$109 Cheap Flights from Pensacola (PNS) to Des Moines (DSM)

View $109 flight on Tue, Feb 17, 2026Opens in a new window

Popular airlines from Pensacola Intl. Airport (PNS) to Des Moines International Airport (DSM)

Cheap Flights from Pensacola to Des Moines (PNS-DSM)

Prices were available within the past 7 days and start at $109 for one-way flights and $217 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Dec 3 - Sat, Dec 6
PNS
Pensacola
DSM
Des Moines
$217 Roundtrip, found 4 days ago
$217
Roundtrip
found 4 days ago
Select American Airlines flight, departing Wed, Dec 3 from Pensacola to Des Moines, returning Sat, Dec 6, priced at $217 found 4 days ago
Delta
Wed, Dec 3 - Sat, Dec 6
PNS
Pensacola
DSM
Des Moines
$222 Roundtrip, found 4 days ago
$222
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 3 from Pensacola to Des Moines, returning Sat, Dec 6, priced at $222 found 4 days ago
Frontier Airlines
Sat, Nov 8 - Thu, Nov 13
PNS
Pensacola
DSM
Des Moines
$230 Roundtrip, found 4 days ago
$230
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sat, Nov 8 from Pensacola to Des Moines, returning Thu, Nov 13, priced at $230 found 4 days ago
Delta
Wed, Dec 3 - Sat, Dec 6
PNS
Pensacola
DSM
Des Moines
$256 Roundtrip, found 4 days ago
$256
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Dec 3 from Pensacola to Des Moines, returning Sat, Dec 6, priced at $256 found 4 days ago
Delta
Sat, Dec 6 - Mon, Dec 8
PNS
Pensacola
DSM
Des Moines
$265 Roundtrip, found 4 days ago
$265
Roundtrip
found 4 days ago
Select Delta flight, departing Sat, Dec 6 from Pensacola to Des Moines, returning Mon, Dec 8, priced at $265 found 4 days ago
Delta
Wed, Feb 18 - Sat, Feb 28
PNS
Pensacola
DSM
Des Moines
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Feb 18 from Pensacola to Des Moines, returning Sat, Feb 28, priced at $267 found 1 day ago
Delta
Thu, Dec 4 - Sat, Dec 6
PNS
Pensacola
DSM
Des Moines
$270 Roundtrip, found 4 days ago
$270
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Dec 4 from Pensacola to Des Moines, returning Sat, Dec 6, priced at $270 found 4 days ago
Delta
Tue, Feb 3 - Tue, Feb 17
PNS
Pensacola
DSM
Des Moines
$272 Roundtrip, found 1 day ago
$272
Roundtrip
found 1 day ago
Select Delta flight, departing Tue, Feb 3 from Pensacola to Des Moines, returning Tue, Feb 17, priced at $272 found 1 day ago
United
Thu, Dec 11 - Sat, Jan 17
PNS
Pensacola
DSM
Des Moines
$296 Roundtrip, found 17 hours ago
$296
Roundtrip
found 17 hours ago
Select United flight, departing Thu, Dec 11 from Pensacola to Des Moines, returning Sat, Jan 17, priced at $296 found 17 hours ago
Southwest Airlines
Thu, Dec 11 - Sat, Jan 17
PNS
Pensacola
DSM
Des Moines
$302 Roundtrip, found 17 hours ago
$302
Roundtrip
found 17 hours ago
Select Southwest Airlines flight, departing Thu, Dec 11 from Pensacola to Des Moines, returning Sat, Jan 17, priced at $302 found 17 hours ago

Find the cheapest month to fly from Pensacola (PNS) to Des Moines (DSM)

September is typically the cheapest month to fly

From $169 - $718 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $462
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $462

Frequently asked questions

How much does a flight from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $109 or cheap return flight from $217 from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight deals on this route.
What is the cheapest month to fly from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM)?
Planning your trip for December can help you save, as it's the cheapest month for flights between PNS and DSM. You'll usually find the lowest fares during off-peak months.
What is the cheapest airline that flies from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare different airlines, travel time and fares all in one place. Select your preferences, then sort by "Price (lowest to highest)" to find out which carrier offers the cheapest PNS to DSM flight.
How many flights per day from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM)?
You'll need to hop on a flight with a layover when traveling from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM). Direct flights don't operate daily on this route. However, simply filter your search to include one or two stops to discover the best option for your trip.
What day of the week has the most flights from PNS to DSM?
You'll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM) route, aim to travel before 3 PM. Flights after this time have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM) last-minute?
Booking your plane ticket from PNS to DSM just before your getaway is typically more expensive. However, if there's some wiggle room with your departure times and dates, you could bag a cheap last-minute fare.
Is it cheaper to book a PNS to DSM flight and hotel package?
Securing a PNS to DSM flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels in one place. Choose from our impressive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Pensacola Intl. Airport (PNS) to Des Moines Intl. Airport (DSM)?
If you booked your PNS to DSM flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

Travel information

Origin airport
Pensacola Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$216
Distance
844 mi

Book with confidence

Pensacola to Des Moines Flights

The cheapest times to fly from Pensacola to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Pensacola to Des Moines are during the month of December. You can find some of the cheapest flights from Pensacola to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Pensacola to Des Moines

Sunday is one of the best days to book for cheap flights from Pensacola to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Pensacola to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Pensacola to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $109 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Pensacola to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Pensacola to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Pensacola to Des Moines Flights

Explore a world of travel with Expedia

*Available to One Key members.