$151 Cheap American Airlines flights Syracuse (SYR) to San Diego (SAN)

Use the “Price (lowest to highest)” filter on Expedia to search for cheap American Airlines return flights from $297 from SYR to SAN. Affordable one-way fares from $151 are available as well.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego are generally more affordable in the off-peak months of January and November. Whether you need a return or one-way ticket, you could find a better deal then.

Start searching one to three months before your departure to score cheaper fares on American Airlines flights from Hancock Intl. Airport (SYR) to San Diego Intl. Airport (SAN). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic trips.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

To figure out if there’s a direct journey from SYR to SAN with American Airlines or any other carriers, check the “Nonstop” filter when browsing for flights.

To find the earliest departures from SYR to SAN with American Airlines, filter your results by “Early Morning” and “Morning.” Booking an early flight generally means you’ll experience fewer cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Diego Intl. Airport (SAN) is the primary San Diego hub for American Airlines flights from Hancock Intl. Airport (SYR).

Depending on the type of fare you purchased, a fee is typically charged if you cancel or reschedule your booking more than 24 hours after it’s been confirmed. To find flexible fares, select our “Changes included” and “No cancel fee” boxes when searching for flights. For more information on changing or canceling your reservation, go to “Trips,” select your flight and tick “Manage Booking.”