$128 Cheap Flights from Buffalo (BUF) to Des Moines (DSM)

View $128 flight on Tue, Sep 23, 2025Opens in a new window

Popular airlines from Buffalo Niagara Intl. Airport (BUF) to Des Moines International Airport (DSM)

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Cheap Flights from Buffalo to Des Moines (BUF-DSM)

Prices were available within the past 7 days and start at $128 for one-way flights and $255 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Oct 8 - Tue, Oct 21
BUF
Buffalo
DSM
Des Moines
$255 Roundtrip, found 18 hours ago
$255
Roundtrip
found 18 hours ago
Select Delta flight, departing Wed, Oct 8 from Buffalo to Des Moines, returning Tue, Oct 21, priced at $255 found 18 hours ago
United
Tue, Sep 30 - Wed, Oct 8
BUF
Buffalo
DSM
Des Moines
$255 Roundtrip, found 3 days ago
$255
Roundtrip
found 3 days ago
Select United flight, departing Tue, Sep 30 from Buffalo to Des Moines, returning Wed, Oct 8, priced at $255 found 3 days ago
American Airlines
Tue, Sep 30 - Wed, Oct 8
BUF
Buffalo
DSM
Des Moines
$259 Roundtrip, found 3 days ago
$259
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Sep 30 from Buffalo to Des Moines, returning Wed, Oct 8, priced at $259 found 3 days ago
United
Tue, Sep 30 - Wed, Oct 8
BUF
Buffalo
DSM
Des Moines
$260 Roundtrip, found 3 days ago
$260
Roundtrip
found 3 days ago
Select United flight, departing Tue, Sep 30 from Buffalo to Des Moines, returning Wed, Oct 8, priced at $260 found 3 days ago
Southwest Airlines
Sat, Sep 27 - Wed, Oct 1
BUF
Buffalo
DSM
Des Moines
$263 Roundtrip, found 1 day ago
$263
Roundtrip
found 1 day ago
Select Southwest Airlines flight, departing Sat, Sep 27 from Buffalo to Des Moines, returning Wed, Oct 1, priced at $263 found 1 day ago
American Airlines
Sat, Oct 4 - Tue, Oct 7
BUF
Buffalo
DSM
Des Moines
$263 Roundtrip, found 23 hours ago
$263
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Sat, Oct 4 from Buffalo to Des Moines, returning Tue, Oct 7, priced at $263 found 23 hours ago
Delta
Sat, Sep 27 - Wed, Oct 1
BUF
Buffalo
DSM
Des Moines
$267 Roundtrip, found 1 day ago
$267
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, Sep 27 from Buffalo to Des Moines, returning Wed, Oct 1, priced at $267 found 1 day ago
United
Sat, Sep 27 - Wed, Oct 1
BUF
Buffalo
DSM
Des Moines
$268 Roundtrip, found 1 day ago
$268
Roundtrip
found 1 day ago
Select United flight, departing Sat, Sep 27 from Buffalo to Des Moines, returning Wed, Oct 1, priced at $268 found 1 day ago
Southwest Airlines
Sat, Oct 25 - Sat, Nov 1
BUF
Buffalo
DSM
Des Moines
$271 Roundtrip, found 16 hours ago
$271
Roundtrip
found 16 hours ago
Select Southwest Airlines flight, departing Sat, Oct 25 from Buffalo to Des Moines, returning Sat, Nov 1, priced at $271 found 16 hours ago
Frontier Airlines
Sun, Oct 5 - Thu, Oct 23
BUF
Buffalo
DSM
Des Moines
$284 Roundtrip, found 18 hours ago
$284
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sun, Oct 5 from Buffalo to Des Moines, returning Thu, Oct 23, priced at $284 found 18 hours ago

Find the cheapest month to fly from Buffalo (BUF) to Des Moines (DSM)

August is typically the cheapest month to fly

From $211 - $526 per traveler.

Graph displaying average flight prices per month

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $351
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $351
Flights from Buffalo (BUF) to Des Moines (DSM)
Origin airport
Buffalo Niagara Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$254
Distance
768 mi

Buffalo to Des Moines Flights

The cheapest times to fly from Buffalo to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Buffalo to Des Moines are during the month of October. You can find some of the cheapest flights from Buffalo to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Buffalo to Des Moines

Sunday is one of the best days to book for cheap flights from Buffalo to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Buffalo to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Buffalo to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $128 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Buffalo to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Buffalo to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM) cost?
Lock in a cheap one-way flight from $128 or cheap return flight from $255 from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to find our cheapest flight offers on this route.
What is the cheapest month to fly from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM)?
Planning your trip for October is a good way to save, as it's the cheapest month for flights between BUF and DSM. You'll typically find the lowest prices during the off-season.
What is the cheapest airline that flies from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM)?
To find the cheapest airline flying from BUF to DSM, use Expedia's filter tool. Tailor your search based on your travel needs, such as preferred carriers and number of stops. You can then sort your results by "Price (lowest to highest)" to see the most affordable options first.
How many flights per day from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM)?
Direct flights from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM) aren't available daily, so you'll need to take a flight with a layover. Explore your options with Expedia's filters. Enter your travel details and choose either "1 Stop" or "2+ Stops."
What day of the week has the most flights from BUF to DSM?
Usually you'll find the most flight options available on a Friday. Tuesdays are often the quietest.* However, this can vary based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM)?
Book a flight from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM) that leaves before 3 PM to reduce the risk of cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until just before your departure to book a flight from BUF to DSM often results in higher prices. While you might find some last-minute offers, they aren't always guaranteed. Be flexible with your travel plans to boost your chances of snagging a bargain.
Is it cheaper to book a BUF to DSM flight and hotel package?
Booking a BUF to DSM flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Buffalo Niagara Intl. Airport (BUF) to Des Moines Intl. Airport (DSM)?
It's usually possible to cancel or reschedule your BUF to DSM flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Refer to your airline's policies in your itinerary to see what changes are possible and if any costs are involved. You'll also find more details on our Customer Service portal.

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*Available to One Key members.