$49 Cheap Flights from St. Louis (STL) to Des Moines (DSM)

View $49 flight on Thu, Oct 9, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Des Moines International Airport (DSM)

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Cheap Flights from St. Louis to Des Moines (STL-DSM)

Prices were available within the past 7 days and start at $49 for one-way flights and $109 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Wed, Oct 15 - Mon, Oct 20
STL
St. Louis
DSM
Des Moines
$109 Roundtrip, found 3 days ago
$109
Roundtrip
found 3 days ago
Select United flight, departing Wed, Oct 15 from St. Louis to Des Moines, returning Mon, Oct 20, priced at $109 found 3 days ago
Southwest Airlines
Sat, Nov 15 - Tue, Nov 18
STL
St. Louis
DSM
Des Moines
$117 Roundtrip, found 3 days ago
$117
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Sat, Nov 15 from St. Louis to Des Moines, returning Tue, Nov 18, priced at $117 found 3 days ago
Southwest Airlines
Wed, Oct 8 - Sat, Oct 11
STL
St. Louis
DSM
Des Moines
$124 Roundtrip, found 6 days ago
$124
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Oct 8 from St. Louis to Des Moines, returning Sat, Oct 11, priced at $124 found 6 days ago
Southwest Airlines
Wed, Oct 8 - Sat, Oct 11
STL
St. Louis
DSM
Des Moines
$127 Roundtrip, found 6 days ago
$127
Roundtrip
found 6 days ago
Select Southwest Airlines flight, departing Wed, Oct 8 from St. Louis to Des Moines, returning Sat, Oct 11, priced at $127 found 6 days ago
American Airlines
Wed, Oct 15 - Mon, Oct 20
STL
St. Louis
DSM
Des Moines
$130 Roundtrip, found 3 days ago
$130
Roundtrip
found 3 days ago
Select American Airlines flight, departing Wed, Oct 15 from St. Louis to Des Moines, returning Mon, Oct 20, priced at $130 found 3 days ago
American Airlines
Fri, Dec 12 - Mon, Dec 15
STL
St. Louis
DSM
Des Moines
$131 Roundtrip, found 3 days ago
$131
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 12 from St. Louis to Des Moines, returning Mon, Dec 15, priced at $131 found 3 days ago
Southwest Airlines
Thu, Nov 27 - Tue, Dec 2
STL
St. Louis
DSM
Des Moines
$134 Roundtrip, found 7 hours ago
$134
Roundtrip
found 7 hours ago
Select Southwest Airlines flight, departing Thu, Nov 27 from St. Louis to Des Moines, returning Tue, Dec 2, priced at $134 found 7 hours ago
United
Wed, Oct 15 - Mon, Oct 20
STL
St. Louis
DSM
Des Moines
$140 Roundtrip, found 3 days ago
$140
Roundtrip
found 3 days ago
Select United flight, departing Wed, Oct 15 from St. Louis to Des Moines, returning Mon, Oct 20, priced at $140 found 3 days ago
Delta
Wed, Nov 19 - Sat, Dec 6
STL
St. Louis
DSM
Des Moines
$177 Roundtrip, found 7 hours ago
$177
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, Nov 19 from St. Louis to Des Moines, returning Sat, Dec 6, priced at $177 found 7 hours ago
Frontier Airlines
Wed, Oct 1 - Wed, Oct 15
STL
St. Louis
DSM
Des Moines
$264 Roundtrip, found 2 days ago
$264
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Oct 1 from St. Louis to Des Moines, returning Wed, Oct 15, priced at $264 found 2 days ago

Find the cheapest month to fly from St. Louis (STL) to Des Moines (DSM)

September is typically the cheapest month to fly

From $96 - $528 per traveler.

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM) cost?
Secure a cheap one-way flight from $49 or cheap return flight from $109 from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight deals on this route.
What is the cheapest month to fly from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
The cheapest month to fly from STL to DSM is October, when there's less demand. Off-peak season is generally when airlines offer better prices between these airports.
Which airlines fly direct from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
If you're departing from Lambert-St. Louis Intl. Airport (STL), you can catch a nonstop flight to Des Moines Intl. Airport (DSM) with Southwest Airlines.
What is the cheapest airline that flies from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from STL to DSM, use Expedia's filter tool. Customize your search based on what's important to you, such as preferred carriers and cabin class. You can then sort your results by "Price (lowest to highest)" to discover the cheapest flight right away.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
On average, just 1 nonstop flight departs each day from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM). Want additional options? Use our filters to discover flights with layovers and explore a new city along the way.
What are the most popular departure times for flights from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
Flights between STL and DSM tend to be busiest at 11 AM. If you'd like a less crowded experience and potentially cheaper tickets, choose a time when demand is lower.
What day of the week has the most flights from STL to DSM?
If you travel on a Friday, you'll get the biggest range of choices for flights from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM).
What is the earliest flight from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
The first flight of the day out of Lambert-St. Louis Intl. Airport (STL) is at around 9:25AM UTC-6. Catch this flight and you'll reach Des Moines Intl. Airport (DSM) at approximately 10:35AM UTC-6. The entire trip takes 1h 10m.
How long does it take to fly from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
Typically, it takes 1 hour and 10 minutes to cover the 260 mi from STL to DSM.
What airline has the least delays from STL to DSM?
Southwest Airlines has the strongest track record for on-time direct flights from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM), with an on-time score of 83%. Use the Expedia App to look up your journey status before you go and receive notifications about any changes.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM) route, fly before 3 PM. Later departures have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Des Moines from Lambert-St. Louis Intl. Airport (STL)?
Des Moines Intl. Airport (DSM) is the only airport in Des Moines with direct flights from Lambert-St. Louis Intl. Airport (STL). Explore the options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from STL to DSM are usually more expensive. For the best rates, start searching for flights as soon as possible. That being said, if you're flexible with your travel dates, it's possible to land a cheap fare right before your journey.
Is it cheaper to book a STL to DSM flight and hotel package?
Opting for a STL to DSM flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your trip in one place. Choose from our wide range of stays and then add flights, car rentals and activities to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Des Moines Intl. Airport (DSM)?
If you booked your STL to DSM flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

Travel information

Travel information

Origin airport
Lambert-St. Louis Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$109
Distance
259 mi
Average flight time
1 hour 7 mins

Book with confidence

Book with confidence

St. Louis to Des Moines Flights

The cheapest times to fly from St. Louis to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Des Moines are during the month of October. You can find some of the cheapest flights from St. Louis to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Des Moines

Sunday is one of the best days to book for cheap flights from St. Louis to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $49 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

St. Louis to Des Moines Flights

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