$120 Cheap Flights from San Antonio (SAT) to Des Moines (DSM)

View $120 flight on Mon, Oct 13, 2025Opens in a new window

Popular airlines from San Antonio International Airport (SAT) to Des Moines International Airport (DSM)

Cheap Flights from San Antonio to Des Moines (SAT-DSM)

Prices were available within the past 7 days and start at $120 for one-way flights and $215 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Nov 17 - Wed, Nov 19
SAT
San Antonio
DSM
Des Moines
$215 Roundtrip, found 5 days ago
$215
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Nov 17 from San Antonio to Des Moines, returning Wed, Nov 19, priced at $215 found 5 days ago
Delta
Mon, Nov 17 - Wed, Nov 19
SAT
San Antonio
DSM
Des Moines
$224 Roundtrip, found 5 days ago
$224
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Nov 17 from San Antonio to Des Moines, returning Wed, Nov 19, priced at $224 found 5 days ago
Southwest Airlines
Tue, Oct 28 - Wed, Nov 5
SAT
San Antonio
DSM
Des Moines
$228 Roundtrip, found 8 hours ago
$228
Roundtrip
found 8 hours ago
Select Southwest Airlines flight, departing Tue, Oct 28 from San Antonio to Des Moines, returning Wed, Nov 5, priced at $228 found 8 hours ago
American Airlines
Sun, Feb 15 - Wed, Feb 18
SAT
San Antonio
DSM
Des Moines
$235 Roundtrip, found 4 days ago
$235
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sun, Feb 15 from San Antonio to Des Moines, returning Wed, Feb 18, priced at $235 found 4 days ago
Delta
Wed, Nov 12 - Sat, Nov 15
SAT
San Antonio
DSM
Des Moines
$237 Roundtrip, found 2 days ago
$237
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, Nov 12 from San Antonio to Des Moines, returning Sat, Nov 15, priced at $237 found 2 days ago
American Airlines
Mon, Nov 17 - Wed, Nov 19
SAT
San Antonio
DSM
Des Moines
$240 Roundtrip, found 5 days ago
$240
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Nov 17 from San Antonio to Des Moines, returning Wed, Nov 19, priced at $240 found 5 days ago
Southwest Airlines
Thu, Oct 30 - Sat, Nov 1
SAT
San Antonio
DSM
Des Moines
$248 Roundtrip, found 4 days ago
$248
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, Oct 30 from San Antonio to Des Moines, returning Sat, Nov 1, priced at $248 found 4 days ago
Southwest Airlines
Thu, Oct 30 - Sat, Nov 1
SAT
San Antonio
DSM
Des Moines
$255 Roundtrip, found 4 days ago
$255
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Thu, Oct 30 from San Antonio to Des Moines, returning Sat, Nov 1, priced at $255 found 4 days ago
Frontier Airlines
Tue, Oct 7 - Wed, Oct 22
SAT
San Antonio
DSM
Des Moines
$284 Roundtrip, found 1 day ago
$284
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Tue, Oct 7 from San Antonio to Des Moines, returning Wed, Oct 22, priced at $284 found 1 day ago
United
Wed, Oct 22 - Wed, Oct 29
SAT
San Antonio
DSM
Des Moines
$297 Roundtrip, found 8 hours ago
$297
Roundtrip
found 8 hours ago
Select United flight, departing Wed, Oct 22 from San Antonio to Des Moines, returning Wed, Oct 29, priced at $297 found 8 hours ago

Find the cheapest month to fly from San Antonio (SAT) to Des Moines (DSM)

October is typically the cheapest month to fly

From $215 - $602 per traveler.

Alternative airports near Des Moines

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Des Moines Intl. DSM. Cheapest and Closest option available. Average driving time to city center is 10 minutes. Flights from $333
DSM
Des Moines Intl.
CheapestClosest
Average driving time to city center10 min
Flights from $333
Flights from San Antonio (SAT) to Des Moines (DSM)
Origin airport
San Antonio Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, United
Roundtrip price
$214
Distance
872 mi

San Antonio to Des Moines Flights

The cheapest times to fly from San Antonio to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Antonio to Des Moines are during the month of November. You can find some of the cheapest flights from San Antonio to Des Moines with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from San Antonio to Des Moines

Sunday is one of the best days to book for cheap flights from San Antonio to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from San Antonio to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Antonio to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $120 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Antonio to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Antonio to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM) cost?
Grab a cheap one-way flight from $120 or cheap return flight from $215 from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM)?
November is the least expensive month to fly from SAT to DSM. Traveling during an off-peak travel window is often the key to finding better fares.
What is the cheapest airline that flies from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM)?
Use the filters on Expedia to compare different airlines and find the cheapest carrier that'll fly you from SAT to DSM. Then, sort your results by "Price (lowest to highest)" to snap up a great deal.
How many flights per day from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM)?
There aren't any daily direct flights from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM). But you can choose flights with layovers. Filter your search on Expedia to include one or two stops, and you'll be on your way in no time at all.
What day of the week has the most flights from SAT to DSM?
Usually you'll find the most flight options available on a Friday. Tuesdays tend to be the quietest.* However, this can change based on the airline, time of year and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM)?
To land at Des Moines Intl. Airport (DSM) on time, opt for a flight that takes off from San Antonio Intl. Airport (SAT) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from SAT to DSM just before your journey is generally more expensive. However, if you're flexible with your departure dates and times, you could snag a cheap last-minute fare.
Is it cheaper to book a SAT to DSM flight and hotel package?
You can save money by booking a SAT to DSM flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it's simple to manage everything in one place. After selecting your preferred flights and accommodations, consider other add-ons like activities, car rentals and tours.
Can I cancel or change the date of my flight from San Antonio Intl. Airport (SAT) to Des Moines Intl. Airport (DSM)?
In most instances, you're able to cancel or reschedule your SAT to DSM flight. However, additional charges may apply, especially if you booked over 24 hours ago. Check your itinerary for the airline's fees and policies on flight changes, or if you want more details, head to our Customer Service portal.

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*Available to One Key members.