$157 Cheap American Airlines flights Myrtle Beach (MYR) to San Diego (SAN)

You’ll find affordable round-trip American Airlines flights from $313 from MYR to SAN by sorting your results from “Price (lowest to highest)” on Expedia. Or search for bargains from $157 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the most affordable months to jet away to San Diego with American Airlines. You could also find excellent prices on one-way and round-trip tickets in November.

Begin your search one to three months ahead of your departure date to get cheap fares on American Airlines flights from Myrtle Beach Intl. Airport (MYR) to San Diego Intl. Airport (SAN). You can save 25% by booking your domestic flight 34 to 86 days in advance compared to last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Get the timing right, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Simply enter your dates, hit search and use the “Nonstop” filter on Expedia to find any direct flights from MYR to SAN with American Airlines or other carriers.

Filter your results by “Morning” and “Early Morning” to browse the earliest flights from MYR to SAN. Taking off early means you’re 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

San Diego Intl. Airport (SAN) is the primary San Diego hub for American Airlines flights from Myrtle Beach Intl. Airport (MYR).

Changes are generally free within 24 hours of making a booking, but your airline may charge you after that. For more details about modifying your reservation, go to your “Trips,” select your flight and click on “Manage Booking.” If you want the freedom to update your itinerary without additional costs, apply the “Changes included” and “No cancel fee” filters when planning your next trip.