Popular airlines from Des Moines International Airport (DSM) to Myrtle Beach Intl. Airport (MYR)
American AirlinesAmerican Airlines
DeltaDelta
UnitedUnited
Southwest AirlinesSouthwest Airlines
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Cheap Flights from Des Moines to Myrtle Beach (DSM-MYR)
Prices were available within the past 7 days and start at $136 for one-way flights and $271 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Frequently asked questions
Travel information
Travel information
Origin airport | Des Moines Intl. |
Destination airport | Myrtle Beach Intl. |
Airlines serving | American Airlines, Delta, Southwest Airlines, United |
Roundtrip price | $270 |
Distance | 969 mi |
Book with confidence
Book with confidence
The cheapest times to fly from Des Moines to Myrtle Beach
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Des Moines to Myrtle Beach are during the month of July. You can find some of the cheapest flights from Des Moines to Myrtle Beach with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Des Moines to Myrtle Beach
Sunday is one of the best days to book for cheap flights from Des Moines to Myrtle Beach: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Des Moines to Myrtle Beach
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Des Moines to Myrtle Beach in 2025. You can also book with separate airlines for your outbound and return journeys, from $136 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Des Moines to Myrtle Beach flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Des Moines to Myrtle Beach airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Flights
- Alaska Airlines
- Air Canada
- Delta
- KLM
- Qatar Airways
- Finnair
- Aer Lingus
- Korean Air
- British Airways
- United
- Frontier Airlines
- Lufthansa
- Aeromexico
- Air France
- American Airlines
- All Nippon Airways
- Delta Des Moines (DSM) to Los Angeles (LAX) flights
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- United Des Moines (DSM) to Newark Liberty Intl. Airport (EWR) flights
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- Delta Minneapolis (MSP) to Myrtle Beach (MYR) flights
- Spirit Airlines Fort Lauderdale (FLL) to Myrtle Beach (MYR) flights
- American Airlines Chicago (ORD) to Myrtle Beach (MYR) flights
- Delta Hartford (BDL) to Myrtle Beach (MYR) flights
- Spirit Airlines Detroit (DTW) to Myrtle Beach (MYR) flights
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- Flights from Newark Liberty Intl. Airport (EWR) to Myrtle Beach (MYR)
- Flights from Dallas (DFW) to Myrtle Beach (MYR)
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