$168 Cheap Flights from McAllen (MFE) to Des Moines (DSM)

View $168 flight on Wed, May 20, 2026Opens in a new window

Popular airlines from Miller Intl. Airport (MFE) to Des Moines International Airport (DSM)

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Cheap Flights from McAllen to Des Moines (MFE-DSM)

Prices were available within the past 7 days and start at $168 for one-way flights and $312 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Wed, May 6 - Wed, May 13
MFE
McAllen
DSM
Des Moines
$312 Roundtrip, found 5 days ago
$312
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, May 6 from McAllen to Des Moines, returning Wed, May 13, priced at $312 found 5 days ago
American Airlines
Tue, May 19 - Tue, Jun 9
MFE
McAllen
DSM
Des Moines
$315 Roundtrip, found 1 day ago
$315
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 19 from McAllen to Des Moines, returning Tue, Jun 9, priced at $315 found 1 day ago
Delta
Wed, May 6 - Wed, May 13
MFE
McAllen
DSM
Des Moines
$320 Roundtrip, found 5 days ago
$320
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, May 6 from McAllen to Des Moines, returning Wed, May 13, priced at $320 found 5 days ago
American Airlines
Fri, May 1 - Sat, May 30
MFE
McAllen
DSM
Des Moines
$327 Roundtrip, found 4 days ago
$327
Roundtrip
found 4 days ago
Select American Airlines flight, departing Fri, May 1 from McAllen to Des Moines, returning Sat, May 30, priced at $327 found 4 days ago
Delta
Wed, Sep 2 - Tue, Sep 8
MFE
McAllen
DSM
Des Moines
$330 Roundtrip, found 6 days ago
$330
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Sep 2 from McAllen to Des Moines, returning Tue, Sep 8, priced at $330 found 6 days ago
American Airlines
Tue, May 19 - Tue, Jun 9
MFE
McAllen
DSM
Des Moines
$335 Roundtrip, found 1 day ago
$335
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 19 from McAllen to Des Moines, returning Tue, Jun 9, priced at $335 found 1 day ago
American Airlines
Tue, Apr 28 - Tue, May 5
MFE
McAllen
DSM
Des Moines
$340 Roundtrip, found 2 days ago
$340
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, Apr 28 from McAllen to Des Moines, returning Tue, May 5, priced at $340 found 2 days ago
American Airlines
Tue, May 19 - Sat, Jun 6
MFE
McAllen
DSM
Des Moines
$342 Roundtrip, found 1 day ago
$342
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, May 19 from McAllen to Des Moines, returning Sat, Jun 6, priced at $342 found 1 day ago
United
Sat, Apr 25 - Sat, May 2
MFE
McAllen
DSM
Des Moines
$345 Roundtrip, found 2 days ago
$345
Roundtrip
found 2 days ago
Select United flight, departing Sat, Apr 25 from McAllen to Des Moines, returning Sat, May 2, priced at $345 found 2 days ago
United
Tue, Apr 28 - Tue, May 5
MFE
McAllen
DSM
Des Moines
$345 Roundtrip, found 2 days ago
$345
Roundtrip
found 2 days ago
Select United flight, departing Tue, Apr 28 from McAllen to Des Moines, returning Tue, May 5, priced at $345 found 2 days ago

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $369
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $369

Frequently asked questions

How much does a flight from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) cost?
You can find cheap one-way flights from $168 and cheap return flights from $312 McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) with Expedia. One-way flights generally range between $165 and $671, and roundtrip flights usually range from $331 to $1252. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see the cheapest fares first, and use the Price Tracking tool to receive alerts when McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) ticket fares go up or down.*Typical price ranges based on flights available on Expedia in the last year. Prices include multi-airline options.
What is the cheapest month to fly from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
April is the cheapest month to fly from McAllen (MFE) to Des Moines (DSM), with average return fares around $300. This is about 30% lower than the average price throughout the year, as demand tends to be lower in spring. Other budget-friendly months include January and September.*Averages based on flights available on Expedia in the last year.
Which airlines fly direct from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Enter MFE to DSM and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
American Airlines is one of the cheapest airlines offering connecting flights from McAllen, TX (MFE) to Des Moines, IA (DSM), with round-trip tickets starting from around $457. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.*Prices based on flights available on Expedia in the last year.
How do I find cheap flights from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
To find a cheap flight from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The best time to fly from McAllen (MFE) to Des Moines (DSM) is in April or September. Average return flight prices are around $300, making these months both affordable and convenient. April brings mild weather, while September offers a pleasant transition into fall, providing a lovely travel experience.*Prices based on flights available on Expedia in the last year.
What is the earliest flight from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The earliest flight from Miller International (MFE) to Des Moines International Airport (DSM) typically departs at around 5:00 AM, operated by American Airlines. This seasonal service is available in March, giving you an early start to your trip to Iowa. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What are the most popular departure times for flights from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
The most popular departure times for flights from McAllen, TX (MFE) to Des Moines, IA (DSM) are in the early morning, from 3am to 6am. About 27% of passengers prefer this time window. Many major carriers, including Delta Air Lines, American Airlines, and United Airlines, offer flights during this window. This timing works well because it allows you to arrive in Des Moines early and make the most of your day.
How long does it take to fly from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
Flights from MFE to DSM with one stop typically take around 5 hours 20 minutes, covering approximately 1,093 miles. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
First class is available on flights from MFE to DSM. First class cabins are available on:

  • Delta Air Lines
  • American Airlines
  • United Airlines

How do I earn miles on a McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight with Expedia?
It's easy to earn miles on a McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Des Moines from Miller Intl. (MFE)?
From Miller Intl. (MFE), you can fly into Des Moines Intl. (DSM) to reach Des Moines. Some flights may connect through major hubs like George Bush Intercontinental (IAH), Austin-Bergstrom Intl. (AUS), Dallas-Fort Worth Intl. (DFW) before reaching Des Moines. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) at the last minute?
Typically, booking a last minute flight from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight and hotel package?
Securing a McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) Des Moines Vacation Packages is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.)?
If you booked your McAllen, TX (MFE-Miller Intl.) to Des Moines, IA (DSM-Des Moines Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Miller Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$311
Distance
1092 mi

Book with confidence

McAllen to Des Moines Flights

The cheapest times to fly from McAllen to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from McAllen to Des Moines are during the month of May. You can find some of the cheapest flights from McAllen to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from McAllen to Des Moines

Sunday is one of the best days to book for cheap flights from McAllen to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from McAllen to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from McAllen to Des Moines in 2026. You can also book with separate airlines for your outbound and return journeys, from $168 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap McAllen to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your McAllen to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

McAllen to Des Moines Flights

*Flight schedules are subject to change.

*Available to One Key members.

 

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