$144 Cheap American Airlines flights Des Moines (DSM) to San Diego (SAN)

Set the “Price (lowest to highest)” filter on Expedia to find cheap American Airlines return flights from $287 from DSM to SAN. Affordable one-way options from $144 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are typically more affordable in the quieter months of January and November. Whether you’re searching for a one-way or a return ticket, you could find a better deal then.

Search for affordable American Airlines flights from Des Moines Intl. Airport (DSM) to San Diego Intl. Airport (SAN) one to three months before your day of departure. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare type and itinerary, the ideal day to book a domestic flight is usually Sunday and the most expensive day is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To see if there’s a direct journey from DSM to SAN with American Airlines or another carrier, check the “Nonstop” box when browsing for tickets.

Browse American Airlines’s earliest flights from DSM to SAN by selecting our “Early Morning” and “Morning” filters. Not only will you get to your destination sooner, early departures also experience 20% fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Des Moines Intl. Airport (DSM) to San Diego land at San Diego Intl. Airport (SAN). This is the main entry point to this destination.

Depending on your ticket type, a fee generally applies if you modify or cancel your flight more than 24 hours after it’s confirmed. To find plane tickets with more flexibility, select our “Changes included” and “No cancel fee” boxes while searching for flights. For more details on modifying or canceling your reservation, head to “Trips,” select your flight and click on “Manage Booking.”