$169 Cheap American Airlines flights Myrtle Beach (MYR) to San Francisco (SFO)

Landing cheap one-way American Airlines flights from MYR to SFO from $169 on Expedia couldn't be easier --- just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares from $337 for your next exciting adventure.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Search for cheap American Airlines flights from Myrtle Beach Intl. Airport (MYR) to San Francisco Intl. Airport (SFO) one to three months before your departure day. Travelers who book domestic flights 34 to 86 days in advance can save 25% compared to those who book just 6 to 12 days ahead. No matter the fare class and journey, the ideal day to book a domestic flight is usually Sunday and the most expensive is typically Monday. Passengers who book on a Sunday can save 6% on average compared to those who book their travel on a Monday.**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to browse the earliest flights from MYR to SFO. Leaving early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.