$159 Cheap Alaska Airlines flights St. Louis (STL) to San Francisco (SFO)

Grab cheap round-trip Alaska Airlines flights from $296 from STL to SFO by organizing your results from “Price (lowest to highest)” on Expedia. Or look for deals from $159 for a one-way trip.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Alaska Airlines flights to San Francisco tend to be more affordable in the off-peak months of February and April. Whether you’re after a one-way or a return ticket, you could find a better deal then.

Search for cheap Alaska Airlines flights from Lambert-St. Louis Intl. Airport (STL) to San Francisco Intl. Airport (SFO) one to three months ahead of your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the ideal day to book a domestic flight is generally Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To figure out if there’s a direct route from STL to SFO with Alaska Airlines or another carrier, use our “Nonstop” filter when searching for flights.

Find Alaska Airlines’s earliest flights from STL to SFO by using our “Early Morning” and “Morning” filters. Not only will you arrive sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

Alaska Airlines flights from Lambert-St. Louis Intl. Airport (STL) to San Francisco land at San Francisco Intl. Airport (SFO). This is the main entry point to this city.

Offering a rewarding loyalty program and top-tier customer service, Alaska Airlines is the leading choice for many passengers flying from STL to SFO. Also, if you’re a Mileage Plan and One Key™ member booking with Expedia, you could earn OneKeyCash™* on eligible flights on top of your airline miles, which can be put toward future trips.*OneKeyCash™ disclaimer - OneKeyCash™ is not redeemable for cash and can only be used on Expedia, Hotels.com and Vrbo.

Changes are generally free within 24 hours of making your booking, but your airline may charge a fee after that. For further details about modifying your reservation, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the flexibility to change your plans without being charged, tick the “No cancel fee” or “Changes included” filter when planning your next adventure.