$819 Cheap American Airlines flights Lyon (LYS) to San Diego (SAN)

Apply the "Price (lowest to highest)" filter on Expedia to find cheap American Airlines round-trip flights from $1,131 from LYS to SAN. Affordable one-way options from $819 are also available.**These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

To get cheap flights from LYS to SAN with American Airlines, start your search about one month before your planned departure. You can save 17% when you lock in your international tickets 18 to 29 days ahead instead of booking four to five months in advance. Another tip? Booking on Sunday offers average savings of 17% compared to Friday (the most expensive day).**Ideal booking window recommendation is based on average round-trip ticket prices for January through November for 2024. Best day of the week to book recommendation is based on average round-trip ticket prices for January through October 2024. All data sourced from ARC's global airline sales database.

Filter your results by "Morning" and "Early Morning" to browse the earliest departures from LYS to SAN. Taking off early means you're 20% less likely to experience cancellations.**Most reliable time of the day recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.