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$309 Cheap Flights from Syracuse (SYR) to Des Moines (DSM)

View $309 flight on Wed, Nov 25, 2026Opens in a new window

Popular airlines from Hancock Intl. Airport (SYR) to Des Moines International Airport (DSM)

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Cheap Flights from Syracuse to Des Moines (SYR-DSM)

Prices were available within the past 7 days and start at $309 for one-way flights and $329 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$329 Roundtrip, found 9 hours ago
$329
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $329 found 9 hours ago
Delta
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$329 Roundtrip, found 9 hours ago
$329
Roundtrip
found 9 hours ago
Select Delta flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $329 found 9 hours ago
United
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$329 Roundtrip, found 9 hours ago
$329
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $329 found 9 hours ago
American Airlines
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$334 Roundtrip, found 9 hours ago
$334
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $334 found 9 hours ago
United
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$335 Roundtrip, found 9 hours ago
$335
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $335 found 9 hours ago
United
Tue, Oct 20 - Wed, Oct 28
SYR
Syracuse
DSM
Des Moines
$336 Roundtrip, found 18 hours ago
$336
Roundtrip
found 18 hours ago
Select United flight, departing Tue, Oct 20 from Syracuse to Des Moines, returning Wed, Oct 28, priced at $336 found 18 hours ago
United
Tue, Oct 20 - Wed, Oct 28
SYR
Syracuse
DSM
Des Moines
$339 Roundtrip, found 18 hours ago
$339
Roundtrip
found 18 hours ago
Select United flight, departing Tue, Oct 20 from Syracuse to Des Moines, returning Wed, Oct 28, priced at $339 found 18 hours ago
United
Wed, Oct 7 - Sat, Oct 10
SYR
Syracuse
DSM
Des Moines
$341 Roundtrip, found 9 hours ago
$341
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Oct 7 from Syracuse to Des Moines, returning Sat, Oct 10, priced at $341 found 9 hours ago
United
Fri, Oct 2 - Sat, Oct 3
SYR
Syracuse
DSM
Des Moines
$344 Roundtrip, found 1 day ago
$344
Roundtrip
found 1 day ago
Select United flight, departing Fri, Oct 2 from Syracuse to Des Moines, returning Sat, Oct 3, priced at $344 found 1 day ago
Delta
Sun, Dec 13 - Sat, Jan 2
SYR
Syracuse
DSM
Des Moines
$349 Roundtrip, found 15 hours ago
$349
Roundtrip
found 15 hours ago
Select Delta flight, departing Sun, Dec 13 from Syracuse to Des Moines, returning Sat, Jan 2, priced at $349 found 15 hours ago

What you need to know for your flight from Hancock Intl. to Des Moines Intl.

Syracuse (SYR) to Des Moines (DSM) at a glance

Explore a range of options for flights from Syracuse (SYR) to Des Moines (DSM) on this domestic short-haul route. Whether you're looking for full-service airlines or budget-friendly choices, you can compare flights to find the best airfares for your trip. Plan your next flight to Des Moines and enjoy the city's renowned attractions and neighborhoods. Check out the key details for flights departing from Hancock International Airport (SYR) to Des Moines International Airport (DSM).

  • Fastest flight duration: around 3h 45m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 900 miles (1,450 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $120–$405, depending on seasonality and how far ahead you book

Flights from Hancock International Airport (SYR) to Des Moines International Airport (DSM)

Based on the latest traveler bookings, here are the most popular airlines flying from Syracuse to Des Moines, often selected for their one-stop services. Common layover airports include O'Hare International Airport, ORD (approximately 1 hour and 15 minutes), Detroit Metropolitan Wayne County Airport, DTW (about 1 hour), and LaGuardia Airport, LGA (around 3 hours and 15 minutes). These options allow you to balance price, total travel time, and cabin class to find the itinerary that best suits your needs.

  • Delta: As a leading full-service airline, Delta provides one-stop service with one-way ticket prices generally between $125 and $395. This carrier represents about 44% of departures on this route, featuring an in-flight duration of 3 hours and 45 minutes, with the overall travel time, including layover, totaling approximately 5 hours.
  • American Airlines: Offering a full-service experience, American Airlines presents one-stop flights with one-way fares typically ranging from $120 to $395. It accounts for roughly 28% of the departures on this route, with a flight time of 3 hours and 45 minutes, leading to a total travel time of around 5 hours, including layovers.
  • United: United Airlines, another full-service option, provides one-stop service with one-way fares generally between $135 and $470. This airline makes up about 27% of all departures for this route, featuring a flight duration of 3 hours and 45 minutes, with the entire journey, including a layover, taking about 5 hours.

