$257 Cheap Flights from Cheyenne (CYS) to Des Moines (DSM)

Book with confidence

Cheyenne to Des Moines Flights

The cheapest times to fly from Cheyenne to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Cheyenne to Des Moines are during the month of November. You can find some of the cheapest flights from Cheyenne to Des Moines with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Cheyenne to Des Moines

Sunday is one of the best days to book for cheap flights from Cheyenne to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Cheyenne to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Cheyenne to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $257 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Cheyenne to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Cheyenne to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently Asked Questions

How much does a flight from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) cost?

You can find cheap one-way flights from $257 and cheap return flights $419 Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights typically cost between $136 and $424, and return flights often range between $273 and $1025. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.

*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.

What is the cheapest month to fly from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

The cheapest month to fly from CYS to DSM is November when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.

Which airlines fly direct from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

Enter CYS to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.

What is the cheapest airline that flies from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

United is one of the cheapest airlines offering connecting flights from Cheyenne, WY (CYS) to Des Moines, IA (DSM), with round-trip tickets starting from around $273. This flight includes a layover in Denver Intl. (DEN). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.

*Prices based on flights available on Expedia in the last year.

How do I find cheap flights from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

To find a cheap flight from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.

What is the best time to fly from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.

What is the earliest flight from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

The earliest flight from Cheyenne Regional (CYS) to Des Moines Intl. (DSM) usually departs at around 6:00 AM, operated by United Airlines. This flight is part of a seasonal service active in May, allowing you to start your day early and make the most of your time in Des Moines. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.

What are the most popular departure times for flights from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

The most popular departure times for flights from Cheyenne (CYS) to Des Moines (DSM) are in the morning, from 6am to 9am. About 66% of passengers prefer this time window. Many major carriers, including United Airlines, offer flights during this window. This timing is popular because it allows travelers to arrive in Des Moines early and make the most of their day.

How long does it take to fly from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

Flying from CYS to DSM with a connection usually takes about 5 hours 50 minutes, traveling roughly 580 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.

Can you fly business or first class from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

Select the "Business class" and "First class" filters when looking for CYS to DSM flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.

How do I earn miles on a Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?

It's easy to earn miles on a Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.

*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.

What airports do you fly into for Des Moines from Cheyenne Regional (CYS)?

From Cheyenne Regional (CYS), you can fly into Des Moines Intl. (DSM) to reach Des Moines. Some flights may connect through major hubs like Denver Intl. (DEN) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.

Is it cheaper to buy a plane ticket from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?

Typically, booking a last minute flight from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.

Is it cheaper to book a Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?

Securing a Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.

Can I cancel or change the date of my flight from Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.)?

If you booked your Cheyenne, WY (CYS-Cheyenne Regional) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.