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$163 Cheap Flights from Greenville (GSP) to Des Moines (DSM)

View $163 flight on Mon, Dec 7, 2026Opens in a new window

Popular airlines from Greenville-Spartanburg Intl. Airport (GSP) to Des Moines International Airport (DSM)

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Cheap Flights from Greenville to Des Moines (GSP-DSM)

Prices were available within the past 7 days and start at $163 for one-way flights and $325 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$325 Roundtrip, found 12 hours ago
$325
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $325 found 12 hours ago
Delta
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$325 Roundtrip, found 12 hours ago
$325
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $325 found 12 hours ago
United
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$325 Roundtrip, found 12 hours ago
$325
Roundtrip
found 12 hours ago
Select United flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $325 found 12 hours ago
United
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$330 Roundtrip, found 12 hours ago
$330
Roundtrip
found 12 hours ago
Select United flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $330 found 12 hours ago
United
Wed, Sep 30 - Mon, Oct 5
GSP
Greenville
DSM
Des Moines
$335 Roundtrip, found 16 hours ago
$335
Roundtrip
found 16 hours ago
Select United flight, departing Wed, Sep 30 from Greenville to Des Moines, returning Mon, Oct 5, priced at $335 found 16 hours ago
Southwest Airlines
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$335 Roundtrip, found 12 hours ago
$335
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $335 found 12 hours ago
Delta
Fri, Nov 13 - Mon, Nov 16
GSP
Greenville
DSM
Des Moines
$340 Roundtrip, found 19 hours ago
$340
Roundtrip
found 19 hours ago
Select Delta flight, departing Fri, Nov 13 from Greenville to Des Moines, returning Mon, Nov 16, priced at $340 found 19 hours ago
Southwest Airlines
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$341 Roundtrip, found 12 hours ago
$341
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $341 found 12 hours ago
Southwest Airlines
Tue, Oct 13 - Tue, Oct 20
GSP
Greenville
DSM
Des Moines
$341 Roundtrip, found 12 hours ago
$341
Roundtrip
found 12 hours ago
Select Southwest Airlines flight, departing Tue, Oct 13 from Greenville to Des Moines, returning Tue, Oct 20, priced at $341 found 12 hours ago
Southwest Airlines
Fri, Nov 13 - Mon, Nov 16
GSP
Greenville
DSM
Des Moines
$345 Roundtrip, found 19 hours ago
$345
Roundtrip
found 19 hours ago
Select Southwest Airlines flight, departing Fri, Nov 13 from Greenville to Des Moines, returning Mon, Nov 16, priced at $345 found 19 hours ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $497
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $497

Find the cheapest month to fly from Greenville (GSP) to Des Moines (DSM)

February is typically the cheapest month to fly

From $232 - $386 per traveler.

What you need to know for your flight from Greenville-Spartanburg Intl. to Des Moines Intl.

Greenville (GSP) to Des Moines (DSM) at a glance

Travel from Greenville-Spartanburg International Airport (GSP) to Des Moines International Airport (DSM) with a selection of airlines offering various routes on this domestic short-haul journey. Discover options for flights from Greenville that cater to different budgets and schedules, whether you seek direct flights from Greenville or prefer connecting itineraries. As you plan your visit to Des Moines, take the time to compare airlines to find the best itinerary for exploring the city’s renowned attractions and neighborhoods.

  • Fastest flight duration: around 3h 30m in-flight, plus roughly 1h 15m layover with one stop
  • Route distance: roughly 800 miles (1,290 km)
  • Flights per week: around 8 departures on average
  • Typical fares (one-way): economy tickets often range from $120–$385, depending on seasonality and how far ahead you book

Flights from Greenville-Spartanburg International Airport (GSP) to Des Moines International Airport (DSM)

Based on recent traveler bookings, here are the top airlines favored for one-stop travel from Greenville to Des Moines. Common layover points include Charlotte-Douglas International Airport (CLT) with a layover of about 1 hour and 15 minutes, Hartsfield-Jackson Atlanta International Airport (ATL) also with a 1 hour and 15 minute layover, and O'Hare International Airport (ORD) with a similar duration. These options allow you to tailor your journey by balancing price, total travel time, and cabin class to find the ideal itinerary.

  • American Airlines: This established full-service airline provides one-stop journeys, with one-way prices generally falling between $120 and $385. It represents about 51% of the flights on this route, featuring an in-flight duration of 3 hours and 30 minutes, totaling around 5 hours when including the layover.
  • Delta: Another major full-service airline, Delta offers one-stop options with one-way fares typically ranging from $120 to $430. It constitutes roughly 31% of the departures on this route, boasting an in-flight time of 3 hours and 30 minutes, resulting in a total travel time of about 5 hours, including layover.
  • United: United Airlines, a full-service provider, offers one-stop flights with one-way fares usually between $150 and $385. It accounts for approximately 18% of the departures along this route, with an in-flight time of 3 hours and 30 minutes and a total journey time of around 5 hours, factoring in the layover.

Best time to fly from Greenville (GSP) to Des Moines (DSM)

The most popular months for travelers flying from Greenville to Des Moines are March, June, and July, when peak temperatures in Des Moines reach up to 74.8°F in July. If you prefer quieter travel, consider December, the least busy and relatively cheaper time to visit with fewer crowds and temperatures around 29.3°F. For better deals, August usually offers the lowest average one-way fare around $173. Flight availability peaks in May, July, October, and November, with approximately 10 flights per week, making it easier to find convenient departure times.