Best time to fly from Syracuse (SYR) to Des Moines (DSM)

The most popular months for travelers flying from Syracuse to Des Moines are May, June, and July, when peak temperatures in Des Moines reach up to 74.8°F in July. If you prefer quieter travel, consider August, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 73.4°F. For better deals, July usually offers the lowest average one-way fare around $202. Flight availability peaks in May, with approximately 11 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: July usually offers good deals with average one-way fare around $202, roughly 15% cheaper than the yearly average.
  • More budget-friendly months to fly: February, October, and April typically offer average one-way fares of around $206.
  • Most flight options: May has the highest number of flights from Syracuse to Des Moines, with approximately 11 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January21.7°F (-5.7°C)Low8$240
February24.1°F (-4.4°C)Average8$203
March39.6°F (4.2°C)Average7$300
April50.2°F (10.1°C)Average8$210
May61.3°F (16.3°C)High11$226
June71.8°F (22.1°C)High9$218
July74.8°F (23.8°C)High9$202
August73.4°F (23.0°C)Low7$229
September66.9°F (19.4°C)Average9$232
October53.2°F (11.8°C)Average9$208
November40.5°F (4.7°C)Low7$354
December29.3°F (-1.5°C)Average9$231

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative routes from Syracuse (SYR) to Des Moines (DSM)

  • Rome to Des Moines (RME-DSM): Griffiss International Airport (RME) lies approximately 36 miles from Hancock International Airport (SYR).
  • Utica to Des Moines (UCA-DSM): Oneida County Airport (UCA) is located about 37 miles from Hancock International Airport (SYR).

How to find the best prices for flights from Syracuse (SYR) to Des Moines (DSM)

Getting some of the best deals on flights from Syracuse to Des Moines is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are usually found when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Afternoon departures (12 PM to 6 PM) often offer lower prices, while morning flights (5 AM to 12 PM) are the most popular. Additionally, flying on Monday typically yields cheaper prices, though Friday remains the busiest travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Des Moines International Airport from Hancock International Airport

Des Moines welcomes travelers from Syracuse with a range of transport options based on price, convenience, and proximity. For departures, Hancock International Airport is roughly a 10-minute drive (covering about 8 miles) from central Syracuse. Here's how to reach Des Moines efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Des Moines, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Des Moines International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Des Moines International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $309 and cheap return flights from $329 Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights usually range from $273 to $911, and return flights typically cost between $347 and $1420. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from SYR to DSM is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter SYR to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from Syracuse, NY (SYR) to Des Moines, IA (DSM), with round-trip tickets starting from around $777 with a layover in Logan Intl. (BOS). Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Hancock International Airport (SYR) in Syracuse to Des Moines International Airport (DSM) typically departs at around 5:05 AM, operated by American Airlines. This seasonal service is available in January, allowing you to make the most of your day in Des Moines. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The most popular departure times for flights from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) are in the early morning, from 6am to 9am. About 36% of passengers prefer this time window. Many major carriers, including Delta, United and American Airlines, offer flights during this window. This timing works well because it allows you to start your day early and arrive in Des Moines with plenty of time to explore.
How long does it take to fly from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Flights from SYR to DSM with one stop typically take around 5 hours 20 minutes, covering approximately 901 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
First class seats are offered on the SYR to DSM route. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Hancock Intl. (SYR)?
If you're planning to travel to Des Moines from Hancock Intl. (SYR), you can fly into Des Moines Intl. (DSM) Some flights may connect through major hubs like Washington Dulles Intl. (IAD), Logan Intl. (BOS), Liberty Intl. (EWR) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Syracuse, NY (SYR-Hancock Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Hancock Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$328
Distance
900 mi

Book with confidence

Syracuse to Des Moines Flights

The cheapest times to fly from Syracuse to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to Des Moines are during the month of October. You can find some of the cheapest flights from Syracuse to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Syracuse to Des Moines

Sunday is one of the best days to book for cheap flights from Syracuse to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Syracuse to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $309 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Syracuse to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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