St. Louis are during the month of August. You can find some of the cheapest flights from Myrtle Beach to St. Louis with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Myrtle Beach to St. Louis

Sunday is one of the best days to book for cheap flights from Myrtle Beach to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Myrtle Beach to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $103 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) cost?
Grab a cheap one-way flight from $103 or cheap return flight from $201 from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
August is the most affordable month to fly from MYR to STL. Avoiding peak travel times is often the key to landing a great deal.
What is the cheapest airline that flies from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from MYR to STL. Then, sort your results by "Price (lowest to highest)" to snag a good deal.
How many flights per day from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
Nonstop flights from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filter tool. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from MYR to STL?
Usually you'll find the widest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* However, this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What airline has the least delays from MYR to STL?
Consider traveling with United Airlines if you'd like to fly straight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) without any delays. This carrier has the strongest track record for punctuality, with an on-time score of 100%. Want to get notified of any changes? You can check your flight status using the Expedia App.
What is the best time to fly from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
To avoid possible delays on the Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) route, aim to fly before 3 PM. Departures after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute bookings from MYR to STL are typically more expensive. To secure the best rates, start looking for flights ahead of time. That said, if your travel plans are flexible, you may find a cheap ticket right before you leave.
Is it cheaper to book a MYR to STL flight and hotel package?
Securing a MYR to STL flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our impressive range of stays and then add car rentals, flights and activities to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Myrtle Beach Intl. Airport (MYR) to Lambert-St. Louis Intl. Airport (STL)?
If you reserved your MYR to STL flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

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*Available to One Key members.