$109 Cheap American Airlines flights Medford (MFR) to San Diego (SAN)

You’ll discover cheap return American Airlines flights from $230 from MFR to SAN by organizing your results from “Price (lowest to highest)” on Expedia. Or search for bargains from $109 for a one-way journey.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

American Airlines flights to San Diego tend to be more affordable in the off-peak months of January and November. Whether you’re in search of a round-trip or one-way ticket, you could find a better deal then.

Start searching one to three months before your departure to score cheap fares on American Airlines flights from Rogue Valley Intl. Airport (MFR) to San Diego Intl. Airport (SAN). You can save 25% by booking your domestic flight 34 to 86 days in advance versus last-minute reservations made 6 to 12 days out. You could also cut costs by buying your fare on a Sunday, as it’s 6% cheaper on average than a Monday, the most expensive day to book.* Time it well, and you can enjoy significant savings on domestic flights.*Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC’s global airline sales database.

Click on the “Nonstop” filter when looking for direct American Airlines flights from MFR to SAN. It’s also an easy way to compare other airlines offering the same direct route.

To find the earliest departure from MFR to SAN with American Airlines, filter your search by “Early Morning” and “Morning.” Choosing an early flight generally means cancellations are less likely.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.

American Airlines flights from Rogue Valley Intl. Airport (MFR) to San Diego land at San Diego Intl. Airport (SAN). This is the main gateway to this destination.

It’s generally possible to modify or cancel your flight, although additional charges may apply if you booked over 24 hours ago. Want to keep your options open? Make use of Expedia’s “Changes included” or “No cancel fee” filter to find flights that won’t charge you extra if you need to revise your plans. To update your itinerary, visit “Trips,” select your flight and click on “Manage Booking” for more information.