$126 Cheap Flights from Louisville (SDF) to Des Moines (DSM)

View $126 flight on Sun, Jan 18, 2026Opens in a new window

Popular airlines from Louisville Intl. Airport (SDF) to Des Moines International Airport (DSM)

Cheap Flights from Louisville to Des Moines (SDF-DSM)

Prices were available within the past 7 days and start at $126 for one-way flights and $223 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sun, Jan 18 - Tue, Jan 20
SDF
Louisville
DSM
Des Moines
$223 Roundtrip, found 3 days ago
$223
Roundtrip
found 3 days ago
Select Delta flight, departing Sun, Jan 18 from Louisville to Des Moines, returning Tue, Jan 20, priced at $223 found 3 days ago
Delta
Thu, Jan 1 - Tue, Jan 20
SDF
Louisville
DSM
Des Moines
$233 Roundtrip, found 4 days ago
$233
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Jan 1 from Louisville to Des Moines, returning Tue, Jan 20, priced at $233 found 4 days ago
Delta
Sun, Jan 18 - Mon, Feb 2
SDF
Louisville
DSM
Des Moines
$242 Roundtrip, found 4 days ago
$242
Roundtrip
found 4 days ago
Select Delta flight, departing Sun, Jan 18 from Louisville to Des Moines, returning Mon, Feb 2, priced at $242 found 4 days ago
United
Wed, Dec 31 - Mon, Jan 5
SDF
Louisville
DSM
Des Moines
$244 Roundtrip, found 5 days ago
$244
Roundtrip
found 5 days ago
Select United flight, departing Wed, Dec 31 from Louisville to Des Moines, returning Mon, Jan 5, priced at $244 found 5 days ago
United
Thu, Nov 27 - Sat, Nov 29
SDF
Louisville
DSM
Des Moines
$245 Roundtrip, found 5 days ago
$245
Roundtrip
found 5 days ago
Select United flight, departing Thu, Nov 27 from Louisville to Des Moines, returning Sat, Nov 29, priced at $245 found 5 days ago
Delta
Mon, Nov 24 - Tue, Dec 2
SDF
Louisville
DSM
Des Moines
$247 Roundtrip, found 1 day ago
$247
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Nov 24 from Louisville to Des Moines, returning Tue, Dec 2, priced at $247 found 1 day ago
American Airlines
Sun, Jan 18 - Wed, Jan 21
SDF
Louisville
DSM
Des Moines
$251 Roundtrip, just found
$251
Roundtrip
just found
Select American Airlines flight, departing Sun, Jan 18 from Louisville to Des Moines, returning Wed, Jan 21, priced at $251 just found
United
Sun, Jan 18 - Wed, Jan 21
SDF
Louisville
DSM
Des Moines
$251 Roundtrip, just found
$251
Roundtrip
just found
Select United flight, departing Sun, Jan 18 from Louisville to Des Moines, returning Wed, Jan 21, priced at $251 just found
American Airlines
Wed, Dec 31 - Mon, Jan 5
SDF
Louisville
DSM
Des Moines
$253 Roundtrip, found 5 days ago
$253
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Dec 31 from Louisville to Des Moines, returning Mon, Jan 5, priced at $253 found 5 days ago
Southwest Airlines
Wed, Dec 10 - Mon, Dec 15
SDF
Louisville
DSM
Des Moines
$256 Roundtrip, found 1 day ago
$256
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Wed, Dec 10 from Louisville to Des Moines, returning Mon, Dec 15, priced at $256 found 1 day ago

Find the cheapest month to fly from Louisville (SDF) to Des Moines (DSM)

August is typically the cheapest month to fly

From $158 - $446 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $367
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $367

Frequently asked questions

How much does a flight from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $126 or cheap return flight from $223 from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
The cheapest month to fly from SDF to DSM is January, when there's less demand. Off-peak season is typically when better flight deals are available between these airports.
What is the cheapest airline that flies from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
Use the filter tool on Expedia to compare different airlines and find the cheapest carrier that'll fly you from SDF to DSM. Then, sort your results by "Price (lowest to highest)" to score the best deal available.
How many flights per day from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
There aren't any daily nonstop flights from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from SDF to DSM?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary based on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) route, fly before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until right before your break to book a flight from SDF to DSM generally means paying more. While you may find some last-minute discounts, they're not always guaranteed. Keep your travel schedule open for the best chance of scoring a bargain.
Is it cheaper to book a SDF to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a SDF to DSM flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the stress out of travel planning. Just pick your flights and select from our wide range of hotels, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
If you booked your SDF to DSM flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Travel information

Origin airport
Louisville Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$222
Distance
478 mi

Book with confidence

Louisville to Des Moines Flights

The cheapest times to fly from Louisville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Louisville to Des Moines are during the month of January. You can find some of the cheapest flights from Louisville to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Louisville to Des Moines

Sunday is one of the best days to book for cheap flights from Louisville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Louisville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Louisville to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $126 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Louisville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Louisville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Louisville to Des Moines Flights

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*Available to One Key members.