$173 Cheap American Airlines flights Harrisburg (MDT) to San Diego (SAN)

You can find cheap round-trip American Airlines flights from $319 from MDT to SAN by filtering your results from “Price (lowest to highest)” on Expedia. Or look for bargains from $173 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego tend to be cheaper in the off-peak months of January and November. Whether you’re searching for a one-way or a return ticket, you could find a better deal then.

For cheap American Airlines fares from Harrisburg Intl. Airport (MDT) to San Diego Intl. Airport (SAN), start searching one to three months before your planned departure. Reserving domestic flights 34 to 86 days in advance could save you 25% compared to booking just 6 to 12 days ahead. The day you book can also impact what you pay. Sunday is generally the most affordable, while Monday is often the most expensive for domestic flights. You can save 6% on average by booking your flight on a Sunday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Use our “Nonstop” filter when searching for direct American Airlines flights from MDT to SAN. It’s also a good way to compare other carriers offering the same nonstop route.

Search American Airlines’s earliest flights from MDT to SAN by using our “Early Morning” and “Morning” filters. Not only will you get to your destination sooner, early departures are also 20% less likely to be canceled.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Diego Intl. Airport (SAN) is the primary San Diego gateway for American Airlines flights from Harrisburg Intl. Airport (MDT).

Depending on your fare type, a fee typically applies if you cancel or reschedule your booking more than 24 hours after it has been confirmed. To secure flexible fares, select our “Changes included” and “No cancel fee” boxes when you look for flights. For additional information on canceling or modifying your reservation, visit “Trips,” select your flight and tick “Manage Booking.”