$108 Cheap Flights from Memphis (MEM) to Des Moines (DSM)

View $108 flight on Wed, Nov 12, 2025Opens in a new window

Popular airlines from Memphis International Airport (MEM) to Des Moines International Airport (DSM)

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Cheap Flights from Memphis to Des Moines (MEM-DSM)

Prices were available within the past 7 days and start at $108 for one-way flights and $215 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Oct 21 - Wed, Oct 22
MEM
Memphis
DSM
Des Moines
$215 Roundtrip, just found
$215
Roundtrip
just found
Select Delta flight, departing Tue, Oct 21 from Memphis to Des Moines, returning Wed, Oct 22, priced at $215 just found
Southwest Airlines
Wed, Nov 5 - Wed, Nov 12
MEM
Memphis
DSM
Des Moines
$220 Roundtrip, found 23 hours ago
$220
Roundtrip
found 23 hours ago
Select Southwest Airlines flight, departing Wed, Nov 5 from Memphis to Des Moines, returning Wed, Nov 12, priced at $220 found 23 hours ago
Southwest Airlines
Wed, Nov 5 - Wed, Nov 12
MEM
Memphis
DSM
Des Moines
$225 Roundtrip, found 23 hours ago
$225
Roundtrip
found 23 hours ago
Select Southwest Airlines flight, departing Wed, Nov 5 from Memphis to Des Moines, returning Wed, Nov 12, priced at $225 found 23 hours ago
Delta
Tue, Oct 21 - Mon, Oct 27
MEM
Memphis
DSM
Des Moines
$229 Roundtrip, just found
$229
Roundtrip
just found
Select Delta flight, departing Tue, Oct 21 from Memphis to Des Moines, returning Mon, Oct 27, priced at $229 just found
Southwest Airlines
Wed, Nov 5 - Wed, Nov 12
MEM
Memphis
DSM
Des Moines
$230 Roundtrip, found 23 hours ago
$230
Roundtrip
found 23 hours ago
Select Southwest Airlines flight, departing Wed, Nov 5 from Memphis to Des Moines, returning Wed, Nov 12, priced at $230 found 23 hours ago
Delta
Tue, Oct 21 - Sat, Oct 25
MEM
Memphis
DSM
Des Moines
$233 Roundtrip, just found
$233
Roundtrip
just found
Select Delta flight, departing Tue, Oct 21 from Memphis to Des Moines, returning Sat, Oct 25, priced at $233 just found
American Airlines
Wed, Nov 5 - Wed, Nov 12
MEM
Memphis
DSM
Des Moines
$238 Roundtrip, found 23 hours ago
$238
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Wed, Nov 5 from Memphis to Des Moines, returning Wed, Nov 12, priced at $238 found 23 hours ago
Delta
Tue, Oct 21 - Fri, Oct 31
MEM
Memphis
DSM
Des Moines
$242 Roundtrip, just found
$242
Roundtrip
just found
Select Delta flight, departing Tue, Oct 21 from Memphis to Des Moines, returning Fri, Oct 31, priced at $242 just found
United
Wed, Nov 12 - Tue, Nov 18
MEM
Memphis
DSM
Des Moines
$251 Roundtrip, found 3 days ago
$251
Roundtrip
found 3 days ago
Select United flight, departing Wed, Nov 12 from Memphis to Des Moines, returning Tue, Nov 18, priced at $251 found 3 days ago
Frontier Airlines
Thu, Oct 2 - Sun, Oct 5
MEM
Memphis
DSM
Des Moines
$344 Roundtrip, found 3 days ago
$344
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Oct 2 from Memphis to Des Moines, returning Sun, Oct 5, priced at $344 found 3 days ago

Find the cheapest month to fly from Memphis (MEM) to Des Moines (DSM)

September is typically the cheapest month to fly

From $174 - $550 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $364
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $364

Frequently asked questions

How much does a flight from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $108 or cheap return flight from $215 from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM)?
October is the most affordable month to fly from MEM to DSM. Traveling during an off-peak travel window is often the key to better flight prices.
What is the cheapest airline that flies from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM)?
Expedia's filter tool lets you easily compare airlines, flight times and fares all in one place. Choose your preferences, then sort by "Price (lowest to highest)" to find the carrier with the cheapest MEM to DSM flight.
How many flights per day from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM)?
There aren't any daily direct flights from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be on your way before you know it.
What day of the week has the most flights from MEM to DSM?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Just remember that flight schedules can change based on various factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM)?
Opt for a flight from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM) last-minute?
Last-minute bookings from MEM to DSM are typically more expensive. To secure the best rates, start looking for flights well in advance. That said, if your travel plans are flexible, it's possible to score a cheap fare right before your trip.
Is it cheaper to book a MEM to DSM flight and hotel package?
Opting for a MEM to DSM flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Pick from our wide range of stays and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Memphis Intl. Airport (MEM) to Des Moines Intl. Airport (DSM)?
In most cases, you can modify or cancel your MEM to DSM flight. However, there may be additional charges, especially if you booked over 24 hours ago. Double-check your itinerary for the airline's rules and fees on flight changes, or if you'd like more information, head to our Customer Service portal.

Travel information

Travel information

Origin airport
Memphis Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$214
Distance
490 mi

Book with confidence

Book with confidence

Memphis to Des Moines Flights

The cheapest times to fly from Memphis to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Memphis to Des Moines are during the month of October. You can find some of the cheapest flights from Memphis to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Memphis to Des Moines

Sunday is one of the best days to book for cheap flights from Memphis to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Memphis to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Memphis to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $108 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Memphis to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Memphis to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Memphis to Des Moines Flights

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*Available to One Key members.