  • Cheapest time to fly: August usually offers good deals with average one-way fare around $173, roughly 21% cheaper than the yearly average.
  • Another budget-friendly time to fly: September typically offers an average one-way fare of around $177.
  • Most flight options: May, July, October, and November have the highest number of flights from Greenville to Des Moines, with approximately 10 flights per week, giving you more flexibility in scheduling your trip.
calendar iconMonthtemperature iconTemperaturecrowd level iconDemandflights iconWeekly Flightsprice iconAverage one-way Fare
January21.7°F (-5.7°C)Moderately Low7$235
February24.1°F (-4.4°C)Moderately Low7$237
March39.6°F (4.2°C)Moderately High8$290
April50.2°F (10.1°C)Average8$235
May61.3°F (16.3°C)Average10$201
June71.8°F (22.1°C)Moderately High8$211
July74.8°F (23.8°C)Moderately High10$214
August73.4°F (23.0°C)Average9$173
September66.9°F (19.4°C)Average8$177
October53.2°F (11.8°C)Average10$213
November40.5°F (4.7°C)Average10$250
December29.3°F (-1.5°C)Moderately Low7$194

*Average one-way fare is based on Expedia flight booking data from January 2025 to April 2026 for the specified route and travel class and may change depending on availability, dates, and demand.

Alternative route from Greenville (GSP) to Des Moines (DSM)

  • Greenville to Fort Dodge (GSP-FOD): Fort Dodge Regional Airport (FOD) is approximately 76 miles from Des Moines International Airport (DSM), providing travelers with convenient access to the region.

How to find the best prices for flights from Greenville (GSP) to Des Moines (DSM)

Getting some of the best deals on flights from Greenville to Des Moines is all about timing and flexibility. Here are some key tips to help you save:

  1. Best times to book and fly: cheaper fares are typically found when booking at least two months in advance, although most travelers tend to book between two to eight weeks ahead. Morning departures, from 5 a.m. to 12 p.m., usually offer lower prices and are also the most popular flight times. Additionally, flying on Saturday often results in cheaper prices, while Friday remains the most popular travel day.
  2. Set up price alerts: stay updated on price changes by using Expedia's Price Tracker. Receive alerts when fares drop for your selected route.
  3. Bundle and save: bundle your flight and hotel to save on Expedia, or unlock a hotel deal after booking your flight.*
  4. Compare flight options: use Expedia's search tool to compare airlines, routes, direct vs. non-direct flights, and flight times. You can also sort by price to find the most affordable options.
  5. Stay flexible with dates: being open to different travel days can sometimes help you find better prices on flights and hotels.
  6. Think about luggage: nowadays, it's important to check the airline's baggage policies to find the best value. That may be paying for an additional carry-on bag or booking a ticket with checked luggage included. Either way, double-check your allowance before confirming your booking to avoid excess baggage fees at the airport.

*Members only. Savings vary and are not available on all bundles. Select hotels.

Arriving at Des Moines International Airport from Greenville-Spartanburg International Airport

Des Moines welcomes travelers from Greenville with a range of transport options based on price, convenience, and proximity. For departures, Greenville-Spartanburg International Airport is roughly a 20-minute drive (covering about 16 miles) from central Greenville. Here's how to reach Des Moines efficiently:

  • Hotel transfer: Transfers offer a convenient way to reach your hotel in Des Moines, with private rides that can be arranged in advance.
  • Car rental: Renting a car from Des Moines International Airport is a great option if you plan to explore and sightsee beyond the city. Browse cheap car rentals at Des Moines International Airport on Expedia.
  • Taxi/ride-hailing: Taxis and ride-hailing services may be available from designated pickup areas outside the terminal, check locally on arrival.

Frequently asked questions

How much does a flight from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $163 and cheap return flights from $325 Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights generally range between $159 and $600, and roundtrip flights usually range from $355 to $1103. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The cheapest month to fly from GSP to DSM is October when demand is low. Traveling in off-peak or shoulder months is usually a good way to secure cheap tickets, just remember to avoid flying during holidays if you're able to. Use the calendar view in your search to see which months have low fares on this route.
Which airlines fly direct from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter GSP to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
What is the earliest flight from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Greenville-Spartanburg International Airport (GSP) to Des Moines International Airport (DSM) generally departs at around 5:00 AM, operated by American Airlines. This seasonal service is available in October, helping you make the most of your day in Des Moines. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
For flights from Greenville, SC (GSP) to Des Moines, IA (DSM), the most popular departure times are in the early morning, from 6am to 9am. This time window accounts for about 33% of total traffic. Airlines such as American Airlines, Delta, and United Airlines operate flights during this period. Many travelers prefer this timing as it allows them to start their day early and arrive in Des Moines with plenty of time to explore.
How long does it take to fly from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Flights from GSP to DSM with one stop typically take around 6 hours 30 minutes, covering approximately 771 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
First class is available on flights from GSP to DSM. First class cabins are available on:

  • American Airlines
  • Delta Air Lines
  • United Airlines

How do I earn miles on a Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Greenville-Spartanburg Intl. (GSP)?
From Greenville-Spartanburg Intl. (GSP), you can fly into Des Moines Intl. (DSM) to reach Des Moines. Some flights may connect through major hubs like Liberty Intl. (EWR), Washington Dulles Intl. (IAD), Baltimore Washington Intl. Thurgood Marshall (BWI) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your Greenville, SC (GSP-Greenville-Spartanburg Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Greenville-Spartanburg Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$324
Distance
770 mi

Book with confidence

Greenville to Des Moines Flights

The cheapest times to fly from Greenville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Greenville to Des Moines are during the month of October. You can find some of the cheapest flights from Greenville to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Greenville to Des Moines

Sunday is one of the best days to book for cheap flights from Greenville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Greenville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Greenville to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $163 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Greenville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Greenville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Greenville to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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